Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

SecurityIONS / Ionis Pharmaceuticals, Inc.
InstitutionFifth Third Bancorp
Latest Disclosed Ownership11,011 shares
Latest Disclosed Value $ 826,806
Fifth Third Bancorp reports 39.59% increase in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 1, 2026 - Fifth Third Bancorp filed a 13F-HR form disclosing ownership of 11,011 shares of Ionis Pharmaceuticals, Inc. (US:IONS) valued at $826,816 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 2, 2026 disclosing 7,888 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of 39.59% during the quarter. The current value of the position is $827,256 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

Upgrade to unlock premium data and export to Excel .

Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-01 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 11,011 3,123 39.59 827 32.37 0.0015
2026-02-02 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 7,888 -56 -0.70 624 20.23 0.0020
2025-11-07 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 7,944 346 4.55 520 73.00 0.0017
2025-07-15 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 7,598 -2,391 -23.94 300 -0.33 0.0010
2025-04-15 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 9,989 458 4.81 301 -9.61 0.0011
2025-01-21 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 9,531 -41 -0.43 333 -13.05 0.0012
2024-10-17 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 9,572 110 1.16 383 -14.89 0.0014
2024-07-22 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 9,462 -171 -1.78 451 7.91 0.0017
2024-04-23 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 9,633 351 3.78 418 -11.09 0.0016
2024-01-19 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 9,282 6,782 271.28 470 315.04 0.0020
2023-10-31 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 2,500 0 0.00 113 10.78 0.0005
2023-07-26 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 2,500 -500 -16.67 103 -4.67 0.0005
2023-04-24 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 3,000 500 20.00 107 13.83 0.0005
2023-01-25 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 2,500 0 0.00 94 -15.32 0.0005
2022-10-25 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 2,500 0 0.00 111 19.35 0.0006
2022-08-04 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 2,500 -214 -7.89 93 -7.92 0.0004
2022-04-19 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 2,714 88 3.35 101 26.25 0.0004
2022-02-01 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 2,626 0 0.00 80 -9.09 0.0003
2021-10-15 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 2,626 72 2.82 88 -13.73 0.0004
2021-08-06 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 2,554 -7,004 -73.28 102 -76.28 0.0004
2021-05-07 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 9,558 -100 -1.04 430 -21.25 0.0020
2021-02-16 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 9,658 -1,404 -12.69 546 4.00 0.0027
2020-11-09 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 11,062 -126 -1.13 525 -20.45 0.0029
2020-08-05 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 11,188 0 0.00 660 24.76 0.0040
2020-05-05 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 11,188 806 7.76 529 -15.63 0.0038
2020-02-14 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 10,382 3,100 42.57 627 43.81 0.0035
2019-11-14 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 7,282 -152 -2.04 436 -8.79 0.0026
2019-08-07 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 7,434 440 6.29 478 -15.85 0.0029
2019-05-14 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 6,994 -77 -1.09 568 48.69 0.0036
2019-02-14 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 7,071 -47 -0.66 382 4.09 0.0028
2018-11-14 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 7,118 -524 -6.86 367 15.41 0.0023
2018-08-14 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 7,642 571 8.08 318 1.92 0.0022
2018-05-15 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 7,071 6,882 3,641.27 312 3,020.00 0.0021
2018-02-14 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 189 0 0.00 10 0.00 0.0001
2017-11-14 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 189 0 0.00 10 0.00 0.0001
2017-08-11 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 189 0 0.00 10 25.00 0.0001
2017-05-12 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 189 0 0.00 8 -11.11 0.0001
2017-02-13 2016-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 189 0 0.00 9 28.57 0.0001
2017-02-09 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 189 0 7 0.0001
2016-11-10 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 189 54 40.00 7 133.33 0.0001
2016-08-11 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 135 0 0.00 3 -40.00 0.0000
2016-05-13 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 135 -60 -30.77 5 -58.33 0.0000
2016-02-16 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 195 -131 -40.18 12 -7.69 0.0001
2015-11-13 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 326 -721 -68.86 13 -78.33 0.0001
2015-08-14 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 1,047 0 0.00 60 -10.45 0.0005
2015-05-14 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 1,047 889 562.66 67 570.00 0.0006
2015-02-13 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 158 -3,343 -95.49 10 -92.65 0.0001
2014-11-17 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 3,501 1,331 61.34 136 81.33 0.0012
2014-08-14 2014-06-30 13F ISIS PHARMACEUTICALS COM 464330109 2,170 -697 -24.31 75 -39.52 0.0007
2014-05-15 2014-03-31 13F ISIS PHARMACEUTICALS COM 464330109 2,867 2,732 2,023.70 124 2,380.00 0.0012
2014-02-14 2013-12-31 13F ISIS PHARMACEUTICALS COM 464330109 135 135 5 0.0000
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.