OPKO Health, Inc.
MX ˙ BMV ˙ US68375N1037
SecurityMX:OPK / OPKO Health, Inc.
InstitutionProShare Advisors LLC
Latest Disclosed Ownership140,658 shares
Latest Disclosed Value $ 160,350
ProShare Advisors LLC reports 10.04% decrease in ownership of OPK / OPKO Health, Inc.

On April 24, 2026 - ProShare Advisors LLC filed a 13F-HR form disclosing ownership of 140,658 shares of OPKO Health, Inc. (MX:OPK) valued at $160,350 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 6, 2026 disclosing 156,354 shares of OPKO Health, Inc.. This represents a change in shares of -10.04% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-04-24 2026-03-31 13F OPKO HEALTH COM 68375N103 140,658 -15,696 -10.04 160 -18.78 0.0002
2026-02-06 2025-12-31 13F OPKO HEALTH COM 68375N103 156,354 85,985 122.19 197 80.73 0.0003
2025-11-06 2025-09-30 13F OPKO HEALTH COM 68375N103 70,369 -3,815 -5.14 109 12.37 0.0002
2025-08-07 2025-06-30 13F OPKO HEALTH COM 68375N103 74,184 5,139 7.44 98 -14.91 0.0002
2025-05-08 2025-03-31 13F OPKO HEALTH COM 68375N103 69,045 -22,685 -24.73 115 -14.93 0.0003
2025-02-14 2024-12-31 13F OPKO HEALTH COM 68375N103 91,730 30,182 49.04 135 47.25 0.0003
2024-11-14 2024-09-30 13F OPKO HEALTH COM 68375N103 61,548 7,521 13.92 92 35.82 0.0002
2024-08-13 2024-06-30 13F OPKO HEALTH COM 68375N103 54,027 -18,443 -25.45 68 -22.09 0.0002
2024-05-08 2024-03-31 13F OPKO HEALTH COM 68375N103 72,470 5,704 8.54 87 -14.00 0.0002
2024-02-14 2023-12-31 13F OPKO HEALTH COM 68375N103 66,766 14,365 27.41 101 20.48 0.0003
2023-11-13 2023-09-30 13F OPKO HEALTH COM 68375N103 52,401 -60 -0.11 84 -26.55 0.0003
2023-08-10 2023-06-30 13F OPKO HEALTH COM 68375N103 52,461 4,942 10.40 114 63.77 0.0003
2023-05-26 2023-03-31 13F/A-1 OPKO HEALTH COM 68375N103 47,519 -4,431 -8.53 69 7.81 0.0002
2023-05-12 2023-03-31 13F OPKO HEALTH COM 68375N103 47,519 -4,431 69 0.0002
2023-02-02 2022-12-31 13F OPKO HEALTH COM 68375N103 51,950 7,444 16.73 65 -23.81 0.0002
2022-11-07 2022-09-30 13F OPKO HEALTH COM 68375N103 44,506 -848 -1.87 84 -26.96 0.0003
2022-08-01 2022-06-30 13F OPKO HEALTH COM 68375N103 45,354 -29,569 -39.47 115 -55.25 0.0004
2022-05-10 2022-03-31 13F OPKO HEALTH COM 68375N103 74,923 -12,374 -14.17 257 -38.81 0.0006
2022-02-08 2021-12-31 13F OPKO HEALTH COM 68375N103 87,297 36,089 70.48 420 124.60 0.0008
2021-11-12 2021-09-30 13F OPKO HEALTH COM 68375N103 51,208 -171,192 -76.97 187 -79.25 0.0005
2021-08-13 2021-06-30 13F OPKO HEALTH COM 68375N103 222,400 23,393 11.75 901 5.50 0.0026
2021-05-14 2021-03-31 13F OPKO HEALTH COM 68375N103 199,007 7,498 3.92 854 12.96 0.0027
2021-02-09 2020-12-31 13F OPKO HEALTH COM 68375N103 191,509 34,808 22.21 756 30.80 0.0028
2020-11-13 2020-09-30 13F OPKO HEALTH COM 68375N103 156,701 -4,387 -2.72 578 5.28 0.0027
