ONCE Insider Trading - Spark Therapeutics, Inc.

Insider-Aktien

61.468.519 shares

Insider-Stimmungswert

Der Insider-Stimmungswert ermittelt die Unternehmen, die von Unternehmensinsidern gekauft werden.

Es ist das Ergebnis eines ausgeklügelten quantitativen Multifaktormodells, das die Unternehmen mit der höchsten Insiderakkumulation identifiziert. Das Scoring-Modell verwendet eine Kombination aus der Nettozahl der Insiderkäufe der letzten 90 Tage, der Gesamtzahl der gekauften Aktien als Prozentsatz des Streubesitzes und der Gesamtzahl der von Insidern gehaltenen Aktien. Die Zahl reicht von 0 bis 100, wobei höhere Zahlen ein höheres Maß an Insiderkäufen anzeigen als bei anderen Unternehmen und 50 den Durchschnitt darstellt.

Aktualisierungshäufigkeit: Täglich

Sehen Sie sich die Top-Optionen der Insider an, die eine Liste der Unternehmen mit der höchsten Insiderakkumulation enthalten.

Siehe Aktien mit dem höchsten Ranking

Führungskräfte-Stimmungswert

Der Führungskräfte-Stimmungswert findet Unternehmen, die von Führungskräften des Unternehmens gekauft werden.

Per Definition sind Führungskräfte des Unternehmens Insider, aber im Gegensatz zu anderen Insidern (10%ige Aktionäre und Vorstandsmitglieder) arbeiten Führungskräfte täglich für das Unternehmen und verwenden beim Handel ihr eigenes Geld. (10%ige Aktionäre und Vorstandsmitglieder sind oft Fondsmanager, die das Geld anderer Leute verwalten.) Daher sind Insider-Geschäfte, die von Führungskräften getätigt werden, viel bedeutender und sollten entsprechend behandelt werden.

Wie der Insider-Stimmungswert ist auch der Führungskräfte-Stimmungswert das Ergebnis eines ausgeklügelten quantitativen Multifaktormodells, das die Unternehmen mit der höchsten Führungskräftekonzentration identifiziert.

Aktualisierungshäufigkeit: Täglich

Sehen Sie sich die Insiders Top-Auswahl an, die eine Liste der Unternehmen mit der höchsten Insider-Stimmung enthalten.

Siehe Aktien mit dem höchsten Ranking

Wichtige Insider-Kennzahlen

Diese Karte zeigt, wie das Unternehmen bei verschiedenen Insider-Kennzahlen abschneidet. Der Perzentil-Rang zeigt, wie dieses Unternehmen im Vergleich zu anderen Unternehmen auf den US-Märkten abschneidet. Höhere Ränge deuten auf eine bessere Situation hin.

Es ist beispielsweise allgemein anerkannt, dass Insiderkäufe ein positiver Indikator sind, so dass Unternehmen mit mehr Insiderkäufen besser abschneiden würden als Unternehmen mit weniger Insiderkäufen (oder sogar Insiderverkäufen).

Nettoanzahl der Insider, die kaufen (Rang)

N/A

Die Nettoanzahl der Insiderkäufe ist die Gesamtzahl der Insiderkäufe abzüglich der Gesamtzahl der Insiderverkäufe in den letzten 90 Tagen. Der Perzentilrang wird hier angezeigt (Bereich von 0 bis 100%).

Prozent des Streubesitzes von Insidern gekauft (Rang)

N/A

Prozent des von Insidern gekauften Streubesitzes ist die Gesamtzahl der von Insidern gekauften Aktien abzüglich der Gesamtzahl der von Insidern in den letzten 90 Tagen verkauften Aktien, geteilt durch den gesamten Streubesitz und multipliziert mit 100.

Diagramm zum Insiderhandel

Spark Therapeutics, Inc. Insider-Trades sind in der folgenden Grafik dargestellt. Insider sind leitende Angestellte, Direktoren oder bedeutende Investoren in einem Unternehmen. Im Allgemeinen ist es für Insider illegal, auf der Grundlage von wesentlichen, nicht-öffentlichen Informationen mit Aktien ihrer Unternehmen zu handeln. Das bedeutet nicht, dass es für sie illegal ist, irgendwelche Geschäfte in ihren eigenen Unternehmen zu tätigen. Sie müssen jedoch alle Geschäfte der SEC über ein Formular 4 melden.

Kennzahlen zu Insiderlisten und Rentabilität

Diese Tabelle zeigt die Liste der bekannten Insider und wird automatisch aus den bei der SEC eingereichten Unterlagen erstellt. Zusätzlich zu den Namen, dem letzten Titel und der Bezeichnung als Direktor, leitender Angestellter oder 10%-iger Anteilseigner geben wir die zuletzt veröffentlichten Bestände an. Zusätzlich stellen wir, wenn möglich, die historische Handelsperformance für den Insider zur Verfügung. Die historische Handelsperformance ist ein gewichteter Durchschnitt der Performance tatsächlicher offener Kauftransaktionen, die von dem Insider getätigt wurden. Weitere Informationen zur Berechnung dieses Wertes finden Sie in diesem YouTube-Webinar.

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Insider	Durchschnittlicher Gewinn (%)	Aktien in Besitz	Split Angepasst

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Erfolgsbilanz der Insiderkäufe - Kurzfristige Gewinnanalyse

In diesem Abschnitt analysieren wir die Rentabilität jedes ungeplanten Insiderkaufs, der auf dem freien Markt in ONCE / Spark Therapeutics, Inc. getätigt wurde. Diese Analyse hilft zu verstehen, ob der Insider beständig abnormale Renditen erzielt und es sich lohnt, ihm zu folgen. Diese Analyse bezieht sich auf ein Jahr nach jedem Handel, und die Ergebnisse sind theoretisch .

Die folgende Tabelle zeigt die jüngsten Käufe am offenen Markt, die nicht Teil eines automatischen Handelsplans waren.

Handelsdatum	Insider	Gemeldete Aktien	Gemeldeter Preis	Angepasste Aktien	Angepasster Preis	Kostenbasis	Tage bis Max
2017-12-08	Furey John	18	73,4800	18	73,4800	1.323	210
2017-10-12	SIGAL ELLIOT	29	90,7500	29	90,7500	2.632
2015-10-07	Altschuler Steven	5.000	49,1060	5.000	49,1060	245.530
2015-02-04	Webster Stephen W	2.500	23,0000	2.500	23,0000	57.500
2015-02-04	Vivaldi Coelho Rogerio	2.500	23,0000	2.500	23,0000	57.500
2015-02-04	SIGAL ELLIOT	5.000	23,0000	5.000	23,0000	115.000
2015-02-04	High Katherine A	700	23,0000	700	23,0000	16.100
2015-02-04	Mehra Anand	225.000	23,0000	225.000	23,0000	5.175.000
2015-02-04	Children's Hospital of Philadelphia Foundation	100.000	23,0000	100.000	23,0000	2.300.000

Bereinigter Preis ist der splitbereinigte Preis. Bereinigte Aktien sind die um den Split bereinigten Aktien.

ONCE / Spark Therapeutics, Inc. Insider Trades

Erfolgsbilanz von Insiderverkäufen - Kurzfristige Verlustanalyse

In diesem Abschnitt analysieren wir die kurzfristige Verlustvermeidung jedes ungeplanten Insider-Verkaufs auf dem freien Markt in ONCE / Spark Therapeutics, Inc.. Ein konsistentes Muster der Verlustvermeidung kann darauf hindeuten, dass zukünftige Verkaufstransaktionen Kursrückgänge vorhersagen können. Diese Analyse bezieht sich auf ein Jahr nach jedem Handel, und die Ergebnisse sind theoretisch .

Die folgende Tabelle zeigt die jüngsten Verkäufe am offenen Markt, die nicht Teil eines automatischen Handelsplans waren.

Handelsdatum	Insider	Gemeldete Aktien	Gemeldeter Preis	Angepasste Aktien	Angepasster Preis	Kostenbasis	Tage bis Min
2019-02-27	Children's Hospital of Philadelphia Foundation	2.000.000	113,0000	2.000.000	113,0000	226.000.000	146
2018-04-12	Furey John	20.000	77,5100	20.000	77,5100	1.550.200
2017-12-11	Furey John	18	46,3300	18	46,3300	834
2017-11-28	SIGAL ELLIOT	29	72,4300	29	72,4300	2.100
2017-09-21	Children's Hospital of Philadelphia Foundation	1.000.000	84,6300	1.000.000	84,6300	84.630.000
2017-05-11	Children's Hospital of Philadelphia Foundation	840.000	56,2700	840.000	56,2700	47.266.800
2016-12-16	Mehra Anand	50.000	54,9100	50.000	54,9100	2.745.500
2016-12-16	Mehra Anand	229.728	53,2600	229.728	53,2600	12.235.313
2016-12-15	Mehra Anand	69.928	53,0700	69.928	53,0700	3.711.079

Bereinigter Preis ist der splitbereinigte Preis. Bereinigte Aktien sind die um den Split bereinigten Aktien.

Transaktionshistorie

Klicken Sie auf das Link-Symbol, um den vollständigen Transaktionsverlauf anzuzeigen. Transaktionen, die im Rahmen eines automatischen Handelsplans 10b5-1 gemeldet werden, sind in der Spalte 10b-5 mit einem X gekennzeichnet.

