OraSure Technologies, Inc.
US ˙ NasdaqGS ˙ US68554V1089

SecurityOSUR / OraSure Technologies, Inc.
InstitutionD. E. Shaw & Co., Inc.
ManagerDE Shaw
Latest Disclosed Ownership1,382,388 shares
Latest Disclosed Value $ 4,147,164
D. E. Shaw & Co., Inc. reports 17.00% decrease in ownership of OSUR / OraSure Technologies, Inc.

On May 15, 2026 - D. E. Shaw & Co., Inc. filed a 13F-HR form disclosing ownership of 1,382,388 shares of OraSure Technologies, Inc. (US:OSUR) valued at $4,147,164 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 1,665,532 shares of OraSure Technologies, Inc.. This represents a change in shares of -17.00% during the quarter. The current value of the position is $5,460,433 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F ORASURE TECHNOLOGIES COM 68554V108 1,382,388 -283,144 -17.00 4,147 2.90 0.0025
2026-02-17 2025-12-31 13F ORASURE TECHNOLOGIES COM 68554V108 1,665,532 -24,139 -1.43 4,031 -25.69 0.0022
2025-11-14 2025-09-30 13F ORASURE TECHNOLOGIES COM 68554V108 1,689,671 34,405 2.08 5,424 9.22 0.0031
2025-08-14 2025-06-30 13F ORASURE TECHNOLOGIES COM 68554V108 1,655,266 -84,147 -4.84 4,966 -15.29 0.0035
2025-05-15 2025-03-31 13F ORASURE TECHNOLOGIES COM 68554V108 1,739,413 221,872 14.62 5,862 6.99 0.0052
2025-02-14 2024-12-31 13F ORASURE TECHNOLOGIES COM 68554V108 1,517,541 976,475 180.47 5,478 137.14 0.0040
2024-11-14 2024-09-30 13F ORASURE TECHNOLOGIES COM 68554V108 541,066 111,207 25.87 2,310 26.16 0.0020
2024-08-14 2024-06-30 13F ORASURE TECHNOLOGIES COM 68554V108 429,859 267,520 164.79 1,831 83.47 0.0017
2024-05-15 2024-03-31 13F ORASURE TECHNOLOGIES COM 68554V108 162,339 -127,392 -43.97 998 -57.98 0.0009
2024-02-14 2023-12-31 13F ORASURE TECHNOLOGIES COM 68554V108 289,731 64,486 28.63 2,376 77.90 0.0021
2023-11-14 2023-09-30 13F ORASURE TECHNOLOGIES COM 68554V108 225,245 -245,193 -52.12 1,336 -43.34 0.0014
2023-08-14 2023-06-30 13F ORASURE TECHNOLOGIES COM 68554V108 470,438 -119,128 -20.21 2,357 -33.93 0.0024
2023-05-15 2023-03-31 13F ORASURE TECHNOLOGIES COM 68554V108 589,566 12,692 2.20 3,567 28.27 0.0038
2023-02-14 2022-12-31 13F ORASURE TECHNOLOGIES COM 68554V108 576,874 185,352 47.34 2,781 87.33 0.0031
2022-11-14 2022-09-30 13F ORASURE TECHNOLOGIES COM 68554V108 391,522 333,807 578.37 1,484 851.28 0.0018
2022-08-15 2022-06-30 13F ORASURE TECHNOLOGIES COM 68554V108 57,715 57,715 156 0.0002
2021-05-17 2021-03-31 13F ORASURE TECHNOLOGIES COM 68554V108 0 -74,496 -100.00 0 -100.00
2021-02-16 2020-12-31 13F ORASURE TECHNOLOGIES COM 68554V108 74,496 -310,919 -80.67 789 -83.18 0.0007
2020-11-16 2020-09-30 13F ORASURE TECHNOLOGIES COM 68554V108 385,415 -1,888,541 -83.05 4,690 -82.27 0.0048
2020-08-14 2020-06-30 13F ORASURE TECHNOLOGIES COM 68554V108 2,273,956 -686,544 -23.19 26,447 -16.98 0.0315
2020-05-15 2020-03-31 13F ORASURE TECHNOLOGIES COM 68554V108 2,960,500 -21,055 -0.71 31,855 33.05 0.0497
