Ionis Pharmaceuticals, Inc.
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionLPL Financial LLC
Latest Disclosed Ownership31,932 shares
Latest Disclosed Value $ 2,397,774
LPL Financial LLC reports 2.78% increase in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 6, 2026 - LPL Financial LLC filed a 13F-HR form disclosing ownership of 31,932 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $2,397,774 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 11, 2026 disclosing 31,069 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of 2.78% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-06 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 31,932 863 2.78 2,398 -2.44 0.0006
2026-02-11 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 31,069 6,606 27.00 2,458 53.56 0.0007
2025-11-12 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 24,463 -409 -1.64 1,600 62.93 0.0005
2025-08-12 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 24,872 906 3.78 983 35.82 0.0003
2025-05-07 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 23,966 -16,410 -40.64 723 -48.76 0.0003
2025-02-11 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 40,376 -2,244 -5.27 1,412 -17.34 0.0006
2024-11-08 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 42,620 -8,794 -17.10 1,707 -30.33 0.0008
2024-08-07 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 51,414 -28,308 -35.51 2,450 -29.09 0.0012
2024-05-10 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 79,722 -7,577 -8.68 3,456 -21.76 0.0019
2024-02-14 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 87,299 5,483 6.70 4,416 19.00 0.0027
2023-11-13 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 81,816 -219 -0.27 3,711 10.28 0.0026
2023-07-31 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 82,035 13,041 18.90 3,366 36.51 0.0024
2023-05-10 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 68,994 -5,105 -6.89 2,466 -11.90 0.0019
2023-02-07 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 74,099 -641 -0.86 2,799 -15.37 0.0024
2022-11-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 74,740 -7,347 -8.95 3,306 8.79 0.0032
2022-08-12 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 82,087 -12,466 -13.18 3,039 -13.22 0.0029
2022-05-16 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 94,553 5,887 6.64 3,502 29.80 0.0030
2022-02-14 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 88,666 5,051 6.04 2,698 -3.78 0.0023
2021-11-15 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 83,615 24,299 40.97 2,804 18.51 0.0026
2021-08-13 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 59,316 4,033 7.30 2,366 -4.83 0.0024
2021-05-14 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 55,283 2,204 4.15 2,486 -17.16 0.0029
2021-02-12 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 53,079 3,222 6.46 3,001 26.84 0.0039
2020-11-09 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 49,857 3,664 7.93 2,366 -13.14 0.0037
2020-08-13 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 46,193 -655 -1.40 2,724 22.98 0.0047
2020-05-14 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 46,848 796 1.73 2,215 -20.38 0.0048
2020-02-14 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 46,052 -43 -0.09 2,782 0.72 0.0051
2019-11-13 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 46,095 241 0.53 2,762 -6.28 0.0056
2019-08-09 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 45,854 1,478 3.33 2,947 -18.18 0.0063
2019-05-08 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 44,376 -851 -1.88 3,602 47.32 0.0082
2019-02-07 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 45,227 714 1.60 2,445 6.49 0.0065
2018-11-14 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 44,513 -1,343 -2.93 2,296 20.15 0.0055
2018-08-14 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 45,856 -244 -0.53 1,911 -5.95 0.0050
2018-05-15 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 46,100 -4,577 -9.03 2,032 -20.28 0.0056
2018-02-14 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 50,677 6,465 14.62 2,549 13.69 0.0078
2017-11-14 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 44,212 37,083 520.17 2,242 517.63 0.0079
2017-08-14 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 7,129 -629 -8.11 363 21.40 0.0014
2017-05-15 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 7,758 -498 -6.03 299 -23.53 0.0020
2017-02-13 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 8,256 -1,193 -12.63 391 16.02 0.0030
2016-11-16 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 9,449 9,449 0.00 337 0.0032
2016-08-15 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 0 -20,699 -100.00 0 -100.00
2016-05-16 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 20,699 -5,991 -22.45 880 -45.91 0.0024
2016-02-12 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 26,690 13,503 102.40 1,627 197.44 0.0045
2015-11-13 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 13,187 -12,546 -48.75 547 -61.67 0.0030
2015-08-14 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 25,733 693 2.77 1,427 -9.80 0.0072
2015-05-14 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 25,040 2,835 12.77 1,582 15.39 0.0081
2015-02-13 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 22,205 761 3.55 1,371 68.84 0.0075
2014-11-10 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 21,444 6,729 45.73 812 60.16 0.0048
2014-08-05 2014-06-30 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 14,715 2,156 17.17 507 -6.63 0.0030
2014-08-05 2014-06-30 13F ISIS PHARMACEUTICALS COM 464330109 14,715 1,693
2014-05-12 2014-03-31 13F ISIS PHARMACEUTICALS COM 464330109 12,559 3,900 45.04 543 57.39 0.0033
2014-02-13 2013-12-31 13F ISIS PHARMACEUTICALS COM 464330109 8,659 8,659 345 0.0022
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.