Datei Datum	Handel Datum	Form	Insider	Ticker	Wertpapier-Titel	Code	Direkt	Ausführung Preis	Einheit Preis	Eimheiten Verändert	Wert Geändert (1K)	Verbleibende Optionen	Verbleibende Aktien
2019-12-18		3	ROCHE HOLDING LTD	ONCE	Common Stock		D						59.493.346
2019-12-18		3	ROCHE HOLDING LTD	ONCE	Common Stock		D						59.493.346
2019-12-18		3	ROCHE HOLDING LTD	ONCE	Common Stock		D						59.493.346
2019-12-18		3	ROCHE HOLDING LTD	ONCE	Common Stock		D						59.493.346
2019-12-17	2019-12-17	4	MILANO VINCENT	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	3,45		-37.203		0
2019-12-17	2019-12-17	4	MILANO VINCENT	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	56,22		-6.000		0
2019-12-17	2019-12-17	4	MILANO VINCENT	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	81,53		-4.000		0
2019-12-17	2019-12-17	4	MILANO VINCENT	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	50,93		-4.000		0
2019-12-17	2019-12-17	4	MILANO VINCENT	ONCE	Common Stock	U - Other	D		114,5000	-3.000	-344		0
2019-12-17	2019-12-17	4	PEREZ ROBERT J	ONCE	Restricted Stock Units	D - Sale to Issuer	D	0,00		-2.000		0
2019-12-17	2019-12-17	4	PEREZ ROBERT J	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	55,76		-8.000		0
2019-12-17	2019-12-17	4	PEREZ ROBERT J	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	81,53		-4.000		0
2019-12-17	2019-12-17	4	PEREZ ROBERT J	ONCE	Common Stock	U - Other	D		114,5000	-2.500	-286		0
2019-12-17	2019-12-17	4	SIGAL ELLIOT	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	3,45		-25.786		0
2019-12-17	2019-12-17	4	SIGAL ELLIOT	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	3,45		-17.203		0
2019-12-17	2019-12-17	4	SIGAL ELLIOT	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	56,22		-6.000		0
2019-12-17	2019-12-17	4	SIGAL ELLIOT	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	81,53		-4.000		0
2019-12-17	2019-12-17	4	SIGAL ELLIOT	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	50,93		-4.000		0
2019-12-17	2019-12-17	4	SIGAL ELLIOT	ONCE	Common Stock	U - Other	D		114,5000	-14.214	-1.628		0
2019-12-17	2019-12-17	4	Webster Stephen W	ONCE	Restricted Stock Units	D - Sale to Issuer	D	0,00		-19.500		0
2019-12-17	2019-12-17	4	Webster Stephen W	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	3,45		-106.015		0
2019-12-17	2019-12-17	4	Webster Stephen W	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	68,45		-60.000		0
2019-12-17	2019-12-17	4	Webster Stephen W	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	40,44		-55.000		0
2019-12-17	2019-12-17	4	Webster Stephen W	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	56,17		-25.000		0
2019-12-17	2019-12-17	4	Webster Stephen W	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	50,55		-28.000		0
2019-12-17	2019-12-17	4	Webster Stephen W	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	42,73		-35.000		0
2019-12-17	2019-12-17	4	Webster Stephen W	ONCE	Common Stock	U - Other	D		114,5000	-6.102	-699		0
2019-12-17	2019-12-17	4	Dalton Lisa	ONCE	Restricted Stock Units	D - Sale to Issuer	D	0,00		-20.325		0
2019-12-17	2019-12-17	4	Dalton Lisa	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	3,45		-19.951		0
2019-12-17	2019-12-17	4	Dalton Lisa	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	68,45		-28.389		0
2019-12-17	2019-12-17	4	Dalton Lisa	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	40,44		-30.000		0
2019-12-17	2019-12-17	4	Dalton Lisa	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	56,17		-19.500		0
2019-12-17	2019-12-17	4	Dalton Lisa	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	50,55		-28.000		0
2019-12-17	2019-12-17	4	Dalton Lisa	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	42,73		-35.000		0
2019-12-17	2019-12-17	4	Dalton Lisa	ONCE	Common Stock	U - Other	D		114,5000	-4.134	-473		0
2019-12-17	2019-12-17	4	Zoth Lota S.	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	37,18		-12.000		0
2019-12-17	2019-12-17	4	Zoth Lota S.	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	56,22		-6.000		0
2019-12-17	2019-12-17	4	Zoth Lota S.	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	50,93		-4.000		0
2019-12-17	2019-12-17	4	Zoth Lota S.	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	81,53		-4.000		0
2019-12-17	2019-12-17	4	Zoth Lota S.	ONCE	Common Stock	U - Other	D		114,5000	-3.000	-344		0
2019-12-17	2019-12-17	4	Altschuler Steven	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	3,45		-37.203		0
2019-12-17	2019-12-17	4	Altschuler Steven	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	56,22		-6.000		0
2019-12-17	2019-12-17	4	Altschuler Steven	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	50,93		-4.000		0
2019-12-17	2019-12-17	4	Altschuler Steven	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	81,53		-4.000		0
2019-12-17	2019-12-17	4	Altschuler Steven	ONCE	Common Stock	U - Other	D		114,5000	-28.000	-3.206		0
2019-12-17	2019-12-17	4	Ekman Lars	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	3,45		-37.203		0
2019-12-17	2019-12-17	4	Ekman Lars	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	56,22		-6.000		0
2019-12-17	2019-12-17	4	Ekman Lars	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	81,53		-4.000		0
2019-12-17	2019-12-17	4	Ekman Lars	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	50,93		-4.000		0
2019-12-17	2019-12-17	4	Ekman Lars	ONCE	Common Stock	U - Other	D		114,5000	-3.000	-344		0
2019-12-17	2019-12-17	4	Faga Daniel	ONCE	Restricted Stock Units	D - Sale to Issuer	D	0,00		-21.500		0
2019-12-17	2019-12-17	4	Faga Daniel	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	37,62		-50.000		0
2019-12-17	2019-12-17	4	Faga Daniel	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	56,17		-14.000		0
2019-12-17	2019-12-17	4	Faga Daniel	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	50,55		-26.250		0
2019-12-17	2019-12-17	4	Faga Daniel	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	42,73		-35.000		0
2019-12-17	2019-12-17	4	Faga Daniel	ONCE	Common Stock	U - Other	D		114,5000	-38.828	-4.446		0
2019-12-17	2019-12-17	4	High Katherine A	ONCE	Restricted Stock Units	D - Sale to Issuer	D	0,00		-21.250		0
2019-12-17	2019-12-17	4	High Katherine A	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	40,44		-13.750		0
2019-12-17	2019-12-17	4	High Katherine A	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	56,17		-15.750		0
2019-12-17	2019-12-17	4	High Katherine A	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	50,55		-23.625		0
2019-12-17	2019-12-17	4	High Katherine A	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	42,73		-35.000		0
2019-12-17	2019-12-17	4	High Katherine A	ONCE	Common Stock	U - Other	D		114,5000	-278.834	-31.926		0
2019-12-17	2019-12-17	4	Marrazzo Jeffrey D	ONCE	Restricted Stock Units	D - Sale to Issuer	D	0,00		-49.250		0
2019-12-17	2019-12-17	4	Marrazzo Jeffrey D	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	3,45		-126.131		0
2019-12-17	2019-12-17	4	Marrazzo Jeffrey D	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	68,45		-125.000		0
2019-12-17	2019-12-17	4	Marrazzo Jeffrey D	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	40,44		-135.000		0
2019-12-17	2019-12-17	4	Marrazzo Jeffrey D	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	56,17		-70.000		0
2019-12-17	2019-12-17	4	Marrazzo Jeffrey D	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	50,55		-52.500		0
2019-12-17	2019-12-17	4	Marrazzo Jeffrey D	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	42,73		-98.000		0
2019-12-17	2019-12-17	4	Marrazzo Jeffrey D	ONCE	Common Stock	U - Other	D		114,5000	-355.215	-40.672		0
2019-12-17	2019-12-17	4	Mingozzi Federico	ONCE	Restricted Stock Units	D - Sale to Issuer	D	0,00		-32.750		0
2019-12-17	2019-12-17	4	Mingozzi Federico	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	59,74		-50.000		0
2019-12-17	2019-12-17	4	Mingozzi Federico	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	50,55		-18.000		0
2019-12-17	2019-12-17	4	Mingozzi Federico	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	42,73		-35.000		0
2019-12-17	2019-12-17	4	Mingozzi Federico	ONCE	Common Stock	U - Other	D		114,5000	-12.615	-1.444		0
2019-12-17	2019-12-17	4	Mehra Anand	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	56,22		-6.000		0
2019-12-17	2019-12-17	4	Mehra Anand	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	81,53		-4.000		0
2019-12-17	2019-12-17	4	Mehra Anand	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	50,93		-4.000		0
2019-12-17	2019-12-17	4	Mehra Anand	ONCE	Common Stock	U - Other	I		114,5000	-481.270	-55.105		0
2019-12-17	2019-12-17	4	Mehra Anand	ONCE	Common Stock	U - Other	D		114,5000	-40.203	-4.603		0
2019-12-17	2019-12-17	4	La Barge Joseph	ONCE	Restricted Stock Units	D - Sale to Issuer	D	0,00		-19.500		0
2019-12-17	2019-12-17	4	La Barge Joseph	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	40,44		-11.250		0
2019-12-17	2019-12-17	4	La Barge Joseph	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	56,17		-12.500		0
2019-12-17	2019-12-17	4	La Barge Joseph	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	50,55		-21.000		0
2019-12-17	2019-12-17	4	La Barge Joseph	ONCE	Stock Option (Right to Buy)	D - Sale to Issuer	D	42,73		-35.000		0
2019-12-17	2019-12-17	4	La Barge Joseph Held by Reporting Person's immediate family members	ONCE	Common Stock	U - Other	I		114,5000	-200	-23		0
2019-12-17	2019-12-17	4	La Barge Joseph	ONCE	Common Stock	U - Other	D		114,5000	-50.193	-5.747		0
2019-06-27	2019-06-26	4	Mingozzi Federico	ONCE	Restricted Stock Units	M - Exercise	D			-8.375		16.750
2019-06-27	2019-06-26	4	Mingozzi Federico	ONCE	Common Stock	F - Taxes	D		102,3100	-2.775	-284		12.615
2019-06-27	2019-06-26	4	Mingozzi Federico	ONCE	Common Stock	M - Exercise	D			8.375			15.390
2019-06-03	2019-05-30	4	Mehra Anand	ONCE	Restricted Stock Units	M - Exercise	D			-1.500		0
2019-06-03	2019-05-30	4	Mehra Anand	ONCE	Common Stock	M - Exercise	D			1.500			40.203
2019-06-03	2019-05-30	4	Altschuler Steven	ONCE	Restricted Stock Units	M - Exercise	D			-1.500		0
2019-06-03	2019-05-30	4	Altschuler Steven	ONCE	Common Stock	M - Exercise	D			1.500			28.000
2019-06-03	2019-05-30	4	Ekman Lars	ONCE	Restricted Stock Units	M - Exercise	D			-1.500		0
