DRNA Insider Trading - Dicerna Pharmaceuticals Inc

Insider-Aktien

14.972.175 shares

Insider-Stimmungswert

Der Insider-Stimmungswert ermittelt die Unternehmen, die von Unternehmensinsidern gekauft werden.

Es ist das Ergebnis eines ausgeklügelten quantitativen Multifaktormodells, das die Unternehmen mit der höchsten Insiderakkumulation identifiziert. Das Scoring-Modell verwendet eine Kombination aus der Nettozahl der Insiderkäufe der letzten 90 Tage, der Gesamtzahl der gekauften Aktien als Prozentsatz des Streubesitzes und der Gesamtzahl der von Insidern gehaltenen Aktien. Die Zahl reicht von 0 bis 100, wobei höhere Zahlen ein höheres Maß an Insiderkäufen anzeigen als bei anderen Unternehmen und 50 den Durchschnitt darstellt.

Aktualisierungshäufigkeit: Täglich

Sehen Sie sich die Top-Optionen der Insider an, die eine Liste der Unternehmen mit der höchsten Insiderakkumulation enthalten.

Siehe Aktien mit dem höchsten Ranking

Führungskräfte-Stimmungswert

Der Führungskräfte-Stimmungswert findet Unternehmen, die von Führungskräften des Unternehmens gekauft werden.

Per Definition sind Führungskräfte des Unternehmens Insider, aber im Gegensatz zu anderen Insidern (10%ige Aktionäre und Vorstandsmitglieder) arbeiten Führungskräfte täglich für das Unternehmen und verwenden beim Handel ihr eigenes Geld. (10%ige Aktionäre und Vorstandsmitglieder sind oft Fondsmanager, die das Geld anderer Leute verwalten.) Daher sind Insider-Geschäfte, die von Führungskräften getätigt werden, viel bedeutender und sollten entsprechend behandelt werden.

Wie der Insider-Stimmungswert ist auch der Führungskräfte-Stimmungswert das Ergebnis eines ausgeklügelten quantitativen Multifaktormodells, das die Unternehmen mit der höchsten Führungskräftekonzentration identifiziert.

Aktualisierungshäufigkeit: Täglich

Sehen Sie sich die Insiders Top-Auswahl an, die eine Liste der Unternehmen mit der höchsten Insider-Stimmung enthalten.

Siehe Aktien mit dem höchsten Ranking

Wichtige Insider-Kennzahlen

Diese Karte zeigt, wie das Unternehmen bei verschiedenen Insider-Kennzahlen abschneidet. Der Perzentil-Rang zeigt, wie dieses Unternehmen im Vergleich zu anderen Unternehmen auf den US-Märkten abschneidet. Höhere Ränge deuten auf eine bessere Situation hin.

Es ist beispielsweise allgemein anerkannt, dass Insiderkäufe ein positiver Indikator sind, so dass Unternehmen mit mehr Insiderkäufen besser abschneiden würden als Unternehmen mit weniger Insiderkäufen (oder sogar Insiderverkäufen).

Nettoanzahl der Insider, die kaufen (Rang)

N/A

Die Nettoanzahl der Insiderkäufe ist die Gesamtzahl der Insiderkäufe abzüglich der Gesamtzahl der Insiderverkäufe in den letzten 90 Tagen. Der Perzentilrang wird hier angezeigt (Bereich von 0 bis 100%).

Prozent des Streubesitzes von Insidern gekauft (Rang)

N/A

Prozent des von Insidern gekauften Streubesitzes ist die Gesamtzahl der von Insidern gekauften Aktien abzüglich der Gesamtzahl der von Insidern in den letzten 90 Tagen verkauften Aktien, geteilt durch den gesamten Streubesitz und multipliziert mit 100.

Diagramm zum Insiderhandel

Dicerna Pharmaceuticals Inc Insider-Trades sind in der folgenden Grafik dargestellt. Insider sind leitende Angestellte, Direktoren oder bedeutende Investoren in einem Unternehmen. Im Allgemeinen ist es für Insider illegal, auf der Grundlage von wesentlichen, nicht-öffentlichen Informationen mit Aktien ihrer Unternehmen zu handeln. Das bedeutet nicht, dass es für sie illegal ist, irgendwelche Geschäfte in ihren eigenen Unternehmen zu tätigen. Sie müssen jedoch alle Geschäfte der SEC über ein Formular 4 melden.

Kennzahlen zu Insiderlisten und Rentabilität

Diese Tabelle zeigt die Liste der bekannten Insider und wird automatisch aus den bei der SEC eingereichten Unterlagen erstellt. Zusätzlich zu den Namen, dem letzten Titel und der Bezeichnung als Direktor, leitender Angestellter oder 10%-iger Anteilseigner geben wir die zuletzt veröffentlichten Bestände an. Zusätzlich stellen wir, wenn möglich, die historische Handelsperformance für den Insider zur Verfügung. Die historische Handelsperformance ist ein gewichteter Durchschnitt der Performance tatsächlicher offener Kauftransaktionen, die von dem Insider getätigt wurden. Weitere Informationen zur Berechnung dieses Wertes finden Sie in diesem YouTube-Webinar.

See our leaderboard of most profitable insider traders.

Insider	Durchschnittlicher Gewinn (%)	Aktien in Besitz	Split Angepasst

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Erfolgsbilanz der Insiderkäufe - Kurzfristige Gewinnanalyse

In diesem Abschnitt analysieren wir die Rentabilität jedes ungeplanten Insiderkaufs, der auf dem freien Markt in DRNA / Dicerna Pharmaceuticals Inc getätigt wurde. Diese Analyse hilft zu verstehen, ob der Insider beständig abnormale Renditen erzielt und es sich lohnt, ihm zu folgen. Diese Analyse bezieht sich auf ein Jahr nach jedem Handel, und die Ergebnisse sind theoretisch .

Die folgende Tabelle zeigt die jüngsten Käufe am offenen Markt, die nicht Teil eines automatischen Handelsplans waren.

Handelsdatum	Insider	Gemeldete Aktien	Gemeldeter Preis	Angepasste Aktien	Angepasster Preis	Kostenbasis	Tage bis Max	Preis bei Max	Max Gewinn ($)	Max Rendite (%)
2021-08-10	KOZIN MARC D	3.000	23,6620	3.000	23,6620	70.986	115	38.25	43.764	61,65
2021-08-10	FAMBROUGH DOUGLAS	5.000	22,0960	5.000	22,0960	110.480
2020-09-01	FAMBROUGH DOUGLAS	10.000	18,0597	10.000	18,0597	180.597
2017-12-18	Bain Capital Life Sciences Investors, LLC	285.000	7,0000	285.000	7,0000	1.995.000
2016-11-15	FAMBROUGH DOUGLAS	16.500	3,6300	16.500	3,6300	59.895
2016-11-14	FAMBROUGH DOUGLAS	16.600	3,7800	16.600	3,7800	62.748
2016-05-12	Weissman James B	530	3,2897	530	3,2897	1.744

Bereinigter Preis ist der splitbereinigte Preis. Bereinigte Aktien sind die um den Split bereinigten Aktien.

DRNA / Dicerna Pharmaceuticals Inc Insider Trades

Erfolgsbilanz von Insiderverkäufen - Kurzfristige Verlustanalyse

In diesem Abschnitt analysieren wir die kurzfristige Verlustvermeidung jedes ungeplanten Insider-Verkaufs auf dem freien Markt in DRNA / Dicerna Pharmaceuticals Inc. Ein konsistentes Muster der Verlustvermeidung kann darauf hindeuten, dass zukünftige Verkaufstransaktionen Kursrückgänge vorhersagen können. Diese Analyse bezieht sich auf ein Jahr nach jedem Handel, und die Ergebnisse sind theoretisch .

Die folgende Tabelle zeigt die jüngsten Verkäufe am offenen Markt, die nicht Teil eines automatischen Handelsplans waren.

Handelsdatum	Insider	Gemeldete Aktien	Gemeldeter Preis	Angepasste Aktien	Angepasster Preis	Kostenbasis	Tage bis Min	Preis bei Min	Max Verlust Vermieden($)	Max Verlust Vermieden(%)
2021-09-17	Aradhye Shreeram	2.056	21,4700	2.056	21,4700	44.142	19	19.26	-4.543	-10,29
2021-09-17	Zeng Ling	1.334	21,4700	1.334	21,4700	28.641
2021-06-25	Paglia Regina M.	1.000	38,0037	1.000	38,0037	38.004
2021-06-22	Paglia Regina M.	13.555	37,0957	13.555	37,0957	502.832
2021-06-22	Paglia Regina M.	4.880	36,7108	4.880	36,7108	179.149
2021-06-17	Paglia Regina M.	8.664	35,7881	8.664	35,7881	310.068
2021-06-16	Paglia Regina M.	31.464	35,6284	31.464	35,6284	1.121.012
2021-06-16	Paglia Regina M.	100	36,1500	100	36,1500	3.615
2020-12-10	Koppel Adam	1.000.000	23,4000	1.000.000	23,4000	23.400.000

Bereinigter Preis ist der splitbereinigte Preis. Bereinigte Aktien sind die um den Split bereinigten Aktien.

Transaktionshistorie

Klicken Sie auf das Link-Symbol, um den vollständigen Transaktionsverlauf anzuzeigen. Transaktionen, die im Rahmen eines automatischen Handelsplans 10b5-1 gemeldet werden, sind in der Spalte 10b-5 mit einem X gekennzeichnet.

