Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

SecurityIONS / Ionis Pharmaceuticals, Inc.
InstitutionEngineers Gate Manager LP
Latest Disclosed Ownership133,827 shares
Latest Disclosed Value $ 10,049,070
Engineers Gate Manager LP reports 503.07% increase in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 15, 2026 - Engineers Gate Manager LP filed a 13F-HR form disclosing ownership of 133,827 shares of Ionis Pharmaceuticals, Inc. (US:IONS) valued at $10,049,069 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 22,191 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of 503.07% during the quarter. The current value of the position is $9,879,109 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

Upgrade to unlock premium data and export to Excel .

Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 133,827 111,636 503.07 10,049 472.59 0.1256
2026-02-17 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 22,191 -3,588 -13.92 1,756 4.09 0.0208
2025-11-14 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 25,779 -7,339 -22.16 1,686 28.90 0.0193
2025-08-14 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 33,118 33,118 1,308 0.0163
2025-02-14 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -78,874 -100.00 0 -100.00
2024-11-14 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 78,874 62,554 383.30 3,160 306.56 0.0617
2024-08-14 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 16,320 -22,272 -57.71 778 -53.53 0.0175
2024-05-15 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 38,592 9,715 33.64 1,673 14.52 0.0440
2024-02-14 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 28,877 28,877 1,461 0.0417
2023-11-14 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 0 -34,047 -100.00 0 -100.00
2023-08-14 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 34,047 -293 -0.85 1,397 13.77 0.0528
2023-05-15 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 34,340 14,363 71.90 1,227 62.73 0.0513
2023-02-14 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 19,977 13,484 207.67 755 162.72 0.0453
2022-11-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 6,493 -10,210 -61.13 287 -53.56 0.0179
2022-08-15 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 16,703 6,835 69.26 618 68.85 0.0227
2022-05-16 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 9,868 -24,512 -71.30 366 -65.01 0.0143
2022-02-14 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 34,380 17,708 106.21 1,046 87.12 0.0470
2021-11-15 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 16,672 16,672 559 0.0319
2021-08-16 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 0 -29,160 -100.00 0 -100.00
2021-05-17 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 29,160 22,040 309.55 1,311 225.31 0.0649
2021-02-16 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 7,120 -7,137 -50.06 403 -40.38 0.0175
2020-11-16 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 14,257 14,257 676 0.0317
2020-08-17 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 0 -7,598 -100.00 0 -100.00
2020-05-15 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 7,598 -6,153 -44.75 359 -56.80 0.0259
2020-02-14 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 13,751 13,751 831 0.0365
2019-08-14 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 0 -27,200 -100.00 0 -100.00
2019-05-15 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 27,200 27,200 2,208 0.1337
2015-11-16 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 0 -9,801 -100.00 0 -100.00
2015-08-14 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 9,801 3,868 65.19 564 49.21 0.0552
2015-05-15 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 5,933 5,933 378 0.0503
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.