Nautilus Biotechnology, Inc.
US ˙ NasdaqCM ˙ US63909J1088

SecurityNAUT / Nautilus Biotechnology, Inc.
InstitutionUBS Group AG
Latest Disclosed Ownership26,903 shares
Latest Disclosed Value $ 104,384
UBS Group AG reports 421.07% increase in ownership of NAUT / Nautilus Biotechnology, Inc.

On May 5, 2026 - UBS Group AG filed a 13F-HR form disclosing ownership of 26,903 shares of Nautilus Biotechnology, Inc. (US:NAUT) valued at $104,384 USD as of March 31, 2026. The entity filed a previous 13F-HR on January 29, 2026 disclosing 5,163 shares of Nautilus Biotechnology, Inc.. This represents a change in shares of 421.07% during the quarter. The current value of the position is $72,100 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-05 2026-03-31 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 26,903 21,740 421.07 104 940.00 0.0000
2026-01-29 2025-12-31 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 5,163 4,693 998.51 10 0.0000
2025-11-13 2025-09-30 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 470 -15,850 -97.12 0 -100.00 0.0000
2025-08-14 2025-06-30 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 16,320 -5,450 -25.03 12 -38.89 0.0000
2025-05-13 2025-03-31 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 21,770 -25,460 -53.91 19 -77.22 0.0000
2025-02-14 2024-12-31 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 47,230 19,449 70.01 79 0.00 0.0000
2024-11-14 2024-09-30 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 27,781 7,628 37.85 79 68.09 0.0000
2024-08-14 2024-06-30 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 20,153 -31,434 -60.93 47 -68.87 0.0000
2024-05-13 2024-03-31 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 51,587 -5,143 -9.07 152 -10.65 0.0000
2024-02-09 2023-12-31 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 56,730 28,999 104.57 170 94.25 0.0001
2023-11-09 2023-09-30 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 27,731 -2,833 -9.27 88 -26.27 0.0000
2023-08-11 2023-06-30 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 30,564 13,251 76.54 118 151.06 0.0000
2023-05-12 2023-03-31 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 17,313 2,864 19.82 48 80.77 0.0000
2023-02-08 2022-12-31 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 14,449 14,449 26 0.0000
2022-08-10 2022-06-30 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 0 -804 -100.00 0 -100.00
2022-05-16 2022-03-31 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 804 -4,827 -85.72 3 -90.00 0.0000
2022-02-14 2021-12-31 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 5,631 -31,682 -84.91 30 -86.90 0.0000
2021-11-15 2021-09-30 13F NAUTILUS BIOTECHNOLOGY COM 63909J108 37,313 37,210 36,126.21 229 11,350.00 0.0001
2020-07-31 2020-06-30 13F ARYA SCIENCES ACQUISITION UNIT 10/04/2023 G3165V117 103 -113 -52.31 2 0.00 0.0000
2020-07-31 2020-06-30 13F ARYA SCIENCES ACQUISITION *W EXP 10/10/202 G3165V125 2,015 1,912 11 4.6451
2020-07-31 2020-06-30 13F ARYA SCIENCES ACQUISITION SHS CL A G3165V109 509 293 8 0.0000
2020-05-01 2020-03-31 13F ARYA SCIENCES ACQUISITION UNIT 10/04/2023 G3165V117 216 100 86.21 2 100.00 0.0000
2020-02-14 2019-12-31 13F ARYA SCIENCES ACQUISITION UNIT 10/04/2023 G3165V117 116 0 0.00 1 0.00 0.0000
2020-02-14 2019-12-31 13F ARYA SCIENCES ACQUISITION SHS CL A G3165V109 24 -92 0
2019-11-14 2019-09-30 13F ARYA SCIENCES ACQUISITION UNIT 10/04/2023 G3165V117 116 -1,200 -91.19 1 -92.86 0.0000
2019-08-14 2019-06-30 13F ARYA SCIENCES ACQUISITION UNIT 10/04/2023 G3165V117 1,316 -1,724 -56.71 14 -54.84 0.0000
2019-05-14 2019-03-31 13F ARYA SCIENCES ACQUISITION UNIT 10/04/2023 G3165V117 3,040 2,200 261.90 31 244.44 0.0000
2019-02-14 2018-12-31 13F ARYA SCIENCES ACQUISITION UNIT 10/04/2023 G3165V117 840 840 9 0.0000
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.