CMPX / Compass Therapeutics, Inc. - SEC-Einreichungen, Jahresbericht, Proxy Statement

Compass Therapeutics, Inc.
US ˙ NasdaqCM ˙ US20454B1044

Basisstatistiken
CIK 1738021
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Compass Therapeutics, Inc.
SEC Filings (Chronological Order)
Auf dieser Seite finden Sie eine vollständige, chronologische Liste der SEC-Einreichungen, mit Ausnahme der Eigentumseinreichungen, die wir an anderer Stelle bereitstellen.
May 5, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 5, 2026 Compass Therapeutics,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 5, 2026 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commission

May 5, 2026 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2026 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

May 5, 2026 EX-99.1

Compass Therapeutics Reports 2026 First Quarter Financial Results and Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Reports 2026 First Quarter Financial Results and Provides Corporate Update As recently announced, tovecimig (DLL4 x VEGF-A bispecific antibody) in combination with paclitaxel demonstrated a highly statistically significant improvement in progression-free survival (PFS) versus paclitaxel alone as well as clear signals of a survival benefit in a Phase 2/3 study of p

April 29, 2026 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934         Filed by the Registrant ☒     Filed by a party other than the Registrant  ☐         Check the appropriate box:  ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by R

April 29, 2026 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy Stat

April 29, 2026 ARS

ARS

2025 Annual Report i Table of Contents Page PART I Item 1. Business 5 Item 1A. Risk Factors 38 Item 1B. Unresolved Staff Comments 89 Item 1C. Cybersecurity 89 Item 2. Properties 90 Item 3. Legal Proceedings 90 Item 4. Mine Safety Disclosures 90 PART II Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities 91 Item 6. [Reserved] 91 Item

April 27, 2026 EX-99.2

Corporate Presentation Nasdaq: CMPX April 27, 2026 This presentation has been prepared by Compass Therapeutics, Inc . ("we," "us," "our," or the “Company”) . Statements contained herein are made as of the date of this presentation unless stated other

Exhibit 99.2 Corporate Presentation Nasdaq: CMPX April 27, 2026 This presentation has been prepared by Compass Therapeutics, Inc . ("we," "us," "our," or the “Company”) . Statements contained herein are made as of the date of this presentation unless stated otherwise, and this presentation shall not under any circumstances create an implication that the information contained herein is correct as o

April 27, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 27, 2026 Compass Therapeuti

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 27, 2026 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commissi

April 27, 2026 EX-99.1

Tovecimig Demonstrates Statistically Significant Benefit in COMPANION-002 Randomized Phase 2/3 Study in Patients with Biliary Tract Cancer

EXHIBIT 99.1 Tovecimig Demonstrates Statistically Significant Benefit in COMPANION-002 Randomized Phase 2/3 Study in Patients with Biliary Tract Cancer Tovecimig (a DLL4 x VEGF-A bispecific antibody) in combination with paclitaxel demonstrated a highly statistically significant improvement versus paclitaxel alone in the key secondary endpoint of median progression-free survival (PFS) of 4.7 months

March 12, 2026 EX-FILING FEES

Table 1: Newly Registered Securities

Calculation of Filing Fee Tables S-8 Compass Therapeutics, Inc. Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee 1 Equity Common Stock, par value $0.0001 per share, 2020 Stock Option and Incentive Plan Other 7,132,940 $ 5.41 $ 3

March 12, 2026 S-8

As filed with the Securities and Exchange Commission on March 12, 2026

S-8 As filed with the Securities and Exchange Commission on March 12, 2026 Registration No.

March 5, 2026 EX-10.18

COMPASS THERAPEUTICS, INC. EMPLOYMENT AGREEMENT

Exhibit 10.18 COMPASS THERAPEUTICS, INC. EMPLOYMENT AGREEMENT This Employment Agreement (“Agreement”), dated as of January 1, 2026, is made between Compass Therapeutics, Inc., a Delaware corporation (including all wholly owned subsidiaries of Compass Therapeutics, Inc., the “Company”), and Cynthia Sirard (the “Executive”). Except with respect to the Restrictive Covenants Agreement and the Equity D

March 5, 2026 EX-99.1

Compass Therapeutics Reports 2025 Financial Results and Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Reports 2025 Financial Results and Provides Corporate Update In the Phase 2/3 COMPANION-002 study of tovecimig (DLL4 x VEGF-A bispecific antibody) in patients with biliary tract cancer, the prespecified event threshold of 80% overall survival (OS) events was reached in Q1 2026; as a result, the analyses of progression-free survival (PFS) and OS are expected to be

March 5, 2026 EX-10.17

COMPASS THERAPEUTICS, INC. EMPLOYMENT AGREEMENT

Exhibit 10.17 COMPASS THERAPEUTICS, INC. EMPLOYMENT AGREEMENT This Employment Agreement (“Agreement”), dated as of January 1, 2026, is made between Compass Therapeutics, Inc., a Delaware corporation (including all wholly owned subsidiaries of Compass Therapeutics, Inc., the “Company”), and Arjun Prasad (the “Executive”). Except with respect to the Restrictive Covenants Agreement and the Equity Doc

March 5, 2026 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 000-55939 Compass Therape

March 5, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 5, 2026 Compass Therapeutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 5, 2026 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commissio

March 5, 2026 EX-10.16

COMPASS THERAPEUTICS, INC. 2025 INDUCEMENT PLAN

Exhibit 10.16 COMPASS THERAPEUTICS, INC. 2025 INDUCEMENT PLAN SECTION 1. GENERAL PURPOSE OF THE PLAN; DEFINITIONS The name of the plan is the Compass Therapeutics, Inc. 2025 Inducement Plan (the “Plan”). The purpose of the Plan is to enable Compass Therapeutics, Inc. (the “Company”) and its Affiliates to grant equity awards to induce highly-qualified prospective officers and employees who are Elig

January 6, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 6, 2026 Compass Therapeut

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 6, 2026 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commiss

January 6, 2026 EX-99.1

Compass Therapeutics Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Provides Corporate Update The analyses of progression-free survival (PFS) and overall survival (OS) remain on track for late Q1 2026 in the ongoing Phase 2/3 COMPANION-002 study of tovecimig (DLL4 x VEGF-A bispecific antibody) in patients with advanced biliary tract cancer (BTC). In the ongoing Phase 1 dose-escalation study of CTX-8371 (PD-1 x PD-L1 bispecific ant

January 5, 2026 CORRESP

COMPASS THERAPEUTICS, INC. 80 GUEST STREET, SUITE 601 BOSTON, MASSACHUSETTS 02135

CORRESP COMPASS THERAPEUTICS, INC. 80 GUEST STREET, SUITE 601 BOSTON, MASSACHUSETTS 02135 VIA EDGAR January 5, 2026 Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Compass Therapeutics, Inc. Registration Statement on Form S-3 (File No. 333-292491) Acceleration Request: Requested Date: January 7, 2026 Requested Time: 10:00 A.M. Easter

January 2, 2026 LETTER

LETTER

January 2, 2026 Barry Shin Chief Financial Officer Compass Therapeutics, Inc. 80 Guest Street Suite 601 Boston, Massachusetts 02135 Re: Compass Therapeutics, Inc. Registration Statement on Form S-3 Filed December 30, 2025 File No. 333-292491 Dear Barry Shin: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding

December 31, 2025 DEL AM

December 31, 2025

DEL AM December 31, 2025 Filed via EDGAR Securities and Exchange Commission 100 F Street, NE Washington, DC 20549 Attn: Division of Corporation Finance Re: Compass Therapeutics, Inc.

December 30, 2025 EX-1.2

COMPASS THERAPEUTICS, INC. Shares of Common Stock ($0.0001 par value per share) SALES AGREEMENT

EX-1.2 Exhibit 1.2 COMPASS THERAPEUTICS, INC. Shares of Common Stock ($0.0001 par value per share) SALES AGREEMENT December 30, 2025 LEERINK PARTNERS LLC 1301 Avenue of the Americas, 12th Floor New York, New York 10019 CANTOR FITZGERALD & CO. 110 East 59th Street New York, NY 10022 Ladies and Gentlemen: Compass Therapeutics, Inc., a Delaware corporation (the “Company”), confirms its agreement (thi

December 30, 2025 EX-FILING FEES

Security Type

Calculation of Filing Fee Tables S-3 Compass Therapeutics, Inc. Table 1: Newly Registered and Carry Forward Securities ☐Not Applicable Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward

December 30, 2025 S-3

As filed with the Securities and Exchange Commission on December 30, 2025.

S-3 Table of Contents As filed with the Securities and Exchange Commission on December 30, 2025.

December 30, 2025 EX-4.3

COMPASS THERAPEUTICS, INC. Dated as of [•], 20_____ Debt Securities

EX-4.3 Exhibit 4.3 COMPASS THERAPEUTICS, INC. Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [•], 20 Debt Securities TABLE OF CONTENTS Page ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 4 Section 2.01 Designation and Terms of Securities 4 Section 2.02 Form of Securities and Trustee’s Certific

November 5, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

November 5, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 5, 2025 Compass Therapeu

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 5, 2025 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commis

November 5, 2025 EX-99.1

Compass Therapeutics Reports Third Quarter 2025 Financial Results and Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Reports Third Quarter 2025 Financial Results and Provides Corporate Update Based on a continuing trend of decreased mortality in the ongoing Phase 2/3 COMPANION-002 study of tovecimig (DLL4 x VEGF-A bispecific antibody) in patients with advanced biliary tract cancer (BTC), the analyses of overall survival (OS) and progression-free survival (PFS) are expected in la

August 13, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 12, 2025 COMPASS THERAPEUT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 12, 2025 COMPASS THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commiss

August 13, 2025 EX-1.1

33,290,000 Shares of Common Stock Pre-Funded Warrants to Purchase 6,710,000 Shares COMPASS THERAPEUTICS, INC. UNDERWRITING AGREEMENT

EX-1.1 Exhibit 1.1 33,290,000 Shares of Common Stock and Pre-Funded Warrants to Purchase 6,710,000 Shares COMPASS THERAPEUTICS, INC. UNDERWRITING AGREEMENT August 12, 2025 JEFFERIES LLC PIPER SANDLER & CO. GUGGENHEIM SECURITIES, LLC As Representatives of the several Underwriters c/o JEFFERIES LLC 520 Madison Avenue New York, New York 10022 c/o PIPER SANDLER & CO. 350 North 5th Street, Suite 1000 M