Datei Datum	Handel Datum	Form	Insider	Ticker	Wertpapier-Titel	Code	Direkt	Ausführung Preis	Einheit Preis	Eimheiten Verändert	Wert Geändert (1K)	Verbleibende Optionen	Verbleibende Aktien
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		-15.000		0
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		-15.000		0
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	15,44		-25.000		0
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	3,42		-25.000		0
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	13,08		-25.000		0
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	3,47		-25.000		0
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-3.333		0
2021-12-29	2021-12-28	4	Koppel Adam See footnotes	DRNA	Common Stock	U - Other	I		38,2500	-3.080.237	-117.819		0
2021-12-29	2021-12-28	4	Koppel Adam	DRNA	Common Stock	U - Other	D		38,2500	-3.333	-127		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	24,05		-68.100		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	22,58		-121.300		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	18,50		-75.000		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	16,30		-111.800		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	11,77		-180.000		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	9,30		-105.000		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	9,09		-33.999		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	2,97		-11.879		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-11.325		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-25.950		0
2021-12-29	2021-12-28	4	Weissman James B	DRNA	Common Stock	U - Other	D		38,2500	-18.100	-692		0
2021-12-29	2021-12-28	4	Zeng Ling	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	24,05		-46.120		0
2021-12-29	2021-12-28	4	Zeng Ling	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	18,69		-81.825		0
2021-12-29	2021-12-28	4	Zeng Ling	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-13.669		0
2021-12-29	2021-12-28	4	Zeng Ling	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-7.688		0
2021-12-29	2021-12-28	4	Zeng Ling	DRNA	Common Stock	U - Other	D		38,2500	-5.032	-192		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		-15.000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	3,26		-15.000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		-15.000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	18,73		-15.000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	3,42		-25.000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	16,30		-25.000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	15,44		-25.000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	13,87		-15.000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	13,08		-25.000		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-3.333		0
2021-12-29	2021-12-28	4	HOFFMAN STEPHEN J	DRNA	Common Stock	U - Other	D		38,2500	-16.157	-618		0
2021-12-29	2021-12-28	4	KOZIN MARC D	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		-15.000		0
2021-12-29	2021-12-28	4	KOZIN MARC D	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		-15.000		0
2021-12-29	2021-12-28	4	KOZIN MARC D	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	10,31		-25.000		0
2021-12-29	2021-12-28	4	KOZIN MARC D	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	15,44		-25.000		0
2021-12-29	2021-12-28	4	KOZIN MARC D	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-3.333		0
2021-12-29	2021-12-28	4	KOZIN MARC D By Marc D. Kozin Revocable Trust	DRNA	Common Stock	D - Sale to Issuer	I		38,2500	-5.000	-191		0
2021-12-29	2021-12-28	4	KOZIN MARC D	DRNA	Common Stock	D - Sale to Issuer	D		38,2500	-6.333	-242		0
2021-12-29	2021-12-28	4	Pagan Douglas W.	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	24,05		-36.900		0
2021-12-29	2021-12-28	4	Pagan Douglas W.	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	20,79		-95.650		0
2021-12-29	2021-12-28	4	Pagan Douglas W.	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-6.150		0
2021-12-29	2021-12-28	4	Pagan Douglas W.	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-20.475		0
2021-12-29	2021-12-28	4	Pagan Douglas W.	DRNA	Common Stock	U - Other	D		38,2500	-7.775	-297		0
2021-12-29	2021-12-28	4	GRAY PATRICK M.	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		-15.000		0
2021-12-29	2021-12-28	4	GRAY PATRICK M.	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		-15.000		0
2021-12-29	2021-12-28	4	GRAY PATRICK M.	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	14,32		-25.000		0
2021-12-29	2021-12-28	4	GRAY PATRICK M.	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-3.333		0
2021-12-29	2021-12-28	4	GRAY PATRICK M.	DRNA	Common Stock	U - Other	D		38,2500	-3.333	-127		0
2021-12-29	2021-12-28	4	Smith Cynthia	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		-15.000		0
2021-12-29	2021-12-28	4	Smith Cynthia	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		-15.000		0
2021-12-29	2021-12-28	4	Smith Cynthia	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	15,44		-25.000		0
2021-12-29	2021-12-28	4	Smith Cynthia	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	14,76		-25.000		0
2021-12-29	2021-12-28	4	Smith Cynthia	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-3.333		0
2021-12-29	2021-12-28	4	Smith Cynthia	DRNA	Common Stock	U - Other	D		38,2500	-3.333	-127		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		-15.000		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		-15.000		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	3,26		-25.000		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	15,44		-25.000		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	13,08		-25.000		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	3,42		-25.000		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-3.333		0
2021-12-29	2021-12-28	4	Freed Martin I	DRNA	Common Stock	U - Other	D		38,2500	-3.333	-127		0
2021-12-29	2021-12-28	4	Doberstein Stephen K	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		-15.000		0
2021-12-29	2021-12-28	4	Doberstein Stephen K	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		-15.000		0
2021-12-29	2021-12-28	4	Doberstein Stephen K	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	15,61		-25.000		0
2021-12-29	2021-12-28	4	Doberstein Stephen K	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-3.333		0
2021-12-29	2021-12-28	4	Doberstein Stephen K	DRNA	Common Stock	U - Other	D		38,2500	-3.333	-127		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	24,05		-247.700		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	22,58		-250.000		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	18,50		-225.000		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	9,09		-225.000		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS By Trust	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	I	16,30		-200.000		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS By Trust	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	I	16,30		-200.000		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	16,30		-71.900		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	11,77		-505.000		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	9,30		-255.000		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	3,42		-55.055		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	3,42		-281.250		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	2,97		-191.330		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-41.250		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-59.850		0
2021-12-29	2021-12-28	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	D - Sale to Issuer	D		38,2500	-231.431	-8.852		0
2021-12-29	2021-12-28	4	Aradhye Shreeram	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	24,05		-51.070		0
2021-12-29	2021-12-28	4	Aradhye Shreeram	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	18,69		-124.700		0
2021-12-29	2021-12-28	4	Aradhye Shreeram	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-8.513		0
2021-12-29	2021-12-28	4	Aradhye Shreeram	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-21.075		0
2021-12-29	2021-12-28	4	Aradhye Shreeram	DRNA	Common Stock	U - Other	D		38,2500	-6.973	-267		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	24,05		-68.100		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	22,58		-121.300		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	18,50		-75.000		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	16,30		-165.050		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	11,77		-180.000		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	9,30		-105.000		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	9,09		-85.000		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-11.325		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-25.950		0
2021-12-29	2021-12-28	4	Brown Bob D	DRNA	Common Stock	U - Other	D		38,2500	-2.367	-91		0
2021-12-29	2021-12-28	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	24,05		-61.500		0
2021-12-29	2021-12-28	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	22,58		-76.144		0
2021-12-29	2021-12-28	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	D - Sale to Issuer	D	15,61		-270.000		0
2021-12-29	2021-12-28	4	Ciappenelli Robert D.	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-17.325		0
2021-12-29	2021-12-28	4	Ciappenelli Robert D.	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-10.275		0
2021-12-29	2021-12-28	4	Ciappenelli Robert D.	DRNA	Common Stock	U - Other	D		38,2500	-14.813	-567		0
2021-12-29	2021-12-28	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	30,47		-15.000		0
2021-12-29	2021-12-28	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	21,61		-21.000		0
2021-12-29	2021-12-28	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	15,44		-33.000		0
2021-12-29	2021-12-28	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	14,76		-25.000		0
2021-12-29	2021-12-28	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	D - Sale to Issuer	D	14,13		-8.000		0
2021-12-29	2021-12-28	4	BUCHI J KEVIN	DRNA	Restricted Stock Units	D - Sale to Issuer	D			-3.333		0
2021-12-29	2021-12-28	4	BUCHI J KEVIN	DRNA	Common Stock	U - Other	D		38,2500	-4.666	-178		0
2021-12-17	2021-12-15	4	Aradhye Shreeram	DRNA	Restricted Stock Units	M - Exercise	D			-2.837		8.513
2021-12-17	2021-12-15	4	Aradhye Shreeram	DRNA	Common Stock	F - Taxes	D		38,0500	-833	-32		6.973
2021-12-17	2021-12-15	4	Aradhye Shreeram	DRNA	Common Stock	M - Exercise	D			2.837			7.806
2021-12-17	2021-12-15	4	Ciappenelli Robert D.	DRNA	Restricted Stock Units	M - Exercise	D			-3.425		10.275
2021-12-17	2021-12-15	4	Ciappenelli Robert D.	DRNA	Common Stock	F - Taxes	D		38,0500	-1.241	-47		14.813
2021-12-17	2021-12-15	4	Ciappenelli Robert D.	DRNA	Common Stock	M - Exercise	D			3.425			16.054
2021-12-17	2021-12-15	4	Pagan Douglas W.	DRNA	Restricted Stock Units	M - Exercise	D			-2.050		6.150
2021-12-17	2021-12-15	4	Pagan Douglas W.	DRNA	Common Stock	F - Taxes	D		38,0500	-602	-23		7.775
2021-12-17	2021-12-15	4	Pagan Douglas W.	DRNA	Common Stock	M - Exercise	D			2.050			8.377
2021-12-17	2021-12-15	4	Zeng Ling	DRNA	Restricted Stock Units	M - Exercise	D			-2.562		7.688
2021-12-17	2021-12-15	4	Zeng Ling	DRNA	Common Stock	F - Taxes	D		38,0500	-752	-29		5.032
2021-12-17	2021-12-15	4	Zeng Ling	DRNA	Common Stock	M - Exercise	D			2.562			5.784
2021-12-17	2021-12-15	4	Brown Bob D	DRNA	Restricted Stock Units	M - Exercise	D			-3.775		11.325
2021-12-17	2021-12-15	4	Brown Bob D	DRNA	Common Stock	F - Taxes	D		38,0500	-1.675	-64		2.367
2021-12-17	2021-12-15	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D			3.775			4.042
2021-12-17	2021-12-15	4	FAMBROUGH DOUGLAS	DRNA	Restricted Stock Units	M - Exercise	D			-13.750		41.250
2021-12-17	2021-12-15	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	F - Taxes	D		38,0500	-5.348	-203		231.431
2021-12-17	2021-12-15	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	M - Exercise	D			13.750			236.779
2021-12-17	2021-12-15	4	Weissman James B	DRNA	Restricted Stock Units	M - Exercise	D			-3.775		11.325
2021-12-17	2021-12-15	4	Weissman James B	DRNA	Common Stock	F - Taxes	D		38,0500	-1.675	-64		18.100
2021-12-17	2021-12-15	4	Weissman James B	DRNA	Common Stock	M - Exercise	D			3.775			19.775
2021-12-14	2021-12-13	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	22,58		-8.856		76.144
2021-12-14	2021-12-13	4	Ciappenelli Robert D.	DRNA	Common Stock	M - Exercise	D		22,5800	8.856	200		12.629
2021-12-13	2021-12-10	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-146.195		55.055
2021-12-13	2021-12-10	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-33.670		191.330
2021-12-13	2021-12-10	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	M - Exercise	D		3,4200	146.195	500		223.029
2021-12-13	2021-12-10	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	M - Exercise	D		2,9700	33.670	100		76.834
2021-11-22	2021-11-18	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-24.936		0
2021-11-22	2021-11-18	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		37,9400	-24.936	-946		267
2021-11-22	2021-11-18	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	24.936	85		25.203
2021-09-21	2021-09-17	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,0596	-21.250	-448		267
2021-09-17	2021-09-17	4	Zeng Ling	DRNA	Common Stock	S - Sale	D		21,4700	-1.334	-29		3.222
2021-09-17	2021-09-15	4	Zeng Ling	DRNA	Restricted Stock Units	M - Exercise	D			-4.556		13.669
2021-09-17	2021-09-15	4	Zeng Ling	DRNA	Common Stock	M - Exercise	D			4.556			4.556
2021-09-17	2021-09-17	4	Aradhye Shreeram	DRNA	Common Stock	S - Sale	D		21,4700	-2.056	-44		4.969
2021-09-17	2021-09-15	4	Aradhye Shreeram	DRNA	Restricted Stock Units	M - Exercise	D			-7.025		21.075
2021-09-17	2021-09-15	4	Aradhye Shreeram	DRNA	Common Stock	M - Exercise	D			7.025			7.025