2020-02-14 2019-12-31 13F ORASURE TECHNOLOGIES COM 68554V108 2,981,555 -62,563 -2.06 23,942 5.29 0.0274
2019-11-14 2019-09-30 13F ORASURE TECHNOLOGIES COM 68554V108 3,044,118 72,252 2.43 22,740 -17.55 0.0280
2019-08-14 2019-06-30 13F ORASURE TECHNOLOGIES COM 68554V108 2,971,866 1,193,709 67.13 27,579 39.10 0.0344
2019-05-15 2019-03-31 13F ORASURE TECHNOLOGIES COM 68554V108 1,778,157 920,123 107.24 19,827 97.83 0.0256
2019-02-14 2018-12-31 13F ORASURE TECHNOLOGIES COM 68554V108 858,034 85,188 11.02 10,022 -16.06 0.0138
2018-11-14 2018-09-30 13F ORASURE TECHNOLOGIES COM 68554V108 772,846 447,315 137.41 11,940 122.72 0.0143
2018-08-14 2018-06-30 13F ORASURE TECHNOLOGIES COM 68554V108 325,531 57,496 21.45 5,361 18.42 0.0070
2018-05-15 2018-03-31 13F ORASURE TECHNOLOGIES COM 68554V108 268,035 -90,745 -25.29 4,527 -33.09 0.0062
2018-02-14 2017-12-31 13F ORASURE TECHNOLOGIES COM 68554V108 358,780 -446,316 -55.44 6,766 -62.65 0.0093
2017-11-14 2017-09-30 13F ORASURE TECHNOLOGIES COM 68554V108 805,096 -118,696 -12.85 18,114 13.60 0.0278
2017-08-14 2017-06-30 13F ORASURE TECHNOLOGIES COM 68554V108 923,792 152,708 19.80 15,945 59.93 0.0264
2017-05-15 2017-03-31 13F ORASURE TECHNOLOGIES COM 68554V108 771,084 168,513 27.97 9,970 88.47 0.0175
2017-02-14 2016-12-31 13F ORASURE TECHNOLOGIES COM 68554V108 602,571 -276,341 -31.44 5,290 -24.48 0.0090
2016-11-14 2016-09-30 13F ORASURE TECHNOLOGIES COM 68554V108 878,912 403,408 84.84 7,005 149.29 0.0124
2016-08-15 2016-06-30 13F ORASURE TECHNOLOGIES COM 68554V108 475,504 210,041 79.12 2,810 46.43 0.0052
2016-05-16 2016-03-31 13F ORASURE TECHNOLOGIES COM 68554V108 265,463 234,823 766.39 1,919 874.11 0.0034
2016-02-16 2015-12-31 13F ORASURE TECHNOLOGIES COM 68554V108 30,640 16,682 119.52 197 217.74 0.0003
2015-11-16 2015-09-30 13F ORASURE TECHNOLOGIES COM 68554V108 13,958 -57,533 -80.48 62 -83.90 0.0001
2015-08-14 2015-06-30 13F ORASURE TECHNOLOGIES COM 68554V108 71,491 -135,371 -65.44 385 -71.54 0.0006
2015-05-15 2015-03-31 13F ORASURE TECHNOLOGIES COM 68554V108 206,862 154,473 294.86 1,353 154.80 0.0021
2015-02-17 2014-12-31 13F ORASURE TECHNOLOGIES COM 68554V108 52,389 15,428 41.74 531 98.88 0.0007
2014-11-14 2014-09-30 13F ORASURE TECHNOLOGIES COM 68554V108 36,961 20,810 128.85 267 92.09 0.0003
2014-08-14 2014-06-30 13F ORASURE TECHNOLOGIES COM 68554V108 16,151 -1,463 -8.31 139 -0.71 0.0002
2014-05-15 2014-03-31 13F ORASURE TECHNOLOGIES COM 68554V108 17,614 -183,146 -91.23 140 -88.92 0.0002
2014-02-14 2013-12-31 13F ORASURE TECHNOLOGIES COM 68554V108 200,760 -32,628 -13.98 1,263 -9.98 0.0017
2013-11-20 2013-09-30 13F/A-1 ORASURE TECHNOLOGIES COM 68554V108 233,388 65,751 39.22 1,403 115.85 0.0022
2013-11-14 2013-09-30 13F ORASURE TECHNOLOGIES COM 68554V108 233,388 1,403
2013-08-14 2013-06-30 13F ORASURE TECHNOLOGIES COM 68554V108 167,637 167,637 650 0.0012
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.