Fmr Llc ownership in IONS / Ionis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc.

US ˙ NasdaqGS ˙ US4622221004

Security	IONS / Ionis Pharmaceuticals, Inc.
Institution	Fmr Llc
Latest Disclosed Ownership	21,520,872 shares
Ownership	15.00%

2024-02-09 - Fmr Llc has filed an SC 13G/A form with the Securities and Exchange Commission (SEC) disclosing ownership of 21,520,872 shares of Ionis Pharmaceuticals, Inc. (US:IONS). This represents 15.0 percent ownership of the company. In their previous filing dated 2023-02-09 , Fmr Llc had reported owning 21,307,519 shares, indicating an increase of 1.00 percent.

Institutional Ownership: 13D/G Filings

This table shows a history of the 13D/G filings made by the investor and/or investor group. Note that the share values in this table are not directly comparable to any numbers shown in the 13F table (if any).

File Date	Effective Date	Form	Prev Shares	Latest Shares	ΔShares (Percent)	Ownership (Percent)	ΔOwnership (Percent)
2024-02-09	2024-02-09	13G/A	21,307,519	21,520,872	1.00	15.00	0.01
2023-02-09	2023-02-09	13G/A	21,181,502	21,307,519	0.59	15.00	0.00
2022-02-09	2022-02-09	13G/A	20,979,722	21,181,502	0.96	15.00	0.00
2021-02-08	2021-02-08	13G/A	21,124,062	20,979,722	-0.68	15.00	0.00
2020-02-07	2020-02-07	13G/A	20,657,943	21,124,062	2.26	15.00	0.00
2019-02-13	2019-02-13	13G/A	18,719,325	20,657,943	10.36	15.00	0.00
2018-02-13	2018-02-13	13G/A	18,180,445	18,719,325	2.96	15.00	0.00
2017-02-14	2017-02-14	13G/A	18,071,779	18,180,445	0.60	15.00	0.00
2016-02-12	2016-02-12	13G/A		18,071,779		15.00
2015-02-13	2015-02-13	13G/A		17,892,555		15.10
2014-02-14	2014-02-14	13G/A		17,679,361		15.14
2013-02-14	2013-02-14	13G/A		15,812,207		15.51
2012-02-14	2012-02-14	13G/A		12,698,141		12.73

Important Note: One of the primary uses of the 13D/G filings is to evaluate the ability of a firm to control a company (ie, the "beneficial ownership"). To that end, firms are required to report not just direct holdings in companies, but indirect holdings that they control. For investment firms, these indirect holdings can include shares in funds they manage, advisory accounts, and in the case of activist campaigns, pledged votes. Therefore, share counts listed in 13D/G filings can differ significantly than share counts listed in 13F filings.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)