2021-08-10	2021-08-10	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	P - Purchase	D		22,0960	5.000	110		43.164
2021-08-10	2021-08-10	4	KOZIN MARC D	DRNA	Common Stock	P - Purchase	D		23,6620	3.000	71		6.333
2021-08-03	2021-08-02	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.312		24.936
2021-08-03	2021-08-02	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		37,3770	-8.312	-311		21.517
2021-08-03	2021-08-02	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.312	28		29.829
2021-07-08	2021-07-06	4	Paglia Regina M.	DRNA	Restricted Stock Units	M - Exercise	D			-1.712		11.988
2021-07-08	2021-07-06	4	Paglia Regina M.	DRNA	Restricted Stock Units	M - Exercise	D			-1.450		7.250
2021-07-08	2021-07-06	4	Paglia Regina M.	DRNA	Common Stock	F - Taxes	D		37,0500	-1.404	-52		2.027
2021-07-08	2021-07-06	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D			1.712			3.431
2021-07-08	2021-07-06	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D			1.450			1.719
2021-07-08	2021-07-06	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		-30.000		33.999
2021-07-08	2021-07-06	4	Weissman James B	DRNA	Common Stock	S - Sale	D		39,0900	-30.000	-1.173		16.000
2021-07-08	2021-07-06	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		9,0900	30.000	273		46.000
2021-07-06	2021-07-01	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.312		33.248
2021-07-06	2021-07-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		37,8466	-1.066	-40		21.517
2021-07-06	2021-07-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		37,3029	-7.246	-270		22.583
2021-07-06	2021-07-01	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.312	28		29.829
2021-06-29	2021-06-25	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	22,58		-1.000		49.221
2021-06-29	2021-06-25	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		38,0037	-1.000	-38		269
2021-06-29	2021-06-25	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		22,5800	1.000	23		1.269
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	24,05		-2.406		55.094
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	22,58		-2.279		50.221
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		-13.750		85.000
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		36,7108	-4.880	-179		269
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		37,0957	-13.555	-503		5.149
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		24,0500	2.406	58		18.704
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		22,5800	2.279	51		16.298
2021-06-24	2021-06-22	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	13.750	178		14.019
2021-06-22	2021-06-17	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	24,05		-4.000		57.500
2021-06-22	2021-06-17	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		-4.664		98.750
2021-06-22	2021-06-17	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		35,7881	-8.664	-310		269
2021-06-22	2021-06-17	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		24,0500	4.000	96		8.933
2021-06-22	2021-06-17	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	4.664	60		4.933
2021-06-17	2021-06-15	4	Pagan Douglas W.	DRNA	Restricted Stock Units	M - Exercise	D			-6.825		20.475
2021-06-17	2021-06-15	4	Pagan Douglas W.	DRNA	Common Stock	F - Taxes	D		35,7400	-2.004	-72		5.760
2021-06-17	2021-06-15	4	Pagan Douglas W.	DRNA	Common Stock	M - Exercise	D			6.825			7.764
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	26,62		-1.564		5.261
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	22,58		-10.000		52.500
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		-20.000		103.414
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		36,1500	-100	-4		269
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		35,6284	-31.464	-1.121		369
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		26,6200	1.564	42		31.833
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		22,5800	10.000	226		30.269
2021-06-17	2021-06-16	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	20.000	259		20.269
2021-06-17	2021-06-15	4	Paglia Regina M.	DRNA	Restricted Stock Units	M - Exercise	D			-381		1.144
2021-06-17	2021-06-15	4	Paglia Regina M.	DRNA	Common Stock	F - Taxes	D		35,7400	-112	-4		269
2021-06-17	2021-06-15	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D			381			381
2021-06-15	2021-06-14	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	15,61		-20.000		270.000
2021-06-15	2021-06-14	4	Ciappenelli Robert D.	DRNA	Common Stock	S - Sale	D		38,0000	-20.000	-760		3.773
2021-06-15	2021-06-14	4	Ciappenelli Robert D.	DRNA	Common Stock	M - Exercise	D		15,6100	20.000	312		23.773
2021-06-15	2021-06-11	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	15,61		-10.000		290.000
2021-06-15	2021-06-11	4	Ciappenelli Robert D.	DRNA	Common Stock	S - Sale	D		35,0000	-10.000	-350		3.773
2021-06-15	2021-06-11	4	Ciappenelli Robert D.	DRNA	Common Stock	M - Exercise	D		15,6100	10.000	156		13.773
2021-06-15	2021-06-11	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		-10.000		85.000
2021-06-15	2021-06-11	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		34,0000	-10.000	-340		21.517
2021-06-15	2021-06-11	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		9,0900	10.000	91		31.517
2021-06-08	2021-06-07	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		-10.000		95.000
2021-06-08	2021-06-07	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		33,0000	-10.000	-330		21.517
2021-06-08	2021-06-07	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		9,0900	10.000	91		31.517
2021-06-07	2021-06-03	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15.000		15.000
2021-06-07	2021-06-03	4	HOFFMAN STEPHEN J	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2021-06-07	2021-06-03	4	HOFFMAN STEPHEN J	DRNA	Restricted Stock Units	M - Exercise	D			-3.333		0
2021-06-07	2021-06-03	4	HOFFMAN STEPHEN J	DRNA	Common Stock	M - Exercise	D			3.333			29.071
2021-06-07	2021-06-03	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15.000		15.000
2021-06-07	2021-06-03	4	Freed Martin I	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2021-06-07	2021-06-03	4	Freed Martin I	DRNA	Restricted Stock Units	M - Exercise	D			-3.333		0
2021-06-07	2021-06-03	4	Freed Martin I	DRNA	Common Stock	M - Exercise	D			3.333			3.333
2021-06-07	2021-06-03	4	Smith Cynthia	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15.000		15.000
2021-06-07	2021-06-03	4	Smith Cynthia	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2021-06-07	2021-06-03	4	Smith Cynthia	DRNA	Restricted Stock Units	M - Exercise	D			-3.333		0
2021-06-07	2021-06-03	4	Smith Cynthia	DRNA	Common Stock	M - Exercise	D			3.333			3.333
2021-06-07	2021-06-03	4	KOZIN MARC D	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15.000		15.000
2021-06-07	2021-06-03	4	KOZIN MARC D	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2021-06-07	2021-06-03	4	KOZIN MARC D	DRNA	Restricted Stock Units	M - Exercise	D			-3.333		0
2021-06-07	2021-06-03	4	KOZIN MARC D	DRNA	Common Stock	M - Exercise	D			3.333			3.333
2021-06-07	2021-06-03	4	GRAY PATRICK M.	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15.000		15.000
2021-06-07	2021-06-03	4	GRAY PATRICK M.	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2021-06-07	2021-06-03	4	GRAY PATRICK M.	DRNA	Restricted Stock Units	M - Exercise	D			-3.333		0
2021-06-07	2021-06-03	4	GRAY PATRICK M.	DRNA	Common Stock	M - Exercise	D			3.333			3.333
2021-06-07	2021-06-03	4	Protopapas Anna	DRNA	Restricted Stock Units	M - Exercise	D			-3.333		0
2021-06-07	2021-06-03	4	Protopapas Anna	DRNA	Common Stock	M - Exercise	D			3.333			3.333
2021-06-07	2021-06-03	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15.000		15.000
2021-06-07	2021-06-03	4	BUCHI J KEVIN	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2021-06-07	2021-06-03	4	BUCHI J KEVIN	DRNA	Restricted Stock Units	M - Exercise	D			-4.666		0
2021-06-07	2021-06-03	4	BUCHI J KEVIN	DRNA	Common Stock	M - Exercise	D			4.666			4.666
2021-06-07	2021-06-03	4	Doberstein Stephen K	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15.000		15.000
2021-06-07	2021-06-03	4	Doberstein Stephen K	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2021-06-07	2021-06-03	4	Doberstein Stephen K	DRNA	Restricted Stock Units	M - Exercise	D			-3.333		0
2021-06-07	2021-06-03	4	Doberstein Stephen K	DRNA	Common Stock	M - Exercise	D			3.333			3.333
2021-06-07	2021-06-03	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	A - Award	D	30,47		15.000		15.000
2021-06-07	2021-06-03	4	Koppel Adam	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2021-06-07	2021-06-03	4	Koppel Adam	DRNA	Restricted Stock Units	M - Exercise	D			-3.333		0
2021-06-07	2021-06-03	4	Koppel Adam	DRNA	Common Stock	M - Exercise	D			3.333			3.333
2021-06-03	2021-06-01	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		-4.431		123.414
2021-06-03	2021-06-01	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		31,9687	-305	-10		0
2021-06-03	2021-06-01	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		30,8599	-4.126	-127		305
2021-06-03	2021-06-01	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	4.431	57		4.431
2021-06-03	2021-06-01	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.312		41.560
2021-06-03	2021-06-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		32,0165	-342	-11		21.517
2021-06-03	2021-06-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		30,8818	-7.970	-246		21.859
2021-06-03	2021-06-01	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.312	28		29.829
2021-05-05	2021-05-03	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		-4.431		127.845
2021-05-05	2021-05-03	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		31,2485	-475	-15		0
2021-05-05	2021-05-03	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		30,1692	-3.956	-119		475
2021-05-05	2021-05-03	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	4.431	57		4.431
2021-05-05	2021-05-03	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.312		49.872
2021-05-05	2021-05-03	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		31,6600	-24	-1		21.517
2021-05-05	2021-05-03	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		31,0103	-1.135	-35		21.541
2021-05-05	2021-05-03	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		30,1574	-7.153	-216		22.676
2021-05-05	2021-05-03	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.312	28		29.829
2021-05-03	2021-04-30	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		-10.000		105.000
2021-05-03	2021-04-30	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		32,0000	-10.000	-320		21.517
2021-05-03	2021-04-30	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		9,0900	10.000	91		31.517
2021-05-03	2021-04-29	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		-10.000		115.000
2021-05-03	2021-04-29	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		31,0000	-10.000	-310		21.517
2021-05-03	2021-04-29	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		9,0900	10.000	91		31.517
2021-04-20	2021-04-16	4	Weissman James B	DRNA	Common Stock	S - Sale	D		29,9900	-4.904	-147		16.000
2021-04-05	2021-04-01	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.312		58.184
2021-04-05	2021-04-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		26,4950	-188	-5		21.517
2021-04-05	2021-04-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		25,8548	-8.124	-210		21.705
2021-04-05	2021-04-01	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.312	28		29.829
2021-04-05	2021-03-01	4/A	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.312		66.496
2021-04-05	2021-03-01	4/A	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.312	28		29.829
2021-04-05	2021-02-03	4/A	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-5.246		0
2021-04-05	2021-02-03	4/A	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-3.066		74.808
2021-04-05	2021-02-03	4/A	Brown Bob D	DRNA	Common Stock	M - Exercise	D		2,9700	5.246	16		29.829
2021-04-05	2021-02-03	4/A	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	3.066	10		24.583
2021-04-05	2021-01-25	4/A	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-16.630		5.246
2021-04-05	2021-01-25	4/A	Brown Bob D	DRNA	Common Stock	M - Exercise	D		2,9700	16.630	49		43.147
2021-04-05	2021-04-01	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		-4.431		132.276
2021-04-05	2021-04-01	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		25,8551	-4.431	-115		0
2021-04-05	2021-04-01	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	4.431	57		4.431
2021-03-02	2021-03-01	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		-8.312		91.746
2021-03-02	2021-03-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		29,4889	-783	-23		21.517
2021-03-02	2021-03-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		28,9031	-7.529	-218		22.300
2021-03-02	2021-03-01	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		9,0900	8.312	76		29.829
2021-03-02	2021-03-01	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		-4.431		136.707
2021-03-02	2021-03-01	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		29,4699	-356	-10		0
2021-03-02	2021-03-01	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		28,9197	-4.075	-118		356
2021-03-02	2021-03-01	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	4.431	57		4.431
2021-02-08	2021-02-05	4	Weissman James B	DRNA	Common Stock	S - Sale	D		26,9900	-7.156	-193		20.904
2021-02-04	2021-02-03	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		-8.312		100.058
2021-02-04	2021-02-03	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		25,0000	-8.312	-208		21.517
2021-02-04	2021-02-03	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		9,0900	8.312	76		29.829
2021-02-04	2021-02-02	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		-4.431		141.138
2021-02-04	2021-02-02	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		24,0000	-4.431	-106		0