2019-06-03	2019-05-30	4	Ekman Lars	ONCE	Common Stock	M - Exercise	D			1.500			3.000
2019-06-03	2019-05-30	4	MILANO VINCENT	ONCE	Restricted Stock Units	M - Exercise	D			-1.500		1.500
2019-06-03	2019-05-30	4	MILANO VINCENT	ONCE	Common Stock	M - Exercise	D			1.500			3.000
2019-06-03	2019-05-30	4	PEREZ ROBERT J	ONCE	Restricted Stock Units	M - Exercise	D			-1.500		0
2019-06-03	2019-05-30	4	PEREZ ROBERT J	ONCE	Common Stock	M - Exercise	D			1.500			2.500
2019-06-03	2019-05-30	4	SIGAL ELLIOT	ONCE	Restricted Stock Units	M - Exercise	D			-1.500		0
2019-06-03	2019-05-30	4	SIGAL ELLIOT	ONCE	Common Stock	M - Exercise	D			1.500			14.214
2019-06-03	2019-05-30	4	Zoth Lota S.	ONCE	Restricted Stock Units	M - Exercise	D			-1.500		0
2019-06-03	2019-05-30	4	Zoth Lota S.	ONCE	Common Stock	M - Exercise	D			1.500			3.000
2019-03-27	2019-03-25	4	Faga Daniel	ONCE	Stock Option (right to buy)	M - Exercise	D	50,55		-8.750		26.250
2019-03-27	2019-03-25	4	Faga Daniel	ONCE	Stock Option (right to buy)	M - Exercise	D	56,17		-14.000		14.000
2019-03-27	2019-03-25	4	Faga Daniel	ONCE	Stock Option (right to buy)	M - Exercise	D	37,62		-80.000		50.000
2019-03-27	2019-03-25	4	Faga Daniel	ONCE	Common Stock	F - Taxes	D		113,4300	-6.228	-706		38.828
2019-03-27	2019-03-25	4	Faga Daniel	ONCE	Common Stock	M - Exercise	D		50,5500	8.750	442		45.056
2019-03-27	2019-03-25	4	Faga Daniel	ONCE	Common Stock	F - Taxes	D		113,4300	-10.325	-1.171		36.306
2019-03-27	2019-03-25	4	Faga Daniel	ONCE	Common Stock	M - Exercise	D		56,1700	14.000	786		46.631
2019-03-27	2019-03-25	4	Faga Daniel	ONCE	Common Stock	F - Taxes	D		113,4200	-51.401	-5.830		32.631
2019-03-27	2019-03-25	4	Faga Daniel	ONCE	Common Stock	M - Exercise	D		37,6200	80.000	3.010		84.032
2019-03-27	2019-03-25	4	La Barge Joseph	ONCE	Stock Option (right to buy)	M - Exercise	D	50,55		-7.000		21.000
2019-03-27	2019-03-25	4	La Barge Joseph	ONCE	Stock Option (right to buy)	M - Exercise	D	56,17		-12.500		12.500
2019-03-27	2019-03-25	4	La Barge Joseph	ONCE	Stock Option (right to buy)	M - Exercise	D	40,44		-33.748		11.250
2019-03-27	2019-03-25	4	La Barge Joseph	ONCE	Stock Option (right to buy)	M - Exercise	D	68,45		-41.755		0
2019-03-27	2019-03-25	4	La Barge Joseph	ONCE	Common Stock	F - Taxes	D		113,3600	-4.770	-541		50.193
2019-03-27	2019-03-25	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		50,5500	7.000	354		54.963
2019-03-27	2019-03-25	4	La Barge Joseph	ONCE	Common Stock	F - Taxes	D		113,3600	-8.873	-1.006		47.963
2019-03-27	2019-03-25	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		56,1700	12.500	702		56.836
2019-03-27	2019-03-25	4	La Barge Joseph	ONCE	Common Stock	F - Taxes	D		113,3800	-21.260	-2.410		44.336
2019-03-27	2019-03-25	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		40,4400	33.748	1.365		65.596
2019-03-27	2019-03-25	4	La Barge Joseph	ONCE	Common Stock	F - Taxes	D		113,4200	-31.389	-3.560		31.848
2019-03-27	2019-03-25	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		68,4500	41.755	2.858		63.237
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	50,55		-7.875		23.625
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	56,17		-15.750		15.750
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	40,44		-41.247		13.750
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	68,45		-64.160		0
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	40,44		-3		54.997
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	68,45		-5.840		64.160
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-73.249		0
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Common Stock	F - Taxes	D		113,2600	-5.367	-608		278.834
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		50,5500	7.875	398		284.201
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Common Stock	F - Taxes	D		113,2600	-11.184	-1.267		276.326
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		56,1700	15.750	885		287.510
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Common Stock	F - Taxes	D		113,2600	-25.993	-2.944		271.760
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		40,4400	21.247	859		297.753
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Common Stock	F - Taxes	D		113,2550	-49.561	-5.613		276.506
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		68,4500	64.160	4.392		326.067
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		40,4400	3	0		261.907
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		68,4500	5.840	400		261.904
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Common Stock	F - Taxes	D		113,2500	-31.653	-3.585		256.064
2019-03-25	2019-03-21	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		3,4500	73.249	253		287.717
2019-03-21	2019-03-19	4	La Barge Joseph	ONCE	Stock Option (right to buy)	M - Exercise	D	40,44		-2		2.473
2019-03-21	2019-03-19	4	La Barge Joseph	ONCE	Stock Option (right to buy)	M - Exercise	D	68,45		-3.245		0
2019-03-21	2019-03-19	4	La Barge Joseph	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-8.683		0
2019-03-21	2019-03-19	4	La Barge Joseph	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-629		0
2019-03-21	2019-03-19	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		40,4400	2	0		21.482
2019-03-21	2019-03-19	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		68,4500	3.245	222		21.480
2019-03-21	2019-03-19	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	8.683	30		18.235
2019-03-21	2019-03-19	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	629	2		9.552
2019-03-19	2019-03-15	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-49.940		126.131
2019-03-19	2019-03-15	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	49.940	172		355.215
2019-03-01	2019-02-27	4	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock	S - Sale	D		113,0000	-2.000.000	-226.000		1.954.957
2019-01-23	2019-01-18	4	Faga Daniel	ONCE	Restricted Stock Units	M - Exercise	D			-2.500		7.500
2019-01-23	2019-01-18	4	Faga Daniel	ONCE	Restricted Stock Units	M - Exercise	D			-2.000		4.000
2019-01-23	2019-01-18	4	Faga Daniel	ONCE	Common Stock	F - Taxes	D		45,0800	-823	-37		4.032
2019-01-23	2019-01-18	4	Faga Daniel	ONCE	Common Stock	M - Exercise	D			2.500			4.855
2019-01-23	2019-01-18	4	Faga Daniel	ONCE	Common Stock	F - Taxes	D		45,0800	-766	-35		2.355
2019-01-23	2019-01-18	4	Faga Daniel	ONCE	Common Stock	M - Exercise	D			2.000			3.121
2019-01-23	2019-01-18	4	La Barge Joseph	ONCE	Restricted Stock Units	M - Exercise	D			-2.000		6.000
2019-01-23	2019-01-18	4	La Barge Joseph	ONCE	Restricted Stock Units	M - Exercise	D			-1.750		3.500
2019-01-23	2019-01-18	4	La Barge Joseph	ONCE	Common Stock	F - Taxes	D		45,0800	-633	-29		8.923
2019-01-23	2019-01-18	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D			2.000			9.556
2019-01-23	2019-01-18	4	La Barge Joseph	ONCE	Common Stock	F - Taxes	D		45,0800	-634	-29		7.556
2019-01-23	2019-01-18	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D			1.750			8.190
2019-01-23	2019-01-18	4	High Katherine A	ONCE	Restricted Stock Units	M - Exercise	D			-2.250		6.750
2019-01-23	2019-01-18	4	High Katherine A	ONCE	Restricted Stock Units	M - Exercise	D			-2.250		6.750
2019-01-23	2019-01-18	4	High Katherine A	ONCE	Common Stock	F - Taxes	D		45,0800	-683	-31		214.468
2019-01-23	2019-01-18	4	High Katherine A	ONCE	Common Stock	M - Exercise	D			2.250			215.151
2019-01-23	2019-01-18	4	High Katherine A	ONCE	Common Stock	M - Exercise	D			2.250			215.151
2019-01-23	2019-01-18	4	High Katherine A	ONCE	Common Stock	F - Taxes	D		45,0800	-808	-36		212.901
2019-01-23	2019-01-18	4	Dalton Lisa	ONCE	Restricted Stock Units	M - Exercise	D			-2.000		6.000
2019-01-23	2019-01-18	4	Dalton Lisa	ONCE	Restricted Stock Units	M - Exercise	D			-2.162		4.325
2019-01-23	2019-01-18	4	Dalton Lisa	ONCE	Common Stock	F - Taxes	D		45,0800	-621	-28		4.134
2019-01-23	2019-01-18	4	Dalton Lisa	ONCE	Common Stock	M - Exercise	D			2.000			4.755
2019-01-23	2019-01-18	4	Dalton Lisa	ONCE	Common Stock	F - Taxes	D		45,0800	-792	-36		2.755
2019-01-23	2019-01-18	4	Dalton Lisa	ONCE	Common Stock	M - Exercise	D			2.162			3.547
2019-01-23	2019-01-18	4	Marrazzo Jeffrey D	ONCE	Restricted Stock Units	M - Exercise	D			-3.750		11.250
2019-01-23	2019-01-18	4	Marrazzo Jeffrey D	ONCE	Restricted Stock Units	M - Exercise	D			-5.000		10.000
2019-01-23	2019-01-18	4	Marrazzo Jeffrey D	ONCE	Common Stock	F - Taxes	D		45,0800	-1.174	-53		305.275
2019-01-23	2019-01-18	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D			3.750			306.449
2019-01-23	2019-01-18	4	Marrazzo Jeffrey D	ONCE	Common Stock	F - Taxes	D		45,0800	-1.655	-75		302.699
2019-01-23	2019-01-18	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D			5.000			304.354
2019-01-23	2019-01-18	4	Webster Stephen W	ONCE	Restricted Stock Units	M - Exercise	D			-2.000		6.000
2019-01-23	2019-01-18	4	Webster Stephen W	ONCE	Restricted Stock Units	M - Exercise	D			-1.750		3.500
2019-01-23	2019-01-18	4	Webster Stephen W	ONCE	Common Stock	F - Taxes	D		45,0800	-629	-28		6.102
2019-01-23	2019-01-18	4	Webster Stephen W	ONCE	Common Stock	M - Exercise	D			2.000			6.731
2019-01-23	2019-01-18	4	Webster Stephen W	ONCE	Common Stock	F - Taxes	D		45,0800	-634	-29		4.731
2019-01-23	2019-01-18	4	Webster Stephen W	ONCE	Common Stock	M - Exercise	D			1.750			5.365
2019-01-23	2019-01-18	4	Mingozzi Federico	ONCE	Restricted Stock Units	M - Exercise	D			-2.000		6.000
2019-01-23	2019-01-18	4	Mingozzi Federico	ONCE	Common Stock	F - Taxes	D		45,0800	-733	-33		7.015
2019-01-23	2019-01-18	4	Mingozzi Federico	ONCE	Common Stock	M - Exercise	D			2.000			7.748
2019-01-23	2018-06-26	4	Mingozzi Federico	ONCE	Restricted Stock Units	M - Exercise	D			-8.375		25.125
2019-01-23	2018-06-26	4	Mingozzi Federico	ONCE	Common Stock	F - Taxes	D		87,9800	-2.627	-231		5.748
2019-01-23	2018-06-26	4	Mingozzi Federico	ONCE	Common Stock	M - Exercise	D			8.375			8.375
2019-01-17	2019-01-15	4	Faga Daniel	ONCE	Restricted Stock Units	A - Award	D			10.000		10.000
2019-01-17	2019-01-15	4	Faga Daniel	ONCE	Employee Stock Option (right to buy)	A - Award	D	42,73		35.000		35.000
2019-01-17	2019-01-15	4	High Katherine A	ONCE	Restricted Stock Units	A - Award	D			10.000		10.000
