Heron Therapeutics, Inc.
US ˙ NasdaqCM ˙ US4277461020

SecurityHRTX / Heron Therapeutics, Inc.
InstitutionSquarepoint Ops LLC
Latest Disclosed Ownership859,958 shares
Latest Disclosed Value $ 688,052
Squarepoint Ops LLC reports 26.85% increase in ownership of HRTX / Heron Therapeutics, Inc.

On May 15, 2026 - Squarepoint Ops LLC filed a 13F-HR form disclosing ownership of 859,958 shares of Heron Therapeutics, Inc. (US:HRTX) valued at $688,052 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 677,947 shares of Heron Therapeutics, Inc.. This represents a change in shares of 26.85% during the quarter. The current value of the position is $384,229 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F HERON THERAPEUTICS COM 427746102 859,958 182,011 26.85 688 -21.91 0.0008
2026-02-13 2025-12-31 13F HERON THERAPEUTICS COM 427746102 677,947 462,840 215.17 881 225.09 0.0009
2025-11-14 2025-09-30 13F HERON THERAPEUTICS COM 427746102 215,107 155,116 258.57 271 118.55 0.0003
2025-08-27 2025-06-30 13F/A-1 HERON THERAPEUTICS COM 427746102 59,991 59,991 124 0.0001
2025-08-14 2025-06-30 13F HERON THERAPEUTICS COM 427746102 59,991 59,991 124 0.0001
2025-02-14 2024-12-31 13F HERON THERAPEUTICS COM 427746102 0 -612,897 -100.00 0 -100.00
2024-11-14 2024-09-30 13F HERON THERAPEUTICS COM 427746102 612,897 249,197 68.52 1,220 -4.17 0.0019
2024-08-14 2024-06-30 13F HERON THERAPEUTICS COM 427746102 363,700 286,160 369.05 1,273 494.39 0.0021
2024-05-15 2024-03-31 13F HERON THERAPEUTICS COM 427746102 77,540 77,540 215 0.0004
2023-11-14 2023-09-30 13F HERON THERAPEUTICS COM 427746102 0 -160,138 -100.00 0 -100.00
2023-08-14 2023-06-30 13F HERON THERAPEUTICS COM 427746102 160,138 134,820 532.51 186 386.84 0.0006
2023-05-15 2023-03-31 13F HERON THERAPEUTICS COM 427746102 25,318 -105,065 -80.58 38 -88.31 0.0002
2023-02-14 2022-12-31 13F HERON THERAPEUTICS COM 427746102 130,383 -77,322 -37.23 326 -62.94 0.0013
2022-11-14 2022-09-30 13F HERON THERAPEUTICS COM 427746102 207,705 207,705 877 0.0044
2022-05-16 2022-03-31 13F HERON THERAPEUTICS COM 427746102 0 -73,893 -100.00 0 -100.00
2022-02-14 2021-12-31 13F HERON THERAPEUTICS COM 427746102 73,893 -177,108 -70.56 675 -74.84 0.0018
2021-11-15 2021-09-30 13F HERON THERAPEUTICS COM 427746102 251,001 39,142 18.48 2,683 -18.40 0.0077
2021-08-16 2021-06-30 13F HERON THERAPEUTICS COM 427746102 211,859 61,114 40.54 3,288 34.53 0.0125
2021-05-17 2021-03-31 13F HERON THERAPEUTICS COM 427746102 150,745 150,745 2,444 0.0143
2021-02-16 2020-12-31 13F HERON THERAPEUTICS COM 427746102 0 -21,846 -100.00 0 -100.00
2020-11-16 2020-09-30 13F HERON THERAPEUTICS COM 427746102 21,846 21,846 324 0.0044
2020-08-14 2020-06-30 13F HERON THERAPEUTICS COM 427746102 0 -211,531 -100.00 0 -100.00
2020-05-15 2020-03-31 13F HERON THERAPEUTICS COM 427746102 211,531 131,851 165.48 2,483 32.64 0.0635
2020-02-14 2019-12-31 13F HERON THERAPEUTICS COM 427746102 79,680 79,680 1,872 0.0111
2019-11-14 2019-09-30 13F HERON THERAPEUTICS COM 427746102 0 -70,381 -100.00 0 -100.00
2019-08-14 2019-06-30 13F HERON THERAPEUTICS COM 427746102 70,381 -7,024 -9.07 1,308 -30.87 0.0127
2019-05-15 2019-03-31 13F HERON THERAPEUTICS COM 427746102 77,405 -28,179 -26.69 1,892 -30.92 0.0200
2019-02-14 2018-12-31 13F HERON THERAPEUTICS COM 427746102 105,584 27,323 34.91 2,739 10.58 0.0319
2018-11-14 2018-09-30 13F HERON THERAPEUTICS COM 427746102 78,261 29,461 60.37 2,477 30.64 0.0296
2018-08-14 2018-06-30 13F HERON THERAPEUTICS COM 427746102 48,800 25,000 105.04 1,896 188.58 0.0251
2018-05-15 2018-03-31 13F HERON THERAPEUTICS COM 427746102 23,800 -87,784 -78.67 657 -67.48 0.0104
2018-02-14 2017-12-31 13F HERON THERAPEUTICS COM 427746102 111,584 76,974 222.40 2,020 261.36 0.0352
2017-11-14 2017-09-30 13F HERON THERAPEUTICS COM 427746102 34,610 -1,303 -3.63 559 12.47 0.0108
2017-08-14 2017-06-30 13F HERON THERAPEUTICS COM 427746102 35,913 35,913 497 0.0098
2017-05-15 2017-03-31 13F HERON THERAPEUTICS COM 427746102 0 -36,467 -100.00 0 -100.00
2017-02-14 2016-12-31 13F HERON THERAPEUTICS COM 427746102 36,467 22,367 158.63 478 96.71 0.0196
2016-11-14 2016-09-30 13F HERON THERAPEUTICS COM 427746102 14,100 2,600 22.61 243 16.83 0.0161
2016-08-15 2016-06-30 13F HERON THERAPEUTICS COM 427746102 11,500 -6,300 -35.39 208 -38.46 0.0130
2016-05-16 2016-03-31 13F HERON THERAPEUTICS COM 427746102 17,800 -2,100 -10.55 338 -36.35 0.0262
2016-02-16 2015-12-31 13F HERON THERAPEUTICS COM 427746102 19,900 19,900 531 0.0582
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.