2021-02-04	2021-02-02	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	4.431	57		4.431
2021-01-27	2021-01-25	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		-16.630		108.370
2021-01-27	2021-01-25	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		25,0000	-21.630	-541		21.517
2021-01-27	2021-01-25	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		9,0900	16.630	151		43.147
2021-01-27	2021-01-25	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		-4.431		145.569
2021-01-27	2021-01-25	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		25,0000	-6.326	-158		0
2021-01-27	2021-01-25	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	4.431	57		6.326
2021-01-13	2021-01-12	4	Weissman James B	DRNA	Common Stock	S - Sale	D		24,0820	-5.808	-140		28.060
2021-01-13	2021-01-12	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		24,0732	-5.808	-140		26.517
2021-01-12	2021-01-12	4	Aradhye Shreeram	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		51.070		51.070
2021-01-12	2021-01-12	4	Aradhye Shreeram	DRNA	Restricted Stock Units	A - Award	D			11.350		11.350
2021-01-12	2021-01-12	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		68.100		68.100
2021-01-12	2021-01-12	4	Weissman James B	DRNA	Restricted Stock Units	A - Award	D			15.100		15.100
2021-01-12	2021-01-11	4	Weissman James B	DRNA	Common Stock	S - Sale	D		23,9900	-3.800	-91		33.868
2021-01-12	2021-01-08	4	Weissman James B	DRNA	Restricted Stock Units	M - Exercise	D			-8.650		25.950
2021-01-12	2021-01-08	4	Weissman James B	DRNA	Common Stock	F - Taxes	D		23,2900	-2.842	-66		37.668
2021-01-12	2021-01-08	4	Weissman James B	DRNA	Common Stock	M - Exercise	D			8.650			40.510
2021-01-12	2021-01-12	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		247.700		247.700
2021-01-12	2021-01-12	4	FAMBROUGH DOUGLAS	DRNA	Restricted Stock Units	A - Award	D			55.000		55.000
2021-01-12	2021-01-08	4	FAMBROUGH DOUGLAS	DRNA	Restricted Stock Units	M - Exercise	D			-19.950		59.850
2021-01-12	2021-01-08	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	F - Taxes	D		23,2900	-6.159	-143		37.030
2021-01-12	2021-01-08	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	M - Exercise	D			19.950			43.189
2021-01-12	2021-01-12	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		68.100		68.100
2021-01-12	2021-01-12	4	Brown Bob D	DRNA	Restricted Stock Units	A - Award	D			15.100		15.100
2021-01-12	2021-01-08	4	Brown Bob D	DRNA	Restricted Stock Units	M - Exercise	D			-8.650		25.950
2021-01-12	2021-01-08	4	Brown Bob D	DRNA	Common Stock	F - Taxes	D		23,2900	-2.842	-66		32.325
2021-01-12	2021-01-08	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D			8.650			35.167
2021-01-12	2021-01-12	4	Zeng Ling	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		46.120		46.120
2021-01-12	2021-01-12	4	Zeng Ling	DRNA	Restricted Stock Units	A - Award	D			10.250		10.250
2021-01-12	2021-01-12	4	Pagan Douglas W.	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		36.900		36.900
2021-01-12	2021-01-12	4	Pagan Douglas W.	DRNA	Restricted Stock Units	A - Award	D			8.200		8.200
2021-01-12	2021-01-12	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		61.500		61.500
2021-01-12	2021-01-12	4	Paglia Regina M.	DRNA	Restricted Stock Units	A - Award	D			13.700		13.700
2021-01-12	2021-01-08	4	Paglia Regina M.	DRNA	Restricted Stock Units	M - Exercise	D			-2.900		8.700
2021-01-12	2021-01-08	4	Paglia Regina M.	DRNA	Common Stock	F - Taxes	D		23,2900	-1.005	-23		1.895
2021-01-12	2021-01-08	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D			2.900			2.900
2021-01-12	2021-01-12	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	24,05		61.500		61.500
2021-01-12	2021-01-12	4	Ciappenelli Robert D.	DRNA	Restricted Stock Units	A - Award	D			13.700		13.700
2021-01-12	2021-01-08	4	Ciappenelli Robert D.	DRNA	Restricted Stock Units	M - Exercise	D			-5.775		17.325
2021-01-12	2021-01-08	4	Ciappenelli Robert D.	DRNA	Common Stock	F - Taxes	D		23,2900	-2.002	-47		3.773
2021-01-12	2021-01-08	4	Ciappenelli Robert D.	DRNA	Common Stock	M - Exercise	D			5.775			5.775
2020-12-14	2020-12-10	4	Koppel Adam See footnotes	DRNA	Common Stock	S - Sale	I		23,4000	-1.000.000	-23.400		3.080.237
2020-12-03	2020-12-01	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.185		0
2020-12-03	2020-12-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		25,1931	-8.185	-206		26.517
2020-12-03	2020-12-01	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.185	28		34.702
2020-12-03	2020-12-01	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-4.360		0
2020-12-03	2020-12-01	4	Weissman James B	DRNA	Common Stock	S - Sale	D		25,2071	-4.360	-110		31.860
2020-12-03	2020-12-01	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	4.360	15		36.220
2020-11-06	2020-11-04	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	12,93		-30.000		150.000
2020-11-06	2020-11-04	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		23,2500	-15.000	-349		0
2020-11-06	2020-11-04	4	Paglia Regina M.	DRNA	Common Stock	S - Sale	D		22,2500	-15.000	-334		15.000
2020-11-06	2020-11-04	4	Paglia Regina M.	DRNA	Common Stock	M - Exercise	D		12,9300	30.000	388		30.000
2020-11-03	2020-11-02	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.185		8.185
2020-11-03	2020-11-02	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,0300	-8.185	-172		26.517
2020-11-03	2020-11-02	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.185	28		34.702
2020-11-03	2020-11-02	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-4.360		4.360
2020-11-03	2020-11-02	4	Weissman James B	DRNA	Common Stock	S - Sale	D		20,9480	-4.360	-91		31.860
2020-11-03	2020-11-02	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	4.360	15		36.220
2020-10-22	2020-10-20	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-10.000		11.879
2020-10-22	2020-10-20	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	10.000	30		31.860
2020-10-20	2020-10-16	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-16.370		16.370
2020-10-20	2020-10-16	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,0000	-16.370	-344		26.517
2020-10-20	2020-10-16	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	16.370	56		42.887
2020-10-19	2020-10-15	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.720		8.720
2020-10-19	2020-10-15	4	Weissman James B	DRNA	Common Stock	S - Sale	D		20,2000	-8.720	-176		21.860
2020-10-19	2020-10-15	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	8.720	30		30.580
2020-10-02	2020-10-01	4	Aradhye Shreeram	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,69		124.700		124.700
2020-10-02	2020-10-01	4	Aradhye Shreeram	DRNA	Restricted Stock Units	A - Award	D			28.100		28.100
2020-10-02	2020-10-01	4	Zeng Ling	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,69		81.825		81.825
2020-10-02	2020-10-01	4	Zeng Ling	DRNA	Restricted Stock Units	A - Award	D			18.225		18.225
2020-09-18	2020-09-16	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-21.250		77.874
2020-09-18	2020-09-16	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	21.250	73		26.517
2020-09-16	2020-09-14	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-267		0
2020-09-16	2020-09-14	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	267	1		5.267
2020-09-04	2020-07-01	4/A	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-4.360		25.980
2020-09-04	2020-07-01	4/A	Weissman James B	DRNA	Common Stock	S - Sale	D		26,8678	-1.307	-35		21.860
2020-09-04	2020-07-01	4/A	Weissman James B	DRNA	Common Stock	S - Sale	D		26,3881	-3.053	-81		23.167
2020-09-04	2020-07-01	4/A	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4.360	13		26.220
2020-09-01	2020-09-01	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	P - Purchase	D		18,0597	10.000	181		22.300
2020-08-05	2020-08-03	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.185		32.740
2020-08-05	2020-08-03	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		22,7999	-2.521	-57		5.000
2020-08-05	2020-08-03	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		22,3355	-5.664	-127		7.521
2020-08-05	2020-08-03	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.185	28		13.185
2020-08-05	2020-08-03	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-259		17.440
2020-08-05	2020-08-03	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-4.101		21.879
2020-08-05	2020-08-03	4	Weissman James B	DRNA	Common Stock	S - Sale	D		22,7993	-1.432	-33		21.860
2020-08-05	2020-08-03	4	Weissman James B	DRNA	Common Stock	S - Sale	D		22,3120	-2.928	-65		23.292
2020-08-05	2020-08-03	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	259	1		26.220
2020-08-05	2020-08-03	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4.101	12		25.961
2020-07-06	2020-07-01	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-4.360		25.980
2020-07-06	2020-07-01	4	Weissman James B	DRNA	Common Stock	S - Sale	D		26,8678	-1.307	-35		21.860
2020-07-06	2020-07-01	4	Weissman James B	DRNA	Common Stock	S - Sale	D		26,3881	-3.053	-81		23.167
2020-07-06	2020-07-01	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4.360	13		26.220
2020-07-06	2020-07-01	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.185		40.925
2020-07-06	2020-07-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		26,8533	-2.371	-64		5.000
2020-07-06	2020-07-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		26,3604	-5.814	-153		7.371
2020-07-06	2020-07-01	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.185	28		13.185
2020-07-02	2020-07-01	4	Paglia Regina M.	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	26,62		6.825		6.825
2020-07-02	2020-07-01	4	Paglia Regina M.	DRNA	Restricted Stock Units	A - Award	D			1.525		1.525
2020-06-23	2020-06-19	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-9.670		21.876
2020-06-23	2020-06-19	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		25,0000	-9.670	-242		5.000
2020-06-23	2020-06-19	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		2,9700	9.670	29		14.670
2020-06-16	2020-06-15	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15.000		15.000
2020-06-16	2020-06-15	4	HOFFMAN STEPHEN J	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2020-06-16	2020-06-15	4	Koppel Adam	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15.000		15.000
2020-06-16	2020-06-15	4	Koppel Adam	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2020-06-16	2020-06-15	4	GRAY PATRICK M.	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15.000		15.000
2020-06-16	2020-06-15	4	GRAY PATRICK M.	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2020-06-16	2020-06-15	4	Doberstein Stephen K	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15.000		15.000
2020-06-16	2020-06-15	4	Doberstein Stephen K	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2020-06-16	2020-06-15	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		21.000		21.000
2020-06-16	2020-06-15	4	BUCHI J KEVIN	DRNA	Restricted Stock Units	A - Award	D			4.666		4.666
2020-06-16	2020-06-15	4	Smith Cynthia	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15.000		15.000
2020-06-16	2020-06-15	4	Smith Cynthia	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2020-06-16	2020-06-15	4	Protopapas Anna	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15.000		15.000
2020-06-16	2020-06-15	4	Protopapas Anna	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2020-06-16	2020-06-15	4	KOZIN MARC D	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15.000		15.000
2020-06-16	2020-06-15	4	KOZIN MARC D	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2020-06-16	2020-06-15	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	A - Award	D	21,61		15.000		15.000
2020-06-16	2020-06-15	4	Freed Martin I	DRNA	Restricted Stock Units	A - Award	D			3.333		3.333
2020-06-02	2020-06-01	4	Pagan Douglas W.	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	20,79		95.650		95.650
2020-06-02	2020-06-01	4	Pagan Douglas W.	DRNA	Restricted Stock Units	A - Award	D			27.300		27.300
2020-06-02	2020-06-01	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.185		49.110
2020-06-02	2020-06-01	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,0091	-8.185	-172		5.000
2020-06-02	2020-06-01	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.185	28		13.185
2020-06-02	2020-06-01	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-4.360		30.340
2020-06-02	2020-06-01	4	Weissman James B	DRNA	Common Stock	S - Sale	D		21,0567	-4.360	-92		21.860
2020-06-02	2020-06-01	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4.360	13		26.220
2020-05-12	2020-05-11	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-13.281		31.546
2020-05-12	2020-05-11	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		24,0000	-13.281	-319		5.000
2020-05-12	2020-05-11	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		2,9700	13.281	39		18.281
2020-05-07	2020-05-05	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.185		57.295
2020-05-07	2020-05-05	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,0000	-8.185	-172		5.000
2020-05-07	2020-05-05	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.185	28		13.185
2020-05-06	2020-05-04	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		4.360		34.700
2020-05-06	2020-05-04	4	Weissman James B	DRNA	Common Stock	S - Sale	D		20,2000	-4.360	-88		21.860
2020-05-06	2020-05-04	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4.360	13		26.220
2020-04-22	2020-04-20	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	5,45		-25.624		186.375
2020-04-22	2020-04-20	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		22,9500	-25.624	-588		19.421
2020-04-22	2020-04-20	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		5,4500	25.624	140		45.045
2020-04-21	2020-04-20	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-13.281		44.827
2020-04-21	2020-04-20	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		23,0000	-13.281	-305		5.000