File Date	Effective Date	Form	Security	Class	ID	Reported Shares	ΔShares	ΔShares (%)	Reported Value (x1000)	ΔValue (%)	Alloc (%)
2026-05-15	2026-03-31	13F	IONIS PHARMACEUTICALS	COM	462222100	24,556,637	484,536	2.01	1,843,958	-3.17	0.0193
2026-02-17	2025-12-31	13F	IONIS PHARMACEUTICALS	COM	462222100	24,072,101	383,063	1.62	1,904,344	22.88	0.0971
2025-11-13	2025-09-30	13F	IONIS PHARMACEUTICALS	COM	462222100	23,689,038	46,048	0.19	1,549,737	65.90	0.0806
2025-08-14	2025-06-30	13F	IONIS PHARMACEUTICALS	COM	462222100	23,642,990	29,405	0.12	934,135	31.12	0.0527
2025-05-12	2025-03-31	13F	IONIS PHARMACEUTICALS	COM	462222100	23,613,585	924,094	4.07	712,422	-10.19	0.0455
2025-02-13	2024-12-31	13F	IONIS PHARMACEUTICALS	COM	462222100	22,689,491	209,962	0.93	793,225	-11.92	0.0473
2024-11-13	2024-09-30	13F	IONIS PHARMACEUTICALS	COM	462222100	22,479,529	584,723	2.67	900,530	-13.70	0.0548
2024-08-13	2024-06-30	13F	IONIS PHARMACEUTICALS	COM	462222100	21,894,806	32,071	0.15	1,043,506	10.10	0.0668
2024-05-13	2024-03-31	13F	IONIS PHARMACEUTICALS	COM	462222100	21,862,735	341,863	1.59	947,750	-12.95	0.0636
2024-02-13	2023-12-31	13F	IONIS PHARMACEUTICALS	COM	462222100	21,520,872	21,950	0.10	1,088,741	11.64	0.0836
2023-11-13	2023-09-30	13F	IONIS PHARMACEUTICALS	COM	462222100	21,498,922	35,106	0.16	975,191	10.73	0.0843
2023-08-11	2023-06-30	13F	IONIS PHARMACEUTICALS	COM	462222100	21,463,816	27,482	0.13	880,660	14.95	0.0738
2023-08-11	2023-03-31	13F/A-1	IONIS PHARMACEUTICALS	COM	462222100	21,436,334	128,815	0.60	766,135	-4.80	0.0701
2023-05-11	2023-03-31	13F	IONIS PHARMACEUTICALS	COM	462222100	21,436,334	128,815		766,135		0.0139
2023-02-13	2022-12-31	13F	IONIS PHARMACEUTICALS	COM	462222100	21,307,519	16,360	0.08	804,785	-14.54	0.0799
2022-11-10	2022-09-30	13F	IONIS PHARMACEUTICALS	COM	462222100	21,291,159	21,599	0.10	941,708	19.60	0.0982
2022-08-12	2022-06-30	13F	IONIS PHARMACEUTICALS	COM	462222100	21,269,560	-51,326	-0.24	787,399	-0.29	0.0785
2022-05-13	2022-03-31	13F	IONIS PHARMACEUTICALS	COM	462222100	21,320,886	139,384	0.66	789,725	22.52	0.0631
2022-02-14	2021-12-31	13F	IONIS PHARMACEUTICALS	COM	462222100	21,181,502	9,348	0.04	644,553	-9.23	0.0476
2022-02-14	2021-09-30	13F/A-1	IONIS PHARMACEUTICALS	COM	462222100	21,172,154	27,699	0.13	710,114	-15.81	0.0563
2021-11-15	2021-09-30	13F	IONIS PHARMACEUTICALS	COM	462222100	21,172,154	27,699		710,114		0.0563
2021-08-13	2021-06-30	13F	IONIS PHARMACEUTICALS	COM	462222100	21,144,455	50,559	0.24	843,452	-11.06	0.0661
2021-05-14	2021-03-31	13F	IONIS PHARMACEUTICALS	COM	462222100	21,093,896	155,862	0.74	948,382	-19.89	0.0810
2021-02-08	2020-12-31	13F	IONIS PHARMACEUTICALS	COM	462222100	20,938,034	71,082	0.34	1,183,836	19.56	0.1053
2020-11-13	2020-09-30	13F	IONIS PHARMACEUTICALS	COM	462222100	20,866,952	56,398	0.27	990,137	-19.30	0.1001
2020-08-24	2020-06-30	13F/A-1	IONIS PHARMACEUTICALS	COM	462222100	20,810,554	-149,673	-0.71	1,226,990	23.81	0.1349
2020-08-13	2020-06-30	13F	IONIS PHARMACEUTICALS	COM	462222100	20,810,554	-149,673		1,226,990		30,143.5537
2020-05-14	2020-03-31	13F	IONIS PHARMACEUTICALS	COM	462222100	20,960,227	0	0.00	990,999	-21.73	0.1372
2020-02-07	2019-12-31	13F	IONIS PHARMACEUTICALS	COM	462222100	20,960,227	24,443	0.12	1,266,207	0.95	0.1397
2019-11-13	2019-09-30	13F	IONIS PHARMACEUTICALS	COM	462222100	20,935,784	26,522	0.13	1,254,263	-6.67	0.1504
2019-08-13	2019-06-30	13F	IONIS PHARMACEUTICALS	COM	462222100	20,909,262	275,564	1.34	1,343,839	-19.76	0.1570
