Ionis Pharmaceuticals, Inc.
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionAdvisor Group Holdings, Inc.
Latest Disclosed Ownership8,710 shares
Latest Disclosed Value $ 654,023
Advisor Group Holdings, Inc. reports 25.21% decrease in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 15, 2026 - Advisor Group Holdings, Inc. filed a 13F-HR form disclosing ownership of 8,710 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $654,023 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 11,646 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of -25.21% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 8,710 -2,936 -25.21 654 -28.99 0.0006
2026-02-17 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 11,646 1,479 14.55 921 49.03 0.0013
2025-11-14 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 10,167 4,871 91.98 618 197.12 0.0009
2025-09-04 2025-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 5,296 2,923 123.18 209 192.96 0.0004
2025-08-13 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 4,227 1,854 158 0.0002
2025-05-12 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 2,373 -1,613 -40.47 72 -28.28 0.0002
2025-06-06 2024-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 3,986 -12,386 -75.65 99 -84.89 0.0002
2025-02-07 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 15,964 -408 588 0.0015
2024-11-13 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 16,372 1,680 11.43 656 -6.43 0.0015
2024-08-13 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 14,692 66 0.45 700 10.58 0.0017
2024-05-10 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 14,626 -4,284 -22.65 634 -33.79 0.0014
2024-02-12 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 18,910 7,462 65.18 956 84.20 0.0017
2023-11-13 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 11,448 2,687 30.67 519 44.57 0.0008
2023-08-21 2023-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 8,761 -774 -8.12 360 5.59 0.0006
2023-08-10 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 8,761 -774 360 0.0001
2023-05-12 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 9,535 -1,294 -11.95 341 -16.67 0.0006
2023-02-10 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 10,829 -706 -6.12 408 -20.00 0.0008
2022-11-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 11,535 -5,889 -33.80 510 -21.05 0.0012
2022-08-10 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 17,424 -2,142 -10.95 646 -11.26 0.0014
2022-05-04 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 19,566 419 2.19 728 24.87 0.0014
2022-02-03 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 19,147 706 3.83 583 -5.82 0.0011
2021-11-05 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 18,441 -2,462 -11.78 619 -25.69 0.0013
2021-08-02 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 20,903 4,937 30.92 833 15.69 0.0018
2021-05-13 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 15,966 2,588 19.35 720 -4.89 0.0017
2021-02-10 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 13,378 794 6.31 757 27.23 0.0020
2020-11-12 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 12,584 -2,097 -14.28 595 -31.37 0.0018
2020-08-14 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 14,681 1,104 8.13 867 34.84 0.0029
2020-05-18 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 13,577 13,577 643 0.0026
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.