2020-04-21	2020-04-20	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		2,9700	13.281	39		18.281
2020-04-21	2020-04-17	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.185		65.480
2020-04-21	2020-04-17	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,1800	-8.185	-173		5.000
2020-04-21	2020-04-17	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.185	28		13.185
2020-04-14	2020-04-13	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-4.360		39.060
2020-04-14	2020-04-13	4	Weissman James B	DRNA	Common Stock	S - Sale	D		20,2000	-4.360	-88		21.860
2020-04-14	2020-04-13	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4.360	13		26.220
2020-04-09	2020-04-07	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-12.968		14.063
2020-04-09	2020-04-07	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	5,45		-7.501		211.999
2020-04-09	2020-04-07	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		19,9500	-20.469	-408		19.421
2020-04-09	2020-04-07	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		2,9700	12.968	39		39.890
2020-04-09	2020-04-07	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		5,4500	7.501	41		26.922
2020-03-16	2020-03-12	4	Doberstein Stephen K	DRNA	Director Stock Option (Right to Buy)	A - Award	D	15,61		25.000		25.000
2020-03-03	2020-03-02	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-4.360		43.420
2020-03-03	2020-03-02	4	Weissman James B	DRNA	Common Stock	S - Sale	D		20,6087	-4.360	-90		21.860
2020-03-03	2020-03-02	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4.360	13		26.220
2020-03-03	2020-03-02	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.185		73.665
2020-03-03	2020-03-02	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,0000	-8.185	-172		5.000
2020-03-03	2020-03-02	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.185	28		13.185
2020-02-11	2020-02-10	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-2.535		99.124
2020-02-11	2020-02-10	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-5.650		81.850
2020-02-11	2020-02-10	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,0000	-8.185	-172		5.000
2020-02-11	2020-02-10	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	2.535	9		13.185
2020-02-11	2020-02-10	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	5.650	19		10.650
2020-02-04	2020-02-03	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-4.360		47.780
2020-02-04	2020-02-03	4	Weissman James B	DRNA	Common Stock	S - Sale	D		20,2000	-4.360	-88		21.860
2020-02-04	2020-02-03	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	4.360	13		26.220
2020-01-21	2020-01-17	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-20.469		27.031
2020-01-21	2020-01-17	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-27.500		47.500
2020-01-21	2020-01-17	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		21,2628	-20.469	-435		19.421
2020-01-21	2020-01-17	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		21,2704	-27.500	-585		39.890
2020-01-21	2020-01-17	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		2,9700	20.469	61		67.390
2020-01-21	2020-01-17	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		2,9700	27.500	82		46.921
2020-01-10	2020-01-08	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	22,58		85.000		85.000
2020-01-10	2020-01-08	4	GREEN JOHN B	DRNA	Restricted Stock Units	A - Award	D			23.100		23.100
2020-01-10	2020-01-08	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	22,58		85.000		85.000
2020-01-10	2020-01-08	4	Ciappenelli Robert D.	DRNA	Restricted Stock Units	A - Award	D			23.100		23.100
2020-01-10	2020-01-08	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	22,58		121.300		121.300
2020-01-10	2020-01-08	4	Weissman James B	DRNA	Restricted Stock Units	A - Award	D			34.600		34.600
2020-01-10	2020-01-08	4	ROSSKAMP RALF	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	22,58		85.000		85.000
2020-01-10	2020-01-08	4	ROSSKAMP RALF	DRNA	Restricted Stock Units	A - Award	D			23.100		23.100
2020-01-10	2020-01-08	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	22,58		121.300		121.300
2020-01-10	2020-01-08	4	Brown Bob D	DRNA	Restricted Stock Units	A - Award	D			34.600		34.600
2020-01-10	2020-01-08	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	22,58		250.000		250.000
2020-01-10	2020-01-08	4	FAMBROUGH DOUGLAS	DRNA	Restricted Stock Units	A - Award	D			79.800		79.800
2020-01-03	2020-01-02	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-2.860		52.140
2020-01-03	2020-01-02	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-1.500		0
2020-01-03	2020-01-02	4	Weissman James B	DRNA	Common Stock	S - Sale	D		21,8753	-4.360	-95		21.860
2020-01-03	2020-01-02	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	2.860	8		26.220
2020-01-03	2020-01-02	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	1.500	5		23.360
2019-12-31	2019-12-31	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-11.941		58.108
2019-12-31	2019-12-31	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-5.000		101.659
2019-12-31	2019-12-31	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		22,0000	-11.941	-263		5.000
2019-12-31	2019-12-31	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		2,9700	11.941	35		16.941
2019-12-31	2019-12-31	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	5.000	17		5.000
2019-12-31	2019-12-30	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-4.951		70.049
2019-12-31	2019-12-30	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-8.185		106.659
2019-12-31	2019-12-30	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		22,0051	-1.340	-29		0
2019-12-31	2019-12-30	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		21,8445	-21.466	-469		1.340
2019-12-31	2019-12-30	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		2,9700	4.951	15		22.806
2019-12-31	2019-12-30	4	Brown Bob D	DRNA	Common Stock	M - Exercise	D		3,4200	8.185	28		17.855
2019-12-27	2019-12-26	4	ROSSKAMP RALF	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,91		-20.000		230.000
2019-12-27	2019-12-26	4	ROSSKAMP RALF	DRNA	Common Stock	S - Sale	D		22,6882	-20.000	-454		3.564
2019-12-27	2019-12-26	4	ROSSKAMP RALF	DRNA	Common Stock	M - Exercise	D		2,9100	20.000	58		23.564
2019-12-19	2019-12-18	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-80.000		201.250
2019-12-19	2019-12-18	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	S - Sale	D		27,0735	-1.431	-39		12.300
2019-12-19	2019-12-18	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	S - Sale	D		25,8479	-78.569	-2.031		13.731
2019-12-19	2019-12-18	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	M - Exercise	D		3,4200	80.000	274		92.300
2019-12-19	2019-12-17	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	S - Sale	D		26,9443	-2.305	-62		12.300
2019-12-19	2019-12-17	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	S - Sale	D		26,1344	-56.716	-1.482		14.605
2019-12-19	2019-12-18	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	9,09		-11.001		63.999
2019-12-19	2019-12-18	4	Weissman James B	DRNA	Common Stock	F - Taxes	D		26,0100	-3.845	-100		21.860
2019-12-19	2019-12-18	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		9,0900	11.001	100		25.705
2019-12-11	2019-12-11	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	5,45		-8.000		219.500
2019-12-11	2019-12-11	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		5,4500	8.000	44		18.698
2019-12-06	2019-12-04	4	Koppel Adam See footnotes	DRNA	Common Stock	S - Sale	I		24,6800	-1.500.000	-37.020		4.080.237
2019-12-03	2019-12-02	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	2,97		-20.000		55.000
2019-12-03	2019-12-02	4	Weissman James B	DRNA	Common Stock	S - Sale	D		26,0000	-20.000	-520		14.704
2019-12-03	2019-12-02	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		2,9700	20.000	59		34.704
2019-12-02	2019-12-02	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		24,9835	-137.176	-3.427		0
2019-12-02	2019-11-29	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		24,2154	-138.000	-3.342		137.176
2019-12-02	2019-11-27	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		24,0433	-368.700	-8.865		275.176
2019-11-27	2019-11-25	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	5,45		-12.500		227.500
2019-11-27	2019-11-25	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		24,9500	-12.500	-312		10.698
2019-11-27	2019-11-25	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		5,4500	12.500	68		23.198
2019-11-26	2019-11-26	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		23,5855	-239.700	-5.653		643.876
2019-11-26	2019-11-25	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		24,0578	-361.200	-8.690		883.576
2019-11-26	2019-11-22	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		22,5164	-197.700	-4.451		1.244.776
2019-11-21	2019-11-19	4	Bain Capital Life Sciences Investors, LLC See Footnotes	DRNA	Common Stock	S - Sale	I		22,0300	-1.750.000	-38.552		5.580.237
2019-11-21	2019-11-21	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		22,9782	-351.505	-8.077		1.442.476
2019-11-21	2019-11-20	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		22,9332	-265.505	-6.089		1.793.981
2019-11-21	2019-11-19	4	Kolchinsky Peter See Note	DRNA	Common Stock	S - Sale	I		23,9217	-397.183	-9.501		2.059.486
2019-11-20	2019-11-18	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	5,45		-12.500		240.000
2019-11-20	2019-11-18	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		21,0500	-12.500	-263		10.698
2019-11-20	2019-11-18	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		5,4500	12.500	68		23.198
2019-11-20	2019-11-19	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-20.000		0
2019-11-20	2019-11-19	4	Weissman James B	DRNA	Common Stock	S - Sale	D		24,0000	-20.000	-480		14.704
2019-11-20	2019-11-19	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	20.000	68		34.704
2019-11-20	2019-11-18	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-20.000		20.000
2019-11-20	2019-11-18	4	Weissman James B	DRNA	Common Stock	S - Sale	D		22,0000	-20.000	-440		14.704
2019-11-20	2019-11-18	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	20.000	68		34.704
2019-11-15	2019-11-14	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		20,0000	-3.562	-71		10.698
2019-11-15	2019-11-14	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-20.000		40.000
2019-11-15	2019-11-14	4	Weissman James B	DRNA	Common Stock	S - Sale	D		20,0000	-20.000	-400		14.704
2019-11-15	2019-11-14	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	20.000	68		34.704
2019-11-01	2019-10-31	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-15.000		17.699
2019-11-01	2019-10-31	4	Weissman James B	DRNA	Common Stock	S - Sale	D		18,0000	-15.000	-270		14.704
2019-11-01	2019-10-31	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	15.000	51		29.704
2019-11-01	2019-10-31	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	5,45		-12.500		252.500
2019-11-01	2019-10-31	4	GREEN JOHN B	DRNA	Common Stock	S - Sale	D		18,0000	-12.500	-225		14.260
2019-11-01	2019-10-31	4	GREEN JOHN B	DRNA	Common Stock	M - Exercise	D		5,4500	12.500	68		26.760
2019-10-18	2019-10-18	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-4.104		60.000
2019-10-18	2019-10-18	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-800		0
2019-10-18	2019-10-18	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	4.104	14		14.704
2019-10-18	2019-10-18	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	800	3		10.600
2019-09-19	2019-09-17	4	GRAY PATRICK M.	DRNA	Director Stock Option (Right to Buy)	A - Award	D	14,32		25.000		25.000
2019-08-23	2019-08-23	4	Weissman James B	DRNA	Common Stock	S - Sale	D		13,0676	-14.680	-192		9.800
2019-07-01	2019-07-01	4	Ciappenelli Robert D.	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	15,61		300.000		300.000
2019-06-21	2019-06-20	4	Smith Cynthia	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25.000		25.000
2019-06-21	2019-06-20	4	Kolchinsky Peter	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25.000		25.000
2019-06-21	2019-06-20	4	Freed Martin I	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25.000		25.000
2019-06-21	2019-06-20	4	BUCHI J KEVIN	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		33.000		33.000
2019-06-21	2019-06-20	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25.000		25.000
2019-06-21	2019-06-20	4	LANGER DENNIS	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25.000		25.000
2019-06-21	2019-06-20	4	Protopapas Anna	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25.000		25.000
2019-06-21	2019-06-20	4	Koppel Adam	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25.000		25.000
2019-06-21	2019-06-20	4	KOZIN MARC D	DRNA	Director Stock Option (right to buy)	A - Award	D	15,44		25.000		25.000
2019-05-31	2019-05-29	4	Bain Capital Life Sciences Investors, LLC See footnotes	DRNA	Common Stock	S - Sale	I		12,5000	-1.600.000	-20.000		7.330.237
2019-04-04	2019-04-02	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-15.000		32.699
2019-04-04	2019-04-02	4	Weissman James B	DRNA	Common Stock	S - Sale	D		15,0000	-15.000	-225		24.480
2019-04-04	2019-04-02	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	15.000	51		39.480
2019-03-29	2019-03-28	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	A - Award	D	14,13		8.000		8.000
2019-01-25	2019-01-23	4	KOZIN MARC D	DRNA	Director Stock Option (Right to Buy)	A - Award	D	10,31		25.000		25.000
2019-01-25	2019-01-23	4	Protopapas Anna	DRNA	Director Stock Option (Right to Buy)	A - Award	D	10,31		25.000		25.000
2019-01-25		3	KOZIN MARC D By Marc D. Kozin Revocable Trust	DRNA	Common Stock		I						10.000
2019-01-25		3	KOZIN MARC D By Marc D. Kozin Revocable Trust	DRNA	Common Stock		I						10.000
2019-01-25		3	KOZIN MARC D By Marc D. Kozin Revocable Trust	DRNA	Common Stock		I						10.000
