Replimune Group, Inc.
US ˙ NasdaqGS ˙ US76029N1063

SecurityREPL / Replimune Group, Inc.
InstitutionTwo Sigma Advisers, Lp
Latest Disclosed Ownership30,700 shares
Latest Disclosed Value $ 298,404
Two Sigma Advisers, Lp ownership in REPL / Replimune Group, Inc.

On February 17, 2026 - Two Sigma Advisers, Lp filed a 13F-HR form disclosing ownership of 30,700 shares of Replimune Group, Inc. (US:REPL) valued at $298,404 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 14, 2025 disclosing 0 shares of Replimune Group, Inc.. The current value of the position is $302,395 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-02-17 2025-12-31 13F REPLIMUNE GROUP COM 76029N106 30,700 30,700 298 0.0006
2025-11-14 2025-09-30 13F REPLIMUNE GROUP COM 76029N106 0 -100.00 0
2025-08-14 2025-06-30 13F REPLIMUNE GROUP COM 76029N106 11,100 -8,500 -43.37 103 -46.07 0.0002
2025-05-15 2025-03-31 13F REPLIMUNE GROUP COM 76029N106 19,600 -150,800 -88.50 191 -90.74 0.0004
2025-02-14 2024-12-31 13F REPLIMUNE GROUP COM 76029N106 170,400 -18,000 -9.55 2,064 -0.05 0.0048
2024-11-14 2024-09-30 13F REPLIMUNE GROUP COM 76029N106 188,400 -21,300 -10.16 2,065 9.38 0.0048
2024-08-14 2024-06-30 13F REPLIMUNE GROUP COM 76029N106 209,700 -12,900 -5.80 1,887 3.80 0.0042
2024-05-15 2024-03-31 13F REPLIMUNE GROUP COM 76029N106 222,600 19,900 9.82 1,819 6.44 0.0042
2024-02-14 2023-12-31 13F REPLIMUNE GROUP COM 76029N106 202,700 -18,700 -8.45 1,709 -54.91 0.0040
2023-11-14 2023-09-30 13F REPLIMUNE GROUP COM 76029N106 221,400 -57,600 -20.65 3,788 -41.53 0.0097
2023-08-14 2023-06-30 13F REPLIMUNE GROUP COM 76029N106 279,000 52,900 23.40 6,478 62.27 0.0165
2023-05-15 2023-03-31 13F REPLIMUNE GROUP COM 76029N106 226,100 114,200 102.06 3,993 31.19 0.0103
2023-02-14 2022-12-31 13F REPLIMUNE GROUP COM 76029N106 111,900 -10,800 -8.80 3,044 43.61 0.0085
2022-11-14 2022-09-30 13F REPLIMUNE GROUP COM 76029N106 122,700 -12,500 -9.25 2,119 -10.33 0.0061
2022-08-15 2022-06-30 13F REPLIMUNE GROUP COM 76029N106 135,200 -59,700 -30.63 2,363 -28.59 0.0067
2022-05-16 2022-03-31 13F REPLIMUNE GROUP COM 76029N106 194,900 69,700 55.67 3,309 -2.48 0.0088
2022-02-14 2021-12-31 13F REPLIMUNE GROUP COM 76029N106 125,200 -75,800 -37.71 3,393 -43.05 0.0085
2021-11-15 2021-09-30 13F REPLIMUNE GROUP COM 76029N106 201,000 -49,100 -19.63 5,958 -38.00 0.0154
2021-08-16 2021-06-30 13F REPLIMUNE GROUP COM 76029N106 250,100 -56,300 -18.37 9,609 2.79 0.0253
2021-05-17 2021-03-31 13F REPLIMUNE GROUP COM 76029N106 306,400 85,600 38.77 9,348 10.97 0.0257
2021-02-16 2020-12-31 13F REPLIMUNE GROUP COM 76029N106 220,800 182,600 478.01 8,424 858.36 0.0225
2020-11-16 2020-09-30 13F REPLIMUNE GROUP COM 76029N106 38,200 38,200 879 0.0025
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.