Arrowhead Pharmaceuticals, Inc.
MX ˙ BMV ˙ US04280A1007
SecurityMX:ARWR / Arrowhead Pharmaceuticals, Inc.
InstitutionComerica Bank
Latest Disclosed Ownership31,183 shares
Latest Disclosed Value $ 2,070,261
Comerica Bank reports 19.96% decrease in ownership of ARWR / Arrowhead Pharmaceuticals, Inc.

On January 29, 2026 - Comerica Bank filed a 13F-HR form disclosing ownership of 31,183 shares of Arrowhead Pharmaceuticals, Inc. (MX:ARWR) valued at $2,070,261 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 14, 2025 disclosing 38,960 shares of Arrowhead Pharmaceuticals, Inc.. This represents a change in shares of -19.96% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-01-29 2025-12-31 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 31,183 -7,777 -19.96 2,070 54.13 0.0083
2025-11-14 2025-09-30 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 38,960 -4,472 -10.30 1,344 95.77 0.0051
2025-08-14 2025-06-30 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 43,432 1,089 2.57 686 27.27 0.0027
2025-05-14 2025-03-31 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 42,343 6,422 17.88 539 -20.15 0.0023
2025-02-14 2024-12-31 13F/A-1 ARROWHEAD PHARMACEUTICALS IN COM 04280A100 35,921 -2,259 -5.92 675 -8.66 0.0027
2025-02-14 2024-12-31 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 35,921 -2,259 675 0.0023
2024-11-14 2024-09-30 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 38,180 -6,092 -13.76 740 -35.74 0.0029
2024-08-15 2024-06-30 13F ARROWHEAD PHARMACEUTICALS IN COMMON 04280A100 44,272 -4,040 -8.36 1,151 -16.73 0.0048
2024-05-16 2024-03-31 13F ARROWHEAD PHARMACEUTICALS IN COMMON 04280A100 48,312 4,855 11.17 1,382 3.91 0.0060
2024-02-14 2023-12-31 13F ARROWHEAD PHARMACEUTICALS IN COMMON 04280A100 43,457 -51 -0.12 1,330 13.69 0.0061
2023-11-21 2023-09-30 13F ARROWHEAD PHARMACEUTICALS IN COMMON 04280A100 43,508 43,508 1,169 0.0061
2023-08-22 2023-06-30 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 0 -46,658 -100.00 0 -100.00
2023-01-26 2022-12-31 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 46,658 -845 -1.78 2 -99.93 0.0134
2022-10-28 2022-09-30 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 47,503 -755 -1.56 1,488 -27.73 0.0125
2022-08-02 2022-06-30 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 48,258 -75 -0.16 2,059 -6.87 0.0169
2022-04-27 2022-03-31 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 48,333 2,281 4.95 2,211 -5.83 0.0160
2022-02-18 2021-12-31 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 46,052 -1,230 -2.60 2,348 -24.79 0.0173
2021-11-22 2021-09-30 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 47,282 -9,475 -16.69 3,122 -5.79 0.0188
2021-08-26 2021-06-30 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 56,757 -883 -1.53 3,314 -19.68 0.0198
2021-04-28 2021-03-31 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 57,640 -2,491 -4.14 4,126 -16.39 0.0246
2021-01-28 2020-12-31 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 60,131 -1,382 -2.25 4,935 36.25 0.0313
2020-10-30 2020-09-30 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 61,513 -460 -0.74 3,622 20.29 0.0263
2020-07-31 2020-06-30 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 61,973 4,549 7.92 3,011 34.84 0.0232
2020-05-01 2020-03-31 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 57,424 12 0.02 2,233 -6.33 0.0205
2020-02-07 2019-12-31 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 57,412 -31,822 -35.66 2,384 -27.56 0.0181
2019-10-31 2019-09-30 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 89,234 627 0.71 3,291 30.23 0.0260
2019-08-02 2019-06-30 13F ARROWHEAD PHARMACEUTICALS IN COM 04280A100 88,607 88,607 2,527 0.0202
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.