2019-01-04	2019-01-02	4	ROSSKAMP RALF	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	11,77		180.000		180.000
2019-01-04	2019-01-02	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	11,77		505.000		505.000
2019-01-04	2019-01-02	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	11,77		180.000		180.000
2019-01-04	2019-01-02	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	11,77		180.000		180.000
2019-01-04	2019-01-02	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	11,77		180.000		180.000
2018-11-09	2018-11-08	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		14,8599	-107.920	-1.604		2.456.669
2018-11-09	2018-11-07	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		14,7402	-250.000	-3.685		2.564.589
2018-11-06	2018-11-06	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		13,8434	-263.300	-3.645		2.814.589
2018-11-06	2018-11-05	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		12,8880	-71.400	-920		3.077.889
2018-11-06	2018-11-02	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		13,4926	-175.700	-2.371		3.149.289
2018-11-06	2018-11-06	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		14,1600	-11	-0		19.150
2018-11-06	2018-11-06	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		14,1600	-1.489	-21		2.586.535
2018-11-06	2018-11-06	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,1800	-761	-10		19.161
2018-11-06	2018-11-06	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,1800	-102.067	-1.345		2.588.024
2018-11-06	2018-11-05	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		12,9800	-295	-4		19.922
2018-11-06	2018-11-05	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		12,9800	-39.606	-514		2.690.091
2018-11-06	2018-11-02	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,4700	-1.412	-19		20.217
2018-11-06	2018-11-02	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,4700	-189.359	-2.551		2.729.697
2018-11-05	2018-11-01	4/A	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,3700	-1.408	-19		21.629
2018-11-05	2018-11-01	4/A	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,3700	-188.867	-2.525		2.919.056
2018-11-05	2018-10-31	4/A	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,6000	-959	-13		23.037
2018-11-05	2018-10-31	4/A	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,6000	-128.670	-1.750		3.107.923
2018-11-05	2018-10-30	4/A	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		14,3100	-678	-10		23.996
2018-11-05	2018-10-30	4/A	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		14,3100	-90.918	-1.301		3.236.593
2018-11-05	2018-10-30	4/A	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,6800	-1.136	-16		24.674
2018-11-05	2018-10-30	4/A	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,6800	-152.364	-2.084		3.327.511
2018-11-01	2018-11-01	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		13,3757	-180.100	-2.409		3.324.989
2018-11-01	2018-10-31	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		13,4619	-178.400	-2.402		3.505.089
2018-11-01	2018-10-30	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		13,8603	-250.000	-3.465		3.683.489
2018-11-01	2018-11-01	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,3700	-1.408	-19		21.629
2018-11-01	2018-11-01	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,3700	-188.167	-2.516		2.919.056
2018-11-01	2018-10-31	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,6000	-959	-13		23.037
2018-11-01	2018-10-31	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,6000	-128.670	-1.750		3.107.923
2018-11-01	2018-10-30	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		14,3100	-678	-10		23.996
2018-11-01	2018-10-30	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		14,3100	-90.918	-1.301		3.236.593
2018-11-01	2018-10-30	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	S - Sale	I		13,6800	-1.136	-16		24.674
2018-11-01	2018-10-30	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	S - Sale	I		13,6800	-152.364	-2.084		3.327.511
2018-09-06	2018-09-05	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-2.301		47.699
2018-09-06	2018-09-05	4	Weissman James B	DRNA	Common Stock	S - Sale	D		17,5000	-2.301	-40		24.480
2018-09-06	2018-09-05	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	2.301	8		26.781
2018-08-20	2018-08-17	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-14.680		64.104
2018-08-20	2018-08-17	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	14.680	50		24.480
2018-08-17	2018-08-15	4	LANGER DENNIS	DRNA	Common Stock	S - Sale	D		16,0000	-14.531	-232		29.064
2018-08-17	2018-08-15	4	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Common Stock	S - Sale	I		16,0000	-23.810	-381		47.978
2018-08-15	2018-08-13	4	Smith Cynthia	DRNA	Director Stock Option (Right to Buy)	A - Award	D	14,76		25.000		25.000
2018-08-15	2018-08-13	4	BUCHI J KEVIN	DRNA	Director Stock Option (Right to Buy)	A - Award	D	14,76		25.000		25.000
2018-06-26	2018-06-21	4	Wise Bart W	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	13,08		25.000		25.000
2018-06-26		3	Wise Bart W	DRNA	Common Stock		D						11.294
2018-06-26		3	Wise Bart W	DRNA	Common Stock		D						11.294
2018-06-26		3	Wise Bart W	DRNA	Common Stock		D						11.294
2018-06-25	2018-06-21	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	A - Award	D	13,08		25.000		25.000
2018-06-25	2018-06-21	4	LANGER DENNIS	DRNA	Director Stock Option (right to buy)	A - Award	D	13,08		25.000		25.000
2018-06-25	2018-06-21	4	Kolchinsky Peter	DRNA	Director Stock Option (right to buy)	A - Award	D	13,08		25.000		25.000
2018-06-25	2018-06-21	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (right to buy)	A - Award	D	13,08		25.000		25.000
2018-06-25	2018-06-21	4	MADDEN DAVID	DRNA	Director Stock Option (right to buy)	A - Award	D	13,08		33.000		33.000
2018-06-25	2018-06-21	4	Halak Brian K	DRNA	Stock Option (Right to Buy)	A - Award	D	13,08		25.000		25.000
2018-06-25	2018-06-21	4	Koppel Adam	DRNA	Director Stock Option (right to buy)	A - Award	D	13,08		25.000		25.000
2018-06-11	2018-06-07	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Warrant to Purchase Common Stock	M - Exercise	I	7,00		-156		0
2018-06-11	2018-06-07	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Warrant to Purchase Common Stock	M - Exercise	I	7,00		-21.041		0
2018-06-11	2018-06-07	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	F - Taxes	I		14,4500	-76	-1		25.810
2018-06-11	2018-06-07	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	F - Taxes	I		14,4500	-10.195	-147		3.479.875
2018-06-11	2018-06-07	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	M - Exercise	I		7,0000	156	1		25.886
2018-06-11	2018-06-07	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	M - Exercise	I		7,0000	21.041	147		3.490.070
2018-05-11	2018-05-09	4	Brown Bob D	DRNA	Common Stock	S - Sale	D		15,0000	-9.669	-145		9.670
2018-05-11	2018-05-09	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-10.000		50.000
2018-05-11	2018-05-09	4	Weissman James B	DRNA	Common Stock	S - Sale	D		15,0000	-10.000	-150		9.800
2018-05-11	2018-05-09	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	10.000	34		19.800
2018-04-24	2018-04-20	4	Weissman James B	DRNA	Common Stock	S - Sale	D		13,0000	-8.965	-117		9.800
2018-03-27	2018-03-23	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,0511	-55.300	-611		3.933.489
2018-03-21	2018-03-19	4	Weissman James B	DRNA	Common Stock	S - Sale	D		13,0000	-1.035	-13		18.765
2018-03-21	2018-03-21	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,1727	-36.224	-405		3.988.789
2018-03-21	2018-03-21	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,1400	-49.000	-546		4.025.013
2018-03-21	2018-03-21	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,0718	-31.145	-345		4.074.013
2018-03-21	2018-03-21	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,2399	-64.600	-726		4.105.158
2018-03-21	2018-03-20	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,1648	-67.985	-759		4.169.758
2018-03-21	2018-03-20	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,1555	-55.200	-616		4.237.743
2018-03-21	2018-03-20	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		11,0000	-50.000	-550		4.292.943
2018-03-21	2018-03-19	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		12,4550	-34.700	-432		4.342.943
2018-03-21	2018-03-19	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		12,6308	-84.670	-1.069		4.377.643
2018-01-30	2018-01-26	4	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Stock Option (Right to Buy)	M - Exercise	I	3,42		-360		0
2018-01-30	2018-01-26	4	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Common Stock	M - Exercise	I		3,4200	360	1		71.788
2018-01-19	2018-01-18	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,2271	-59.700	-551		4.462.313
2018-01-19	2018-01-17	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,3254	-220.900	-2.060		4.522.013
2018-01-08	2018-01-04	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,30		105.000		105.000
2018-01-08	2018-01-04	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,30		255.000		255.000
2018-01-08	2018-01-04	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,30		105.000		105.000
2018-01-08	2018-01-04	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,30		105.000		105.000
2018-01-08	2018-01-04	4	ROSSKAMP RALF	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,30		57.750		57.750
2018-01-08	2018-01-05	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,1461	-18.100	-166		4.742.913
2018-01-08	2018-01-04	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,1978	-77.400	-712		4.761.013
2018-01-03	2018-01-03	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,2533	-59.100	-547		4.838.413
2018-01-03	2018-01-02	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,4655	-68.000	-644		4.897.513
2018-01-03	2017-12-29	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,1288	-23.100	-211		4.965.513
2018-01-03	2017-12-29	4	Kolchinsky Peter See Note	DRNA	Common Stock	D - Sale to Issuer	I		9,1026	-85.400	-777		4.988.613
2017-12-20	2017-12-18	4	RA CAPITAL MANAGEMENT, LLC See Note	DRNA	Redeemable Convertible Preferred Stock	M - Exercise	I		3,1900	-76.500	-244	0
2017-12-20	2017-12-18	4	RA CAPITAL MANAGEMENT, LLC See Note	DRNA	Common Stock	M - Exercise	I			2.645.442			5.074.013
2017-12-20	2017-12-18	4	Kolchinsky Peter See Note	DRNA	Redeemable Convertible Preferred Stock	M - Exercise	I		3,1900	-76.500	-244	0
2017-12-20	2017-12-18	4	Kolchinsky Peter See Note	DRNA	Common Stock	M - Exercise	I			2.645.442			5.074.013
2017-12-20	2017-12-18	4	Domain Partners VIII, L.P.	DRNA	Redeemable Convertible Preferred Stock	C - Conversion	D	3,19		-49.632		0
2017-12-20	2017-12-18	4	Domain Partners VIII, L.P.	DRNA	Common Stock	A - Award	D			37.890			3.469.029
2017-12-20	2017-12-18	4	Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	D		3,1900	1.678.432	5.354		3.431.139
2017-12-20	2017-12-18	4	DP VIII Associates, L.P.	DRNA	Redeemable Convertible Preferred Stock	C - Conversion	D	3,19		-368		0
2017-12-20	2017-12-18	4	DP VIII Associates, L.P.	DRNA	Common Stock	A - Award	D			282			25.730
2017-12-20	2017-12-18	4	DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	D		3,1900	12.444	40		25.448
2017-12-19	2017-12-18	4	Bain Capital Life Sciences Investors, LLC See footnotes	DRNA	Redeemable Convertible Preferred Stock	M - Exercise	I		3,1900	-250.000	-798	0
2017-12-19	2017-12-18	4	Bain Capital Life Sciences Investors, LLC See footnotes	DRNA	Common Stock	A - Award	I			190.849			8.930.237
2017-12-19	2017-12-18	4	Bain Capital Life Sciences Investors, LLC See footnotes	DRNA	Common Stock	M - Exercise	I			8.454.388			8.739.388
2017-12-19	2017-12-18	4	Bain Capital Life Sciences Investors, LLC See footnotes	DRNA	Common Stock	P - Purchase	I		7,0000	285.000	1.995		285.000
2017-07-24	2017-07-18	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (right to buy)	A - Award	D	3,42		25.000		25.000
2017-07-20	2017-07-18	4	Kolchinsky Peter	DRNA	Director Stock Option (right to buy)	A - Award	D	3,42		25.000		25.000
2017-07-20	2017-07-18	4	PEACOCK BRUCE	DRNA	Director Stock Option (right to buy)	A - Award	D	3,42		25.000		25.000
2017-07-20	2017-07-18	4	LANGER DENNIS	DRNA	Director Stock Option (right to buy)	A - Award	D	3,42		25.000		25.000
2017-07-20	2017-07-18	4	Freed Martin I	DRNA	Director Stock Option (Right to Buy)	A - Award	D	3,42		25.000		25.000
2017-07-20	2017-07-18	4	MADDEN DAVID	DRNA	Director Stock Option (right to buy)	A - Award	D	3,42		33.000		33.000
2017-07-20	2017-07-18	4	Koppel Adam	DRNA	Director Stock Option (right to buy)	A - Award	D	3,42		25.000		25.000
2017-07-20	2017-07-18	4	Halak Brian K	DRNA	Stock Option (Right to Buy)	A - Award	D	3,42		25.000		25.000
2017-06-16	2017-06-15	4	ROSSKAMP RALF	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	2,91		250.000		250.000
2017-04-13	2017-04-11	4	Koppel Adam	DRNA	Employee Stock Option (Right to buy)	A - Award	D	3,47		25.000		25.000
2017-04-13	2017-04-11	4	RA CAPITAL MANAGEMENT, LLC See Note 1	DRNA	Redeemable Convertible Preferred Stock	J - Other	I	3,19	100,0000	76.500	7.650	76.500
2017-04-12	2017-04-11	4	DP VIII Associates, L.P.	DRNA	Redeemable Convertible Preferred Stock	P - Purchase	D	3,19	100,0000	368	37	368
2017-04-12	2017-04-11	4	Domain Partners VIII, L.P.	DRNA	Redeemable Convertible Preferred Stock	P - Purchase	D	3,19	100,0000	49.632	4.963	49.632
2017-01-05	2017-01-03	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	2,97		75.000		75.000
2017-01-05	2017-01-03	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	2,97		225.000		225.000
2017-01-05	2017-01-03	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy	A - Award	D	2,97		75.000		75.000
2017-01-05	2017-01-03	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	2,97		75.000		75.000
2016-11-17	2016-11-16	4	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Common Stock	S - Sale	I		3,5200	-23.766	-84		71.428
