OPKO Health, Inc.
US ˙ NasdaqGS ˙ US68375N1037

SecurityOPK / OPKO Health, Inc.
InstitutionEngineers Gate Manager LP
Latest Disclosed Ownership0 shares
Latest Disclosed Value $ 0
Engineers Gate Manager LP closes position in OPK / OPKO Health, Inc.

On November 14, 2025 - Engineers Gate Manager LP filed a 13F-HR form disclosing ownership of 0 shares of OPKO Health, Inc. (US:OPK) valued at $0 USD as of September 30, 2025. The entity filed a previous 13F-HR on August 14, 2025 disclosing 55,124 shares of OPKO Health, Inc.. The current value of the position is $0 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2025-11-14 2025-09-30 13F OPKO HEALTH COM 68375N103 0 -100.00 0
2025-08-14 2025-06-30 13F OPKO HEALTH COM 68375N103 55,124 -161,233 -74.52 73 -79.94 0.0009
2025-05-15 2025-03-31 13F OPKO HEALTH COM 68375N103 216,357 -198,096 -47.80 359 -41.05 0.0061
2025-02-14 2024-12-31 13F OPKO HEALTH COM 68375N103 414,453 -11,589 -2.72 609 -3.94 0.0106
2024-11-14 2024-09-30 13F OPKO HEALTH COM 68375N103 426,042 -71,660 -14.40 635 1.93 0.0124
2024-08-14 2024-06-30 13F OPKO HEALTH COM 68375N103 497,702 5,655 1.15 622 5.42 0.0140
2024-05-15 2024-03-31 13F OPKO HEALTH COM 68375N103 492,047 171,628 53.56 590 22.15 0.0155
2024-02-14 2023-12-31 13F OPKO HEALTH COM 68375N103 320,419 -27,107 -7.80 484 -13.13 0.0138
2023-11-14 2023-09-30 13F OPKO HEALTH COM 68375N103 347,526 25,432 7.90 556 -20.34 0.0206
2023-08-14 2023-06-30 13F OPKO HEALTH COM 68375N103 322,094 16,436 5.38 699 56.50 0.0264
2023-05-15 2023-03-31 13F OPKO HEALTH COM 68375N103 305,658 -10,687 -3.38 446 12.91 0.0186
2023-02-14 2022-12-31 13F OPKO HEALTH COM 68375N103 316,345 3,235 1.03 395 -33.28 0.0238
2022-11-14 2022-09-30 13F OPKO HEALTH COM 68375N103 313,110 88,486 39.39 592 4.23 0.0368
2022-08-15 2022-06-30 13F OPKO HEALTH COM 68375N103 224,624 152,935 213.33 568 129.96 0.0208
2022-05-16 2022-03-31 13F OPKO HEALTH COM 68375N103 71,689 32,294 81.97 247 30.69 0.0097
2022-02-14 2021-12-31 13F OPKO HEALTH COM 68375N103 39,395 -44,776 -53.20 189 -38.44 0.0085
2021-11-15 2021-09-30 13F OPKO HEALTH COM 68375N103 84,171 6,385 8.21 307 -2.54 0.0175
2021-08-16 2021-06-30 13F OPKO HEALTH COM 68375N103 77,786 31,423 67.78 315 58.29 0.0203
2021-05-17 2021-03-31 13F OPKO HEALTH COM 68375N103 46,363 -37,797 -44.91 199 -40.06 0.0099
2021-02-16 2020-12-31 13F OPKO HEALTH COM 68375N103 84,160 -139,668 -62.40 332 -59.81 0.0144
2020-11-16 2020-09-30 13F OPKO HEALTH COM 68375N103 223,828 146,228 188.44 826 211.70 0.0388
2020-08-17 2020-06-30 13F OPKO HEALTH COM 68375N103 77,600 14,200 22.40 265 211.76 0.0135
2020-05-15 2020-03-31 13F OPKO HEALTH COM 68375N103 63,400 34,690 120.83 85 102.38 0.0061
2020-02-14 2019-12-31 13F OPKO HEALTH COM 68375N103 28,710 -23,329 -44.83 42 -61.47 0.0018
2019-11-14 2019-09-30 13F OPKO HEALTH COM 68375N103 52,039 52,039 81.26 109 159.52 0.0055
2018-08-03 2018-06-30 13F OPKO HEALTH COM 68375N103 0 -148,707 -100.00 0 -100.00
2018-05-07 2018-03-31 13F OPKO HEALTH COM 68375N103 148,707 148,707 471 0.0314
2017-11-13 2017-09-30 13F OPKO HEALTH COM 68375N103 0 -17,807 -100.00 0 -100.00
2017-08-10 2017-06-30 13F OPKO HEALTH COM 68375N103 17,807 17,807 117 0.0105
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.