2020-08-03 2020-06-30 13F OPKO HEALTH COM 68375N103 161,088 46,863 41.03 549 258.82 0.0029
2020-05-15 2020-03-31 13F OPKO HEALTH COM 68375N103 114,225 -81,980 -41.78 153 -46.87 0.0011
2020-02-12 2019-12-31 13F OPKO HEALTH COM 68375N103 196,205 -11,053 -5.33 288 -33.49 0.0013
2019-11-12 2019-09-30 13F OPKO HEALTH COM 68375N103 207,258 -16,390 -7.33 433 -20.70 0.0024
2019-08-13 2019-06-30 13F OPKO HEALTH COM 68375N103 223,648 -25,848 -10.36 546 -16.13 0.0033
2019-05-15 2019-03-31 13F OPKO HEALTH COM 68375N103 249,496 15,021 6.41 651 -7.79 0.0039
2019-02-14 2018-12-31 13F OPKO HEALTH COM 68375N103 234,475 -45,988 -16.40 706 -27.22 0.0049
2018-11-14 2018-09-30 13F OPKO HEALTH COM 68375N103 280,463 -5,691 -1.99 970 -27.88 0.0066
2018-08-13 2018-06-30 13F OPKO HEALTH COM 68375N103 286,154 18,184 6.79 1,345 58.42 0.0090
2018-05-14 2018-03-31 13F OPKO HEALTH COM 68375N103 267,970 -43,216 -13.89 849 -44.33 0.0055
2018-02-14 2017-12-31 13F OPKO HEALTH COM 68375N103 311,186 -12,560 -3.88 1,525 -31.34 0.0106
2017-11-13 2017-09-30 13F OPKO HEALTH COM 68375N103 323,746 28,997 9.84 2,221 14.54 0.0204
2017-08-11 2017-06-30 13F OPKO HEALTH COM 68375N103 294,749 -10,536 -3.45 1,939 -20.60 0.0193
2017-05-12 2017-03-31 13F/A-2 OPKO HEALTH COM 68375N103 305,285 -68,238 -18.27 2,442 -29.71 0.0255
2017-05-08 2017-03-31 13F/A-1 OPKO HEALTH COM 68375N103 305,285 0 2,442 0.0255
2017-04-25 2017-03-31 13F OPKO HEALTH COM 68375N103 305,285 2,442
2017-02-13 2016-12-31 13F OPKO HEALTH COM 68375N103 373,523 373,523 22.35 3,474 42.26 0.0385
2016-11-10 2016-09-30 13F OPKO HEALTH COM 68375N103 0 -10,655 -100.00 0 -100.00
2016-08-12 2016-06-30 13F OPKO HEALTH COM 68375N103 10,655 10,655 0.00 100 0.0013
2016-05-06 2016-03-31 13F OPKO HEALTH COM 68375N103 0 -11,935 -100.00 0 -100.00
2016-02-05 2015-12-31 13F OPKO HEALTH COM 68375N103 11,935 274 2.35 120 22.45 0.0015
2015-11-06 2015-09-30 13F OPKO HEALTH COM 68375N103 11,661 11,661 -2.30 98 -18.33 0.0014
2015-08-11 2015-06-30 13F OPKO HEALTH COM 68375N103 0 -38,073 -100.00 0 -100.00
2015-05-08 2015-03-31 13F OPKO HEALTH COM 68375N103 38,073 38,073 0.00 539 0.0063
2015-01-30 2014-12-31 13F OPKO HEALTH COM 68375N103 0 -78,284 -100.00 0 -100.00
2014-11-06 2014-09-30 13F OPKO HEALTH COM 68375N103 78,284 -17,747 -18.48 666 -21.55 0.0088
2014-08-08 2014-06-30 13F OPKO HEALTH COM 68375N103 96,031 -95,116 -49.76 849 -52.33 0.0110
2014-05-07 2014-03-31 13F OPKO HEALTH COM 68375N103 191,147 176,927 1,244.21 1,781 1,384.17 0.0223
2014-02-04 2013-12-31 13F OPKO HEALTH COM 68375N103 14,220 -105,045 -88.08 120 -88.58 0.0018
2013-11-07 2013-09-30 13F OPKO HEALTH COM 68375N103 119,265 49,714 71.48 1,051 112.75 0.0249
2013-07-25 2013-06-30 13F OPKO HEALTH COM 68375N103 69,551 69,551 494 0.0097
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.