2019-01-17	2019-01-15	4	High Katherine A	ONCE	Employee Stock Option (right to buy)	A - Award	D	42,73		35.000		35.000
2019-01-17	2019-01-15	4	Dalton Lisa	ONCE	Restricted Stock Units	A - Award	D			10.000		10.000
2019-01-17	2019-01-15	4	Dalton Lisa	ONCE	Employee Stock Option (right to buy)	A - Award	D	42,73		35.000		35.000
2019-01-17	2019-01-15	4	Marrazzo Jeffrey D	ONCE	Restricted Stock Units	A - Award	D			28.000		28.000
2019-01-17	2019-01-15	4	Marrazzo Jeffrey D	ONCE	Employee Stock Option (right to buy)	A - Award	D	42,73		98.000		98.000
2019-01-17	2019-01-15	4	Webster Stephen W	ONCE	Restricted Stock Units	A - Award	D			10.000		10.000
2019-01-17	2019-01-15	4	Webster Stephen W	ONCE	Employee Stock Option (right to buy)	A - Award	D	42,73		35.000		35.000
2019-01-17	2019-01-15	4	La Barge Joseph	ONCE	Restricted Stock Units	A - Award	D			10.000		10.000
2019-01-17	2019-01-15	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	A - Award	D	42,73		35.000		35.000
2019-01-17	2019-01-15	4	Mingozzi Federico	ONCE	Restricted Stock Units	A - Award	D			10.000		10.000
2019-01-17	2019-01-15	4	Mingozzi Federico	ONCE	Employee Stock Option (right to buy)	A - Award	D	42,73		35.000		35.000
2019-01-08	2019-01-04	4	Mehra Anand	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-37.203		0
2019-01-08	2019-01-04	4	Mehra Anand	ONCE	Common Stock	M - Exercise	D		3,4500	37.203	128		38.703
2019-01-04	2019-01-03	4	PEREZ ROBERT J	ONCE	Restricted Stock Units	M - Exercise	D			-1.000		2.000
2019-01-04	2019-01-03	4	PEREZ ROBERT J	ONCE	Common Stock	M - Exercise	D			1.000			1.000
2019-01-02	2018-12-28	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-6.000		176.071
2019-01-02	2018-12-28	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	6.000	21		299.354
2018-06-01	2018-05-31	4	Mehra Anand	ONCE	Restricted Stock Units	M - Exercise	D			-1.500		0
2018-06-01	2018-05-31	4	Mehra Anand	ONCE	Common Stock	M - Exercise	D			1.500			1.500
2018-06-01	2018-05-30	4	Mehra Anand	ONCE	Restricted Stock Units	A - Award	D			1.500		1.500
2018-06-01	2018-05-30	4	Mehra Anand	ONCE	Stock Option (right to buy)	A - Award	D	81,53		4.000		4.000
2018-06-01	2018-05-30	4	PEREZ ROBERT J	ONCE	Restricted Stock Units	A - Award	D			1.500		1.500
2018-06-01	2018-05-30	4	PEREZ ROBERT J	ONCE	Stock Option (right to buy)	A - Award	D	81,53		4.000		4.000
2018-05-31	2018-05-31	4	Altschuler Steven	ONCE	Restricted Stock Units	M - Exercise	D			-1.500		0
2018-05-31	2018-05-31	4	Altschuler Steven	ONCE	Common Stock	M - Exercise	D			1.500			26.500
2018-05-31	2018-05-30	4	Altschuler Steven	ONCE	Restricted Stock Units	A - Award	D			1.500		1.500
2018-05-31	2018-05-30	4	Altschuler Steven	ONCE	Stock Option (right to buy)	A - Award	D	81,53		4.000		4.000
2018-05-31	2018-05-31	4	MILANO VINCENT	ONCE	Restricted Stock Units	M - Exercise	D			-1.500		0
2018-05-31	2018-05-31	4	MILANO VINCENT	ONCE	Common Stock	M - Exercise	D			1.500			1.500
2018-05-31	2018-05-30	4	MILANO VINCENT	ONCE	Restricted Stock Units	A - Award	D			1.500		1.500
2018-05-31	2018-05-30	4	MILANO VINCENT	ONCE	Stock Option (right to buy)	A - Award	D	81,53		4.000		4.000
2018-05-31	2018-05-31	4	SIGAL ELLIOT	ONCE	Restricted Stock Units	M - Exercise	D			-1.500		0
2018-05-31	2018-05-31	4	SIGAL ELLIOT	ONCE	Common Stock	M - Exercise	D			1.500			12.714
2018-05-31	2018-05-30	4	SIGAL ELLIOT	ONCE	Stock Option (right to buy)	A - Award	D	81,53		4.000		4.000
2018-05-31	2018-05-30	4	SIGAL ELLIOT	ONCE	Restricted Stock Units	A - Award	D			1.500		1.500
2018-05-31	2018-05-31	4	Ekman Lars	ONCE	Restricted Stock Units	M - Exercise	D			-1.500		0
2018-05-31	2018-05-31	4	Ekman Lars	ONCE	Common Stock	M - Exercise	D			1.500			1.500
2018-05-31	2018-05-30	4	Ekman Lars	ONCE	Restricted Stock Units	A - Award	D			1.500		1.500
2018-05-31	2018-05-30	4	Ekman Lars	ONCE	Stock Option (right to buy)	A - Award	D	81,53		4.000		4.000
2018-05-31	2018-05-31	4	Zoth Lota S.	ONCE	Restricted Stock Units	M - Exercise	D			-1.500		0
2018-05-31	2018-05-31	4	Zoth Lota S.	ONCE	Common Stock	M - Exercise	D			1.500			1.500
2018-05-31	2018-05-30	4	Zoth Lota S.	ONCE	Restricted Stock Units	A - Award	D			1.500		1.500
2018-05-31	2018-05-30	4	Zoth Lota S.	ONCE	Stock Option (right to buy)	A - Award	D	81,53		4.000		4.000
2018-04-24	2018-04-20	4	Furey John	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	49,74		-6.723		120.000
2018-04-24	2018-04-20	4	Furey John	ONCE	Common Stock	S - Sale	D		82,5000	-6.723	-555		0
2018-04-24	2018-04-20	4	Furey John	ONCE	Common Stock	M - Exercise	D		49,7400	6.723	334		6.723
2018-04-19	2018-04-18	4	Furey John	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	49,74		-11.000		126.723
2018-04-19	2018-04-18	4	Furey John	ONCE	Common Stock	S - Sale	D		82,5300	-11.000	-908		0
2018-04-19	2018-04-18	4	Furey John	ONCE	Common Stock	M - Exercise	D		49,7400	11.000	547		11.000
2018-04-19	2018-04-17	4	Furey John	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	49,74		-2.277		137.723
2018-04-19	2018-04-17	4	Furey John	ONCE	Common Stock	S - Sale	D		82,5000	-2.277	-188		0
2018-04-19	2018-04-17	4	Furey John	ONCE	Common Stock	M - Exercise	D		49,7400	2.277	113		2.277
2018-04-16	2018-04-12	4	Furey John	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	49,74		-20.000		140.000
2018-04-16	2018-04-12	4	Furey John	ONCE	Common Stock	S - Sale	D		77,5100	-20.000	-1.550		0
2018-04-16	2018-04-12	4	Furey John	ONCE	Common Stock	M - Exercise	D		49,7400	20.000	995		20.000
2018-04-16	2017-11-28	4	SIGAL ELLIOT	ONCE	Common Stock	S - Sale	D		72,4300	-29	-2		11.214
2018-04-16	2017-10-12	4	SIGAL ELLIOT	ONCE	Common Stock	P - Purchase	D		90,7500	29	3		11.243
2018-02-23		3	Dalton Lisa	ONCE	Common Stock		D						2.770
2018-02-23		3	Dalton Lisa	ONCE	Common Stock		D						2.770
2018-01-22	2017-12-11	4	Furey John By mother-in-law	ONCE	Common Stock	S - Sale	I		46,3300	-18	-1		0
2018-01-22	2017-12-08	4	Furey John By mother-in-law	ONCE	Common Stock	P - Purchase	I		73,4800	18	1		18
2018-01-22	2018-01-18	4	La Barge Joseph	ONCE	Restricted Stock Units	M - Exercise	D			-1.750		5.250
2018-01-22	2018-01-18	4	La Barge Joseph	ONCE	Restricted Stock Units	A - Award	D			8.000		8.000
2018-01-22	2018-01-18	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	A - Award	D	50,55		28.000		28.000
2018-01-22	2018-01-18	4	La Barge Joseph	ONCE	Common Stock	F - Taxes	D		50,5500	-635	-32		6.440
2018-01-22	2018-01-18	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D			1.750			7.075
2018-01-22	2018-01-18	4	Faga Daniel	ONCE	Restricted Stock Units	M - Exercise	D			-2.000		6.000
2018-01-22	2018-01-18	4	Faga Daniel	ONCE	Restricted Stock Units	A - Award	D			10.000		10.000
2018-01-22	2018-01-18	4	Faga Daniel	ONCE	Employee Stock Option (right to buy)	A - Award	D	50,55		35.000		35.000
2018-01-22	2018-01-18	4	Faga Daniel	ONCE	Common Stock	F - Taxes	D		50,5500	-879	-44		1.121
2018-01-22	2018-01-18	4	Faga Daniel	ONCE	Common Stock	M - Exercise	D			2.000			2.000
2018-01-22	2018-01-18	4	High Katherine A	ONCE	Restricted Stock Units	M - Exercise	D			-2.250		6.750
2018-01-22	2018-01-18	4	High Katherine A	ONCE	Restricted Stock Units	A - Award	D			9.000		9.000
2018-01-22	2018-01-18	4	High Katherine A	ONCE	Employee Stock Option (right to buy)	A - Award	D	50,55		31.500		31.500
2018-01-22	2018-01-18	4	High Katherine A	ONCE	Common Stock	F - Taxes	D		50,5500	-791	-40		211.459
2018-01-22	2018-01-18	4	High Katherine A	ONCE	Common Stock	M - Exercise	D			2.250			212.250
2018-01-22	2018-01-18	4	Furey John	ONCE	Restricted Stock Units	A - Award	D			17.500		17.500
2018-01-22	2018-01-18	4	Furey John	ONCE	Employee Stock Option (right to buy)	A - Award	D	50,55		35.000		35.000
2018-01-22	2018-01-18	4	Marrazzo Jeffrey D	ONCE	Restricted Stock Units	M - Exercise	D			-5.000		15.000
2018-01-22	2018-01-18	4	Marrazzo Jeffrey D	ONCE	Restricted Stock Units	A - Award	D			15.000		15.000
2018-01-22	2018-01-18	4	Marrazzo Jeffrey D	ONCE	Employee Stock Option (right to buy)	A - Award	D	50,55		52.500		52.500
2018-01-22	2018-01-18	4	Marrazzo Jeffrey D	ONCE	Common Stock	F - Taxes	D		50,5500	-1.646	-83		293.354
2018-01-22	2018-01-18	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D			5.000			295.000
2018-01-22	2018-01-18	4	Webster Stephen W	ONCE	Restricted Stock Units	M - Exercise	D			-1.750		5.250
2018-01-22	2018-01-18	4	Webster Stephen W	ONCE	Restricted Stock Units	A - Award	D			8.000		8.000
2018-01-22	2018-01-18	4	Webster Stephen W	ONCE	Employee Stock Option (right to buy)	A - Award	D	50,55		28.000		28.000
2018-01-22	2018-01-18	4	Webster Stephen W	ONCE	Common Stock	F - Taxes	D		50,5500	-635	-32		3.615
2018-01-22	2018-01-18	4	Webster Stephen W	ONCE	Common Stock	M - Exercise	D			1.750			4.250
2018-01-04	2018-01-03	4	PEREZ ROBERT J	ONCE	Restricted Stock Units	A - Award	D			3.000		3.000
2018-01-04	2018-01-03	4	PEREZ ROBERT J	ONCE	Stock Option (right to buy)	A - Award	D	55,76		8.000		8.000
2017-12-20	2017-12-19	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-60.000		182.071
2017-12-20	2017-12-19	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	60.000	207		290.000
2017-11-29	2017-11-28	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-5.000		73.249
2017-11-29	2017-11-28	4	High Katherine A	ONCE	Common Stock	S - Sale	D		72,2700	-1.500	-108		210.000
2017-11-29	2017-11-28	4	High Katherine A	ONCE	Common Stock	S - Sale	D		70,9100	-3.500	-248		211.500
2017-11-29	2017-11-28	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		3,4500	5.000	17		215.000
2017-11-20	2017-11-16	4	Webster Stephen W	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-10.000		106.015
2017-11-20	2017-11-16	4	Webster Stephen W	ONCE	Common Stock	S - Sale	D		70,1400	-10.000	-701		2.500
2017-11-20	2017-11-16	4	Webster Stephen W	ONCE	Common Stock	M - Exercise	D		3,4500	10.000	34		12.500
2017-11-13	2017-11-13	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	3,45		-2.191		629
2017-11-13	2017-11-13	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		71,6500	-2.191	-157		5.325
2017-11-13	2017-11-13	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	2.191	8		10.825
2017-11-13	2017-11-09	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	3,45		-488		8.683
2017-11-13	2017-11-09	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	3,45		-2.821		2.820
