Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionComerica Bank
Latest Disclosed Ownership67,686 shares
Latest Disclosed Value $ 30,686,265
Comerica Bank reports 0.50% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On January 29, 2026 - Comerica Bank filed a 13F-HR form disclosing ownership of 67,686 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $30,686,125 USD as of December 31, 2025. The entity filed a previous 13F-HR on November 14, 2025 disclosing 68,025 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -0.50% during the quarter. The current value of the position is $29,899,614 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-01-29 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 67,686 -339 -0.50 30,686 15.18 0.1224
2025-11-14 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 68,025 3,350 5.18 26,641 -7.47 0.1002
2025-08-14 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 64,675 -746 -1.14 28,793 -9.22 0.1118
2025-05-14 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 65,421 15,843 31.96 31,717 58.86 0.1332
2025-02-14 2024-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 49,578 -4,045 -7.54 19,965 -19.94 0.0805
2025-02-14 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 49,578 -4,045 19,965 0.0669
2024-11-14 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 53,623 893 1.69 24,939 0.91 0.0986
2024-08-15 2024-06-30 13F VERTEX PHARMACEUTICALS COMMON 92532F100 52,730 -1,650 -3.03 24,716 8.73 0.1029
2024-05-16 2024-03-31 13F VERTEX PHARMACEUTICALS COMMON 92532F100 54,380 -3,706 -6.38 22,732 -3.82 0.0980
2024-02-14 2023-12-31 13F VERTEX PHARMACEUTICALS COMMON 92532F100 58,086 -2,070 -3.44 23,635 12.98 0.1089
2023-11-21 2023-09-30 13F VERTEX PHARMACEUTICALS COMMON 92532F100 60,156 42,333 237.52 20,919 0.1090
2023-08-22 2023-06-30 13F VERTEX PHARMACEUTICALS EQU 92532F100 17,823 -20,913 -53.99 0 -100.00 0.0093
2023-01-26 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 38,736 3,190 8.97 12 -99.89 0.0940
2022-10-28 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 35,546 1,063 3.08 11,037 10.52 0.0930
2022-08-02 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 34,483 -136 -0.39 9,986 1.10 0.0820
2022-04-27 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 34,619 294 0.86 9,877 26.71 0.0717
2022-02-18 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 34,325 -52,411 -60.43 7,795 -52.70 0.0574
2021-11-22 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 86,736 37,937 77.74 16,479 73.14 0.0992
2021-08-26 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 48,799 -1,552 -3.08 9,518 -13.24 0.0568
2021-04-28 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 50,351 -685 -1.34 10,971 -9.52 0.0654
2021-01-28 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 51,036 -5,189 -9.23 12,126 1.93 0.0769
2020-10-30 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 56,225 1,309 2.38 11,896 -25.62 0.0864
2020-07-31 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 54,916 2,364 4.50 15,993 12.77 0.1232
2020-05-01 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 52,552 -388 -0.73 14,182 16.31 0.1301
2020-02-07 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 52,940 -3,264 -5.81 12,193 11.56 0.0924
2019-10-31 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 56,204 560 1.01 10,930 10.89 0.0864
2019-08-02 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 55,644 1,063 1.95 9,857 -5.13 0.0789
2019-05-02 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 54,581 -191 -0.35 10,390 1.78 0.0842
2019-02-06 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 54,772 -353 -0.64 10,208 6.32 0.0867
2018-11-01 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 55,125 -14,899 -21.28 9,601 -24.90 0.0774
2018-08-01 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 70,024 106 0.15 12,785 14.61 0.0894
2018-05-01 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 69,918 -1,296 -1.82 11,155 -6.46 0.0797
2018-02-02 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 71,214 10,801 17.88 11,925 32.00 0.0794
2017-11-06 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 60,413 669 1.12 9,034 -8.97 0.0654
2017-08-03 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 59,744 -275 -0.46 9,924 40.83 0.0743
2017-05-03 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 60,019 -898 -1.47 7,047 39.10 0.0535
2017-02-08 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 60,917 1,940 3.29 5,066 -16.47 0.0401
2016-08-11 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 58,977 -814 -1.36 6,065 24.08 0.0524
2016-05-11 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 59,791 864 1.47 4,888 -25.08 0.0436
2016-02-05 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 58,927 -1,891 -3.11 6,524 3.00 0.0640
2015-11-12 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 60,818 -63,672 -51.15 6,334 -58.80 0.0600
2015-08-13 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 124,490 60,715 95.20 15,372 104.31 0.0660
2015-05-15 2015-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 63,775 -61,701 -49.17 7,524 -49.52 0.0637
2015-02-13 2014-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 125,476 61,520 96.19 14,906 107.52 0.0645
2014-10-21 2014-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 63,956 -2,779 -4.16 7,183 13.67 0.0634
2014-08-12 2014-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 66,735 -19,328 -22.46 6,319 3.81 0.0537
2014-05-15 2014-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 86,063 324 0.38 6,087 -4.46 0.0466
2014-02-11 2013-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 85,739 -16,649 -16.26 6,371 -17.93 0.0494
2013-11-12 2013-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 102,388 102,388 7,763 0.0540
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.