August 13, 2025 EX-99.1

Compass Therapeutics Announces Proposed Public Offering

EX-99.1 Exhibit 99.1 Compass Therapeutics Announces Proposed Public Offering BOSTON, August 12, 2025 – Compass Therapeutics, Inc. (“Compass”) (Nasdaq: CMPX), a clinical-stage, oncology-focused biopharmaceutical company developing proprietary antibody-based therapeutics to treat multiple human diseases, today announced the launch of an underwritten public offering of its common stock and, in lieu o

August 13, 2025 424B5

33,290,000 Shares of Common Stock Pre-Funded Warrants to Purchase 6,710,000 Shares of Common Stock

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-281891 PROSPECTUS SUPPLEMENT (To Prospectus Dated September 6, 2024) 33,290,000 Shares of Common Stock Pre-Funded Warrants to Purchase 6,710,000 Shares of Common Stock We are offering 33,290,000 shares of our common stock and, in lieu of common stock to certain investors that so choose, pre-funded warrants to purchase 6,

August 13, 2025 EX-4.1

FORM OF PRE-FUNDED WARRANT TO PURCHASE COMMON STOCK

EX-4.1 Exhibit 4.1 FORM OF PRE-FUNDED WARRANT TO PURCHASE COMMON STOCK Number of Shares: [   ] (subject to adjustment) Warrant No.   Original Issue Date: [ ], 2025 COMPASS THERAPEUTICS, INC. Compass Therapeutics, Inc., a Delaware corporation (the “Company”), hereby certifies that, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, [ ] or its register

August 13, 2025 EX-99.2

Compass Therapeutics Announces Pricing of Upsized $120 Million Public Offering

EX-99.2 Exhibit 99.2 Compass Therapeutics Announces Pricing of Upsized $120 Million Public Offering BOSTON, August 12, 2025 – Compass Therapeutics, Inc. (“Compass”) (Nasdaq: CMPX), a clinical-stage, oncology-focused biopharmaceutical company developing proprietary antibody-based therapeutics to treat multiple human diseases, today announced the pricing of an underwritten public offering of 33,290,

August 12, 2025 424B5

SUBJECT TO COMPLETION, DATED AUGUST 12, 2025

424B5 Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-281891 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been filed with the Securities and Exchange Commission and is effective. This preliminary prospectus supplement and the accompanying prospectus are not an offer to

August 11, 2025 EX-99.3

Corporate Presentation Nasdaq: CMPX August 2025 This presentation has been prepared by Compass Therapeutics, Inc . ("we," "us," "our," or the “Company”) . Statements contained herein are made as of the date of this presentation unless stated otherwis

Exhibit 99.3 Corporate Presentation Nasdaq: CMPX August 2025 This presentation has been prepared by Compass Therapeutics, Inc . ("we," "us," "our," or the “Company”) . Statements contained herein are made as of the date of this presentation unless stated otherwise, and this presentation shall not under any circumstances create an implication that the information contained herein is correct as of a

August 11, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

August 11, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2025 Compass Therapeut

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 11, 2025 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commiss

August 11, 2025 EX-99.2

This presentation has been prepared by Compass Therapeutics, Inc . ("we," "us," "our," or the “Company”) . Statements contained herein are made as of the date of this presentation unless stated otherwise, and this presentation shall not under any cir

Exhibit 99.2 This presentation has been prepared by Compass Therapeutics, Inc . ("we," "us," "our," or the “Company”) . Statements contained herein are made as of the date of this presentation unless stated otherwise, and this presentation shall not under any circumstances create an implication that the information contained herein is correct as of any time after such date or that information will

August 11, 2025 EX-99.1

Compass Therapeutics Reports 2025 Second Quarter Financial Results and Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Reports 2025 Second Quarter Financial Results and Provides Corporate Update In the ongoing Phase 2/3 study of tovecimig (DLL4 x VEGF-A bispecific antibody) in patients with advanced biliary tract cancer, fewer deaths have been observed than originally projected. We believe this may suggest that tovecimig could be affecting overall survival in the patient populatio

June 12, 2025 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 11, 2025 COMPASS THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commissio

May 8, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 8, 2025 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commission

May 8, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

May 8, 2025 EX-99.1

Compass Therapeutics Reports 2025 First Quarter Financial Results and Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Reports 2025 First Quarter Financial Results and Provides Corporate Update Tovecimig (DLL4 x VEGF-A bispecific antibody) met the primary endpoint in the ongoing randomized Phase 2/3 Study in patients with biliary tract cancer (BTC). Achieved a 17.1% overall response rate (ORR), including one complete response, compared to a 5.3% ORR for paclitaxel alone, in patien

April 29, 2025 ARS

FORM ARS

2024 Annual Report i Table of Contents Page PART I Item 1. Business 7 Item 1A. Risk Factors 44 Item 1B. Unresolved Staff Comments 99 Item 1C. Cybersecurity 99 Item 2. Properties 100 Item 3. Legal Proceedings 100 Item 4. Mine Safety Disclosures 100 PART II Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities 101 Item 6. [Reserved] 101

April 29, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy Stat

April 29, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Definitive Proxy Stat

April 1, 2025 EX-99.1

Tovecimig (CTX-009) Meets Primary Endpoint in the Ongoing Randomized Phase 2/3 Study in Patients with Biliary Tract Cancer

EXHIBIT 99.1 Tovecimig (CTX-009) Meets Primary Endpoint in the Ongoing Randomized Phase 2/3 Study in Patients with Biliary Tract Cancer Tovecimig (a DLL4 x VEGF-A bispecific antibody) in combination with paclitaxel achieved a 17.1% overall response rate (ORR), including one complete response, compared to 5.3% ORR for paclitaxel alone, in patients with biliary tract cancer (BTC) treated in the seco

April 1, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2025 Compass Therapeutic

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 1, 2025 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commissio

April 1, 2025 EX-99.2

COMPANION - 002 Data Disclosure Presentation Nasdaq: CMPX April 1, 2025 This presentation has been prepared by Compass Therapeutics, Inc . ("we," "us," "our," or the “Company”) . Statements contained herein are made as of the date of this presentatio

Exhibit 99.2 COMPANION - 002 Data Disclosure Presentation Nasdaq: CMPX April 1, 2025 This presentation has been prepared by Compass Therapeutics, Inc . ("we," "us," "our," or the “Company”) . Statements contained herein are made as of the date of this presentation unless stated otherwise, and this presentation shall not under any circumstances create an implication that the information contained h

March 27, 2025 EX-FILING FEES

Filing Fee Table

EX-FILING FEES Exhibit 107 CALCULATION OF REGISTRATION FEE Form S-8 (Form Type) Compass Therapeutics, Inc.

March 27, 2025 S-8

As filed with the Securities and Exchange Commission on March 26, 2025

As filed with the Securities and Exchange Commission on March 26, 2025 Registration No.

February 27, 2025 EX-99.1

Compass Therapeutics Reports 2024 Financial Results and Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Reports 2024 Financial Results and Provides Corporate Update Top-line Phase 2/3 data readout for COMPANION-002, evaluating tovecimig (CTX-009 - a DLL4 x VEGF-A bispecific antibody) in patients with biliary tract cancer (BTC), is on track for the end of the first quarter 2025. Supported initiation of an Investigator Sponsored Study (IST) evaluating tovecimig in pat

February 27, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 000-55939 Compass Therape

February 27, 2025 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 27, 2025 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commi

February 27, 2025 EX-19.1

Insider Trading Compliance Policy

Exhibit 19.1 COMPASS THERAPEUTICS, INC. INSIDER TRADING COMPLIANCE POLICY Compass Therapeutics, Inc., a Delaware corporation (“Compass” or the “Company”) prohibits: ● insider trading in the Company’s securities (“Securities”)1; and ● the unauthorized disclosure of confidential information that might enable others to engage in insider trading in the Securities. Compass adopted this Insider Trading

February 4, 2025 EX-99

EX-99

EX-99 3 ITEM7.txt EXHIBIT 99: ITEM 7 BlackRock Advisors, LLC BlackRock Investment Management (UK) Limited BlackRock Asset Management Canada Limited BlackRock Fund Advisors BlackRock Institutional Trust Company, National Association BlackRock Financial Management, Inc. BlackRock Japan Co., Ltd. BlackRock Investment Management, LLC *Entity beneficially owns 5% or greater of the outstanding shares of

February 4, 2025 EX-24

EX-24

EX-24 2 PowerOfAttorney.txt EXHIBIT 24: POWER OF ATTORNEY POWER OF ATTORNEY The undersigned, BlackRock, Inc., a corporation duly organized under the laws of the State of Delaware, United States (the "Company"), does hereby make, constitute and appoint each of Eric Andruczyk, Richard Cundiff, R. Andrew Dickson, III, Spencer Fleming, Laura Hildner, David Maryles, Christopher Meade, Charles Park, Jam

January 16, 2025 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT In accordance with Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, the undersigned agree to the joint filing of a Statement on Schedule 13G (including any and all amendments thereto) with respect to the Common Stock, $0.0001 par value per share, of Compass Therapeutics, Inc. and further agree to the filing of this agreement as an exhibit

January 8, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 8, 2025 Compass Therapeut

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 8, 2025 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commiss

January 8, 2025 EX-99.1

Compass Therapeutics Provides Corporate Update and Announces Advancement of a New Drug Candidate

EXHIBIT 99.1 Compass Therapeutics Provides Corporate Update and Announces Advancement of a New Drug Candidate Top-line Phase 2/3 data readout for CTX-009, now named tovecimig (a DLL4 x VEGF-A bispecific), in patients with biliary tract cancer (BTC) is on track for end of Q1 2025. CTX-10726 (a novel PD-1 x VEGF-A bispecific) is advancing as a new drug candidate after a year of preclinical developme

December 10, 2024 EX-10.1

Employment Agreement between Compass Therapeutics, Inc. and Barry Shin, dated December 9, 2024 (incorporated by reference to Exhibit 10.1 to the Current Report on Form 8-K filed with the SEC on December 10, 2024)

Exhibit 10.1 COMPASS THERAPEUTICS, INC. EMPLOYMENT AGREEMENT This Employment Agreement (“Agreement”), dated as of December 9, 2024, is made between Compass Therapeutics, Inc., a Delaware corporation (including all wholly owned subsidiaries of Compass Therapeutics, Inc., the “Company”), and Barry Shin (the “Executive”). Except with respect to the Restrictive Covenants Agreement and the Equity Docum

December 10, 2024 8-K

Regulation FD Disclosure, Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 9, 2024 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commis

December 10, 2024 EX-99.1

Compass Therapeutics Appoints Biopharmaceutical Industry Leader Barry Shin as Chief Financial Officer

EXHIBIT 99.1 Compass Therapeutics Appoints Biopharmaceutical Industry Leader Barry Shin as Chief Financial Officer BOSTON, Dec. 10, 2024 (GLOBE NEWSWIRE) - Compass Therapeutics, Inc. (Nasdaq: CMPX), a clinical-stage, oncology-focused biopharmaceutical company developing proprietary antibody-based therapeutics to treat multiple human diseases, today announced the appointment of Barry Shin as Chief

November 14, 2024 SC 13G/A

CMPX / Compass Therapeutics, Inc. / JANUS HENDERSON GROUP PLC - JANUS CLOSEOUT Passive Investment

SC 13G/A 1 Compass093024.txt JANUS CLOSEOUT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Amendment No.: 1* Name of Issuer: COMPASS THERAPEUTICS, INC. Title of Class of Securities: Common Stock CUSIP Number: 20454B104 Date of Event Which Requires Filing of this Statement: 9/30/2024 Check the appropriate box to designa

November 12, 2024 EX-10.13

Lease Agreement, effective as of September 27, 2024, by and between Ice Box, LLC and Compass Therapeutics, Inc.

