Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

SecurityIONS / Ionis Pharmaceuticals, Inc.
InstitutionTruist Financial Corp
Latest Disclosed Ownership12,846 shares
Latest Disclosed Value $ 964,606
Truist Financial Corp reports 1.48% increase in ownership of IONS / Ionis Pharmaceuticals, Inc.

On April 27, 2026 - Truist Financial Corp filed a 13F-HR form disclosing ownership of 12,846 shares of Ionis Pharmaceuticals, Inc. (US:IONS) valued at $964,606 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 2, 2026 disclosing 12,659 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of 1.48% during the quarter. The current value of the position is $948,292 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-04-27 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 12,846 187 1.48 965 -3.70 0.0013
2026-02-02 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 12,659 7,847 163.07 1,001 218.79 0.0013
2025-11-03 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 4,812 4,812 315 0.0004
2025-04-29 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -6,847 -100.00 0 -100.00
2025-01-31 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 6,847 -501 -6.82 239 -18.71 0.0004
2024-11-13 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 7,348 -655 -8.18 294 -22.83 0.0005
2024-08-21 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 8,003 -1,496 -15.75 381 -7.30 0.0006
2024-05-13 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 9,499 -466 -4.68 412 -18.45 0.0006
2024-02-02 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 9,965 9,965 504 0.0008
2023-02-17 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -6,420 -100.00 0 -100.00
2022-10-26 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 6,420 -15,944 -71.29 284 -65.70 0.0005
2022-07-22 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 22,364 -8,906 -28.48 828 -28.50 0.0015
2022-04-22 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 31,270 333 1.08 1,158 23.06 0.0018
2022-02-14 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 30,937 -40 -0.13 941 -9.43 0.0014
2021-11-05 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 30,977 5,876 23.41 1,039 3.80 0.0017
2021-08-16 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 25,101 3,437 15.87 1,001 2.77 0.0016
2021-05-17 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 21,664 10,408 92.47 974 53.14 0.0017
2021-11-19 2020-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 11,256 -207 -1.81 636 16.70 0.0012
2021-02-18 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 20,941 9,478 1,184 0.0022
2021-11-05 2020-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 11,463 -392 -3.31 545 -21.92 0.0012
2020-11-13 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 11,463 -392 545 0.0012
2021-11-16 2020-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 11,855 183 1.57 698 26.68 0.0016
2020-08-14 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 11,855 183 698 0.0015
2021-11-05 2020-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 11,672 -1,609 -12.12 551 -31.30 0.0015
2020-05-15 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 11,672 -1,609 551 0.0014
2021-11-16 2019-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 13,281 13,281 802 0.0016
2020-02-14 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 13,281 802 0.0016
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.