2016-11-16	2016-11-15	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	P - Purchase	D		3,6300	16.500	60		55.579
2016-11-16	2016-11-14	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	P - Purchase	D		3,7800	16.600	63		39.079
2016-06-16	2016-06-14	4	Halak Brian K	DRNA	Stock Option (Right to Buy)	A - Award	D	3,26		15.000		15.000
2016-06-15	2016-06-14	4	PEACOCK BRUCE	DRNA	Director Stock Option (right to buy)	A - Award	D	3,26		15.000		15.000
2016-06-15	2016-06-14	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (right to buy)	A - Award	D	3,26		15.000		15.000
2016-06-15	2016-06-14	4	LANGER DENNIS	DRNA	Director Stock Option (right to buy)	A - Award	D	3,26		15.000		15.000
2016-06-15	2016-06-14	4	MADDEN DAVID	DRNA	Director Stock Option (right to buy)	A - Award	D	3,26		20.000		20.000
2016-06-15	2016-06-14	4	Kolchinsky Peter	DRNA	Director Stock Option (right to buy)	A - Award	D	3,26		15.000		15.000
2016-06-15	2016-06-14	4	Freed Martin I	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	3,26		25.000		25.000
2016-05-16	2016-05-12	4	Weissman James B	DRNA	Common Stock	P - Purchase	D		3,2899	4.170	14		19.800
2016-05-16	2016-05-12	4	Weissman James B	DRNA	Common Stock	P - Purchase	D		3,2897	530	2		15.630
2016-05-16	2016-05-12	4	Weissman James B	DRNA	Common Stock	P - Purchase	D		3,2399	300	1		15.100
2016-04-18	2016-04-14	4	GREEN JOHN B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	5,45		265.000		265.000
2016-02-05	2016-02-03	4	LANGER DENNIS	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-34.722		6.945
2016-02-05	2016-02-03	4	LANGER DENNIS	DRNA	Common Stock	M - Exercise	D		3,4200	34.722	119		43.595
2016-01-12	2016-01-08	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,09		225.000		225.000
2016-01-12	2016-01-08	4	Ashburn Theodore	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,09		-75.000		75.000
2016-01-12	2016-01-08	4	Bhargava Pankaj	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,09		75.000		75.000
2016-01-12	2016-01-08	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,09		75.000		75.000
2016-01-12	2016-01-08	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	9,09		125.000		125.000
2015-06-29	2015-06-25	4	Halak Brian K	DRNA	Stock Option (Right to Buy)	A - Award	D	13,87		15.000		15.000
2015-06-29	2015-06-25	4	Kolchinsky Peter	DRNA	Director Stock Option (right to buy)	A - Award	D	13,87		15.000		15.000
2015-06-29	2015-06-25	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (right to buy)	A - Award	D	13,87		15.000		15.000
2015-06-26	2015-06-25	4	LANGER DENNIS	DRNA	Director Stock Option (right to buy)	A - Award	D	13,87		15.000		15.000
2015-06-26	2015-06-25	4	MADDEN DAVID	DRNA	Director Stock Option (right to buy)	A - Award	D	13,87		20.000		20.000
2015-06-26	2015-06-25	4	PEACOCK BRUCE	DRNA	Director Stock Option (right to buy)	A - Award	D	13,87		15.000		15.000
2015-02-24	2015-02-20	4	Skyline Venture Partners V LP	DRNA	Common Stock	S - Sale	I		26,0200	-37.532	-977		1.719.671
2015-01-13	2015-01-09	4	Brown Bob D	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,50		75.000		75.000
2015-01-13	2015-01-09	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,50		225.000		225.000
2015-01-13	2015-01-09	4	Ashburn Theodore	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,50		3.333		3.333
2015-01-13	2015-01-09	4	Dentzer James E	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,50		75.000		75.000
2015-01-13	2015-01-09	4	Bhargava Pankaj	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,50		56.250		56.250
2015-01-13	2015-01-09	4	Weissman James B	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	18,50		75.000		75.000
2014-12-19	2014-12-17	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-1.450		0
2014-12-19	2014-12-17	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (Right to Buy)	M - Exercise	D	3,42		-1.050		0
2014-12-19	2014-12-17	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	M - Exercise	D		3,4200	2.500	9		19.800
2014-12-16	2014-12-15	4	Ashburn Theodore	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	13,08		115.000		115.000
2014-12-16	2014-12-15	4	Ashburn Theodore	DRNA	Employee Stock Option (Right to Buy)	A - Award	D	13,08		115.000		115.000
2014-12-16		3	Ashburn Theodore	DRNA	No securities are beneficially owned		D						0
2014-12-11	2014-12-09	4	PEACOCK BRUCE	DRNA	Director Stock Option (right to buy)	A - Award	D	11,04		25.000		25.000
2014-11-25	2014-11-25	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	S - Sale	I		11,5000	-55.035	-633		800.794
2014-11-25	2014-11-25	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	S - Sale	I		11,5000	-48.027	-552		698.822
2014-11-25	2014-11-25	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	S - Sale	I		11,5000	-18.903	-217		275.046
2014-11-25	2014-11-24	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	S - Sale	I		11,5400	-3.785	-44		855.829
2014-11-25	2014-11-24	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	S - Sale	I		11,5400	-3.303	-38		746.849
2014-11-25	2014-11-24	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	S - Sale	I		11,5500	-14.199	-164		293.949
2014-11-25	2014-11-24	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	S - Sale	I		11,5500	-41.339	-477		859.614
2014-11-25	2014-11-24	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	S - Sale	I		11,5500	-36.074	-417		750.152
2014-11-25	2014-11-24	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	S - Sale	I		11,5400	-1.300	-15		308.148
2014-11-25	2014-11-21	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	S - Sale	I		11,0000	-45.124	-496		900.953
2014-11-25	2014-11-21	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	S - Sale	I		11,0000	-39.377	-433		786.226
2014-11-25	2014-11-21	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	S - Sale	I		11,0000	-15.499	-170		309.448
2014-11-10	2014-11-07	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	S - Sale	I		9,3300	-30.100	-281		0
2014-11-10	2014-11-07	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	S - Sale	I		9,2700	-3.500	-32		30.100
2014-11-10	2014-11-07	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	S - Sale	I		9,0000	-180.564	-1.625		33.600
2014-10-15	2014-10-15	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	S - Sale	I		10,0100	-51.449	-515		214.164
2014-10-15	2014-10-14	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	S - Sale	I		11,0200	-14.464	-159		946.077
2014-10-15	2014-10-14	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	S - Sale	I		11,0200	-12.622	-139		825.603
2014-10-15	2014-10-14	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	S - Sale	I		11,0200	-4.061	-45		265.613
2014-10-15	2014-10-14	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	S - Sale	I		11,0200	-4.968	-55		324.947
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	S - Sale	I		12,0020	-246	-3		960.541
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	S - Sale	I		12,0020	-215	-3		838.225
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	S - Sale	I		12,0020	-69	-1		269.674
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	S - Sale	I		12,0020	-84	-1		330
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	S - Sale	I		12,1350	-11.855	-144		960.787
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	S - Sale	I		12,1350	-10.345	-126		838.440
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	S - Sale	I		12,1350	-3.328	-40		269.743
2014-10-15	2014-10-10	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	S - Sale	I		12,1350	-4.072	-49		329.999
2014-06-24	2014-06-18	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (right to buy)	A - Award	D	18,73		15.000		15.000
2014-06-23	2014-06-18	4	Kolchinsky Peter	DRNA	Director Stock Option (right to buy)	A - Award	D	18,73		15.000		15.000
2014-06-23	2014-06-18	4	Miles Vincent J	DRNA	Director Stock Option (right to buy)	A - Award	D	18,73		15.000		15.000
2014-06-20	2014-06-18	4	Halak Brian K	DRNA	Stock Option (Right to Buy)	A - Award	D	18,73		15.000		15.000
2014-06-20	2014-06-18	4	MADDEN DAVID	DRNA	Director Stock Option (right to buy)	A - Award	D	18,73		20.000		20.000
2014-06-20	2014-06-18	4	LANGER DENNIS	DRNA	Director Stock Option (right to buy)	A - Award	D	18,73		15.000		15.000
2014-05-08	2014-04-16	4/A	Kolchinsky Peter	DRNA	Director Stock Option (right to buy)	A - Award	D	16,30		25.000		25.000
2014-04-30	2014-04-16	4/A	Halak Brian K	DRNA	Stock Option (Right to Buy)	A - Award	D	16,30		25.000		25.000
2014-04-21	2014-02-04	4/A	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Series C Preferred	C - Conversion	I			-71.428		0
2014-04-21	2014-02-04	4/A	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Series B Preferred	C - Conversion	I			-8.586		0
2014-04-21	2014-02-04	4/A	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Series A Preferred	C - Conversion	I			-15.000		0
2014-04-21	2014-02-04	4/A	LANGER DENNIS Langer Family Holdings, LLLP	DRNA	Common Stock	C - Conversion	I			95.014			95.194
2014-04-21	2014-04-16	4	RA CAPITAL MANAGEMENT, LLC See Footnotes	DRNA	Director Stock Option (right to buy)	A - Award	I	16,30		25.000		25.000
2014-04-18	2014-04-16	4	Halak Brian K	DRNA	Stock Option (Right to Buy)	A - Award	D	16,30		25.000		25.000
2014-04-18	2014-04-16	4	LANGER DENNIS	DRNA	Director Stock Option (right to buy)	A - Award	D	16,30		25.000		25.000
2014-04-18	2014-04-16	4	HOFFMAN STEPHEN J	DRNA	Director Stock Option (right to buy)	A - Award	D	16,30		25.000		25.000
2014-04-18	2014-04-16	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (right to buy)	A - Award	D	16,30		471.900		471.900
2014-04-18	2014-04-16	4	Miles Vincent J See footnotes	DRNA	Director Stock Option (right to buy	A - Award	I	16,30		25.000		25.000
2014-04-18	2014-04-16	4	MADDEN DAVID	DRNA	Director Stock Option (right to buy)	A - Award	D	16,30		30.000		30.000
2014-04-18	2014-04-16	4	Dentzer James E	DRNA	Employee Stock Option (right to buy)	A - Award	D	16,30		108.750		108.750
2014-04-18	2014-04-16	4	Brown Bob D	DRNA	Employee Stock Option (right to buy)	A - Award	D	16,30		165.050		165.050
2014-04-18	2014-04-16	4	Weissman James B	DRNA	Employee Stock Option (right to buy)	A - Award	D	16,30		111.800		111.800
2014-04-18	2014-04-16	4	Bhargava Pankaj	DRNA	Employee Stock Option (right to buy)	A - Award	D	16,30		264.808		264.808
2014-04-11	2014-03-18	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		38,6200	-14.937	-577		1.550.862
2014-04-11	2014-03-18	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		37,7500	-250.000	-9.438		1.565.799
2014-04-11	2014-03-17	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		36,5000	-9.301	-339		1.815.799
2014-04-11	2014-03-14	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		35,5000	-200.000	-7.100		1.825.100
2014-04-11	2014-03-14	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		35,3300	-50.400	-1.781		2.025.100
2014-04-11	2014-03-12	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		37,7700	-1.500	-57		2.075.500
2014-04-11	2014-03-11	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		38,3700	-2.900	-111		2.077.000
2014-04-11	2014-03-11	4	Bain Capital Public Equity Management, LLC	DRNA	Common Stock	S - Sale	I		38,0000	-257.100	-9.770		2.079.900
2014-04-03		3	Bhargava Pankaj	DRNA	No securities are beneficially owned		D						0
2014-02-20	2014-01-29	4/A	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Series C Preferred	C - Conversion	I			-71.428		0
2014-02-20	2014-01-29	4/A	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Series B Preferred	C - Conversion	I			-8.586		0
2014-02-20	2014-01-29	4/A	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Series A Preferred	C - Conversion	I			-10.000		0
2014-02-20	2014-01-29	4/A	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Common Stock	C - Conversion	I			90.014			90.014
2014-02-20	2014-01-27	4/A	LANGER DENNIS	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		-540		0
2014-02-20	2014-01-27	4/A	LANGER DENNIS	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		-8.333		41.667
2014-02-20	2014-01-27	4/A	LANGER DENNIS	DRNA	Common Stock	M - Exercise	D		3,4200	8.873	30		8.873
2014-02-20	2013-09-24	4/A	LANGER DENNIS	DRNA	Employee Stock Option (right to buy)	A - Award	D	3,42		50.000		50.000
2014-02-20	2014-01-29	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	P - Purchase	D		15,0000	5.000	75		17.300
2014-02-20	2013-11-11	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		-4.350		1.450
2014-02-20	2013-11-11	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		-4.950		1.050
2014-02-20	2013-11-11	4	FAMBROUGH DOUGLAS	DRNA	Common Stock	M - Exercise	D		3,4200	9.300	32		12.300
2014-02-20	2013-09-24	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (right to buy)	A - Award	D	3,42		281.250		281.250
2014-02-20	2013-09-24	4	FAMBROUGH DOUGLAS	DRNA	Employee Stock Option (right to buy)	A - Award	D	3,42		281.250		281.250
2014-02-20	2014-01-29	4	MADDEN DAVID	DRNA	Common Stock	P - Purchase	D		15,0000	7.500	112		120.011
2014-02-20	2014-01-24	4	MADDEN DAVID	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		-110.000		0
2014-02-20	2014-01-24	4	MADDEN DAVID	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		-1.311		0
2014-02-20	2014-01-24	4	MADDEN DAVID	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		-1.200		0
2014-02-20	2014-01-24	4	MADDEN DAVID	DRNA	Common Stock	M - Exercise	D		3,4200	112.511	385		112.511
2014-02-20	2013-09-24	4	MADDEN DAVID	DRNA	Employee Stock Option (right to buy)	A - Award	D	3,42		110.000		110.000
2014-02-20	2014-01-29	4	Weissman James B	DRNA	Common Stock	P - Purchase	D		15,0000	1.000	15		13.116
2014-02-20	2014-01-27	4	Weissman James B	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		-67		800
2014-02-20	2014-01-27	4	Weissman James B	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		-11.216		78.784
2014-02-20	2014-01-27	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,2400	11.283	37		12.116
2014-02-20	2013-11-11	4	Weissman James B	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		-100		1.500