Exhibit 10.13 LEASE BETWEEN COMPASS THERAPEUTICS, INC., AS TENANT AND ICE BOX, LLC, AS LANDLORD 80 Guest Street, Brighton, MA TABLE OF CONTENTS PAGE ARTICLE 1 BASIC DATA; DEFINITIONS 1 1.1 Basic Data 1 1.2 Additional Definitions 4 1.3 Enumeration of Exhibits 7 ARTICLE 2 PREMISES AND APPURTENANT RIGHTS 8 2.1 Lease of Premises 8 2.2 Appurtenant Rights and Reservations 8 2.3 Parking 10 2.4 Shuttle Se

November 12, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 12, 2024 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commi

November 12, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

November 12, 2024 EX-99.1

Compass Therapeutics Reports 2024 Third Quarter Financial Results and Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Reports 2024 Third Quarter Financial Results and Provides Corporate Update Fully enrolled the Phase 2/3 trial of lead asset CTX-009 (DLL4 and VEGF-A bispecific antibody) in patients with biliary tract cancers (BTC); top-line data readout is on track for the end of the first quarter of 2025. Designing a Phase 2 trial of CTX-009 in combination with chemotherapy in p

September 4, 2024 CORRESP

COMPASS THERAPEUTICS, INC. 80 Guest Street Suite 601 Boston, Massachusetts 02135

COMPASS THERAPEUTICS, INC. 80 Guest Street Suite 601 Boston, Massachusetts 02135 September 4, 2024 Via EDGAR Transmission United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Compass Therapeutics, Inc.: Registration Statement on Form S-3 filed August 30, 2024 (File No. 333-281891) Ladies and Gentlemen: Pursuant to Rule 461 u

September 3, 2024 LETTER

LETTER

September 3, 2024 Thomas Schuetz Chief Executive Officer Compass Therapeutics, Inc.

August 30, 2024 S-3

As filed with the Securities and Exchange Commission on August 30, 2024.

Table of Contents As filed with the Securities and Exchange Commission on August 30, 2024.

August 30, 2024 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Compass Therapeutics, Inc.

August 30, 2024 EX-4.3

Form of Indenture

EX-4.3 Exhibit 4.3 COMPASS THERAPEUTICS, INC. Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [•], 20 Debt Securities TABLE OF CONTENTS Page ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 4 Section 2.01 Designation and Terms of Securities 4 Section 2.02 Form of Securities and Trustee’s Certific

August 30, 2024 EX-1.3

Amendment No. 1 to the Open Market Sale AgreementSM , dated August 30, 2024, by and between Compass Therapeutics, Inc. and Jefferies LLC

Exhibit 1.3 AMENDMENT NO. 1 TO THE OPEN MARKET SALE AGREEMENTSM August 30, 2024 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: This Amendment No. 1 to the Open Market Sale AgreementSM (this “Amendment”) is entered into as of the date first written above by Compass Therapeutics, Inc., a Delaware corporation (the “Company”), and Jefferies LLC (the “Agent”), who are p

August 12, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

August 12, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 12, 2024 Compass Therapeut

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 12, 2024 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commiss

August 12, 2024 EX-99.1

Compass Therapeutics Reports 2024 Second Quarter Financial Results and Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Reports 2024 Second Quarter Financial Results and Provides Corporate Update Completed enrollment of the 150 patients in the COMPANION-002 Study, a Phase 2/3 trial of CTX-009 (DLL4 and VEGF-A bispecific antibody) plus paclitaxel versus paclitaxel monotherapy in patients with previously treated, unresectable advanced metastatic or recurrent biliary tract cancers (BT

August 2, 2024 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 d854024dex991.htm EX-99.1 Exhibit 99.1 JOINT FILING AGREEMENT Pursuant to and in accordance with the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and the rules and regulations thereunder, the undersigned hereby agree to the joint filing on behalf of each of them of any filing required by such party under Section 13 of the Exchange Act or any rule or regulation thereu

August 2, 2024 SC 13G

CMPX / Compass Therapeutics, Inc. / Blackstone Holdings II L.P. - SC 13G Passive Investment

SC 13G 1 d854024dsc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Compass Therapeutics, Inc. (Name of Issuer) Common Stock, $0.0001 par value per share (Title of Class of Securities) 20454B104 (CUSIP Number) July 23, 2024 (Date of Event which Requires Filing of this Statement) Check the a

June 17, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 13, 2024 COMPASS THERAPEUTIC

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 13, 2024 COMPASS THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commissio

May 29, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy Stat

May 28, 2024 EX-10.2

Consulting Agreement, dated May 28, 2024, by and between Compass Therapeutics, Inc. and Vered Bisker-Leib, PhD

EdgarFiling Exhibit 10.2 CONSULTING AGREEMENT THIS AGREEMENT is between Vered Bisker-Leib (“Consultant”) and Compass Therapeutics, Inc. (the “Company”) (each a “Party” and collectively the “Parties”). This Agreement is made and entered into effective as of (and, as applicable, retroactive to) the “Employment Separation Date” of the Separation Agreement to which this Consulting Agreement is attache

May 28, 2024 EX-99.1

Compass Therapeutics Announces CEO Transition

EXHIBIT 99.1 Compass Therapeutics Announces CEO Transition BOSTON, May 28, 2024 (GLOBE NEWSWIRE) - Compass Therapeutics, Inc. (Nasdaq: CMPX), a clinical-stage, oncology-focused biopharmaceutical company developing proprietary antibody-based therapeutics to treat multiple human diseases, today announced that its Board of Directors has appointed Thomas Schuetz, M.D., Ph.D., President of Research and

May 28, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 28, 2024 Compass Therapeutics

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 28, 2024 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commission

May 28, 2024 EX-10.1

Separation Agreement, dated May 28, 2024, by and between Compass Therapeutics, Inc. and Vered Bisker-Leib, PhD

EdgarFiling Exhibit 10.1 May 28, 2024 PERSONAL AND CONFIDENTIAL Vered Bisker-Leib Re: Separation Agreement Dear Vered: As we have discussed, this letter confirms your separation from employment with Compass Therapeutics, Inc. (the “Company”), and your resignation from your Board and officer positions with the Company, effective on May 28, 2024 (the “Employment Separation Date”). The Company greatl

May 13, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

May 13, 2024 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2024 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commission

May 13, 2024 EX-99.1

Compass Therapeutics Reports 2024 First Quarter Financial Results and Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Reports 2024 First Quarter Financial Results and Provides Corporate Update Received FDA Fast Track Designation for the investigation of CTX-009 in combination with paclitaxel for the treatment of patients with metastatic or locally advanced biliary tract tumors. Enrollment is progressing well in COMPANION-002, a Phase 2/3 randomized study of CTX-009 (DLL4 x VEGF-A

April 29, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant  ☐ Check the appropriate box:  ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ D

April 29, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy Stat

April 29, 2024 ARS

ARS

2023 Annual ReportTable of Contents Page PART I Item 1. Business 7 Item 1A. Risk Factors 52 Item 1B. Unresolved Staff Comments 105 Item 1C. Cybersecurity 105 Item 2. Properties 106 Item 3. Legal Proceedings 106 Item 4. Mine Safety Disclosures 106 PART II Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities 107 Item 6. [Reserved] 107 I

April 25, 2024 EX-99.1

Compass Therapeutics Receives FDA Fast Track Designation for the Investigation of CTX-009 in Combination with Paclitaxel for the Treatment of Patients with Metastatic or Locally Advanced Biliary Tract Tumors That Have Been Previously Treated

EXHIBIT 99.1 Compass Therapeutics Receives FDA Fast Track Designation for the Investigation of CTX-009 in Combination with Paclitaxel for the Treatment of Patients with Metastatic or Locally Advanced Biliary Tract Tumors That Have Been Previously Treated CTX-009, the Company’s bispecific DLL4/VEGF-A antibody, in combination with paclitaxel, has shown promising clinical responses in patients with a

April 25, 2024 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 25, 2024 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commissi

March 22, 2024 SC 13D/A

CMPX / Compass Therapeutics, Inc. / ORBIMED ADVISORS LLC - AMENDMENT NO. 4 Activist Investment

SC 13D/A 1 ss3178815sc13da.htm AMENDMENT NO. 4 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 4) Compass Therapeutics, Inc. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 20454B104 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP V LLC OrbiMed Genesis GP LLC OrbiMed Capital LLC 601 Le

March 22, 2024 EX-99.1

JOINT FILING AGREEMENT

EX-99.1 2 ss3178815ex9901.htm JOINT FILING AGREEMENT Exhibit 1 JOINT FILING AGREEMENT The undersigned hereby agree that Amendment No. 4 to the Statement on Schedule 13D, dated March 21, 2024, with respect to the common stock, par value $0.0001 per share, of Compass Therapeutics, Inc. is filed on behalf of each of us pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Secur

March 21, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 21, 2024 Compass Therapeuti

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 21, 2024 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commissi

March 21, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 000-55939 Compass Therape

