Ionis Pharmaceuticals, Inc.
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionBLB&B Advisors, LLC
Latest Disclosed Ownership35,170 shares
Latest Disclosed Value $ 2,640,916
BLB&B Advisors, LLC reports 42.83% decrease in ownership of IONS / Ionis Pharmaceuticals, Inc.

On April 28, 2026 - BLB&B Advisors, LLC filed a 13F-HR form disclosing ownership of 35,170 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $2,640,916 USD as of March 31, 2026. The entity filed a previous 13F-HR on January 26, 2026 disclosing 61,520 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of -42.83% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-04-28 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 35,170 -26,350 -42.83 2,641 -45.75 0.0925
2026-01-26 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 61,520 -57,080 -48.13 4,867 -37.28 0.2035
2025-10-31 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 118,600 -32,950 -21.74 7,759 29.58 0.3349
2025-08-04 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 151,550 -650 -0.43 5,988 30.41 0.2798
2025-04-28 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 152,200 150 0.10 4,592 -13.62 0.2337
2025-01-28 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 152,050 -200 -0.13 5,316 -12.85 0.2712
2024-10-22 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 152,250 -1,500 -0.98 6,099 -16.76 0.3116
2024-07-26 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 153,750 7,650 5.24 7,328 15.70 0.4015
2024-04-26 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 146,100 -1,000 -0.68 6,333 -14.89 0.3571
2024-01-19 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 147,100 -550 -0.37 7,442 11.11 0.4694
2023-10-25 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 147,650 -2,650 -1.76 6,697 8.61 0.4781
2023-07-20 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 150,300 1,340 0.90 6,167 15.84 0.4311
2023-04-24 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 148,960 0 0.00 5,324 -5.39 0.3967
2023-01-18 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 148,960 -110 -0.07 5,626 -14.67 0.4360
2022-10-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 149,070 -180 -0.12 6,593 19.33 0.5483
2022-07-18 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 149,250 -495 -0.33 5,525 -0.40 0.4374
2022-04-20 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 149,745 -1,190 -0.79 5,547 20.77 0.3729
2022-01-21 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 150,935 -5,265 -3.37 4,593 -12.33 0.2985
2021-10-19 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 156,200 -1,290 -0.82 5,239 -16.60 0.3499
2021-07-20 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 157,490 870 0.56 6,282 -10.79 0.4543
2021-04-19 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 156,620 -1,065 -0.68 7,042 -21.02 0.5536
2021-01-19 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 157,685 -19,665 -11.09 8,916 5.95 0.7222
2020-10-20 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 177,350 -585 -0.33 8,415 -19.79 0.8457
2020-07-16 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 177,935 -2,310 -1.28 10,491 23.10 1.1370
2020-04-21 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 180,245 -2,384 -1.31 8,522 -22.76 1.1130
2020-01-21 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 182,629 54 0.03 11,033 0.87 1.1473
2019-10-22 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 182,575 -1,305 -0.71 10,938 -7.45 1.2328
2019-07-29 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 183,880 -435 -0.24 11,818 -21.01 1.3568
2019-04-19 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 184,315 -62,841 -25.43 14,961 11.98 1.7595
2019-01-17 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 247,156 -2,390 -0.96 13,361 3.80 1.8343
2018-10-12 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 249,546 -1,910 -0.76 12,872 22.85 1.6017
2018-07-11 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 251,456 -1,250 -0.49 10,478 -5.93 1.4224
2018-04-09 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 252,706 195,555 342.17 11,139 287.44 1.4884
2018-01-16 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 57,151 -4,396 -7.14 2,875 -7.85 0.4109
2017-10-16 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 61,547 -1,595 -2.53 3,120 -2.86 0.4806
2017-08-04 2017-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 63,142 -769 -1.20 3,212 25.03 0.5329
2017-07-20 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 63,911 0 2,569
2017-04-14 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 63,911 1,315 2.10 2,569 -14.20 0.4363
2017-02-03 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 62,596 -435 -0.69 2,994 29.67 0.5215
2016-10-17 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 63,031 -800 -1.25 2,309 55.28 0.4202
2016-07-19 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 63,831 8,031 14.39 1,487 -34.20 0.2806
2016-04-18 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 55,800 2,469 4.63 2,260 -31.58 0.4546
2016-01-15 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 53,331 1,295 2.49 3,303 57.06 0.6983
2015-10-20 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 52,036 205 0.40 2,103 -29.50 0.4659
2015-07-16 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 51,831 1,556 3.09 2,983 -6.81 0.6197
2015-04-17 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 50,275 -190 -0.38 3,201 2.73 0.6668
2015-01-22 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 50,465 -190 -0.38 3,116 58.41 0.6588
2014-10-21 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 50,655 -46,605 -47.92 1,967 -41.30 0.4254
2014-07-17 2014-06-30 13F ISIS PHARMACEUTICALS COM 464330109 97,260 -465 -0.48 3,351 -20.65 0.7160
2014-04-11 2014-03-31 13F ISIS PHARMACEUTICALS COM 464330109 97,725 2,030 2.12 4,223 10.78 0.9303
2014-01-17 2013-12-31 13F ISIS PHARMACEUTICALS COM 464330109 95,695 -6,599 -6.45 3,812 -0.73 0.9126
2013-10-16 2013-09-30 13F ISIS PHARMACEUTICALS COM 464330109 102,294 -596 -0.58 3,840 38.88 1.0117
2013-07-11 2013-06-30 13F ISIS PHARMACEUTICALS COM 464330109 102,890 102,890 2,765 0.7691
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.