Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

SecurityIONS / Ionis Pharmaceuticals, Inc.
InstitutionKBC Group NV
Latest Disclosed Ownership30,213 shares
Latest Disclosed Value $ 2,269
KBC Group NV reports 233.77% increase in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 7, 2026 - KBC Group NV filed a 13F-HR form disclosing ownership of 30,213 shares of Ionis Pharmaceuticals, Inc. (US:IONS) valued at $2,268,694 USD as of March 31, 2026. The entity filed a previous 13F-HR on January 26, 2026 disclosing 9,052 shares of Ionis Pharmaceuticals, Inc.. The current value of the position is $2,230,324 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-07 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 30,213 21,161 233.77 2 0.0057
2026-01-26 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 9,052 4,353 92.64 1 0.0016
2026-01-20 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 4,699 0 0.00 0 0.0007
2025-08-08 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 4,699 -1,816 -27.87 0 0.0005
2025-04-25 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 6,515 31 0.48 0 0.0006
2025-01-22 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 6,484 2,676 70.27 0 0.0006
2024-11-06 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 3,808 419 12.36 0 0.0005
2024-07-17 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 3,389 244 7.76 0 0.0005
2024-05-08 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 3,145 476 17.83 0 0.0004
2024-02-13 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 2,669 0 0.00 0 0.0005
2024-02-15 2023-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 2,669 1,291 93.69 0 0.0005
2023-11-22 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 1,378 0 0 0.0002
2024-02-15 2023-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,378 0 0.00 0 0.0002
2023-07-28 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,378 0 0 0.0002
2024-02-14 2023-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,378 0 0.00 0 0.0002
2023-05-04 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,378 0 0 0.0002
2024-02-14 2022-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,378 0 0.00 0 0.0003
2023-02-13 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,378 0 0 0.0000
2024-02-15 2022-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,378 0 0.00 0 0.0003
2022-11-08 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 1,378 0 61 0.0003
2024-02-14 2022-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,378 -6,661 -82.86 0 -100.00 0.0003
2022-07-26 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,378 -6,661 51 0.0003
2024-02-14 2022-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 8,039 22 0.27 0 -100.00 0.0012
2022-05-06 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 8,039 22 298 0.0011
2024-02-14 2021-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 8,017 -895 -10.04 0 -100.00 0.0008
2022-02-03 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 8,017 -895 244 0.0008
2021-11-10 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 8,912 -2,899 -24.54 299 -36.52 0.0011
2022-02-15 2021-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 11,811 300 2.61 471 -9.07 0.0017
2021-08-11 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 11,811 300 471 0.0017
2022-02-14 2021-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 11,511 -200 -1.71 518 -92.18 0.0021
2021-04-26 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 11,511 -200 518 0.0021
2022-02-14 2020-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 11,711 0 0.00 6,621 1,090.83 0.0031
2021-02-10 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 11,711 0 662 0.0030
2022-02-14 2020-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 11,711 0 0.00 556 -19.42 0.0033
2020-10-28 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 11,711 0 556 0.0033
2022-02-14 2020-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 11,711 740 6.75 690 32.95 0.0046
2020-08-10 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 11,711 740 691 0.0046
2020-05-04 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 10,971 1,096 11.10 519 -13.07 0.0043
2020-02-11 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 9,875 289 3.01 597 4.01 0.0038
2019-11-07 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 9,586 8,791 1,105.79 574 1,025.49 0.0042
2019-12-03 2019-06-30 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 795 0 0.00 51 -21.54 0.4431
2019-12-03 2019-03-31 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 795 0 0.00 65 51.16 0.5907
2019-12-03 2018-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 795 0 0.00 43 4.88 0.5023
2019-12-03 2018-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 795 0 0.00 41 24.24 0.4045
2019-12-03 2018-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 795 175 28.23 33 22.22 0.3645
2018-08-03 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,869 0 78 679.0847
2019-12-03 2018-03-31 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 620 -1,249 -66.83 27 -71.28 0.2878
2018-08-03 2018-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,869 1,249 82 0.0008
2018-05-09 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,869 0 82
2018-08-03 2017-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,869 0 0.00 94 -1.05 0.0008
2018-02-07 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,869 0 94
2017-11-13 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 1,869 0 0.00 95 0.00 0.0009
2017-08-04 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,869 0 0.00 95 26.67 0.0009
2017-05-10 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,869 0 0.00 75 -15.73 0.0007
2017-02-16 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,869 -13,238 -87.63 89 -83.94 0.0009
2016-11-03 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 15,107 6,378 73.07 554 172.91 0.0065
2016-08-03 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 8,729 0 0.00 203 -42.66 0.0029
2016-05-11 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 8,729 -1,381 -13.66 354 -43.45 0.0059
2016-02-11 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 10,110 -9,166 -47.55 626 -19.64 0.0115
2015-11-12 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 19,276 -7,126 -26.99 779 -48.72 0.0157
2015-12-16 2015-06-30 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 26,402 -3,004 -10.22 1,519 -18.86 0.0195
2015-07-31 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 26,402 1,519
2015-12-16 2015-03-31 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 29,406 29,406 1,872 0.0238
2015-04-30 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 29,406 1,872 0.0239
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.