Castle Biosciences, Inc.
US ˙ NasdaqGM ˙ US14843C1053

SecurityCSTL / Castle Biosciences, Inc.
InstitutionFmr Llc
Latest Disclosed Ownership50,412 shares
Latest Disclosed Value $ 1,237,611
Fmr Llc reports 19.22% increase in ownership of CSTL / Castle Biosciences, Inc.

On May 15, 2026 - Fmr Llc filed a 13F-HR form disclosing ownership of 50,412 shares of Castle Biosciences, Inc. (US:CSTL) valued at $1,237,615 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 42,286 shares of Castle Biosciences, Inc.. This represents a change in shares of 19.22% during the quarter. The current value of the position is $1,088,899 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F CASTLE BIOSCIENCES COM 14843C105 50,412 8,126 19.22 1,238 -24.76 0.0000
2026-02-17 2025-12-31 13F CASTLE BIOSCIENCES COM 14843C105 42,286 13,744 48.15 1,645 153.31 0.0001
2025-11-13 2025-09-30 13F CASTLE BIOSCIENCES COM 14843C105 28,542 4,542 18.93 650 32.45 0.0000
2025-08-14 2025-06-30 13F CASTLE BIOSCIENCES COM 14843C105 24,000 22,844 1,976.12 490 2,030.43 0.0000
2025-05-12 2025-03-31 13F CASTLE BIOSCIENCES COM 14843C105 1,156 75 6.94 23 -17.86 0.0000
2025-02-13 2024-12-31 13F CASTLE BIOSCIENCES COM 14843C105 1,081 63 6.19 29 -3.45 0.0000
2024-11-13 2024-09-30 13F CASTLE BIOSCIENCES COM 14843C105 1,018 -202 -16.56 29 11.54 0.0000
2024-08-13 2024-06-30 13F CASTLE BIOSCIENCES COM 14843C105 1,220 348 39.91 27 36.84 0.0000
2024-05-13 2024-03-31 13F CASTLE BIOSCIENCES COM 14843C105 872 -73 -7.72 19 -5.00 0.0000
2024-02-13 2023-12-31 13F CASTLE BIOSCIENCES COM 14843C105 945 -65 -6.44 20 17.65 0.0000
2023-11-13 2023-09-30 13F CASTLE BIOSCIENCES COM 14843C105 1,010 349 52.80 17 88.89 0.0000
2023-08-11 2023-06-30 13F CASTLE BIOSCIENCES COM 14843C105 661 -52 -7.29 9 -43.75 0.0000
2023-08-11 2023-03-31 13F/A-1 CASTLE BIOSCIENCES COM 14843C105 713 -61 -7.88 16 -11.11 0.0000
2023-05-11 2023-03-31 13F CASTLE BIOSCIENCES COM 14843C105 713 -61 16 0.0000
2023-02-13 2022-12-31 13F CASTLE BIOSCIENCES COM 14843C105 774 -7 -0.90 18 -10.00 0.0000
2022-11-10 2022-09-30 13F CASTLE BIOSCIENCES COM 14843C105 781 224 40.22 20 66.67 0.0000
2022-08-12 2022-06-30 13F CASTLE BIOSCIENCES COM 14843C105 557 106 23.50 12 -40.00 0.0000
2022-05-13 2022-03-31 13F CASTLE BIOSCIENCES COM 14843C105 451 451 20 0.0000
2022-02-14 2021-12-31 13F CASTLE BIOSCIENCES COM 14843C105 0 -2 -100.00 0 0.0000
2022-02-14 2021-09-30 13F/A-1 CASTLE BIOSCIENCES COM 14843C105 2 -2 -50.00 0 0.0000
2021-11-15 2021-09-30 13F CASTLE BIOSCIENCES COM 14843C105 2 -2 0 0.0000
2021-08-13 2021-06-30 13F CASTLE BIOSCIENCES COM 14843C105 4 -335,241 -100.00 0 -100.00
2021-05-14 2021-03-31 13F CASTLE BIOSCIENCES COM 14843C105 335,245 -247,706 -42.49 22,951 -41.37 0.0020
2021-02-08 2020-12-31 13F CASTLE BIOSCIENCES COM 14843C105 582,951 167,027 40.16 39,146 82.93 0.0035
2020-11-13 2020-09-30 13F CASTLE BIOSCIENCES COM 14843C105 415,924 112,456 37.06 21,399 87.09 0.0022
2020-08-24 2020-06-30 13F/A-1 CASTLE BIOSCIENCES COM 14843C105 303,468 303,468 11,438 0.0013
2020-08-13 2020-06-30 13F CASTLE BIOSCIENCES COM 14843C105 303,468 11,438 0.0013
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.