March 21, 2024 EX-99.1

Compass Therapeutics Reports 2023 Financial Results and Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Reports 2023 Financial Results and Provides Corporate Update Enrollment in COMPANION-002, the Phase 2/3 randomized study of CTX-009 (DLL4 x VEGF-A bispecific antibody) in patients with advanced biliary tract cancer (BTC), continues to progress well; top-line data from this study are expected by the end of 2024. Enrollment in COMPANION-003, the Phase 2 study of CTX

March 21, 2024 EX-97.1

Registrant’s Compensation Clawback Policy

Exhibit 97.1 COMPASS THERAPEUTICS, INC. COMPENSATION RECOVERY POLICY Compass Therapeutics, Inc. a Delaware corporation (“Compass” or the “Company”) has adopted this Compensation Recovery Policy (this “Policy”) as described below. 1. Overview The Policy sets forth the circumstances and procedures under which the Compass will recover Erroneously Awarded Compensation (as defined herein) from current

March 21, 2024 EX-10.10

Employment Agreement between Compass Therapeutics, Inc. and Thomas J. Schuetz, M.D., Ph.D., dated January 8, 2024

Exhibit 10.10 COMPASS THERAPEUTICS, INC. EMPLOYMENT AGREEMENT This Employment Agreement (“Agreement”), dated as of January 8, 2024, is made between Compass Therapeutics, Inc., a Delaware corporation (including all wholly-owned subsidiaries of Compass Therapeutics, Inc., the “Company”), and Thomas J. Schuetz (the “Executive”). Except with respect to the Restrictive Covenants Agreement and the Equit

March 21, 2024 EX-10.11

Employment Agreement between Compass Therapeutics, Inc. and Vered Bisker-Leib, Ph.D., M.B.A., dated January 8, 2024

Exhibit 10.11 COMPASS THERAPEUTICS, INC. EMPLOYMENT AGREEMENT This Employment Agreement (“Agreement”), dated as of January 8, 2024, is made between Compass Therapeutics, Inc., a Delaware corporation (including all wholly-owned subsidiaries of Compass Therapeutics, Inc., the “Company”), and Vered Bisker-Leib (the “Executive”). Except with respect to the Restrictive Covenants Agreement and the Equit

February 9, 2024 SC 13G/A

CMPX / Compass Therapeutics, Inc. / FMR LLC Passive Investment

SC 13G/A 1 filing.txt SCHEDULE 13G Amendment No.4 COMPASS THERAPEUTICS INC COMMON STOCK Cusip #20454B104 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [ ] Rule 13d-1(b) [x] Rule 13d-1(c) [ ] Rule 13d-1(d) Cusip #20454B104 Item 1: Reporting Person - FMR LLC Item 2: (a) [ ] (b) [ ] Item 4: Delaware Item 5: 4,550,950 Item 6: 0 Item 7: 4,551,506 Item 8: 0 It

February 7, 2024 SC 13G/A

CMPX / Compass Therapeutics, Inc. / ADAGE CAPITAL PARTNERS GP, L.L.C. - COMPASS THERAPEUTICS, INC. Passive Investment

SC 13G/A 1 p24-0377sc13ga.htm COMPASS THERAPEUTICS, INC. SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* Compass Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 20454B104 (CUSIP Number) December 31, 2023 (Date of Event Which Requires Filing of This Stat

February 1, 2024 SC 13G

CMPX / Compass Therapeutics, Inc. / JANUS HENDERSON GROUP PLC - JANUS HENDERSON GROUP PLC OWNS 6.00% OF COMPASS THERAPEUTICS, INC. Passive Investment

SC 13G 1 JHBIFCompass012224.txt JANUS HENDERSON GROUP PLC OWNS 6.00% OF COMPASS THERAPEUTICS, INC. UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 Amendment No.: 0* Name of Issuer: COMPASS THERAPEUTICS, INC. Title of Class of Securities: Common Stock CUSIP Number: 20454B104 Date of Event Which Requires Filing of this St

January 9, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 8, 2024 COMPASS THERAPEUT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 8, 2024 COMPASS THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commiss

January 5, 2024 EX-99.1

Compass Therapeutics Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Provides Corporate Update We continue to open clinical sites and enroll patients in COMPANION-002, the Phase 2/3 randomized study of CTX-009 (DLL4 x VEGF-A bispecific antibody) in patients with advanced biliary tract cancer (BTC). Consistent with prior guidance, top line data from this study continue to be expected in the second half of 2024. Enrollment of patient

January 5, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 5, 2024 Compass Therapeut

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 5, 2024 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commiss

November 27, 2023 SC 13G

CMPX / Compass Therapeutics Inc / ADAGE CAPITAL PARTNERS GP, L.L.C. - COMPASS THERAPEUTICS, INC. Passive Investment

SC 13G 1 p23-2863sc13g.htm COMPASS THERAPEUTICS, INC. SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* Compass Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 20454B104 (CUSIP Number) November 16, 2023 (Date of Event Which Requires Filing of This Statement)

November 9, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

November 9, 2023 EX-99.1

Compass Therapeutics Reports Third Quarter 2023 Financial Results and Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Reports Third Quarter 2023 Financial Results and Provides Corporate Update Opened 29 clinical sites and continue to enroll patients in COMPANION-002, a U.S. Phase 2/3 study of CTX-009 in combination with Paclitaxel in patients with advanced biliary tract cancers (BTC); top line data from this study is expected in the second half of 2024 Continue to enroll and foll

November 9, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 9, 2023 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commis

August 3, 2023 EX-99.1

Compass Therapeutics Reports Second Quarter 2023 Financial Results and Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Reports Second Quarter 2023 Financial Results and Provides Corporate Update Continuing to enroll patients in a U.S. Phase 2 study of CTX-009 (DLL4 /VEGF-A bispecific antibody) in patients with advanced colorectal cancer (CRC); initial data from this study is expected in the second half of 2023 Opened 20 clinical sites and continues to enroll patients in a U.S. Pha

August 3, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 3, 2023 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commissi

August 3, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

June 15, 2023 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 15, 2023 COMPASS THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commissio

May 4, 2023 EX-99.1

Compass Therapeutics Reports First Quarter Financial Results and Provides Corporate Update

EXHIBIT 99.1 Compass Therapeutics Reports First Quarter Financial Results and Provides Corporate Update Initiated patient enrollment in a U.S. Phase 2/3 study of CTX-009 (DLL4 /VEGF-A bispecific antibody) in patients with advanced biliary tract cancers (BTC). Top line data is expected in the first half of 2024 Continue to enroll in a U.S. Phase 2 study of CTX-009 in patients with advanced colorect

May 4, 2023 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 4, 2023 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commission

May 4, 2023 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

April 27, 2023 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant  ☐ Check the appropriate box:  ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ D

April 27, 2023 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ☒ Filed by a party other than the Registrant  ☐ Check the appropriate box:  ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ Definitive Proxy St

April 27, 2023 ARS

ARS

202 Annual Report i Table of Contents Page PART I Item 1. Business 7 Item 1A. Risk Factors 52 Item 1B. Unresolved Staff Comments 107 Item 2. Properties 107 Item 3. Legal Proceedings 107 Item 4. Mine Safety Disclosures 107 PART II Item 5. Market for Registrant’s Common Equity, Related Stockholder Matters and Issuer Purchases of Equity Securities 108 Item 6. [Reserved] 109 Item 7. Management’s Disc

April 24, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 21, 2023 COMPASS THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commissi

March 15, 2023 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 000-55939 Compass Therape

March 10, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 10, 2023 COMPASS THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commissi

February 24, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 20, 2023 COMPASS THERAPE

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 20, 2023 COMPASS THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) Commis

February 14, 2023 SC 13G/A

US20454B1044 / COMPASS THERAPEUTICS INC / Rock Springs Capital Management LP Passive Investment

SC 13G/A 1 rocksprings-cmpx123122a2.htm UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 Schedule 13G/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* Compass Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 20454B104 (CUSIP Number) December 31, 2022 (Date of Event Which Requires Filing of this Statement

February 13, 2023 SC 13G/A

US20454B1044 / COMPASS THERAPEUTICS INC / Foresite Capital Fund V, L.P. - SC 13G/A Passive Investment

SC 13G/A 1 tm236260d2sc13ga.htm SC 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1 (b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (b) (Amendment No. 1)* Compass Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001 (Title of Class of Securities) 20454B10

February 10, 2023 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 8, 2023 COMPASS THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commis

February 9, 2023 SC 13G/A

US20454B1044 / COMPASS THERAPEUTICS INC / FMR LLC Passive Investment

SC 13G/A 1 filing.txt SCHEDULE 13G Amendment No.3 COMPASS THERAPEUTICS INC COMMON STOCK Cusip #20454B104 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [ ] Rule 13d-1(b) [x] Rule 13d-1(c) [ ] Rule 13d-1(d) Cusip #20454B104 Item 1: Reporting Person - FMR LLC Item 2: (a) [ ] (b) [ ] Item 4: Delaware Item 5: 6,354,814 Item 6: 0 Item 7: 6,354,814 Item 8: 0 It

January 24, 2023 424B3

25,000,000 Shares of Common Stock

Filed Pursuant to Rule 424(b)(3) File No. 333-268652 PROSPECTUS 25,000,000 Shares of Common Stock This prospectus relates to the offering and resale by the selling stockholders identified herein (the “selling stockholders”) of up to 25,000,000 shares of common stock, par value $0.0001 per share, of Compass Therapeutics, Inc., privately issued to the selling stockholders on November 4, 2022 in conn

January 19, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 19, 2023 Compass Therapeu

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 19, 2023 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commis

January 19, 2023 EX-99.1

Compass Therapeutics Announces that the Phase 2 Data of CTX-009 in Combination with Paclitaxel in Patients with Biliary Tract Cancers (BTC) will be Presented at the ASCO GI Cancers Symposium on January 20, 2023 Compass to Host Investor Event on Monda

EX-99.1 2 exh991.htm PRESS RELEASE EXHIBIT 99.1 Compass Therapeutics Announces that the Phase 2 Data of CTX-009 in Combination with Paclitaxel in Patients with Biliary Tract Cancers (BTC) will be Presented at the ASCO GI Cancers Symposium on January 20, 2023 Compass to Host Investor Event on Monday, January 23rd at 8:30am ET CTX-009 in combination with paclitaxel demonstrated a 37.5% overall respo

