Krystal Biotech, Inc.
US ˙ NasdaqGS ˙ US5011471027

SecurityKRYS / Krystal Biotech, Inc.
InstitutionSei Investments Co
Latest Disclosed Ownership32,310 shares
Latest Disclosed Value $ 7,965,738
Sei Investments Co reports 38.12% increase in ownership of KRYS / Krystal Biotech, Inc.

On February 13, 2026 - Sei Investments Co filed a 13F-HR form disclosing ownership of 32,310 shares of Krystal Biotech, Inc. (US:KRYS) valued at $7,965,707 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 13, 2025 disclosing 23,393 shares of Krystal Biotech, Inc.. This represents a change in shares of 38.12% during the quarter. The current value of the position is $9,751,804 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-02-13 2025-12-31 13F KRYSTAL BIOTECH COM 501147102 32,310 8,917 38.12 7,966 92.90 0.0079
2025-11-13 2025-09-30 13F KRYSTAL BIOTECH COM 501147102 23,393 4,093 21.21 4,130 55.69 0.0044
2025-08-14 2025-06-30 13F KRYSTAL BIOTECH COM 501147102 19,300 609 3.26 2,653 -21.28 0.0031
2025-05-14 2025-03-31 13F/A-1 KRYSTAL BIOTECH COM 501147102 18,691 -2,473 -11.68 3,370 1.63 0.0043
2025-05-13 2025-03-31 13F KRYSTAL BIOTECH COM 501147102 21,168 4 3,316 0.0036
2025-02-11 2024-12-31 13F KRYSTAL BIOTECH COM 501147102 21,164 -13,085 -38.21 3,316 -46.82 0.0043
2024-11-12 2024-09-30 13F KRYSTAL BIOTECH COM 501147102 34,249 -5,866 -14.62 6,234 -15.37 0.0081
2024-08-13 2024-06-30 13F KRYSTAL BIOTECH COM 501147102 40,115 6,363 18.85 7,367 22.66 0.0104
2024-05-07 2024-03-31 13F KRYSTAL BIOTECH COM 501147102 33,752 18,968 128.30 6,005 227.43 0.0088
2024-02-14 2023-12-31 13F KRYSTAL BIOTECH COM 501147102 14,784 -20,117 -57.64 1,834 -54.69 0.0029
2023-11-14 2023-09-30 13F KRYSTAL BIOTECH COM 501147102 34,901 21,670 163.78 4,049 160.66 0.0073
2023-08-11 2023-06-30 13F KRYSTAL BIOTECH COM 501147102 13,231 279 2.15 1,553 49.90 0.0027
2023-05-12 2023-03-31 13F KRYSTAL BIOTECH COM 501147102 12,952 -3,558 -21.55 1,037 -20.73 0.0019
2023-02-10 2022-12-31 13F KRYSTAL BIOTECH COM 501147102 16,510 -380 -2.25 1,308 11.05 0.0029
2022-11-14 2022-09-30 13F KRYSTAL BIOTECH COM 501147102 16,890 -200 -1.17 1,177 4.90 0.0026
2022-08-15 2022-06-30 13F KRYSTAL BIOTECH COM 501147102 17,090 -2,323 -11.97 1,122 -13.16 0.0024
2022-05-13 2022-03-31 13F KRYSTAL BIOTECH COM 501147102 19,413 2,998 18.26 1,292 12.54 0.0026
2022-02-14 2021-12-31 13F KRYSTAL BIOTECH COM 501147102 16,415 9,437 135.24 1,148 215.38 0.0022
2021-11-12 2021-09-30 13F KRYSTAL BIOTECH COM 501147102 6,978 -133 -1.87 364 -24.79 0.0008
2021-08-06 2021-06-30 13F KRYSTAL BIOTECH COM 501147102 7,111 -139 -1.92 484 -13.42 0.0011
2021-05-12 2021-03-31 13F KRYSTAL BIOTECH COM 501147102 7,250 -256 -3.41 559 24.22 0.0014
2021-02-08 2020-12-31 13F KRYSTAL BIOTECH COM 501147102 7,506 0 0.00 450 39.32 0.0012
2020-12-04 2020-09-30 13F/A-1 KRYSTAL BIOTECH COM 501147102 7,506 0 0.00 323 3.86 0.0009
2020-11-06 2020-09-30 13F KRYSTAL BIOTECH COM 501147102 7,506 0 323 777.7122
2020-08-17 2020-06-30 13F/A-1 KRYSTAL BIOTECH COM 501147102 7,506 -2,084 -21.73 311 -25.06 0.0010
2020-05-14 2020-03-31 13F KRYSTAL BIOTECH COM 501147102 9,590 938 10.84 415 -13.36 0.0015
2020-02-06 2019-12-31 13F KRYSTAL BIOTECH COM 501147102 8,652 -2,148 -19.89 479 27.73 0.0014
2019-11-12 2019-09-30 13F KRYSTAL BIOTECH COM 501147102 10,800 -1,301 -10.75 375 -23.00 0.0010
2019-08-14 2019-06-30 13F KRYSTAL BIOTECH COM 501147102 12,101 12,101 487 0.0016
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.