2017-11-13	2017-11-09	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		71,9000	-200	-14		7.516
2017-11-13	2017-11-09	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		71,2700	-3.109	-222		7.716
2017-11-13	2017-11-09	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	488	2		8.634
2017-11-13	2017-11-09	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	2.821	10		8.146
2017-11-13	2017-11-13	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-20.000		242.071
2017-11-13	2017-11-13	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		71,5400	-20.000	-1.431		230.000
2017-11-13	2017-11-13	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	20.000	69		250.000
2017-11-06	2017-10-31	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-5.000		78.249
2017-11-06	2017-10-31	4	High Katherine A	ONCE	Common Stock	S - Sale	D		83,3000	-5.000	-416		210.000
2017-11-06	2017-10-31	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		3,4500	5.000	17		215.000
2017-10-24	2017-10-24	4	Faga Daniel	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	37,62		-1.500		130.000
2017-10-24	2017-10-24	4	Faga Daniel	ONCE	Common Stock	S - Sale	D		85,0000	-1.500	-128		0
2017-10-24	2017-10-24	4	Faga Daniel	ONCE	Common Stock	M - Exercise	D		37,6200	1.500	56		1.500
2017-10-24	2017-10-20	4	Faga Daniel	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	37,62		-6.000		131.500
2017-10-24	2017-10-20	4	Faga Daniel	ONCE	Common Stock	S - Sale	D		79,9500	-6.000	-480		0
2017-10-24	2017-10-20	4	Faga Daniel	ONCE	Common Stock	M - Exercise	D		37,6200	6.000	226		6.000
2017-09-28	2017-09-26	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-5.000		83.249
2017-09-28	2017-09-26	4	High Katherine A	ONCE	Common Stock	S - Sale	D		86,6700	-3.519	-305		210.000
2017-09-28	2017-09-26	4	High Katherine A	ONCE	Common Stock	S - Sale	D		84,9500	-1.481	-126		213.519
2017-09-28	2017-09-26	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		3,4500	5.000	17		215.000
2017-09-27	2017-09-27	4	Children's Hospital of Philadelphia Foundation By Affiliate	ONCE	Stock Option (right to buy)	M - Exercise	I	56,22		-6.000		0
2017-09-27	2017-09-27	4	Children's Hospital of Philadelphia Foundation By Affiliate	ONCE	Stock Option (right to buy)	M - Exercise	I	23,00		-20.250		0
2017-09-27	2017-09-27	4	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock	M - Exercise	D		56,2200	6.000	337		3.954.957
2017-09-27	2017-09-27	4	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock	M - Exercise	D		23,0000	20.250	466		3.948.957
2017-09-26	2017-09-21	4	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock	S - Sale	D		84,6300	-1.000.000	-84.630		3.928.707
2017-09-20	2017-09-19	4	Faga Daniel	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	37,62		-1.500		137.500
2017-09-20	2017-09-19	4	Faga Daniel	ONCE	Common Stock	S - Sale	D		85,0000	-1.500	-128		0
2017-09-20	2017-09-19	4	Faga Daniel	ONCE	Common Stock	M - Exercise	D		37,6200	1.500	56		1.500
2017-09-14	2017-09-12	4	Faga Daniel	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	37,62		-6.000		139.000
2017-09-14	2017-09-12	4	Faga Daniel	ONCE	Common Stock	S - Sale	D		83,3600	-900	-75		0
2017-09-14	2017-09-12	4	Faga Daniel	ONCE	Common Stock	S - Sale	D		82,3500	-5.100	-420		900
2017-09-14	2017-09-12	4	Faga Daniel	ONCE	Common Stock	M - Exercise	D		37,6200	6.000	226		6.000
2017-09-11	2017-09-07	4	Faga Daniel	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	37,62		-3.000		145.000
2017-09-11	2017-09-07	4	Faga Daniel	ONCE	Common Stock	S - Sale	D		85,0300	-1.500	-128		0
2017-09-11	2017-09-07	4	Faga Daniel	ONCE	Common Stock	S - Sale	D		85,0000	-1.500	-128		1.500
2017-09-11	2017-09-07	4	Faga Daniel	ONCE	Common Stock	M - Exercise	D		37,6200	3.000	113		3.000
2017-09-06	2017-09-05	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	3,45		-5.500		9.171
2017-09-06	2017-09-05	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		81,1700	-2.010	-163		5.325
2017-09-06	2017-09-05	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		80,1500	-990	-79		7.335
2017-09-06	2017-09-05	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		81,2000	-2.500	-203		8.325
2017-09-06	2017-09-05	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	5.500	19		10.825
2017-09-01	2017-08-29	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-10.000		88.249
2017-09-01	2017-08-29	4	High Katherine A	ONCE	Common Stock	S - Sale	D		81,1600	-1.839	-149		210.000
2017-09-01	2017-08-29	4	High Katherine A	ONCE	Common Stock	S - Sale	D		80,0500	-8.161	-653		211.839
2017-09-01	2017-08-29	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		3,4500	10.000	34		220.000
2017-08-24	2017-08-23	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-21.350		262.071
2017-08-24	2017-08-23	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		80,0100	-21.350	-1.708		230.000
2017-08-24	2017-08-23	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	21.350	74		251.350
2017-08-15	2017-08-11	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-15.000		283.421
2017-08-15	2017-08-11	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		75,1000	-15.000	-1.126		230.000
2017-08-15	2017-08-11	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	15.000	52		245.000
2017-08-15	2017-08-15	4	Webster Stephen W	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-10.000		116.015
2017-08-15	2017-08-15	4	Webster Stephen W	ONCE	Common Stock	S - Sale	D		79,3800	-10.000	-794		2.500
2017-08-15	2017-08-15	4	Webster Stephen W	ONCE	Common Stock	M - Exercise	D		3,4500	10.000	34		12.500
2017-08-04	2017-08-02	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-28.650		298.421
2017-08-04	2017-08-02	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		80,0100	-28.650	-2.292		230.000
2017-08-04	2017-08-02	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	28.650	99		258.650
2017-08-02	2017-07-31	4	Webster Stephen W	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-2.337		126.015
2017-08-02	2017-07-31	4	Webster Stephen W	ONCE	Common Stock	S - Sale	D		71,1200	-2.337	-166		2.500
2017-08-02	2017-07-31	4	Webster Stephen W	ONCE	Common Stock	M - Exercise	D		3,4500	2.337	8		4.837
2017-07-26	2017-07-24	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		73,1000	-518	-38		481.270
2017-07-26	2017-07-24	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		72,2800	-4.679	-338		481.788
2017-07-26	2017-07-24	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		71,5900	-7.350	-526		486.467
2017-07-26	2017-07-24	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		70,0400	-199.311	-13.960		493.817
2017-07-26	2017-07-25	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-10.000		98.249
2017-07-26	2017-07-25	4	High Katherine A	ONCE	Common Stock	S - Sale	D		74,1100	-1.500	-111		210.000
2017-07-26	2017-07-25	4	High Katherine A	ONCE	Common Stock	S - Sale	D		72,2500	-8.500	-614		211.500
2017-07-26	2017-07-25	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		3,4500	10.000	34		220.000
2017-07-26	2017-07-24	4	Faga Daniel	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	37,62		-3.000		148.000
2017-07-26	2017-07-24	4	Faga Daniel	ONCE	Common Stock	S - Sale	D		70,0000	-3.000	-210		0
2017-07-26	2017-07-24	4	Faga Daniel	ONCE	Common Stock	M - Exercise	D		37,6200	3.000	113		3.000
2017-07-26	2017-07-24	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	3,45		-3.000		14.671
2017-07-26	2017-07-24	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		70,0000	-3.000	-210		5.325
2017-07-26	2017-07-24	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	3.000	10		8.325
2017-07-07	2017-07-05	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-5.669		327.071
2017-07-07	2017-07-05	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		65,0000	-5.669	-368		230.000
2017-07-07	2017-07-05	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	5.669	20		235.669
2017-06-29	2017-06-29	4	Faga Daniel	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	37,62		-4.500		151.000
2017-06-29	2017-06-29	4	Faga Daniel	ONCE	Common Stock	S - Sale	D		62,7100	-4.500	-282		0
2017-06-29	2017-06-29	4	Faga Daniel	ONCE	Common Stock	M - Exercise	D		37,6200	4.500	169		4.500
2017-06-29	2017-06-27	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-10.000		108.249
2017-06-29	2017-06-27	4	High Katherine A	ONCE	Common Stock	S - Sale	D		60,9600	-10.000	-610		210.000
2017-06-29	2017-06-27	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		3,4500	10.000	34		220.000
2017-06-22	2017-06-21	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-8.797		332.740
2017-06-22	2017-06-21	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		65,0000	-8.797	-572		230.000
2017-06-22	2017-06-21	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	8.797	30		238.797
2017-06-22	2017-06-20	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-534		341.537
2017-06-22	2017-06-20	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		65,0000	-534	-35		230.000
2017-06-22	2017-06-20	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	534	2		230.534
2017-06-22	2017-06-21	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		65,0000	-5.282	-343		693.128
2017-06-22	2017-06-20	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		65,0000	-1.020	-66		698.410
2017-06-21	2017-06-19	4	Webster Stephen W	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-7.663		128.352
2017-06-21	2017-06-19	4	Webster Stephen W	ONCE	Common Stock	S - Sale	D		60,0000	-7.663	-460		2.500
2017-06-21	2017-06-19	4	Webster Stephen W	ONCE	Common Stock	M - Exercise	D		3,4500	7.663	26		10.163
2017-06-21	2017-06-19	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-10.000		118.249
2017-06-21	2017-06-19	4	High Katherine A	ONCE	Common Stock	S - Sale	D		60,0000	-10.000	-600		210.000
2017-06-21	2017-06-19	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		3,4500	10.000	34		220.000
2017-06-08	2017-06-07	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	3,45		-758		17.671
2017-06-08	2017-06-07	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	3,45		-4.242		5.641
2017-06-08	2017-06-07	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		55,0000	-5.000	-275		5.325
2017-06-08	2017-06-07	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	758	3		10.325