January 19, 2023 CORRESP

COMPASS THERAPEUTICS, INC. 80 Guest Street Suite 601 Boston, Massachusetts 02135

CORRESP 1 filename1.htm COMPASS THERAPEUTICS, INC. 80 Guest Street Suite 601 Boston, Massachusetts 02135 January 19, 2023 Via EDGAR Transmission United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Compass Therapeutics, Inc.: Registration Statement on Form S-3 filed December 2, 2022 (File No. 333-268652) Ladies and Gentlemen

January 17, 2023 CORRESP

COMPASS THERAPEUTICS, INC. 80 Guest Street Suite 601 Boston, Massachusetts 02135

CORRESP 1 filename1.htm COMPASS THERAPEUTICS, INC. 80 Guest Street Suite 601 Boston, Massachusetts 02135 January 17, 2023 Via EDGAR Transmission United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Attn: Re: Withdrawal of Acceleration Request—Compass Therapeutics, Inc.: Registration Statement on Form S-3 filed December 2, 2022 (

January 13, 2023 CORRESP

COMPASS THERAPEUTICS, INC. 80 Guest Street Suite 601 Boston, Massachusetts 02135

CORRESP 1 filename1.htm COMPASS THERAPEUTICS, INC. 80 Guest Street Suite 601 Boston, Massachusetts 02135 January 13, 2023 Via EDGAR Transmission United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Compass Therapeutics, Inc.: Registration Statement on Form S-3 filed December 2, 2022 (File No. 333-268652) Ladies and Gentlemen

December 7, 2022 LETTER

LETTER

United States securities and exchange commission logo December 7, 2022 Thomas Schuetz Chief Executive Officer Compass Therapeutics, Inc.

December 2, 2022 S-3

As filed with the Securities and Exchange Commission on December 2, 2022.

Table of Contents As filed with the Securities and Exchange Commission on December 2, 2022.

December 2, 2022 EX-FILING FEES

Filing Fee Table

Exhibit 107 Calculation of Filing Fee Table S-3 (Form Type) Compass Therapeutics, Inc.

November 29, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 29, 2022 COMPASS THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commi

November 14, 2022 SC 13D

US20454B1044 / COMPASS THERAPEUTICS INC / Commander Aggregator, LP - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 SCHEDULE 13D UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No.

November 14, 2022 EX-99.1

JOINT FILING AGREEMENT

Exhibit 99.1 JOINT FILING AGREEMENT The undersigned hereby agree that a single Schedule 13D (and any amendment thereto) relating to the Common Stock of Compass Therapeutics, Inc. shall be filed on behalf of each of the undersigned and that this Agreement shall be filed as an exhibit to such Schedule 13D. Commander Aggregator, LP By: /s/ James P. Boylan Name: James P. Boylan Title: Chief Executive

November 10, 2022 EX-99.1

JOINT FILING AGREEMENT

Exhibit 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13D, dated November 8, 2022, with respect to the common stock, par value $0.

November 10, 2022 SC 13D/A

US20454B1044 / COMPASS THERAPEUTICS INC / ORBIMED ADVISORS LLC - AMENDMENT NO. 3 Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 3) Compass Therapeutics, Inc. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 20454B104 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP V LLC OrbiMed Genesis GP LLC OrbiMed Capital LLC 601 Lexington Avenue, 54th Floor New York, NY 10022 T

November 9, 2022 EX-99.1

Press release titled "Compass Therapeutics Reports Third Quarter 2022 Financial Results and Provides Corporate Update".

Exhibit 99.1 Compass Therapeutics Reports Third Quarter 2022 Financial Results and Provides Corporate Update ? Study site initiations in the United States for a randomized Phase 2/3 study of CTX-009 with paclitaxel in patients with Biliary Tract Cancers (BTC) and a Phase 2 of CTX-009 in patients with Colorectal Cancer (CRC) are ongoing; patient enrollment for both studies is expected during the fo

November 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

November 9, 2022 EX-10.2

Securities Purchase Agreement dated November 2, 2022.

Exhibit 10.2 EXECUTION VERSION SECURITIES PURCHASE AGREEMENT This SECURITIES PURCHASE AGREEMENT (this ?Agreement?) is made and entered into as of November 2, 2022 by and among Compass Therapeutics, Inc., a Delaware corporation (the ?Company?), and the Investors identified on Exhibit A attached hereto (each an ?Investor? and collectively the ?Investors?). RECITALS WHEREAS, the Company and the Inves

November 9, 2022 EX-10.1

Registration Rights Agreement dated November 2, 2022.

Exhibit 10.1 EXECUTION VERSION REGISTRATION RIGHTS AGREEMENT This REGISTRATION RIGHTS AGREEMENT (this ?Agreement?) is made and entered into as of November 2, 2022 by and among Compass Therapeutics, Inc., a Delaware corporation (the ?Company?), and the ?Investors? named in that certain Securities Purchase Agreement by and among the Company and the Investors (the ?Purchase Agreement?). Capitalized t

November 2, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 2, 2022 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commis

November 2, 2022 EX-99.1

Compass Therapeutics Announces $80 Million Private Placement

EXHIBIT 99.1 Compass Therapeutics Announces $80 Million Private Placement BOSTON, Nov. 02, 2022 (GLOBE NEWSWIRE) - Compass Therapeutics, Inc. (Nasdaq: CMPX), (?Compass?), a clinical-stage biopharmaceutical company developing proprietary antibody-based therapeutics to treat cancer, today announced that it has entered into a securities purchase agreement with a select group of institutional investor

August 19, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): August 17, 2022 COMPASS THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commiss

August 1, 2022 424B5

Up to $75,000,000 Common Stock

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-257821 PROSPECTUS SUPPLEMENT (To Prospectus Dated July 9, 2021) Up to $75,000,000 Common Stock We have entered into an Open Market Sale AgreementSM, or the sales agreement, with Jefferies LLC, or Jefferies, relating to the sale of shares of our common stock, par value $0.0001 per share, offered by this prospectus supplement an

August 1, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

August 1, 2022 EX-99.1

Press release titled "Compass Therapeutics Reports Second Quarter 2022 Financial Results and Provides Corporate Update"

Exhibit 99.1 Compass Therapeutics Reports Second Quarter 2022 Financial Results and Provides Corporate Update ? Phase 2/3 trial of CTX-009 (DLL4 X VEGF-A bispecific) and paclitaxel in biliary tract cancer (BTC) anticipated to begin in the United States in Q3 2022 ? A Phase 2 trial of CTX-009 as a monotherapy in advanced colorectal cancer (CRC) is on track to begin in Q4 2022 ? A fourth partial res

August 1, 2022 8-K

Entry into a Material Definitive Agreement, Termination of a Material Definitive Agreement, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event Reported): July 22, 2022 Compass Therapeutics, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 000-55939 82-4876496 (State or Other Jurisdiction of Incorporation) (Commission Fi

August 1, 2022 EX-1.1

Form 8-K

Exhibit 1.1 OPEN MARKET SALE AGREEMENTSM August 1, 2022 JEFFERIES LLC 520 Madison Avenue New York, New York 10022 Ladies and Gentlemen: Compass Therapeutics, Inc., a Delaware corporation (the ?Company?), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the ?Agent?), shares of the Company?s commo

May 31, 2022 8-K

Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 31, 2022 COMPASS THERAPEUTICS, INC. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commission

May 18, 2022 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? ? ? Filed by a party other than the Registrant ?? Check the appropriate box: ?? ? ? Preliminary Proxy Statement ?? ? ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ?? ? ? De

May 9, 2022 EX-99.1

Press release titled "Compass Therapeutics Reports First Quarter 2022 Financial Results and Highlights Recent Company Progress"

EXHIBIT 99.1 Compass Therapeutics Reports First Quarter 2022 Financial Results and Highlights Recent Company Progress ? The FDA cleared the investigational new drug application for CTX-009 (DLL4 X VEGF-A bispecific) in January allowing the Company to expand the ongoing Phase 2 study in patients with biliary tract cancer (BTC) to a global study and initiate dosing patients in the United States in e

May 9, 2022 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

May 4, 2022 8-K

Regulation FD Disclosure, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 4, 2022 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commission

May 4, 2022 EX-99.1

Compass Therapeutics Reports Positive Interim Phase 2 Data of CTX-009 in Combination with Paclitaxel in Biliary Tract Cancers CTX-009 Demonstrated a 42% Overall Response Rate (ORR) Based on 10 Partial Responses (PRs) in 24 Enrolled Patients CTX-009 C

EXHIBIT 99.1 Compass Therapeutics Reports Positive Interim Phase 2 Data of CTX-009 in Combination with Paclitaxel in Biliary Tract Cancers CTX-009 Demonstrated a 42% Overall Response Rate (ORR) Based on 10 Partial Responses (PRs) in 24 Enrolled Patients CTX-009 Continues to be Well Tolerated, Consistent with the Phase 1 Studies Compass Plans to Initiate Stage 2 of the Phase 2 Study in the U.S. in

May 4, 2022 EX-99.2

DO NOT DISTRIBUTE WITHOUT PERMISSION | © 2022 Compass Therapeutics Presentation May 4, 2022 DISCLAIMER This presentation has been prepared by Compass Therapeutics, Inc. ("we," "us," "our," or the “Company”). Statements contained herein are made as of

Exhibit 99.2 DO NOT DISTRIBUTE WITHOUT PERMISSION | ? 2022 Compass Therapeutics Presentation May 4, 2022 DISCLAIMER This presentation has been prepared by Compass Therapeutics, Inc. ("we," "us," "our," or the ?Company?). Statements contained herein are made as of the date of this presentation unless stated otherwise, and this presentation shall not under any circumstances create an implication tha

April 28, 2022 DEF 14A

definitive proxy statement

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? ? ? Filed by a party other than the Registrant ?? Check the appropriate box: ?? ? ? Preliminary Proxy Statement ?? ? ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-

April 26, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 26, 2022 (April 22, 2022) Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorpo

April 26, 2022 EX-99.1

Compass Therapeutics Announces Appointment of Two New Directors to its Board

EXHIBIT 99.1 Compass Therapeutics Announces Appointment of Two New Directors to its Board BOSTON, April 26, 2022 (GLOBE NEWSWIRE) - Compass Therapeutics, Inc. (Nasdaq: CMPX), a clinical-stage, oncology-focused biopharmaceutical company developing proprietary antibody-based therapeutics to treat multiple human diseases, today is pleased to announce the appointment of two new directors to its board.