2014-02-20	2013-11-11	4	Weissman James B	DRNA	Employee Stock Option (right to buy)	M - Exercise	D	3,42		-733		867
2014-02-20	2013-11-05	4	Weissman James B	DRNA	Common Stock	M - Exercise	D		3,4200	833	3		833
2014-02-20	2013-09-24	4	Weissman James B	DRNA	Employee Stock Option (right to buy)	A - Award	D	3,42		90.000		90.000
2014-02-20	2013-09-24	4	Weissman James B	DRNA	Employee Stock Option (right to buy)	A - Award	D	3,42		60.000		60.000
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Common Stock Warrant (right to buy)	C - Conversion	I	7,00		21.697		21.697
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Series C Preferred Stock Warrants	C - Conversion	I	7,00		-21.697		0
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Common Stock Warrant	C - Conversion	I	250,00		755		755
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Series C Preferred Stock	C - Conversion	I			-1.043.429		0
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Series B Preferred Stock	C - Conversion	I			-179.322		0
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Series A Preferred Stock	C - Conversion	I			-312.000		0
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Common Stock	P - Purchase	I		15,0000	200.000	3.000		1.734.751
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Common Stock	C - Conversion	I			1.043.429			1.534.751
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Common Stock	C - Conversion	I			179.322			491.322
2014-02-05	2014-02-04	4	HOFFMAN STEPHEN J	DRNA	Common Stock	C - Conversion	I			312.000			312.000
2014-02-05	2014-02-04	4	RA CAPITAL MANAGEMENT, LLC	DRNA	Series C Preferred Stock, par value $0.0001	C - Conversion	D			-1.428.571		0
2014-02-05	2014-02-04	4	RA CAPITAL MANAGEMENT, LLC See Footnotes	DRNA	Common Stock, par value $0.0001 per share	P - Purchase	I		15,0000	1.000.000	15.000		2.428.571
2014-02-05	2014-02-04	4	RA CAPITAL MANAGEMENT, LLC See Footnotes	DRNA	Common Stock, par value $0.0001 per share	C - Conversion	I			1.428.571			1.428.571
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Common Stock Warrant (right to buy)	C - Conversion	I	7,00		21.697		21.697
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Series C Preferred Stock Warrants	C - Conversion	I	7,00		-21.697		0
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Common Stock Warrant	C - Conversion	I	250,00		755		755
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Series C Preferred Stock	C - Conversion	I			-1.043.429		0
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Series B Preferred Stock	C - Conversion	I			-179.322		0
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Series A Preferred Stock	C - Conversion	I			-312.000		0
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Common Stock	P - Purchase	I		15,0000	200.000	3.000		1.734.751
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Common Stock	C - Conversion	I			1.043.429			1.534.751
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Common Stock	C - Conversion	I			179.322			491.322
2014-02-05	2014-02-04	4	Skyline Venture Partners V LP	DRNA	Common Stock	C - Conversion	I			312.000			312.000
2014-02-04	2014-02-04	4	BLAIR JAMES C By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		156		156
2014-02-04	2014-02-04	4	BLAIR JAMES C By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		-156		0
2014-02-04	2014-02-04	4	BLAIR JAMES C By DP VIII Associates, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-9.469		0
2014-02-04	2014-02-04	4	BLAIR JAMES C By DP VIII Associates, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			-3.535		0
2014-02-04	2014-02-04	4	BLAIR JAMES C By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		21.041		21.041
2014-02-04	2014-02-04	4	BLAIR JAMES C By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		-21.041		0
2014-02-04	2014-02-04	4	BLAIR JAMES C By Domain Partners VIII, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-1.276.243		0
2014-02-04	2014-02-04	4	BLAIR JAMES C By Domain Partners VIII, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			-476.464		0
2014-02-04	2014-02-04	4	BLAIR JAMES C By DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	I			13.004			13.004
2014-02-04	2014-02-04	4	BLAIR JAMES C By Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	I			1.752.707			1.752.707
2014-02-04	2014-02-04	4	DOVEY BRIAN H By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		156		156
2014-02-04	2014-02-04	4	DOVEY BRIAN H By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		-156		0
2014-02-04	2014-02-04	4	DOVEY BRIAN H By DP VIII Associates, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-9.469		0
2014-02-04	2014-02-04	4	DOVEY BRIAN H By DP VIII Associates, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			-3.535		0
2014-02-04	2014-02-04	4	DOVEY BRIAN H By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		21.041		21.041
2014-02-04	2014-02-04	4	DOVEY BRIAN H By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		-21.041		0
2014-02-04	2014-02-04	4	DOVEY BRIAN H By Domain Partners VIII, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-1.276.243		0
2014-02-04	2014-02-04	4	DOVEY BRIAN H By Domain Partners VIII, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			-476.464		0
2014-02-04	2014-02-04	4	DOVEY BRIAN H By DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	I			13.004			13.004
2014-02-04	2014-02-04	4	DOVEY BRIAN H By Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	I			1.752.707			1.752.707
2014-02-04	2014-02-04	4	TREU JESSE I By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		156		156
2014-02-04	2014-02-04	4	TREU JESSE I By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		-156		0
2014-02-04	2014-02-04	4	TREU JESSE I By DP VIII Associates, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-9.469		0
2014-02-04	2014-02-04	4	TREU JESSE I By DP VIII Associates, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			-3.535		0
2014-02-04	2014-02-04	4	TREU JESSE I By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		21.041		21.041
2014-02-04	2014-02-04	4	TREU JESSE I By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		-21.041		0
2014-02-04	2014-02-04	4	TREU JESSE I By Domain Partners VIII, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-1.276.243		0
2014-02-04	2014-02-04	4	TREU JESSE I By Domain Partners VIII, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			-476.464		0
2014-02-04	2014-02-04	4	TREU JESSE I By DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	I			13.004			13.004
2014-02-04	2014-02-04	4	TREU JESSE I By Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	I			1.752.707			1.752.707
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		156		156
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		-156		0
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-9.469		0
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			-3.535		0
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		21.041		21.041
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		-21.041		0
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-1.276.243		0
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			-476.464		0
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	I			13.004			13.004
2014-02-04	2014-02-04	4	SCHOEMAKER KATHLEEN K By Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	I			1.752.707			1.752.707
2014-02-04	2014-02-04	4	VITULLO NICOLE By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		156		156
2014-02-04	2014-02-04	4	VITULLO NICOLE By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		-156		0
2014-02-04	2014-02-04	4	VITULLO NICOLE By DP VIII Associates, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-9.469		0
2014-02-04	2014-02-04	4	VITULLO NICOLE By DP VIII Associates, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			-3.535		0
2014-02-04	2014-02-04	4	VITULLO NICOLE By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		21.041		21.041
2014-02-04	2014-02-04	4	VITULLO NICOLE By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		-21.041		0
2014-02-04	2014-02-04	4	VITULLO NICOLE By Domain Partners VIII, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-1.276.243		0
2014-02-04	2014-02-04	4	VITULLO NICOLE By Domain Partners VIII, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			-476.464		0
2014-02-04	2014-02-04	4	VITULLO NICOLE By DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	I			13.004			13.004
2014-02-04	2014-02-04	4	VITULLO NICOLE By Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	I			1.752.707			1.752.707
2014-02-04	2014-02-04	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		156		156
2014-02-04	2014-02-04	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	I	7,00		-156		0
2014-02-04	2014-02-04	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-9.469		0
2014-02-04	2014-02-04	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			-3.535		0
2014-02-04	2014-02-04	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		21.041		21.041
2014-02-04	2014-02-04	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	I	7,00		-21.041		0
2014-02-04	2014-02-04	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-1.276.243		0
2014-02-04	2014-02-04	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Series B Preferred Stock	C - Conversion	I			-476.464		0
2014-02-04	2014-02-04	4	Halak Brian K By DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	I			13.004			13.004
2014-02-04	2014-02-04	4	Halak Brian K By Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	I			1.752.707			1.752.707
2014-02-04	2014-02-04	4	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Series C Preferred	C - Conversion	I			-71.428		0
2014-02-04	2014-02-04	4	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Series B Preferred	C - Conversion	I			-8.586		0
2014-02-04	2014-02-04	4	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Series A Preferred	C - Conversion	I			-10.000		0
2014-02-04	2014-02-04	4	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Common Stock	C - Conversion	I			90.014			90.194
2014-02-04		3	Brookside Capital Trading Fund, L.P.	DRNA	Common Stock		I						2.337.000
2014-02-04	2014-02-04	4	DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	D	7,00		156		156
2014-02-04	2014-02-04	4	DP VIII Associates, L.P.	DRNA	Warrant	C - Conversion	D	7,00		-156		0
2014-02-04	2014-02-04	4	DP VIII Associates, L.P.	DRNA	Series C Preferred Stock	C - Conversion	D			-9.469		0
2014-02-04	2014-02-04	4	DP VIII Associates, L.P.	DRNA	Series B Preferred Stock	C - Conversion	D			-3.535		0
2014-02-04	2014-02-04	4	DP VIII Associates, L.P.	DRNA	Common Stock	C - Conversion	D			13.004			13.004
2014-02-04	2014-02-04	4	Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	D	7,00		21.041		21.041
2014-02-04	2014-02-04	4	Domain Partners VIII, L.P.	DRNA	Warrant	C - Conversion	D	7,00		-21.041		0
2014-02-04	2014-02-04	4	Domain Partners VIII, L.P.	DRNA	Series C Preferred Stock	C - Conversion	D			-1.276.243		0
2014-02-04	2014-02-04	4	Domain Partners VIII, L.P.	DRNA	Series B Preferred Stock	C - Conversion	D			-476.464		0
2014-02-04	2014-02-04	4	Domain Partners VIII, L.P.	DRNA	Common Stock	C - Conversion	D			1.752.707			1.752.707
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-572.142		0
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-499.285		0
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-161.071		0
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Series C Preferred Stock	C - Conversion	I			-196.071		0
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	P - Purchase	I		15,0000	400.500	6.008		972.642
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	P - Purchase	I		15,0000	349.500	5.242		848.785
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	P - Purchase	I		15,0000	112.000	1.680		273.071
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	P - Purchase	I		15,0000	138.000	2.070		334.071
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Private Design International II, L.P.	DRNA	Common Stock	C - Conversion	I			572.142			972.642
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Private Design Fund II, L.P.	DRNA	Common Stock	C - Conversion	I			499.285			848.785
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Special Situations International Master Fund, L.P.	DRNA	Common Stock	C - Conversion	I			161.071			273.071
2014-02-04	2014-02-04	4	Flynn James E Through Deerfield Special Situations Fund, L.P.	DRNA	Common Stock	C - Conversion	I			196.071			334.071
2014-01-29		3	FAMBROUGH DOUGLAS	DRNA	Common Stock		D						12.300
2014-01-29		3	MADDEN DAVID	DRNA	Common Stock		D						112.511
2014-01-29		3	LANGER DENNIS	DRNA	Common Stock		D						8.873
2014-01-29		3	LANGER DENNIS Langer Family Holdings, LLP	DRNA	Common Stock		I						180
2014-01-29		3	Miles Vincent J	DRNA	No securities are beneficially owned		D						0
2014-01-29		3	Brown Bob D	DRNA	Common Stock		D						19.339
2014-01-29		3	Weissman James B	DRNA	Common Stock		D						12.116

Offener Markt oder privater Kauf von nicht-derivativen oder derivativen Wertpapieren

Freiverkauf oder privater Verkauf von nicht-derivativen oder derivativen Wertpapieren

Gewährung, Vergabe oder sonstiger Erwerb von Wertpapieren des Unternehmens (z. B. eine Option)

Umwandlung von Derivaten

Verkauf oder Rückübertragung von Wertpapieren an das Unternehmen

Zahlung des Ausübungspreises oder der Steuerschuld mit einem Teil der vom Unternehmen erhaltenen Wertpapiere

Schenkung von Wertpapieren durch oder an den Insider

Aktien-Swaps und ähnliche Absicherungstransaktionen

Ausübung oder Umwandlung eines vom Unternehmen erhaltenen derivativen Wertpapiers (z. B. einer Option)

Eine freiwillig auf Formular 4 gemeldete Transaktion

Sonstige (mit einer Fußnote zur Beschreibung der Transaktion)

DRNA / Dicerna Pharmaceuticals Inc - Insider Trading and Ownership Report - SEC Form 3, 4, 5