Replimune Group, Inc.
US ˙ NasdaqGS ˙ US76029N1063

SecurityREPL / Replimune Group, Inc.
InstitutionD. E. Shaw & Co., Inc.
ManagerDE Shaw
Latest Disclosed Ownership2,336,528 shares
Latest Disclosed Value $ 17,874,440
D. E. Shaw & Co., Inc. reports 9.26% decrease in ownership of REPL / Replimune Group, Inc.

On May 15, 2026 - D. E. Shaw & Co., Inc. filed a 13F-HR form disclosing ownership of 2,336,528 shares of Replimune Group, Inc. (US:REPL) valued at $17,874,439 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 2,575,042 shares of Replimune Group, Inc.. This represents a change in shares of -9.26% during the quarter. The current value of the position is $23,318,549 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F REPLIMUNE GROUP COM 76029N106 2,336,528 -238,514 -9.26 17,874 -28.59 0.0107
2026-02-17 2025-12-31 13F REPLIMUNE GROUP COM 76029N106 2,575,042 2,171,547 538.18 25,029 1,381.01 0.0137
2025-11-14 2025-09-30 13F REPLIMUNE GROUP COM 76029N106 403,495 -103,101 -20.35 1,691 -64.09 0.0010
2025-08-14 2025-06-30 13F REPLIMUNE GROUP COM 76029N106 506,596 -289,984 -36.40 4,706 -39.40 0.0033
2025-05-15 2025-03-31 13F REPLIMUNE GROUP COM 76029N106 796,580 -175,995 -18.10 7,767 -34.06 0.0069
2025-02-14 2024-12-31 13F REPLIMUNE GROUP COM 76029N106 972,575 104,892 12.09 11,778 23.85 0.0086
2024-11-14 2024-09-30 13F REPLIMUNE GROUP COM 76029N106 867,683 -64,097 -6.88 9,510 13.39 0.0082
2024-08-14 2024-06-30 13F REPLIMUNE GROUP COM 76029N106 931,780 -66,006 -6.62 8,386 2.88 0.0078
2024-05-15 2024-03-31 13F REPLIMUNE GROUP COM 76029N106 997,786 754,780 310.60 8,152 298.00 0.0070
2024-02-14 2023-12-31 13F REPLIMUNE GROUP COM 76029N106 243,006 162,303 201.11 2,049 48.41 0.0018
2023-11-14 2023-09-30 13F REPLIMUNE GROUP COM 76029N106 80,703 -6,879 -7.85 1,381 -32.12 0.0014
2023-08-14 2023-06-30 13F REPLIMUNE GROUP COM 76029N106 87,582 -48,557 -35.67 2,034 -15.43 0.0021
2023-05-15 2023-03-31 13F REPLIMUNE GROUP COM 76029N106 136,139 7,170 5.56 2,404 -31.45 0.0026
2023-02-14 2022-12-31 13F REPLIMUNE GROUP COM 76029N106 128,969 128,969 3,508 0.0039
2022-08-15 2022-06-30 13F REPLIMUNE GROUP COM 76029N106 0 -18,922 -100.00 0 -100.00
2022-05-16 2022-03-31 13F REPLIMUNE GROUP COM 76029N106 18,922 18,922 321 0.0003
2021-08-16 2021-06-30 13F REPLIMUNE GROUP COM 76029N106 0 -121,257 -100.00 0 -100.00
2021-05-17 2021-03-31 13F REPLIMUNE GROUP COM 76029N106 121,257 14,098 13.16 3,700 -9.49 0.0036
2021-02-16 2020-12-31 13F REPLIMUNE GROUP COM 76029N106 107,159 79,163 282.77 4,088 534.78 0.0037
2020-11-16 2020-09-30 13F REPLIMUNE GROUP COM 76029N106 27,996 27,996 644 0.0007
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.