March 18, 2022 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 000-55939 Compass Therape

February 25, 2022 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 22, 2022 COMPASS THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commi

February 15, 2022 SC 13G/A

US20454B1044 / COMPASS THERAPEUTICS INC / Rock Springs Capital Management LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 Schedule 13G/A Under the Securities Exchange Act of 1934 (Amendment No.

February 9, 2022 SC 13G/A

US20454B1044 / COMPASS THERAPEUTICS INC / FMR LLC Passive Investment

SCHEDULE 13G Amendment No. 2 COMPASS THERAPEUTICS INC COMMON STOCK Cusip #20454B104 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [ ] Rule 13d-1(b) [x] Rule 13d-1(c) [ ] Rule 13d-1(d) Cusip #20454B104 Item 1: Reporting Person - FMR LLC Item 2: (a) [ ] (b) [ ] Item 4: Delaware Item 5: 4,122,414 Item 6: 0 Item 7: 6,872,414 Item 8: 0 Item 9: 6,872,414 Item

January 20, 2022 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 20, 2022 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commis

January 20, 2022 EX-99.1

Compass Therapeutics Announces US FDA Clearance of Investigational New Drug Application for a Phase 2 Study of CTX-009, a Bispecific Antibody That Simultaneously Targets Delta-like Ligand 4 (DLL4) and Vascular Endothelial Growth Factor A (VEGF-A)

EXHIBIT 99.1 Compass Therapeutics Announces US FDA Clearance of Investigational New Drug Application for a Phase 2 Study of CTX-009, a Bispecific Antibody That Simultaneously Targets Delta-like Ligand 4 (DLL4) and Vascular Endothelial Growth Factor A (VEGF-A) BOSTON, Jan. 20, 2022 (GLOBE NEWSWIRE) - Compass Therapeutics, Inc. (Nasdaq: CMPX), a clinical-stage biopharmaceutical company developing pr

December 30, 2021 SC 13G

CMPX / Compass Therapeutics Inc / Rock Springs Capital Management LP Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.

December 21, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 20, 2021 COMPASS THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commi

December 17, 2021 SC 13G/A

CMPX / Compass Therapeutics Inc / ANDERSON ERRIK Passive Investment

SCHEDULE 13G Amendment No. 1 COMPASS THERAPEUTICS INC COMMON STOCK Cusip # 20454B104 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [ ] Rule 13d-1(b) [x] Rule 13d-1(c) [ ] Rule 13d-1(d) Cusip # 20454B104 Item 1: Reporting Person - Errik Anderson Item 2: (a) [x] (b) [ ] Item 4: United States Item 5: 3,546,730 Item 6: 0 Item 7: 3,546,730 Item 8: 0 Item 9: 3

December 15, 2021 424B5

Common Stock

Table of Contents Filed pursuant to Rule 424(b)(5) Registration No. 333-257821 PROSPECTUS $75,000,000 Common Stock We have entered into a sales agreement, or the sales agreement, with B. Riley Securities, Inc., or B. Riley Securities, relating to shares of our common stock offered by this prospectus. In accordance with the terms of the sales agreement, we may offer and sell shares of our common st

December 15, 2021 424B5

62,323,147 Shares of Common Stock

Table of Contents Filed pursuant to Rule 424(b)(5) Registration No. 333-257821 PROSPECTUS 62,323,147 Shares of Common Stock This prospectus relates to the offering and resale by the selling stockholders identified herein of up to 62,323,147 shares of common stock, par value $0.0001 per share, of Compass Therapeutics, Inc., which include (i) 39,030,599 shares of common stock privately issued to the

November 12, 2021 SC 13G

CMPX / Compass Therapeutics Inc / Foresite Capital Fund V, L.P. - SC 13G Passive Investment

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G (Rule 13d-102) INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1 (b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (b) (Amendment No. )* Compass Therapeutics, Inc. (Name of Issuer) Common Stock, par value $0.0001. (Title of Class of Securities) 20454B104 (CUSIP Number) November 2, 2021 (Date o

November 12, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

November 12, 2021 EX-99.1

Press release titled "Compass Therapeutics Reports Third Quarter 2021 Financial Results and Provides Corporate Update"

Exhibit 99.1 Compass Therapeutics Reports Third Quarter 2021 Financial Results and Provides Corporate Update ? CTX-009 (DLL4 X VEGF-A bispecific) is ready to advance to the second stage of a Phase 2a study based on 5 partial responses in 17 evaluable patients observed in the first stage of the study ? Continued the advancement of CTX-471 (CD137 agonist) in Phase 1b development and reported a secon

November 9, 2021 EX-99.3

Compass Therapeutics, Inc. Public Offering of Common Stock

EXECUTION VERSION Compass Therapeutics, Inc. Public Offering of Common Stock October 31, 2021 SVB Leerink LLC As Representative of the several Underwriters, c/o SVB Leerink LLC 53 State Street, 40th Floor Boston, MA 02109 Ladies and Gentlemen: This letter is being delivered to you in connection with the proposed underwriting agreement (the ?Underwriting Agreement?), between Compass Therapeutics, I

November 9, 2021 SC 13D/A

CMPX / Compass Therapeutics Inc / ORBIMED ADVISORS LLC - AMENDMENT NO. 2 Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 2) Compass Therapeutics, Inc. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 20454B104 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP V LLC OrbiMed Genesis GP LLC OrbiMed Capital LLC 601 Lexington Avenue, 54th Floor New York, NY 10022 T

November 9, 2021 EX-99.1

JOINT FILING AGREEMENT

Exhibit 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13D, dated November 9, 2021, with respect to the common shares of Compass Therapeutics, Inc.

November 3, 2021 EX-99.1

Compass Therapeutics Announces Pricing of Approximately $125 Million Public Offering of Common Stock and Uplisting to Nasdaq Capital Market

EXHIBIT 99.1 Compass Therapeutics Announces Pricing of Approximately $125 Million Public Offering of Common Stock and Uplisting to Nasdaq Capital Market Boston, November 1, 2021 ? Compass Therapeutics, Inc. (the ?Company?), a clinical-stage biopharmaceutical company developing proprietary antibody-based therapeutics to treat cancer, today announced that it has priced an underwritten public offerin

November 3, 2021 EX-1.1

Underwriting Agreement, dated November 1, 2021, by and among Compass Therapeutics, Inc. and SVB Leerink LLC, as representative of the several underwriters named therein

EXHIBIT 1.1 Compass Therapeutics, Inc. (a Delaware corporation) 35,715,000 Shares of Common Stock UNDERWRITING AGREEMENT November 1, 2021 SVB Leerink LLC as Representative of the several Underwriters c/o SVB Leerink LLC 53 State Street, 40th Floor Boston, MA 02109 Ladies and Gentlemen: Compass Therapeutics, Inc., a Delaware corporation (the ?Company?), confirms its agreement with SVB Leerink LLC (

November 3, 2021 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 01, 2021 COMPASS THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commi

November 3, 2021 424B5

35,715,000 Shares Common stock

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-257821 Prospectus Supplement (To prospectus dated July 9, 2021) 35,715,000 Shares Common stock We are offering 35,715,000 shares of our common stock. Our common stock is currently trading on the OTCQB Market under the stock symbol ?CMPX.? On October 29, 2021, the closing price for our common stock, as reported on the OTCQB Mar

November 1, 2021 8-A12B

Form 8-A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 82-4876496 (State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identification

November 1, 2021 8-K

Financial Statements and Exhibits, Results of Operations and Financial Condition, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 01, 2021 COMPASS THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commi

November 1, 2021 EX-99.2

Compass Therapeutics Announces Proposed Public Offering of Common Stock and Uplisting to Nasdaq Capital Market

Exhibit 99.2 Compass Therapeutics Announces Proposed Public Offering of Common Stock and Uplisting to Nasdaq Capital Market BOSTON, November 1, 2021 ? Compass Therapeutics, Inc. (the ?Company?), a clinical stage biopharmaceutical company developing proprietary antibody-based therapeutics to treat cancer, today announced that it intends to offer and sell shares of common stock in an underwritten pu

November 1, 2021 CERT

CERT

November 1, 2021 EX-99.1

Compass Reports the Advancement of CTX-009, a Bispecific Antibody, to Phase 2a Development in Patients with Biliary Tract Cancers (BTC), and the Clearance of a Key Clinical Hurdle

Exhibit 99.1 Compass Reports the Advancement of CTX-009, a Bispecific Antibody, to Phase 2a Development in Patients with Biliary Tract Cancers (BTC), and the Clearance of a Key Clinical Hurdle ? Phase 2a study was initiated by Handok Pharmaceuticals in Q1 2021 in patients with Biliary Tract Cancers (cholangiocarcinoma). ? Enrollment in the first part of the study has been completed and the criteri

November 1, 2021 424B5

Subject to completion, dated November 1, 2021

Table of Contents Filed Pursuant to Rule 424(b)(5) Registration No. 333-257821 The information in this preliminary prospectus supplement is not complete and may be changed. A registration statement relating to these securities has been filed with the Securities and Exchange Commission and is effective. This preliminary prospectus supplement and the accompanying prospectus are not an offer to sell

October 8, 2021 EX-99.1

CTX-009 (ABL001/ES104) Clinical Data Presented Today at the New Drugs on the Horizon Plenary Session of the 2021 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

CTX-009 (ABL001/ES104) Clinical Data Presented Today at the New Drugs on the Horizon Plenary Session of the 2021 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics ? CTX-009 was well tolerated and demonstrated single agent activity in heavily pre-treated patients with solid tumor who are resistant to anti-VEGF therapies, mostly of colorectal and gastric origins ?

October 8, 2021 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 08, 2021 COMPASS THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 001-39696 82-4876496 (State or Other Jurisdiction of Incorporation) (Commis

August 16, 2021 EX-10.1

Research and Development Collaboration and License Agreement, dated November 30, 2018, between Trigr Therapeutics, Inc. and ABL Bio Inc. (incorporated by reference to Exhibit 10.1 to the Quarterly Report on Form 10-Q filed with the SEC on August 16, 2021)

Exhibit 10.1 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT HAVE BEEN OMITTED AND REPLACED WITH ?[***]?. SUCH IDENTIFIED INFORMATION HAS BEEN EXCLUDED FROM THIS EXHIBIT BECAUSE IT IS (I) NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO THE COMPANY IF DISCLOSED. RESEARCH AND DEVELOPMENT COLLABORATION AND LICENSE AGREEMENT ? ABL 001 THIS RESEARCH AND DEVELOPMENT COLLABORATION AND LICENSE

August 16, 2021 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 001-39696 COMPASS THERAPEUTICS, INC.