2017-06-08	2017-06-07	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	4.242	15		9.567
2017-06-02	2017-05-31	4	Altschuler Steven	ONCE	Restricted Stock Units	A - Award	D			1.500		1.500
2017-06-02	2017-05-31	4	Altschuler Steven	ONCE	Stock Option (right to buy)	A - Award	D	50,93		4.000		4.000
2017-06-02	2017-05-31	4	MILANO VINCENT	ONCE	Restricted Stock Units	A - Award	D			1.500		1.500
2017-06-02	2017-05-31	4	MILANO VINCENT	ONCE	Stock Option (right to buy)	A - Award	D	50,93		4.000		4.000
2017-06-02	2017-05-31	4	Betz Alert Lorris	ONCE	Restricted Stock Units	A - Award	D			1.500		1.500
2017-06-02	2017-05-31	4	Betz Alert Lorris	ONCE	Stock Option (right to buy)	A - Award	D	50,93		4.000		4.000
2017-06-02	2017-05-31	4	Zoth Lota S.	ONCE	Restricted Stock Units	A - Award	D			1.500		1.500
2017-06-02	2017-05-31	4	Zoth Lota S.	ONCE	Stock Option (right to buy)	A - Award	D	50,93		4.000		4.000
2017-06-02	2017-05-31	4	Mehra Anand	ONCE	Restricted Stock Units	A - Award	D			1.500		1.500
2017-06-02	2017-05-31	4	Mehra Anand	ONCE	Stock Option (right to buy)	A - Award	D	50,93		4.000		4.000
2017-06-02	2017-05-31	4	SIGAL ELLIOT	ONCE	Restricted Stock Units	A - Award	D			1.500		1.500
2017-06-02	2017-05-31	4	SIGAL ELLIOT	ONCE	Stock Option (right to buy)	A - Award	D	50,93		4.000		4.000
2017-06-02	2017-05-31	4	Ekman Lars	ONCE	Restricted Stock Units	A - Award	D			1.500		1.500
2017-06-02	2017-05-31	4	Ekman Lars	ONCE	Stock Option (right to buy)	A - Award	D	50,93		4.000		4.000
2017-05-17	2017-05-15	4	Faga Daniel	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	37,62		-4.500		155.500
2017-05-17	2017-05-15	4	Faga Daniel	ONCE	Common Stock	S - Sale	D		56,9000	-4.500	-256		0
2017-05-17	2017-05-15	4	Faga Daniel	ONCE	Common Stock	M - Exercise	D		37,6200	4.500	169		4.500
2017-05-15	2017-05-11	4	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock	S - Sale	D		56,2700	-840.000	-47.267		4.928.707
2017-05-02	2017-04-28	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-15.000		128.249
2017-05-02	2017-04-28	4	High Katherine A	ONCE	Common Stock	S - Sale	D		58,0600	-15.000	-871		210.000
2017-05-02	2017-04-28	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		3,4500	15.000	52		225.000
2017-04-26	2017-04-25	4	Webster Stephen W	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-8.102		136.015
2017-04-26	2017-04-25	4	Webster Stephen W	ONCE	Common Stock	S - Sale	D		55,2200	-8.102	-447		2.500
2017-04-26	2017-04-25	4	Webster Stephen W	ONCE	Common Stock	M - Exercise	D		3,4500	8.102	28		10.602
2017-04-26	2017-04-24	4	Webster Stephen W	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-1.898		144.117
2017-04-26	2017-04-24	4	Webster Stephen W	ONCE	Common Stock	S - Sale	D		55,0000	-1.898	-104		2.500
2017-04-26	2017-04-24	4	Webster Stephen W	ONCE	Common Stock	M - Exercise	D		3,4500	1.898	7		4.398
2017-04-26	2017-04-25	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-12.940		143.249
2017-04-26	2017-04-25	4	High Katherine A	ONCE	Common Stock	S - Sale	D		56,0100	-110	-6		210.000
2017-04-26	2017-04-25	4	High Katherine A	ONCE	Common Stock	S - Sale	D		55,3800	-12.830	-711		210.110
2017-04-26	2017-04-25	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		3,4500	12.940	45		222.940
2017-04-26	2017-04-24	4	High Katherine A	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-2.060		156.189
2017-04-26	2017-04-24	4	High Katherine A	ONCE	Common Stock	S - Sale	D		55,0100	-2.060	-113		210.000
2017-04-26	2017-04-24	4	High Katherine A	ONCE	Common Stock	M - Exercise	D		3,4500	2.060	7		212.060
2017-04-05	2017-04-03	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	3,45		-5.000		18.429
2017-04-05	2017-04-03	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		53,6800	-500	-27		5.325
2017-04-05	2017-04-03	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		52,6200	-4.500	-237		5.825
2017-04-05	2017-04-03	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	5.000	17		10.325
2017-03-06	2017-03-02	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		65,0100	-15.275	-993		699.430
2017-03-02	2017-03-01	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	3,45		-5.000		9.883
2017-03-02	2017-03-01	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		64,7000	-2.266	-147		5.325
2017-03-02	2017-03-01	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		64,1700	-2.734	-175		7.591
2017-03-02	2017-03-01	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	5.000	17		10.325
2017-03-01	2017-03-01	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		65,0100	-17.470	-1.136		714.705
2017-03-01	2017-02-28	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		65,0200	-25.274	-1.643		732.175
2017-03-01	2017-02-27	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		65,0200	-41.910	-2.725		757.449
2017-02-22	2017-02-17	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		65,0100	-7.535	-490		799.359
2017-02-16	2017-02-16	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		65,0100	-2.900	-189		806.894
2017-02-16	2017-02-15	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		65,0300	-31.497	-2.048		809.794
2017-02-16	2017-02-14	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		65,0200	-950	-62		841.291
2017-02-13	2017-02-09	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		65,0600	-37.411	-2.434		842.241
2017-02-07	2017-02-07	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		65,0400	-1.994	-130		879.652
2017-02-07	2017-02-06	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		65,0000	-1.010	-66		881.646
2017-02-07	2017-02-03	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		65,0600	-22.330	-1.453		882.656
2017-01-20	2017-01-18	4	Webster Stephen W	ONCE	Restricted Stock Units	A - Award	D			7.000		7.000
2017-01-20	2017-01-18	4	Webster Stephen W	ONCE	Employee Stock Option (right to buy)	A - Award	D	56,17		25.000		25.000
2017-01-20	2017-01-18	4	High Katherine A	ONCE	Restricted Stock Units	A - Award	D			9.000		18.000
2017-01-20	2017-01-18	4	High Katherine A	ONCE	Employee Stock Option (right to buy)	A - Award	D	56,17		31.500		31.500
2017-01-20	2017-01-18	4	Marrazzo Jeffrey D	ONCE	Restricted Stock Units	A - Award	D			20.000		40.000
2017-01-20	2017-01-18	4	Marrazzo Jeffrey D	ONCE	Employee Stock Option (right to buy)	A - Award	D	56,17		70.000		70.000
2017-01-20	2017-01-18	4	La Barge Joseph	ONCE	Restricted Stock Units	A - Award	D			7.000		7.000
2017-01-20	2017-01-18	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	A - Award	D	56,17		25.000		25.000
2017-01-20	2017-01-18	4	Faga Daniel	ONCE	Restricted Stock Units	A - Award	D			8.000		8.000
2017-01-20	2017-01-18	4	Faga Daniel	ONCE	Employee Stock Option (right to buy)	A - Award	D	56,17		28.000		28.000
2016-12-19	2016-12-16	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		54,9100	-50.000	-2.746		904.986
2016-12-19	2016-12-16	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		53,2600	-229.728	-12.235		954.986
2016-12-19	2016-12-15	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		53,0700	-69.928	-3.711		1.184.714
2016-12-16	2016-12-15	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	3,45		-3.000		14.883
2016-12-16	2016-12-15	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		53,6900	-200	-11		5.325
2016-12-16	2016-12-15	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		52,9300	-2.800	-148		5.525
2016-12-16	2016-12-15	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	3.000	10		8.325
2016-12-13	2016-12-13	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		53,3200	-22.281	-1.188		1.254.642
2016-12-13	2016-12-09	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		57,2400	-33.840	-1.937		1.276.923
2016-12-13	2016-12-09	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		56,5500	-10.900	-616		1.310.763
2016-12-13	2016-12-09	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		55,2700	-22.113	-1.222		1.321.663
2016-12-13	2016-12-09	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		54,0300	-24.498	-1.324		1.343.776
2016-12-13	2016-12-09	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		53,0700	-8.900	-472		1.368.274
2016-12-05	2016-12-01	4	Furey John	ONCE	Employee Stock Option (right to buy)	A - Award	D	49,74		160.000		160.000
2016-11-16	2016-11-14	4	High Katherine A	ONCE	Common Stock	S - Sale	D		60,3000	-10.000	-603		210.000
2016-10-19	2016-10-17	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-5.000		342.071
2016-10-19	2016-10-17	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		55,7100	-300	-17		230.000
2016-10-19	2016-10-17	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		55,1100	-2.300	-127		230.300
2016-10-19	2016-10-17	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		54,1000	-2.400	-130		232.600
2016-10-19	2016-10-17	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	5.000	17		235.000
2016-10-05	2016-10-03	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	3,45		-3.000		23.429
2016-10-05	2016-10-03	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		60,6600	-1.089	-66		5.325
2016-10-05	2016-10-03	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		59,8400	-1.911	-114		6.414
2016-10-05	2016-10-03	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	3.000	10		8.325
2016-09-19	2016-09-15	4	High Katherine A	ONCE	Common Stock	S - Sale	D		61,2000	-500	-31		220.000
2016-09-19	2016-09-15	4	High Katherine A	ONCE	Common Stock	S - Sale	D		60,3300	-9.500	-573		220.500
2016-09-19	2016-09-16	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-10.000		347.071
2016-09-19	2016-09-16	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		63,5400	-3.810	-242		230.000
2016-09-19	2016-09-16	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		62,5300	-3.369	-211		233.810
2016-09-19	2016-09-16	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		61,7100	-2.821	-174		237.179
2016-09-19	2016-09-16	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	10.000	34		240.000
2016-08-18	2016-08-16	4	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock	S - Sale	D		60,9000	-1.000.000	-60.900		5.768.707
2016-08-17	2016-08-15	4	High Katherine A	ONCE	Common Stock	S - Sale	D		64,5900	-200	-13		230.000
2016-08-17	2016-08-15	4	High Katherine A	ONCE	Common Stock	S - Sale	D		63,9400	-3.342	-214		230.200
