Lexicon Pharmaceuticals, Inc.
US ˙ NasdaqCM ˙ US5288723027

SecurityLXRX / Lexicon Pharmaceuticals, Inc.
InstitutionArtal Group S.A.
Latest Disclosed Ownership154,734,327 shares
Latest Disclosed Value $ 241,385,550
Artal Group S.A. reports 13.62% increase in ownership of LXRX / Lexicon Pharmaceuticals, Inc.

On May 14, 2026 - Artal Group S.A. filed a 13F-HR form disclosing ownership of 154,734,327 shares of Lexicon Pharmaceuticals, Inc. (US:LXRX) valued at $241,385,550 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 12, 2026 disclosing 136,180,481 shares of Lexicon Pharmaceuticals, Inc.. This represents a change in shares of 13.62% during the quarter. The current value of the position is $293,995,221 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-14 2026-03-31 13F Lexicon Pharmaceuticals COM NEW 528872302 154,734,327 18,553,846 13.62 241,386 54.13 23.8858
2026-02-12 2025-12-31 13F Lexicon Pharmaceuticals COM NEW 528872302 136,180,481 0 0.00 156,608 -14.81 21.9144
2025-11-12 2025-09-30 13F Lexicon Pharmaceuticals COM NEW 528872302 136,180,481 0 0.00 183,844 42.11 24.2467
2025-08-13 2025-06-30 13F Lexicon Pharmaceuticals COM NEW 528872302 136,180,481 0 0.00 129,371 106.52 13.9075
2025-05-14 2025-03-31 13F Lexicon Pharmaceuticals COM NEW 528872302 136,180,481 0 0.00 62,643 -37.84 7.0845
2025-02-14 2024-12-31 13F Lexicon Pharmaceuticals COM NEW 528872302 136,180,481 0 0.00 100,774 -52.87 8.5891
2024-11-13 2024-09-30 13F Lexicon Pharmaceuticals COM NEW 528872302 136,180,481 -38,918,903 -22.23 213,803 -27.32 8.9752
2024-08-14 2024-06-30 13F Lexicon Pharmaceuticals COM NEW 528872302 175,099,384 57,546,100 48.95 294,167 4.27 7.4993
2024-05-17 2024-03-31 13F/A-1 Lexicon Pharmaceuticals COM NEW 528872302 117,553,284 0 0.00 282,128 157,512.85 7.1879
2024-05-13 2024-03-31 13F Lexicon Pharmaceuticals COM NEW 528872302 117,553,284 0 282,128 7.1978
2024-02-09 2023-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 117,553,284 0 0.00 180 39.84 5.9791
2023-11-13 2023-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 117,553,284 0 0.00 128 -52.42 5.4937
2023-08-11 2023-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 117,553,284 27,775,050 30.94 269 23.39 8.3424
2023-05-12 2023-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 89,778,234 0 0.00 218 27.49 12.9633
2023-02-13 2022-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 89,778,234 0 0.00 171 -99.92 9.5710
2022-11-14 2022-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 89,778,234 18,599,870 26.13 215,468 62.75 9.1955
2022-08-11 2022-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 71,178,364 0 0.00 132,392 -11.00 7.0713
2022-05-12 2022-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 71,178,364 0 0.00 148,763 -46.95 6.2284
2022-02-11 2021-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 71,178,364 0 0.00 280,443 -18.09 7.6096
2021-11-12 2021-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 71,178,364 0 0.00 342,368 4.79 7.6603
2021-08-13 2021-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 71,178,364 0 0.00 326,708 -21.81 6.6309
2021-05-14 2021-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 71,178,364 0 0.00 417,817 71.64 7.3824
2021-02-11 2020-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 71,178,364 10,937,500 18.16 243,430 180.62 5.2259
2020-11-13 2020-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 60,240,864 0 0.00 86,746 -27.82 2.1059
2020-08-14 2020-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 60,240,864 0 0.00 120,181 2.31 3.3625
2020-05-14 2020-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 60,240,864 0 0.00 117,470 -53.01 4.9643
2020-02-13 2019-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 60,240,864 0 0.00 249,999 37.87 9.6583
2019-11-13 2019-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 60,240,864 0 0.00 181,325 -52.15 7.2700
2019-08-09 2019-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 60,240,864 0 0.00 378,915 13.13 15.3248
2019-05-10 2019-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 60,240,864 0 0.00 334,939 -16.27 13.6767
2019-02-11 2018-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 60,240,864 0 0.00 400,000 -37.77 14.8151
2018-11-09 2018-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 60,240,864 0 0.00 642,770 -11.08 16.7221
2018-08-10 2018-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 60,240,864 1,966,214 3.37 722,891 44.75 15.3640
2018-05-10 2018-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 58,274,650 0 0.00 499,413 -13.26 6.2496
2018-02-09 2017-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 58,274,650 756,673 1.32 575,754 -18.55 8.6844
2017-11-08 2017-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 57,517,977 0 0.00 706,896 -25.29 12.1770
2017-08-11 2017-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 57,517,977 0 0.00 946,170 14.71 16.5300
2017-05-15 2017-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 57,517,977 0 0.00 824,807 3.69 18.3083
2017-02-14 2016-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 57,517,977 0 0.00 795,474 -23.46 17.6580
2016-11-14 2016-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 57,517,977 0 0.00 1,039,349 25.92 20.5788
2016-08-11 2016-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 57,517,977 0 0.00 825,383 20.08 17.0374
2016-05-12 2016-03-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 57,517,977 0 0.00 687,340 -10.22 13.4080
2016-02-12 2015-12-31 13F LEXICON PHARMACEUTICALS COM NEW 528872302 57,517,977 -1 -0.00 765,564 23.93 14.3712
2015-11-13 2015-09-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 57,517,978 0 0.00 617,743 33.42 13.8019
2015-08-13 2015-06-30 13F LEXICON PHARMACEUTICALS COM NEW 528872302 57,517,978 -345,107,888 -85.71 463,019 22.33 19.9301
2015-05-13 2015-03-31 13F LEXICON PHARMACEUTICALS COM 528872104 402,625,866 0 0.00 378,492 3.30 17.4978
2015-02-13 2014-12-31 13F LEXICON PHARMACEUTICALS COM 528872104 402,625,866 149,253,731 58.91 366,389 2.56 12.8592
2014-11-13 2014-09-30 13F LEXICON PHARMACEUTICALS COM 528872104 253,372,135 0 0.00 357,255 -12.42 13.1479
2014-08-14 2014-06-30 13F LEXICON PHARMACEUTICALS COM 528872104 253,372,135 0 0.00 407,929 -6.94 16.4912
2014-05-15 2014-03-31 13F LEXICON PHARMACEUTICALS COM 528872104 253,372,135 0 0.00 438,334 -3.89 15.8667
2014-02-14 2013-12-31 13F LEXICON PHARMACEUTICALS COM 528872104 253,372,135 0 0.00 456,064 -24.37 16.3551
2013-11-14 2013-09-30 13F LEXICON PHARMACEUTICALS COM 528872104 253,372,135 0 0.00 603,026 9.68 19.6319
2013-08-13 2013-06-30 13F LEXICON PHARMACEUTICALS COM 528872104 253,372,135 253,372,135 549,818 17.2988
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.