2019-05-13	2019-03-31	13F	IONIS PHARMACEUTICALS	COM	462222100	20,633,698	123,948	0.60	1,674,837	51.06	0.2007
2019-02-13	2018-12-31	13F	IONIS PHARMACEUTICALS	COM	462222100	20,509,750	45,911	0.22	1,108,757	5.04	0.1519
2018-11-09	2018-09-30	13F	IONIS PHARMACEUTICALS	COM	462222100	20,463,839	1,635,782	8.69	1,055,525	34.54	0.1187
2018-08-10	2018-06-30	13F	IONIS PHARMACEUTICALS	COM	462222100	18,828,057	17,575	0.09	784,565	-5.38	0.0926
2018-05-14	2018-03-31	13F	IONIS PHARMACEUTICALS	COM	462222100	18,810,482	91,157	0.49	829,166	-11.94	0.0984
2018-02-12	2017-12-31	13F	IONIS PHARMACEUTICALS	COM	462222100	18,719,325	66,122	0.35	941,582	-0.44	0.1104
2017-11-13	2017-09-30	13F	IONIS PHARMACEUTICALS	COM	462222100	18,653,203	58,369	0.31	945,717	-0.02	0.1143
2017-08-29	2017-06-30	13F/A-1	IONIS PHARMACEUTICALS	COM	462222100	18,594,834	32,414	0.17	945,919	26.76	0.1176
2017-08-11	2017-06-30	13F	IONIS PHARMACEUTICALS	COM	462222100	18,594,834	32,414		945,919
2017-05-11	2017-03-31	13F	IONIS PHARMACEUTICALS	COM	462222100	18,562,420	381,975	2.10	746,210	-14.19	0.0948
2017-02-10	2016-12-31	13F	IONIS PHARMACEUTICALS	COM	462222100	18,180,445	42,591	0.23	869,570	30.85	0.1162
2016-11-14	2016-09-30	13F	IONIS PHARMACEUTICALS	COM	462222100	18,137,854	20,406	0.11	664,571	57.50	0.0885
2016-08-11	2016-06-30	13F	IONIS PHARMACEUTICALS	COM	462222100	18,117,448	325,351	1.83	421,955	-41.44	0.0576
2016-05-16	2016-03-31	13F	IONIS PHARMACEUTICALS	COM	462222100	17,792,097	81,140	0.46	720,580	-34.30	0.0997
2016-02-12	2015-12-31	13F	IONIS PHARMACEUTICALS	COM	462222100	17,710,957	23,310	0.13	1,096,840	53.42	0.1476
2015-11-10	2015-09-30	13F	ISIS PHARMACEUTICALS	COM	464330109	17,687,647	37,345	0.21	714,935	-29.62	0.1018
2015-08-25	2015-06-30	13F/A-1	ISIS PHARMACEUTICALS	COM	464330109	17,650,302	104,252	0.59	1,015,775	-9.08	0.1302
2015-08-13	2015-06-30	13F	ISIS PHARMACEUTICALS	COM	464330109	17,650,302			1,015,775
2015-05-14	2015-03-31	13F	ISIS PHARMACEUTICALS	COM	464330109	17,546,050	14,317	0.08	1,117,157	3.21	0.1423
2015-02-17	2014-12-31	13F	ISIS PHARMACEUTICALS	COM	464330109	17,531,733	-18,000	-0.10	1,082,409	58.84	0.1408
2014-11-14	2014-09-30	13F	ISIS PHARMACEUTICALS	COM	464330109	17,549,733	0	0.00	681,456	12.71	0.0923
2014-08-14	2014-06-30	13F	ISIS PHARMACEUTICALS	COM	464330109	17,549,733	0	0.00	604,588	-20.27	0.0810
2014-05-15	2014-03-31	13F	ISIS PHARMACEUTICALS	COM	464330109	17,549,733	592,014	3.49	758,324	12.25	0.1053
2014-02-13	2013-12-31	13F	ISIS PHARMACEUTICALS	COM	464330109	16,957,719	-30,000	-0.18	675,595	5.94	0.0955
2013-11-14	2013-09-30	13F	ISIS PHARMACEUTICALS	COM	464330109	16,987,719	765,455	4.72	637,719	46.30	0.0977
2013-09-24	2013-06-30	13F/A-1	ISIS PHARMACEUTICALS	COM	464330109	16,222,264	16,222,264		435,892		0.0714
2013-08-14	2013-06-30	13F	ISIS PHARMACEUTICALS	COM	464330109	16,222,264			435,892		0.0714

Legend

Shares: The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value: The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price: The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class: This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred

Allocation (%): The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation: The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%): The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis: The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss: This is the market value of the position as of the effective date minus the cost basis.