2016-08-17	2016-08-15	4	High Katherine A	ONCE	Common Stock	S - Sale	D		62,7900	-1.458	-92		233.542
2016-08-17	2016-08-15	4	High Katherine A	ONCE	Common Stock	S - Sale	D		61,8800	-5.000	-309		235.000
2016-08-17	2016-08-15	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-10.000		357.071
2016-08-17	2016-08-15	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		64,6400	-100	-6		230.000
2016-08-17	2016-08-15	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		63,9600	-3.400	-217		230.100
2016-08-17	2016-08-15	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		62,8400	-1.500	-94		233.500
2016-08-17	2016-08-15	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		61,8400	-5.000	-309		235.000
2016-08-17	2016-08-15	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	10.000	34		240.000
2016-08-12	2016-08-11	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		61,4800	-500	-31		1.377.174
2016-08-12	2016-08-11	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		60,1400	-22.563	-1.357		1.377.674
2016-08-12	2016-08-10	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		60,0200	-6.900	-414		1.400.237
2016-08-12	2016-08-10	4	High Katherine A	ONCE	Common Stock	S - Sale	D		60,0000	-1.890	-113		240.000
2016-08-12	2016-08-11	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-9.999		367.071
2016-08-12	2016-08-11	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		60,0600	-9.999	-601		230.000
2016-08-12	2016-08-11	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	9.999	34		239.999
2016-08-12	2016-08-10	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-6.971		377.070
2016-08-12	2016-08-10	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		60,0200	-6.971	-418		230.000
2016-08-12	2016-08-10	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	6.971	24		236.971
2016-08-10	2016-08-08	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		60,4700	-100	-6		1.407.137
2016-08-08	2016-08-08	4	High Katherine A	ONCE	Common Stock	S - Sale	D		60,3000	-400	-24		241.890
2016-08-08	2016-08-04	4	High Katherine A	ONCE	Common Stock	S - Sale	D		60,0000	-100	-6		242.290
2016-08-08	2016-08-08	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-800		384.041
2016-08-08	2016-08-08	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		60,2700	-800	-48		230.000
2016-08-08	2016-08-08	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	800	3		230.800
2016-08-08	2016-08-04	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-100		384.841
2016-08-08	2016-08-04	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		60,0000	-100	-6		230.000
2016-08-08	2016-08-04	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	100	0		230.100
2016-08-05	2016-08-04	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		60,0000	-452	-27		1.407.237
2016-08-05	2016-08-03	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		60,0000	-4.612	-277		1.407.689
2016-08-03	2016-08-01	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		60,0300	-22.665	-1.361		1.412.301
2016-08-03	2016-08-03	4	High Katherine A	ONCE	Common Stock	S - Sale	D		60,0000	-3.627	-218		242.390
2016-08-03	2016-08-01	4	High Katherine A	ONCE	Common Stock	S - Sale	D		60,0200	-13.983	-839		246.017
2016-08-03	2016-08-03	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-4.182		384.941
2016-08-03	2016-08-03	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		60,0000	-4.182	-251		230.000
2016-08-03	2016-08-03	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	4.182	14		234.182
2016-08-03	2016-08-01	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-12.348		389.123
2016-08-03	2016-08-01	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		60,0300	-12.348	-741		230.000
2016-08-03	2016-08-01	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	12.348	43		242.348
2016-07-19	2016-07-15	4	Vivaldi Coelho Rogerio	ONCE	Stock Option (right to buy)	M - Exercise	D	7,50		-5.000		155.186
2016-07-19	2016-07-15	4	Vivaldi Coelho Rogerio	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-1.000		10.203
2016-07-19	2016-07-15	4	Vivaldi Coelho Rogerio	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-1.000		10.203
2016-07-19	2016-07-15	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	S - Sale	D		53,3200	-1.400	-75		18.716
2016-07-19	2016-07-15	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	S - Sale	D		52,9600	-5.600	-297		20.116
2016-07-19	2016-07-15	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	M - Exercise	D		7,5000	5.000	38		25.716
2016-07-19	2016-07-15	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	M - Exercise	D		3,4500	1.000	3		20.716
2016-07-19	2016-07-15	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	M - Exercise	D		3,4500	1.000	3		20.716
2016-07-19	2016-07-18	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-5.000		401.471
2016-07-19	2016-07-18	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		52,5300	-5.000	-263		230.000
2016-07-19	2016-07-18	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	5.000	17		235.000
2016-07-07	2016-07-05	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	3,45		-3.000		26.429
2016-07-07	2016-07-05	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		52,8000	-1.100	-58		5.325
2016-07-07	2016-07-05	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		51,9200	-1.900	-99		6.425
2016-07-07	2016-07-05	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	3.000	10		8.325
2016-06-22	2016-06-20	4	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock	S - Sale	D		42,3000	-1.000.000	-42.300		6.768.707
2016-06-16	2016-06-15	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-5.000		406.471
2016-06-16	2016-06-15	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		49,0400	-300	-15		230.000
2016-06-16	2016-06-15	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		47,7500	-900	-43		230.300
2016-06-16	2016-06-15	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		46,5300	-1.300	-60		231.200
2016-06-16	2016-06-15	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		45,7100	-2.500	-114		232.500
2016-06-16	2016-06-15	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	5.000	17		235.000
2016-06-03	2016-06-01	4	Ekman Lars	ONCE	Stock Option (right to buy)	A - Award	D	56,22		6.000		6.000
2016-06-03	2016-06-01	4	SIGAL ELLIOT	ONCE	Stock Option (right to buy)	A - Award	D	56,22		6.000		6.000
2016-06-03	2016-06-01	4	Zoth Lota S.	ONCE	Stock Option (right to buy)	A - Award	D	56,22		6.000		6.000
2016-06-03	2016-06-01	4	Mehra Anand	ONCE	Stock Option (right to buy)	A - Award	D	56,22		6.000		6.000
2016-06-03	2016-06-01	4	Altschuler Steven	ONCE	Stock Option (right to buy)	A - Award	D	56,22		6.000		6.000
2016-06-03	2016-06-01	4	MILANO VINCENT	ONCE	Stock Option (right to buy)	A - Award	D	56,22		6.000		6.000
2016-06-03	2016-06-01	4	Betz Alert Lorris	ONCE	Stock Option (right to buy)	A - Award	D	56,22		6.000		6.000
2016-06-02	2016-05-31	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		60,0000	-500	-30		1.434.966
2016-06-02	2016-05-31	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-600		411.471
2016-06-02	2016-05-31	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		60,0000	-600	-36		230.000
2016-06-02	2016-05-31	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	600	2		230.600
2016-05-27	2016-05-24	4	High Katherine A	ONCE	Common Stock	S - Sale	D		54,0000	-10.000	-540		260.000
2016-05-24	2016-05-20	4	Webster Stephen W	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-20.000		146.015
2016-05-24	2016-05-20	4	Webster Stephen W	ONCE	Common Stock	S - Sale	D		50,3800	-9.000	-453		2.500
2016-05-24	2016-05-20	4	Webster Stephen W	ONCE	Common Stock	S - Sale	D		50,4000	-11.000	-554		11.500
2016-05-24	2016-05-20	4	Webster Stephen W	ONCE	Common Stock	M - Exercise	D		3,4500	20.000	69		22.500
2016-05-24	2016-05-23	4	High Katherine A	ONCE	Common Stock	S - Sale	D		54,9100	-100	-5		270.000
2016-05-24	2016-05-23	4	High Katherine A	ONCE	Common Stock	S - Sale	D		54,4200	-9.900	-539		270.100
2016-05-23	2016-05-19	4	Marrazzo Jeffrey D	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-25.000		412.071
2016-05-23	2016-05-19	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		47,1400	-4.658	-220		230.000
2016-05-23	2016-05-19	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		46,4900	-6.038	-281		234.658
2016-05-23	2016-05-19	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		45,4400	-14.304	-650		240.696
2016-05-23	2016-05-19	4	Marrazzo Jeffrey D	ONCE	Common Stock	M - Exercise	D		3,4500	25.000	86		255.000
2016-05-23	2016-05-20	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	3,45		-2.500		29.429
2016-05-23	2016-05-20	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		50,0000	-2.500	-125		5.325
2016-05-23	2016-05-20	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	2.500	9		7.825
2016-05-23	2016-05-19	4	La Barge Joseph	ONCE	Employee Stock Option (right to buy)	M - Exercise	D	3,45		-7.500		17.883
2016-05-23	2016-05-19	4	La Barge Joseph	ONCE	Common Stock	S - Sale	D		46,8700	-7.500	-352		5.325
2016-05-23	2016-05-19	4	La Barge Joseph	ONCE	Common Stock	M - Exercise	D		3,4500	7.500	26		12.825
2016-05-04		3	La Barge Joseph Held by Reporting Person's immediate family members	ONCE	Common Stock		I						5.725
2016-05-04		3	La Barge Joseph	ONCE	Common Stock		D						10.850
2016-05-04		3	La Barge Joseph Held by Reporting Person's immediate family members	ONCE	Common Stock		I						5.725
2016-05-04		3	La Barge Joseph	ONCE	Common Stock		D						10.850
2016-05-04	2016-05-02	4	Faga Daniel	ONCE	Employee Stock Option (right to buy)	A - Award	D	37,62		160.000		160.000
2016-04-29	2016-04-27	4	Altschuler Steven	ONCE	Common Stock	A - Award	D			20.000			25.000
2016-04-22	2016-04-21	4	Vivaldi Coelho Rogerio	ONCE	Stock Option (right to buy)	M - Exercise	D	7,50		-200		160.186
2016-04-22	2016-04-21	4	Vivaldi Coelho Rogerio	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-1.000		10.116
2016-04-22	2016-04-21	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	S - Sale	D		40,0200	-1.200	-48		18.716
2016-04-22	2016-04-21	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	M - Exercise	D		7,5000	200	2		19.916