August 5, 2021 8-K/A

Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 25, 2021 COMPASS THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 000-55939 82-4876496 (State or Other Jurisdiction of Incor

August 5, 2021 EX-99.3

UNAUDITED PRO FORMA COMBINED FINANCIAL STATEMENTS

Exhibit 99.3 UNAUDITED PRO FORMA COMBINED FINANCIAL STATEMENTS On June 25, 2021, Compass Therapeutics, Inc. (?Company?) acquired 100% of the outstanding equity of Trigr Therapeutics, Inc. (?TRIGR?), a private biotechnology company. The acquisition was consummated to acquire TRIGR?s main product candidate, CTX-009, which is a is an anti-DLL4 x VEGF-A bispecific antibody that is undergoing clinical

August 5, 2021 EX-99.1

Financial Statements For the Year Ended December 31, 2020

EXHIBIT 99.1 Financial Statements For the Year Ended December 31, 2020 Index 1. Independent Auditor?s Report 2 2. Financial Statements a. Balance Sheet 3 b. Statement of Operations 4 c. Statement of Stockholders? Deficit 5 d. Statement of Cash Flows 6 e. Notes to Financial Statements 7-12 1 Independent Auditor?s Report To the Board of Directors of Trigr Therapeutics, Inc. We have audited the accom

August 5, 2021 EX-99.2

Financial Statements For the Quarters Ended March 31, 2021 and 2020

Exhibit 99.2 Financial Statements For the Quarters Ended March 31, 2021 and 2020 Financial Statements (unaudited) a. Condensed Balance Sheets 2 b. Condensed Statements of Operations 3 c. Condensed Statements of Stockholders? Equity (Deficit) 4 d. Condensed Statements of Cash Flows 5 e. Notes to Condensed Financial Statements 6 ? 10 1 Trigr Therapeutics, Inc. Condensed Balance Sheets (in 000?s, exc

July 16, 2021 CORRESP

Sincerely,

July 16, 2021 Via EDGAR Transmission United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.

July 15, 2021 LETTER

LETTER

United States securities and exchange commission logo July 15, 2021 Thomas J. Schuetz, M.D., Ph.D. Chief Executive Officer Compass Therapeutics, Inc. 80 Guest Street Suite 601 Boston, MA 02135 Re: Compass Therapeutics, Inc. Registration Statement on Form S-3 Filed July 9, 2021 File No. 333-257821 Dear Dr. Schuetz: This is to advise you that we have not reviewed and will not review your registratio

July 14, 2021 EX-99.1

JOINT FILING AGREEMENT

Exhibit 1 JOINT FILING AGREEMENT The undersigned hereby agree that the Statement on Schedule 13D, dated July 14, 2021, with respect to the common shares of Compass Therapeutics, Inc.

July 14, 2021 SC 13D/A

CMPX / Compass Therapeutics Inc / ORBIMED ADVISORS LLC - AMENDMENT NO. 1 Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 (Amendment No. 1) Compass Therapeutics, Inc. (Name of Issuer) COMMON STOCK (Title of Class of Securities) 20454B104 (CUSIP Number) OrbiMed Advisors LLC OrbiMed Capital GP V LLC 601 Lexington Avenue, 54th Floor New York, NY 10022 Telephone: (212) 739-6400 (Name, Address and

July 9, 2021 EX-1.2

At Market Issuance Sales Agreement

Exhibit 1.2 COMPASS THERAPEUTICS, INC. Common Stock (par value $0.0001 per share) At Market Issuance Sales Agreement July 9, 2021 B. Riley Securities, Inc. 299 Park Avenue, 21st Floor New York, NY 10171 Ladies and Gentlemen: Compass Therapeutics, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with B. Riley Securities, Inc. (the “Agent”) as follows: 1. Issua

July 9, 2021 S-3

As filed with the Securities and Exchange Commission on July 9, 2021.

Table of Contents As filed with the Securities and Exchange Commission on July 9, 2021.

July 9, 2021 EX-4.3

Form of Indenture

Exhibit 4.3 COMPASS THERAPEUTICS, INC. Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [?], 20 Debt Securities TABLE OF CONTENTS Page ARTICLE 1 DEFINITIONS 1 Section 1.01 Definitions of Terms 1 ARTICLE 2 ISSUE, DESCRIPTION, TERMS, EXECUTION, REGISTRATION AND EXCHANGE OF SECURITIES 4 Section 2.01 Designation and Terms of Securities 4 Section 2.02 Form of Securities and Trustee?s Certificate 5 S

July 9, 2021 EX-5.3

Opinion of Goodwin Procter LLP relating to the Selling Stockholder Prospectus

Exhibit 5.3 July 9, 2020 Compass Therapeutics, Inc. 80 Guest St. Boston, Ma 02135 Re: Shares Being Registered under Registration Statement on Form S-3 We have acted as counsel to you in connection with your filing of a Registration Statement on Form S-3 (as amended or supplemented, the ?Registration Statement?) filed on the date hereof with the Securities and Exchange Commission (the ?Commission?)

June 30, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Entry into a Material Definitive Agreement, Unregistered Sales of Equity Securities, Financial Statements and Exhibits, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant, Completion of Acquisition or Disposition of Assets, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 25, 2021 COMPASS THERAPEUTICS, INC. (Exact name of Registrant as Specified in Its Charter) Delaware 000-55939 82-4876496 (State or Other Jurisdiction of Incorporation) (Commissio

June 30, 2021 EX-10.1

CONSULTING AGREEMENT

Exhibit 10.1 CONSULTING AGREEMENT THIS CONSULTING AGREEMENT is entered into and effective as of June 25, 2021 (the ?Effective Date?), by and between COMPASS THERAPEUTICS, INC., a Delaware limited liability company (the ?Company?), and MIRANDA TOLEDANO, an individual, (the ?Consultant?). The Company desires to retain Consultant as an independent contractor to perform consulting services for the Com

June 4, 2021 8-K

Submission of Matters to a Vote of Security Holders

8-K 1 d175899d8k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 3, 2021 Compass Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 000-55939 82-4876496 (State or Other Jurisdiction of I

May 13, 2021 EX-99.1

Compass Therapeutics, Inc. to Acquire TRIGR Therapeutics, Inc. To Obtain Global Rights to TR009, A Novel bispecific antibody and Inhibitor of the Notch Pathway Targeting DLL4 and VEGF-A

EXHIBIT 99.1 Compass Therapeutics, Inc. to Acquire TRIGR Therapeutics, Inc. To Obtain Global Rights to TR009, A Novel bispecific antibody and Inhibitor of the Notch Pathway Targeting DLL4 and VEGF-A BOSTON & IRVINE, Calif. May 13th , 2021 - (BUSINESS WIRE) ? Compass Therapeutics, Inc. (?Compass?; OTCQB: CMPX), a clinical-stage biotechnology company developing proprietary antibody therapeutics to t

May 13, 2021 EX-10.1

Merger Agreement, dated May 13, 2021, by and among Compass Therapeutics, Inc., Compass Intermediate Acquisition Company, Inc., Compass Acquisition Company, LLC, TRIGR Therapeutics, Inc. and PENG Ventures, LLC, as Stockholder Representative

EXHIBIT 10.1 AGREEMENT AND PLAN OF MERGER AND REORGANIZATION BY AND AMONG COMPASS THERAPEUTICS, INC. COMPASS INTERMEDIATE ACQUISITION COMPANY, INC., COMPASS ACQUISITION COMPANY, LLC, TRIGR THERAPEUTICS, INC. AND PENG VENTURES, LLC, AS STOCKHOLDER REPRESENTATIVE Dated as of May 13, 2021 i ACTIVE/108710474.16 TABLE OF CONTENTS Page ARTICLE I DEFINITIONS2 ARTICLE II THE MERGER14 2.1 First Merger and

May 13, 2021 8-K

Regulation FD Disclosure, Entry into a Material Definitive Agreement, Financial Statements and Exhibits

8-K 1 cmpx-8k20210512.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 13, 2021 Compass Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 000-55939 82-4876496 (State or Other Jurisdiction

April 30, 2021 424B3

Compass Therapeutics, Inc. 52,112,143 Shares of Common Stock

Filed pursuant to Rule 424(b)(3) Registration No. 333-244353 PROSPECTUS SUPPLEMENT NO. 1 (To Prospectus Dated March 8, 2021) Compass Therapeutics, Inc. 52,112,143 Shares of Common Stock This prospectus supplement no. 1 supplements the prospectus dated March 8, 2021, relating to the offering and resale of up to 52,112,143 shares of common stock, par value $0.0001 per share, that were privately issu

April 30, 2021 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 000-55939 COMPASS THERAPEUTICS, INC.

April 29, 2021 DEF 14A

definitive proxy statement

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 Filed by the Registrant ? Filed by a party other than the Registrant ? Check the appropriate box: ? Preliminary Proxy Statement ? Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ? Definitive Proxy State

April 19, 2021 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 14, 2021 Compass Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 000-55939 82-4876496 (State or Other Jurisdiction of Incorporation) (Commissi

April 19, 2021 EX-10.1

Employment Agreement between Compass Therapeutics, Inc. and Thomas J. Schuetz, M.D., Ph.D.

