Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionMorgan Stanley
Latest Disclosed Ownership3,188,881 shares
Latest Disclosed Value $ 1,423,964,743
Morgan Stanley reports 2.20% increase in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 15, 2026 - Morgan Stanley filed a 13F-HR form disclosing ownership of 3,188,881 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $1,423,962,922 USD as of March 31, 2026. The entity filed a previous 13F-HR/A on May 27, 2026 disclosing 3,120,310 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of 2.20% during the quarter. The current value of the position is $1,365,925,288 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,188,881 68,571 2.20 1,423,965 0.66 0.0858
2026-05-27 2025-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 3,120,310 11,905 0.38 1,414,625 16.20 0.0845
2026-02-13 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,120,310 11,905 1,414,625 0.0845
2026-05-27 2025-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 3,108,405 -223,034 -6.69 1,217,377 -17.92 0.0737
2025-11-14 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,108,405 -223,034 1,217,377 0.0737
2025-08-15 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,331,439 -77,081 -2.26 1,483,158 -10.25 0.0966
2025-05-15 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,408,520 237,133 7.48 1,652,521 29.39 0.1182
2025-05-15 2024-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 3,171,387 132,950 4.38 1,277,118 -9.62 0.0895
2025-02-14 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,171,387 132,950 1,277,118 0.0895
2025-05-14 2024-09-30 13F/A-2 VERTEX PHARMACEUTICALS COM 92532F100 3,038,437 -220,191 -6.76 1,413,118 -7.48 0.1025
2025-02-14 2024-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 3,038,437 -220,191 1,413,118 0.1025
2024-11-14 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,038,437 -220,191 1,413,118 0.0122
2025-05-14 2024-06-30 13F/A-2 VERTEX PHARMACEUTICALS COM 92532F100 3,258,628 74,162 2.33 1,527,386 14.74 0.1182
2024-10-17 2024-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 3,258,628 74,162 1,527,386 0.1182
2024-08-14 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,258,628 74,162 1,527,386 0.1182
2024-10-17 2024-03-31 13F/A-2 VERTEX PHARMACEUTICALS COM 92532F100 3,184,466 204,011 6.84 1,331,140 9.76 0.1068
2024-08-16 2024-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 3,184,466 204,011 1,331,140 0.1068
2024-05-15 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,184,466 204,011 1,331,140 0.1068
2024-08-16 2023-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 2,980,455 110,354 3.84 1,212,719 21.51 0.1069
2024-02-13 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,980,455 110,354 1,212,719 0.1069
2023-11-15 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,870,101 89,217 3.21 998,050 1.99 0.1015
2023-08-14 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,780,884 427,823 18.18 978,622 32.00 0.0965
2023-05-15 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,353,061 -225,383 -8.74 741,380 -0.43 0.0795
2023-02-14 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,578,444 640,899 33.08 744,603 32.73 0.0846
2022-11-14 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,937,545 110,320 6.04 560,996 8.95 0.0765
2022-10-27 2022-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 1,827,225 1,001,376 121.25 514,894 138.91 0.0668
2022-08-15 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,827,225 1,001,376 514,894 0.0668
2022-10-27 2022-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 825,849 -143,958 -14.84 215,521 1.20 0.0291
2022-05-13 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 825,849 -143,958 215,521 0.0291
2022-02-14 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 969,807 -72,706 -6.97 212,970 12.62 0.0263
2021-11-15 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,042,513 -178,813 -14.64 189,100 -23.21 0.0255
2021-08-23 2021-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 1,221,326 325,944 36.40 246,259 27.99 0.0325
2021-08-16 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,221,326 325,944 246,259 0.0068
2021-05-17 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 895,382 -22,466 -2.45 192,407 -11.30 0.0283
2021-02-16 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 917,848 144,325 18.66 216,924 3.06 0.0335
2020-11-13 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 773,523 84,605 12.28 210,491 5.25 0.0407
2020-08-14 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 688,918 13,423 1.99 200,000 24.43 0.0443
2020-05-26 2020-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 675,495 -95,051 -12.34 160,733 -4.73 0.0437
2020-05-15 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 675,495 -95,051 160,733 12,347.6451
2020-02-14 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 770,546 204,727 36.18 168,710 75.99 0.0392
2019-11-14 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 565,819 17,022 3.10 95,862 -4.74 0.0254
2019-08-14 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 548,797 37,505 7.34 100,637 7.00 0.0268
2019-05-15 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 511,292 -235,848 -31.57 94,052 -24.03 0.0266
2019-02-14 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 747,140 56,373 8.16 123,808 -7.01 0.0370
2019-04-23 2018-09-30 13F/A-2 VERTEX PHARMACEUTICALS COM 92532F100 690,767 69,242 11.14 133,137 26.03 0.0333
2018-11-20 2018-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 690,767 0 133,137 0.0333
2018-11-14 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 690,767 69,242 133,137
2019-04-23 2018-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 621,525 -171,161 -21.59 105,636 -18.23 0.0285
2018-08-14 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 621,525 -171,161 105,636
2019-04-23 2018-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 792,686 -503,385 -38.84 129,192 -33.48 0.0359
2018-05-14 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 792,686 -503,385 129,192
2019-04-23 2017-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 1,296,071 461,814 55.36 194,229 53.13 0.0532
2018-02-14 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,296,071 461,814 194,229
2017-11-14 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 834,257 -830,154 -49.88 126,841 -40.86 0.0380
2017-08-11 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,664,411 1,060,009 175.38 214,491 224.53 0.0648
2017-05-22 2017-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 604,402 325,994 117.09 66,093 222.25 0.0203
2017-05-12 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 604,402 66,093
2017-02-22 2016-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 278,408 -447,413 -61.64 20,510 -67.60 0.0067
2017-02-13 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 278,408 20,510
2016-11-10 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 725,821 529,262 269.26 63,300 274.38 0.0216
2016-08-12 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 196,559 -162,543 -45.26 16,908 -40.77 0.0061
2016-05-12 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 359,102 49,276 15.90 28,544 -26.78 0.0110
2016-02-09 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 309,826 112,441 56.97 38,986 89.66 0.0141
2016-02-08 2015-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 197,385 733 0.37 20,556 -15.34 0.0076
2015-11-09 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 197,385 20,556
2015-08-12 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 196,652 -16,436 -7.71 24,282 -3.40 0.0084
2015-05-14 2015-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 213,088 -70,998 -24.99 25,137 -25.52 0.0093
2015-02-13 2014-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 284,086 26,947 10.48 33,749 16.87 0.0123
2014-12-16 2014-09-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 257,139 70,958 38.11 28,878 119.30 0.0111
2014-11-14 2014-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 257,139 28,878
2014-05-13 2014-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 186,181 -69,328 -27.13 13,168 -30.64 0.0055
2014-02-13 2013-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 255,509 -133,621 -34.34 18,985 -35.65 0.0081
2013-11-13 2013-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 389,130 110,169 39.49 29,505 32.11 0.0139
2013-08-08 2013-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 278,961 278,961 22,333 0.0113
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.