2016-04-22	2016-04-21	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	M - Exercise	D		3,4500	1.000	3		19.716
2016-04-22	2016-04-20	4	Vivaldi Coelho Rogerio	ONCE	Stock Option (right to buy)	M - Exercise	D	7,50		-4.800		160.386
2016-04-22	2016-04-20	4	Vivaldi Coelho Rogerio	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-1.000		11.203
2016-04-22	2016-04-20	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	S - Sale	D		40,0200	-5.800	-232		18.716
2016-04-22	2016-04-20	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	M - Exercise	D		7,5000	4.800	36		24.516
2016-04-22	2016-04-20	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	M - Exercise	D		3,4500	1.000	3		19.716
2016-01-08	2016-01-06	4	Zoth Lota S.	ONCE	Stock Option (right to buy)	A - Award	D	37,18		12.000		12.000
2016-01-07	2016-01-05	4	Webster Stephen W	ONCE	Employee Stock Option (right to buy)	A - Award	D	40,44		55.000		55.000
2016-01-07	2016-01-05	4	Vivaldi Coelho Rogerio	ONCE	Employee Stock Option (right to buy)	A - Award	D	40,44		55.000		55.000
2016-01-07	2016-01-05	4	Marrazzo Jeffrey D	ONCE	Employee Stock Option (right to buy)	A - Award	D	40,44		135.000		135.000
2016-01-07	2016-01-05	4	High Katherine A	ONCE	Employee Stock Option (right to buy)	A - Award	D	40,44		55.000		55.000
2016-01-04	2015-12-28	4	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock	S - Sale	D		44,1800	-131.505	-5.810		7.768.707
2015-12-22	2015-12-21	4	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock	S - Sale	D		44,1800	-1.000.000	-44.180		7.900.212
2015-12-04	2015-12-01	4	High Katherine A	ONCE	Common Stock	S - Sale	D		55,3100	-10.000	-553		280.000
2015-11-30	2015-11-27	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		60,0200	-5.350	-321		1.435.466
2015-11-30	2015-11-25	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		60,0100	-17.611	-1.057		1.440.816
2015-11-18	2015-11-16	4	High Katherine A	ONCE	Common Stock	S - Sale	D		53,7700	-10.000	-538		290.000
2015-11-12	2015-11-12	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		60,0000	-1.074	-64		1.458.427
2015-11-12	2015-11-11	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		60,1300	-97.644	-5.871		1.459.501
2015-11-12	2015-11-10	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		60,0100	-5.932	-356		1.557.145
2015-11-12	2015-11-09	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		60,0700	-25.955	-1.559		1.563.077
2015-10-14	2015-10-12	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		50,0800	-21.735	-1.088		230.000
2015-10-14	2015-10-12	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		51,0000	-2.500	-128		251.735
2015-10-14	2015-10-12	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		48,1100	-10.765	-518		254.235
2015-10-14	2015-10-12	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		47,3000	-40.000	-1.892		265.000
2015-10-14	2015-10-14	4	High Katherine A	ONCE	Common Stock	S - Sale	D		50,0300	-10.000	-500		300.000
2015-10-14	2015-10-14	4	High Katherine A	ONCE	Common Stock	S - Sale	D		49,0000	-20.000	-980		310.000
2015-10-14	2015-10-13	4	High Katherine A	ONCE	Common Stock	S - Sale	D		48,0000	-10.000	-480		330.000
2015-10-14	2015-10-13	4	Vivaldi Coelho Rogerio	ONCE	Stock Option (right to buy)	M - Exercise	D	7,50		-37.333		165.186
2015-10-14	2015-10-13	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	S - Sale	D		48,1500	-24.000	-1.156		18.716
2015-10-14	2015-10-13	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	M - Exercise	D		7,5000	37.333	280		42.716
2015-10-09	2015-10-08	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		46,3800	-11.316	-525		1.589.032
2015-10-09	2015-10-08	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		45,2700	-145.723	-6.597		1.600.348
2015-10-09	2015-10-08	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		44,3800	-120.593	-5.352		1.746.071
2015-10-09	2015-10-07	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		47,1400	-13.402	-632		1.866.664
2015-10-09	2015-10-07	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		46,2300	-153.008	-7.074		1.880.066
2015-10-09	2015-10-07	4	Mehra Anand	ONCE	Common Stock	S - Sale	I		45,5600	-85.502	-3.895		2.033.074
2015-10-09	2015-10-09	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		48,1700	-20.000	-963		305.000
2015-10-09	2015-10-09	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		47,4800	-4.983	-237		325.000
2015-10-09	2015-10-07	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		47,0200	-25.000	-1.176		329.983
2015-10-09	2015-10-07	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		48,3300	-24.117	-1.166		354.983
2015-10-09	2015-10-07	4	Marrazzo Jeffrey D	ONCE	Common Stock	S - Sale	D		50,4000	-900	-45		379.100
2015-10-09	2015-10-07	4	Altschuler Steven	ONCE	Common Stock	P - Purchase	D		49,1060	5.000	246		5.000
2015-10-09	2015-10-07	4	Vivaldi Coelho Rogerio	ONCE	Stock Option (right to buy)	M - Exercise	D	7,50		-30.000		202.519
2015-10-09	2015-10-07	4	Vivaldi Coelho Rogerio	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-5.000		12.203
2015-10-09	2015-10-07	4	Vivaldi Coelho Rogerio	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-5.000		12.203
2015-10-09	2015-10-07	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	S - Sale	D		50,4000	-1.000	-50		5.383
2015-10-09	2015-10-07	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	S - Sale	D		48,8100	-40.000	-1.952		6.383
2015-10-09	2015-10-07	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	M - Exercise	D		7,5000	30.000	225		46.383
2015-10-09	2015-10-07	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	M - Exercise	D		3,4500	10.000	34		16.383
2015-10-09	2015-10-07	4	Webster Stephen W	ONCE	Stock Option (right to buy)	M - Exercise	D	3,45		-20.000		166.015
2015-10-09	2015-10-07	4	Webster Stephen W	ONCE	Common Stock	S - Sale	D		48,8600	-20.000	-977		2.500
2015-10-09	2015-10-07	4	Webster Stephen W	ONCE	Common Stock	M - Exercise	D		3,4500	20.000	69		22.500
2015-03-18	2015-03-16	4	High Katherine A	ONCE	Employee Stock Option (right to buy)	A - Award	D	68,45		70.000		70.000
2015-03-18	2015-03-16	4	Marrazzo Jeffrey D	ONCE	Employee Stock Option (right to buy)	A - Award	D	68,45		125.000		125.000
2015-03-18	2015-03-16	4	Webster Stephen W	ONCE	Employee Stock Option (right to buy)	A - Award	D	68,45		60.000		60.000
2015-02-06	2015-02-04	4	Mehra Anand	ONCE	Series B Preferred Stock	C - Conversion	I			-1.893.576		0
2015-02-06	2015-02-04	4	Mehra Anand	ONCE	Series B Preferred Stock	A - Award	I			30.222		1.893.576
2015-02-06	2015-02-04	4	Mehra Anand	ONCE	Common Stock	P - Purchase	I		23,0000	225.000	5.175		2.118.576
2015-02-06	2015-02-04	4	Mehra Anand	ONCE	Common Stock	C - Conversion	I			1.893.576			1.893.576
2015-02-06	2015-02-04	4	SIGAL ELLIOT	ONCE	Series B Preferred Stock	C - Conversion	I			-31.559		0
2015-02-06	2015-02-04	4	SIGAL ELLIOT	ONCE	Series B Preferred Stock	A - Award	I			503		31.559
2015-02-06	2015-02-04	4	SIGAL ELLIOT	ONCE	Common Stock	P - Purchase	D		23,0000	5.000	115		11.214
2015-02-06	2015-02-04	4	SIGAL ELLIOT	ONCE	Common Stock	C - Conversion	I			31.559			31.559
2015-02-06	2015-02-04	4	Webster Stephen W	ONCE	Common Stock	P - Purchase	D		23,0000	2.500	58		2.500
2015-02-06	2015-02-04	4	High Katherine A	ONCE	Common Stock	P - Purchase	I		23,0000	700	16		700
2015-02-06	2015-02-04	4	Vivaldi Coelho Rogerio	ONCE	Common Stock	P - Purchase	D		23,0000	2.500	58		6.383
2015-02-05	2015-02-04	4	Children's Hospital of Philadelphia Foundation	ONCE	Accrued Preferred Stock Dividends	C - Conversion	D			-61.552		0
2015-02-05	2015-02-04	4	Children's Hospital of Philadelphia Foundation	ONCE	Series B Preferred Stock	C - Conversion	D			-2.795.031		0
2015-02-05	2015-02-04	4	Children's Hospital of Philadelphia Foundation	ONCE	Series A Preferred Stock	C - Conversion	D			-1.000.000		0
2015-02-05	2015-02-04	4	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock	P - Purchase	D		23,0000	100.000	2.300		8.900.212
2015-02-05	2015-02-04	4	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock	C - Conversion	D			61.552			8.800.212
2015-02-05	2015-02-04	4	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock	C - Conversion	D			2.795.031			8.738.660
2015-02-05	2015-02-04	4	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock	C - Conversion	D			1.000.000			5.943.629
2015-02-03	2015-01-30	4	Betz Alert Lorris	ONCE	Stock Option (right to buy)	A - Award	D	23,00		27.000		27.000
2015-02-03	2015-01-30	4	Children's Hospital of Philadelphia Foundation By Affiliate	ONCE	Stock Option (right to buy)	A - Award	I	23,00		-27.000		27.000
2015-01-29		3	High Katherine A	ONCE	Common Stock		D						680.000
2015-01-29		3	High Katherine A	ONCE	Common Stock		D						680.000
2015-01-29		3	Marrazzo Jeffrey D	ONCE	Common Stock		D						760.000
2015-01-29		3	Marrazzo Jeffrey D	ONCE	Common Stock		D						760.000
2015-01-29		3	Vivaldi Coelho Rogerio	ONCE	Common Stock		D						7.766
2015-01-29		3	Vivaldi Coelho Rogerio	ONCE	Common Stock		D						7.766
2015-01-29		3	Betz Alert Lorris	ONCE	No securities are beneficially owned		D						0
2015-01-29		3	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock		D						9.887.258
2015-01-29		3	Children's Hospital of Philadelphia Foundation	ONCE	Common Stock		D						9.887.258
2015-01-29		3	SIGAL ELLIOT	ONCE	Common Stock		D						12.428
2015-01-29		3	SIGAL ELLIOT	ONCE	Common Stock		D						12.428

Offener Markt oder privater Kauf von nicht-derivativen oder derivativen Wertpapieren

Freiverkauf oder privater Verkauf von nicht-derivativen oder derivativen Wertpapieren

Gewährung, Vergabe oder sonstiger Erwerb von Wertpapieren des Unternehmens (z. B. eine Option)

Umwandlung von Derivaten

Verkauf oder Rückübertragung von Wertpapieren an das Unternehmen

Zahlung des Ausübungspreises oder der Steuerschuld mit einem Teil der vom Unternehmen erhaltenen Wertpapiere

Schenkung von Wertpapieren durch oder an den Insider

Aktien-Swaps und ähnliche Absicherungstransaktionen

Ausübung oder Umwandlung eines vom Unternehmen erhaltenen derivativen Wertpapiers (z. B. einer Option)

Eine freiwillig auf Formular 4 gemeldete Transaktion

Sonstige (mit einer Fußnote zur Beschreibung der Transaktion)

ONCE / Spark Therapeutics, Inc. - Insider Trading and Ownership Report - SEC Form 3, 4, 5