Design Therapeutics, Inc.
US ˙ NasdaqGS ˙ US25056L1035

SecurityDSGN / Design Therapeutics, Inc.
InstitutionFmr Llc
Latest Disclosed Ownership798,411 shares
Latest Disclosed Value $ 8,495,094
Fmr Llc reports 3.52% increase in ownership of DSGN / Design Therapeutics, Inc.

On May 15, 2026 - Fmr Llc filed a 13F-HR form disclosing ownership of 798,411 shares of Design Therapeutics, Inc. (US:DSGN) valued at $8,495,093 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 771,268 shares of Design Therapeutics, Inc.. This represents a change in shares of 3.52% during the quarter. The current value of the position is $8,335,411 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F DESIGN THERAPEUTICS COM 25056L103 798,411 27,143 3.52 8,495 17.43 0.0001
2026-02-17 2025-12-31 13F DESIGN THERAPEUTICS COM 25056L103 771,268 30,419 4.11 7,234 29.69 0.0004
2025-11-13 2025-09-30 13F DESIGN THERAPEUTICS COM 25056L103 740,849 -210,349 -22.11 5,579 74.04 0.0003
2025-08-14 2025-06-30 13F DESIGN THERAPEUTICS COM 25056L103 951,198 3,148 0.33 3,206 -12.41 0.0002
2025-05-12 2025-03-31 13F DESIGN THERAPEUTICS COM 25056L103 948,050 -3,832 -0.40 3,659 -37.70 0.0002
2025-02-13 2024-12-31 13F DESIGN THERAPEUTICS COM 25056L103 951,882 123,217 14.87 5,873 31.74 0.0004
2024-11-13 2024-09-30 13F DESIGN THERAPEUTICS COM 25056L103 828,665 747,649 922.84 4,458 1,545.02 0.0003
2024-08-13 2024-06-30 13F DESIGN THERAPEUTICS COM 25056L103 81,016 2,675 3.41 271 -13.97 0.0000
2024-05-13 2024-03-31 13F DESIGN THERAPEUTICS COM 25056L103 78,341 -671 -0.85 316 50.72 0.0000
2024-02-13 2023-12-31 13F DESIGN THERAPEUTICS COM 25056L103 79,012 8,954 12.78 209 26.67 0.0000
2023-11-13 2023-09-30 13F DESIGN THERAPEUTICS COM 25056L103 70,058 -567,712 -89.02 165 -95.89 0.0000
2023-08-11 2023-06-30 13F DESIGN THERAPEUTICS COM 25056L103 637,770 -320,133 -33.42 4,018 -27.32 0.0003
2023-08-11 2023-03-31 13F/A-1 DESIGN THERAPEUTICS COM 25056L103 957,903 -161,634 -14.44 5,527 -51.88 0.0005
2023-05-11 2023-03-31 13F DESIGN THERAPEUTICS COM 25056L103 957,903 -161,634 5,527 0.0001
2023-02-13 2022-12-31 13F DESIGN THERAPEUTICS COM 25056L103 1,119,537 36,675 3.39 11,486 -36.56 0.0011
2022-11-10 2022-09-30 13F DESIGN THERAPEUTICS COM 25056L103 1,082,862 55,922 5.45 18,105 25.93 0.0019
2022-08-12 2022-06-30 13F DESIGN THERAPEUTICS COM 25056L103 1,026,940 -426 -0.04 14,377 -13.35 0.0014
2022-05-13 2022-03-31 13F DESIGN THERAPEUTICS COM 25056L103 1,027,366 27,366 2.74 16,592 -22.50 0.0013
2022-02-14 2021-12-31 13F DESIGN THERAPEUTICS COM 25056L103 1,000,000 0 0.00 21,410 45.75 0.0016
2022-02-14 2021-09-30 13F/A-1 DESIGN THERAPEUTICS COM 25056L103 1,000,000 0 0.00 14,690 -26.14 0.0012
2021-11-15 2021-09-30 13F DESIGN THERAPEUTICS COM 25056L103 1,000,000 0 14,690 0.0002
2021-08-13 2021-06-30 13F DESIGN THERAPEUTICS COM 25056L103 1,000,000 0 0.00 19,890 -33.48 0.0016
2021-05-14 2021-03-31 13F DESIGN THERAPEUTICS COM 25056L103 1,000,000 1,000,000 29,900 0.0026
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.