Exhibit 10.1 COMPASS THERAPEUTICS, INC. EMPLOYMENT AGREEMENT This Employment Agreement (?Agreement?), dated as of April 14, 2021, is made between Compass Therapeutics, Inc., a Delaware corporation (including all wholly-owned subsidiaries of Compass Therapeutics, Inc., the ?Company?), and Thomas J. Schuetz, M.D., Ph.D. (the ?Executive?). Except with respect to the Restrictive Covenants Agreement an

April 19, 2021 EX-10.2

Employment Agreement between Compass Therapeutics, Inc. and Vered Bisker-Leib, Ph.D., dated April 14, 2021 (incorporated by reference to Exhibit 10.2 to the Current Report on Form 8-K filed with the SEC on April 19, 2021)

Exhibit 10.2 COMPASS THERAPEUTICS, INC. EMPLOYMENT AGREEMENT This Employment Agreement (?Agreement?), dated as of April 14, 2021, is made between Compass Therapeutics, Inc., a Delaware corporation (including all wholly-owned subsidiaries of Compass Therapeutics, Inc., the ?Company?), and Vered Bisker-Leib (the ?Executive?). Except with respect to the Restrictive Covenants Agreement and the Equity

March 11, 2021 424B3

52,112,143 Shares of Common Stock

Filed Pursuant to Rule 424(b)(3) File No. 333-244353 PROSPECTUS 52,112,143 Shares of Common Stock This prospectus relates to the offering and resale by the selling stockholders identified herein of up to 52,112,143 shares of common stock, par value $0.0001 per share, of Compass Therapeutics, Inc., which include (i) 39,015,701 shares of common stock privately issued to the selling stockholders on J

March 5, 2021 EX-4.2

Description of Registered Securities

EX-4.2 2 cmpx-ex42124.htm EX-4.2 - DESCRIPTION OF SECURITIES Exhibit 4.2 Description of the Registrant’s Securities Registered Pursuant to Section 12 of the Securities Exchange Act of 1934, as amended The common stock, par value $0.0001 per share (“Common Stock”), of Compass Therapeutics, Inc. (“Compass,” “we,” or “our”) is registered under Section 12 of the Securities Exchange Act of 1934, as ame

March 5, 2021 EX-10.16

Sublease Agreement, effective as of December 1, 2020, by and between Roche Diagnostic Operations, Inc. and Compass Therapeutics, Inc.

EX-10.16 3 cmpx-ex101691.htm EX-10.16 - SUBLEASE Exhibit 10.16 SUBLEASE THIS SUBLEASE (this “Sublease”) is dated for reference purposes as of 1 December 2020 (“Effective Date”), and is made by and between Roche Diagnostics Operations, Inc., a Delaware corporation (“Sublandlord”), and Compass Therapeutics, Inc., a Delaware corporation (“Subtenant”). Sublandlord and Subtenant hereby agree as follows

March 5, 2021 10-K

Annual Report - 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ? ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 000-55939 Compass Therape

March 5, 2021 POS AM

- POS AM

As filed with the Securities and Exchange Commission on March 5, 2021 Registration Number 333-244353 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

March 5, 2021 EX-16.1

Letter from Raich Ende Malter & Co. LLP as to the change in certifying accountant

Exhibit 16.1 March 5, 2021 Securities and Exchange Commission 100 F Street NE Washington, D.C. 20549 Ladies and Gentlemen: We have read the section under the heading ?Changes in and Disagreements with Accountants on Accounting and Financial Disclosure? included in the Post-Effective Amendment No. 1 to Form S-1 of Compass Therapeutics, Inc., to be filed on or about March 5, 2021, and agree with the

February 8, 2021 SC 13G/A

SC 13G/A

SCHEDULE 13G Amendment No. 1 COMPASS THERAPEUTICS INC COMMON STOCK Cusip #20454B104 Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [ ] Rule 13d-1(b) [x] Rule 13d-1(c) [ ] Rule 13d-1(d) Cusip #20454B104 Item 1: Reporting Person - FMR LLC Item 2: (a) [ ] (b) [ ] Item 4: Delaware Item 5: 3,049,891 Item 6: 0 Item 7: 4,122,414 Item 8: 0 Item 9: 4,122,414 Item

January 14, 2021 S-8

- FORM S-8

As filed with the Securities and Exchange Commission on January 14, 2021 Registration No.

December 17, 2020 8-K

Entry into a Material Definitive Agreement, Creation of a Direct Financial Obligation or an Obligation under an Off-Balance Sheet Arrangement of a Registrant

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 12, 2020 Compass Therapeutics, Inc. (Exact name of Registrant as Specified in Its Charter) Delaware 000-55939 82-4876496 (State or Other Jurisdiction of Incorporation) (Commi

November 13, 2020 RW

- REGISTRATION WITHDRAWAL

Registration Withdrawal Compass Therapeutics, Inc. 245 First Street 3rd Floor Cambridge, Massachusetts 02142 November 13, 2020 VIA EDGAR United States Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549 Re: Compass Therapeutics, Inc. Withdrawal of Registration Statement on Form S-1 File No. 333-249536 Ladies and Gentlemen: Compass Therapeuti

November 12, 2020 CERT

- 8A CERT

begin 644 8ACertCMPX.pdf M)5!$1BTQ+C4-"B6UM;6U#0HQ(# @;V)J#0H\/"]4>7!E+T-A=&%L;V7!E+U!A9V5S+T-O=6YT(#$O2VED'0O26UA9V5"+TEM86=E M0R]);6%G94E=(#X^+TUE9&EA0F]X6R P(# @-C$R+C$R(#2]#4R]$979I8V521T(^/B]486)S+U,O4W1R=6-T4&%R96YT)S-6VU3XT82DX5V%JZZK.3L&@>9$TNMIR%1A( M]F[92A92^1#RP0@!NC4V6 +"+\O?2W>/),N@P1]L^G=;WMGSW?9WH^CZWPR*O/I9.TX:+$ MIA^RT64V&PS8P>&0W6]O!3S ?XF0@@4L$I(+R>*$3K-L>^N7[]AD>^O@;'MK M[U@P(7

November 10, 2020 8-A12B

- 8-A12B

8-A12B UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 Compass Therapeutics, Inc. (Exact name of registrant as specified in its charter) Delaware 82-4876496 (State or other jurisdiction of incorporation or organization) (I.R.S. Employer Identifi

November 9, 2020 424B3

Compass Therapeutics, Inc. 52,127,041 Shares of Common Stock

424B3 Filed pursuant to Rule 424(b)(3) Registration No. 333-244353 PROSPECTUS SUPPLEMENT NO. 1 (To Prospectus Dated September 18, 2020) Compass Therapeutics, Inc. 52,127,041 Shares of Common Stock This prospectus supplement no. 1 supplements the prospectus dated September 18, 2020, relating to the offering and resale of up to 52,127,041 shares of common stock, par value $0.0001 per share, that wer

November 9, 2020 EX-16.1

Letter from Raich Ende Malter & Co. LLP as to the change in certifying accountant, dated as of November 9, 2020

EX-16.1 Exhibit 16.1 November 9, 2020 Securities and Exchange Commission 100 F Street NE Washington, D.C. 20549 Ladies and Gentlemen: We have read the section under the heading “Changes in and Disagreements with Accountants on Accounting and Financial Disclosure” included in Form S-1 of Compass Therapeutics, Inc., to be filed on or about November 9, 2020, and agree with the statements contained th

November 9, 2020 EX-1.1

Form of Underwriting Agreement

Exhibit 1.1 Compass Therapeutics, Inc. [•] Shares1 Common Stock ($0.0001 par value) Underwriting Agreement New York, New York [•], 2020 Citigroup Global Markets Inc. Credit Suisse Securities (USA) LLC Stifel, Nicolaus & Company, Incorporated As Representatives of the several Underwriters, c/o Citigroup Global Markets Inc. 388 Greenwich Street New York, New York 10013 c/o Credit Suisse Securities (

November 9, 2020 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2020 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 000-55939 COMPASS THERAPEUTICS, INC.

November 9, 2020 S-1/A

As filed with the Securities and Exchange Commission on November 9, 2020

S-1/A Table of Contents As filed with the Securities and Exchange Commission on November 9, 2020 Registration Number 333-249536 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

October 19, 2020 EX-4.1

Specimen Certificate for Common Stock (incorporated by reference to Exhibit 4.1 to the Registration Statement on Form S-1 (Registration No. 333-249536) filed with the SEC on November 9, 2020)

EX-4.1 Exhibit 4.1 NUMBER COMPASS THERAPEUTICS, INC. INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE SHARES SEE REVERSE SIDE FOR CERTAIN DEFINITIONS THIS CERTIFIES THAT is the owner of FULLY PAID AND NON-ASSESSABLE COMMON SHARES, $0.0001 PAR VALUE, OF COMPASS THERAPEUTICS, INC. transferable on the books of the Corporation by the holder hereof in person or by Attorney upon surrender of this ce

October 19, 2020 S-1

Registration Statement - S-1

S-1 Table of Contents As filed with the Securities and Exchange Commission on October 19, 2020 Registration Number 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

September 25, 2020 424B3

52,127,041 Shares of Common Stock

424B3 Table of Contents File pursuant to Rule 424(b)(3) Registration No. 333-244353 PROSPECTUS 52,127,041 Shares of Common Stock This prospectus relates to the offering and resale by the selling stockholders identified herein of up to 52,127,041 shares of common stock, par value $0.0001 per share, of Compass Therapeutics, Inc., which include (i) 39,030,599 shares of common stock privately issued t

September 23, 2020 CORRESP

-

CORRESP VIA EDGAR September 23, 2020 United States Securities and Exchange Commission Division of Corporation Finance Office of Life Sciences Mail Stop 4561 100 F Street, N.

September 23, 2020 DRS

-

DRS Table of Contents Confidential Treatment Requested by Compass Therapeutics, Inc.

September 18, 2020 S-1/A

- S-1/A

S-1/A Table of Contents As filed with the Securities and Exchange Commission on September 18, 2020 Registration Number 333-244353 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.

September 15, 2020 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

8-K 1 d939365d8k.htm 8-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event Reported): September 10, 2020 Compass Therapeutics, Inc. (Exact Name of Registrant as Specified in Charter) Delaware 000-55939 82-4876496 (State or Other Jurisdiction of

September 15, 2020 EX-99.1

Compass Therapeutics, Inc. Provides Corporate Update

EX-99.1 Exhibit 99.1 Compass Therapeutics, Inc. Provides Corporate Update CAMBRIDGE, Mass., September 15th, 2020 — Compass Therapeutics, Inc. a clinical-stage biotechnology company developing proprietary antibody therapeutics intended to engage the immune system to treat both solid tumors and hematological malignancies, today announced the promotion of Vered Bisker-Leib, PhD, MBA to President, in

August 14, 2020 LETTER

LETTER

United States securities and exchange commission logo August 14, 2020 Vered Bisker-Leib Chief Operating Officer Compass Therapeutics, Inc.

August 14, 2020 TEXT-EXTRACT

-

United States securities and exchange commission logo August 14, 2020 Vered Bisker-Leib Chief Operating Officer Compass Therapeutics, Inc.

August 13, 2020 10-Q

Quarterly Report - 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 10-Q (Mark One) ? QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2020 OR ? TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number: 000-55939 COMPASS THERAPEUTICS, INC.

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