Spero Therapeutics, Inc.
US ˙ NasdaqGS ˙ US84833T1034

SecuritySPRO / Spero Therapeutics, Inc.
InstitutionCitigroup Inc
Latest Disclosed Ownership19,135 shares
Latest Disclosed Value $ 44,776
Citigroup Inc reports 112,458.82% increase in ownership of SPRO / Spero Therapeutics, Inc.

On May 11, 2026 - Citigroup Inc filed a 13F-HR form disclosing ownership of 19,135 shares of Spero Therapeutics, Inc. (US:SPRO) valued at $44,776 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 13, 2026 disclosing 17 shares of Spero Therapeutics, Inc.. The current value of the position is $57,022 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date
Effective
Date
Form Security Class ID Avg Price
Paid (Est)
Reported
Shares
ΔShares ΔShares
(%)
Reported
Value
(x1000)
ΔValue
(%)
Alloc
(%)
ΔAlloc ΔAlloc (%) Cost Basis
(x1000)
Unrealized
Gain/Loss
(x1000)
2026-05-11 2026-03-31 13F SPERO THERAPEUTICS COM 84833T103 19,135 19,118 112,458.82 45 0.0000
2026-02-13 2025-12-31 13F SPERO THERAPEUTICS COM 84833T103 17 17 0 0.0000
2023-02-09 2022-12-31 13F SPERO THERAPEUTICS COM 84833T103 0 -495 -100.00 0 -100.00
2022-11-10 2022-09-30 13F SPERO THERAPEUTICS COM 84833T103 495 -13,867 -96.55 1 -90.91 0.0000
2022-08-10 2022-06-30 13F SPERO THERAPEUTICS COM 84833T103 14,362 12,781 808.41 11 -21.43 0.0000
2022-05-12 2022-03-31 13F SPERO THERAPEUTICS COM 84833T103 1,581 -31,323 -95.20 14 -97.34 0.0000
2022-02-10 2021-12-31 13F SPERO THERAPEUTICS COM 84833T103 32,904 16,819 104.56 527 78.04 0.0003
2021-11-10 2021-09-30 13F SPERO THERAPEUTICS COM 84833T103 16,085 -23,245 -59.10 296 -46.08 0.0002
2021-08-10 2021-06-30 13F SPERO THERAPEUTICS COM 84833T103 39,330 -46,618 -54.24 549 -56.60 0.0003
2021-05-13 2021-03-31 13F SPERO THERAPEUTICS COM 84833T103 85,948 80,845 1,584.26 1,265 1,177.78 0.0008
2021-02-11 2020-12-31 13F SPERO THERAPEUTICS COM 84833T103 5,103 3,483 215.00 99 450.00 0.0001
2020-11-12 2020-09-30 13F SPERO THERAPEUTICS COM 84833T103 1,620 -1,356 -45.56 18 -55.00 0.0000
2020-08-12 2020-06-30 13F SPERO THERAPEUTICS COM 84833T103 2,976 -1,066 -26.37 40 21.21 0.0000
2020-05-12 2020-03-31 13F SPERO THERAPEUTICS COM 84833T103 4,042 1,644 68.56 33 43.48 0.0000
2020-02-12 2019-12-31 13F SPERO THERAPEUTICS COM 84833T103 2,398 1,108 85.89 23 64.29 0.0000
2019-11-08 2019-09-30 13F SPERO THERAPEUTICS COM 84833T103 1,290 -1,339 -50.93 14 -54.84 0.0000
2019-08-12 2019-06-30 13F SPERO THERAPEUTICS COM 84833T103 2,629 625 31.19 31 24.00 0.0000
2019-05-13 2019-03-31 13F SPERO THERAPEUTICS COM 84833T103 2,004 -256 -11.33 25 78.57 0.0000
2019-02-12 2018-12-31 13F SPERO THERAPEUTICS COM 84833T103 2,260 -73 -3.13 14 -41.67 0.0000
2018-11-13 2018-09-30 13F SPERO THERAPEUTICS COM 84833T103 2,333 1,018 77.41 24 26.32 0.0000
2018-08-10 2018-06-30 13F SPERO THERAPEUTICS COM 84833T103 1,315 513 63.97 19 72.73 0.0000
2018-05-11 2018-03-31 13F SPERO THERAPEUTICS COM 84833T103 802 121 17.77 11 37.50 0.0000
2018-02-12 2017-12-31 13F SPERO THERAPEUTICS COM 84833T103 681 681 8 0.0000
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.