Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

SecurityIONS / Ionis Pharmaceuticals, Inc.
InstitutionMan Group plc
Latest Disclosed Ownership24,013 shares
Latest Disclosed Value $ 1,803,136
Man Group plc reports 85.54% decrease in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 15, 2026 - Man Group plc filed a 13F-HR form disclosing ownership of 24,013 shares of Ionis Pharmaceuticals, Inc. (US:IONS) valued at $1,803,136 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 166,042 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of -85.54% during the quarter. The current value of the position is $1,772,640 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 24,013 -142,029 -85.54 1,803 -86.27 0.0033
2026-02-17 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 166,042 -167,778 -50.26 13,136 -39.85 0.0223
2025-11-14 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 333,820 324,851 3,621.93 21,839 6,068.93 0.0380
2025-08-14 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 8,969 -1,064 -10.61 354 17.22 0.0007
2025-05-15 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 10,033 1,718 20.66 303 4.14 0.0008
2025-02-14 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 8,315 -587,948 -98.61 291 -98.79 0.0008
2024-11-14 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 596,263 -37,146 -5.86 23,886 -20.88 0.0622
2024-08-14 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 633,409 380,188 150.14 30,188 175.01 0.0762
2024-05-15 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 253,221 174,746 222.68 10,977 176.50 0.0277
2024-02-14 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 78,475 3,970 -46.61 0.0111
2023-11-14 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 7,437 -16.87 0.0230
2023-05-15 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 8,946 2.75 0.0318
2023-02-14 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 230,525 52,928 29.80 8,707 10.83 0.0312
2022-11-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 177,597 7,855 1,677.15 0.0365
2022-08-15 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 442 0.0019
2021-02-16 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -6,204 -100.00 0 -100.00
2020-11-16 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 6,204 -109,808 -94.65 294 -95.70 0.0012
2020-08-14 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 116,012 106,312 1,096.00 6,840 1,390.20 0.0345
2020-05-15 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 9,700 -48,970 -83.47 459 -87.05 0.0030
2020-02-18 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 58,670 4,422 8.15 3,544 9.05 0.0117
2019-11-14 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 54,248 -28,707 -34.61 3,250 -39.04 0.0121
2019-08-14 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 82,955 62,031 296.46 5,331 213.96 0.0193
2019-05-15 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 20,924 15,800 308.35 1,698 513.00 0.0064
2019-02-14 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 5,124 -6,953 -57.57 277 -55.54 0.0012
2018-11-14 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 12,077 -6,032 -33.31 623 -17.48 0.0023
2018-08-14 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 18,109 13,509 293.67 755 271.92 0.0031
2018-05-15 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 4,600 4,600 203 0.0009
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.