Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

SecurityIONS / Ionis Pharmaceuticals, Inc.
InstitutionMacquarie Group Ltd
Latest Disclosed Ownership0 shares
Latest Disclosed Value $ 0
Macquarie Group Ltd closes position in IONS / Ionis Pharmaceuticals, Inc.

On February 13, 2026 - Macquarie Group Ltd filed a 13F-HR form disclosing ownership of 0 shares of Ionis Pharmaceuticals, Inc. (US:IONS) valued at $0 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 13, 2025 disclosing 1,131,936 shares of Ionis Pharmaceuticals, Inc.. The current value of the position is $0 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-13 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -100.00 0
2025-11-13 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 1,131,936 -302,137 -21.07 74,051 30.69 0.0864
2025-08-14 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,434,073 -233,121 -13.98 56,660 12.65 0.0695
2025-08-14 2025-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,667,194 -102,549 -5.79 50,299 -18.70 0.0624
2025-05-15 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,667,194 -102,549 50,299 0.0411
2025-02-14 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,769,743 -100,063 -5.35 61,870 -17.40 0.0751
2024-11-14 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 1,869,806 -3,862 -0.21 74,904 -16.12 0.0809
2024-08-09 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,873,668 -1,326,910 -41.46 89,299 -35.64 0.1024
2024-05-14 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 3,200,578 112,343 3.64 138,745 -11.19 0.1574
2024-02-14 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 3,088,235 152,311 5.19 156,234 17.32 0.1805
2023-11-14 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 2,935,924 1,437,042 95.87 133,174 116.55 0.1673
2023-10-27 2023-06-30 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 1,498,882 4,979 0.33 61,499 15.18 0.0703
2023-10-12 2023-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,498,882 4,979 61,499 0.0618
2023-08-14 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 1,498,882 4,979 61,499 0.0624
2023-06-01 2023-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 1,493,903 2,216 0.15 53,392 -5.23 0.0634
2023-05-15 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 1,493,903 2,216 53,392 0.0490
2023-02-21 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 1,491,687 657,646 78.85 56,341 52.42 0.0665
2022-11-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 834,041 800,773 2,407.04 36,965 2,900.41 0.0453
2022-08-17 2022-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 33,268 1,262 3.94 1,232 3.97 0.0014
2022-08-15 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 33,268 1,262 1,232 0.0004
2022-05-16 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 32,006 -543 -1.67 1,185 19.58 0.0009
2022-02-11 2021-12-31 13F Ionis Pharmaceuticals COM 462222100 32,549 121 0.37 991 -8.92 0.0008
2021-11-12 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 32,428 0 0.00 1,088 -15.92 0.0009
2021-08-13 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 32,428 1,971 6.47 1,294 -5.55 0.0011
2021-05-14 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 30,457 6,344 26.31 1,370 0.44 0.0019
2021-02-16 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 24,113 348 1.46 1,364 20.92 0.0020
2020-11-13 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 23,765 -221 -0.92 1,128 -20.23 0.0019
2020-08-11 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 23,986 -6,616 -21.62 1,414 -2.28 0.0024
2020-05-15 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 30,602 2,539 9.05 1,447 -14.68 0.0030
2020-03-18 2019-12-31 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 28,063 7,440 36.08 1,696 37.22 0.0024
2020-02-28 2019-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 28,063 0 1,696 0.0024
2020-02-14 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 28,063 7,440 1,696 2,128.3363
2019-11-14 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 20,623 2,606 14.46 1,236 6.74 0.0021
2019-11-06 2019-06-30 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 18,017 491 2.80 1,158 -18.62 0.0020
2019-09-24 2019-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 18,017 0 1,158 0.0020
2019-08-14 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 18,017 491 1,158
2019-05-15 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 17,526 -6,463 -26.94 1,423 9.71 0.0024
2019-02-15 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 23,989 623 2.67 1,297 7.63 0.0025
2018-11-15 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 23,366 -6,377 -21.44 1,205 -2.74 0.0020
2019-03-21 2018-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 29,743 29,743 1,239 0.0021
2018-08-14 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 29,743 29,743 1,239
2016-08-15 2016-06-30 13F IONIS PHARMACEUTICALS COMMON 462222100 0 -1,842 -100.00 0 -100.00
2016-05-16 2016-03-31 13F IONIS PHARMACEUTICALS COMMON 462222100 1,842 0 0.00 75 -34.21 0.0002
2016-02-16 2015-12-31 13F IONIS PHARMACEUTICALS COMMON 462222100 1,842 101 5.80 114 62.86 0.0002
2015-11-16 2015-09-30 13F ISIS PHARMACEUTICALS COMMON 464330109 1,741 -43,343 -96.14 70 -97.30 0.0002
2015-08-21 2015-06-30 13F/A-1 ISIS PHARMACEUTICALS COMMON 464330109 45,084 -139,997 -75.64 2,595 -77.98 0.0051
2015-08-14 2015-06-30 13F ISIS PHARMACEUTICALS COMMON 464330109 45,084 2,595
2015-05-18 2015-03-31 13F ISIS PHARMACEUTICALS COMMON 464330109 185,081 59,666 47.57 11,784 52.19 0.0231
2015-02-17 2014-12-31 13F ISIS PHARMACEUTICALS COMMON 464330109 125,415 38,849 44.88 7,743 130.38 0.0160
2014-11-14 2014-09-30 13F ISIS PHARMACEUTICALS COMMON 464330109 86,566 86,566 3,361 0.0072
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.