Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionNorthern Trust Corp
Latest Disclosed Ownership2,564,264 shares
Latest Disclosed Value $ 1,145,046,448
Northern Trust Corp reports 0.59% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 14, 2026 - Northern Trust Corp filed a 13F-HR form disclosing ownership of 2,564,264 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $1,145,046,447 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 2,579,457 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -0.59% during the quarter. The current value of the position is $1,098,376,842 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-14 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,564,264 -15,193 -0.59 1,145,046 -2.08 0.0310
2026-02-17 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,579,457 -48,430 -1.84 1,169,423 13.63 0.0307
2025-11-14 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,627,887 -30,694 -1.15 1,029,186 -13.05 0.0300
2025-08-13 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,658,581 39,189 1.50 1,183,600 -6.80 0.1628
2025-05-13 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,619,392 -101,657 -3.74 1,269,934 15.89 0.1885
2025-02-14 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,721,049 355,057 15.01 1,095,766 -0.42 0.1552
2024-11-13 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,365,992 -167,912 -6.63 1,100,376 -7.35 0.1801
2024-08-14 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,533,904 -44,533 -1.73 1,187,691 10.19 0.2001
2024-05-14 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,578,437 -102,160 -3.81 1,077,812 -1.18 0.1862
2024-02-13 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,680,597 -132,966 -4.73 1,090,708 11.48 0.1974
2023-11-13 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,813,563 131,539 4.90 978,388 3.66 0.1895
2023-08-11 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,682,024 -94,671 -3.41 943,831 7.88 0.1814
2023-05-15 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,776,695 -74,864 -2.63 874,853 6.24 0.1734
2023-02-13 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,851,559 -36,439 -1.26 823,473 -1.52 0.1728
2022-11-14 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,887,998 -48,936 -1.67 836,191 1.04 0.1910
2022-08-12 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,936,934 46,981 1.63 827,598 9.73 0.1773
2022-05-13 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,889,953 -18,399 -0.63 754,191 18.09 0.1327
2022-02-08 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,908,352 -86,138 -2.88 638,674 17.58 0.1046
2021-11-15 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,994,490 21,674 0.73 543,171 -9.38 0.0961
2021-08-13 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,972,816 -5,434 -0.18 599,408 -6.34 0.1056
2021-05-12 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,978,250 -44,254 -1.46 639,996 -10.41 0.1190
2021-02-11 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,022,504 -75,401 -2.43 714,337 -15.26 0.1391
2020-11-16 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,097,905 119,997 4.03 843,002 -2.49 0.1849
2020-08-14 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,977,908 117,949 4.12 864,516 27.04 0.2048
2020-05-14 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,859,959 18,222 0.64 680,528 9.37 0.1954
2020-02-14 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,841,737 -110,483 -3.74 622,199 24.40 0.1393
2019-11-13 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,952,220 8,440 0.29 500,164 -7.35 0.1197
2019-08-13 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,943,780 33,009 1.13 539,830 0.82 0.1281
2019-05-13 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,910,771 31,978 1.11 535,437 12.24 0.1322
2019-02-12 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,878,793 98,585 3.55 477,044 -10.98 0.1338
2018-11-14 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,780,208 -22,732 -0.81 535,857 12.48 0.1311
2018-09-18 2018-06-30 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 2,802,940 -6,684 -0.24 476,388 4.03 0.1210
2018-08-14 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,819,187 9,563 479,150
2018-05-09 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,809,624 -33,696 -1.19 457,913 7.47 0.1191
2018-02-14 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,843,320 -50,060 -1.73 426,100 -3.14 0.1079
2017-11-13 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,893,380 182,130 6.72 439,910 25.90 0.1147
2017-08-11 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,711,250 6,055 0.22 349,400 18.12 0.0977
2017-05-12 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,705,195 59,428 2.25 295,813 51.77 0.0853
2017-02-13 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,645,767 -327,029 -11.00 194,914 -24.82 0.0598
2016-11-09 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,972,796 29,351 1.00 259,258 2.39 0.0808
2016-08-12 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,943,445 30,442 1.05 253,195 5.47 0.0822
2016-08-19 2016-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 2,913,003 8,430 0.29 240,061 -34.32 0.0796
2016-05-13 2016-03-31 13F Vertex Pharmaceutica COMM 92532F100 2,912,990 231,554
2016-02-12 2015-12-31 13F Vertex Pharmaceutica COMM 92532F100 2,904,573 -233,754 -7.45 365,481 11.83 0.1212
2015-11-12 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,138,327 3,138,327 0.00 326,825 0.1091
2015-08-13 2015-06-30 13F Vertex Pharmaceutica COMM 92532F100 0 -3,148,559 -100.00 0 -100.00
2015-05-14 2015-03-31 13F Vertex Pharmaceutica COMM 92532F100 3,148,559 -49,433 -1.55 371,435 -2.23 0.1117
2015-02-12 2014-12-31 13F Vertex Pharmaceutica COM 92532F100 3,197,992 21,376 0.67 379,922 6.49 0.1147
2014-11-13 2014-09-30 13F Vertex Pharmaceutica COMM 92532F100 3,176,616 239,143 8.14 356,766 28.28 0.1120
2014-08-14 2014-06-30 13F VERTEX PHARMACEUTICALS com 92532F100 2,937,473 -275,784 -8.58 278,119 22.39 0.0867
2014-05-14 2014-03-31 13F VERTEX PHARMACEUTICALS COMM 92532F100 3,213,257 227,875 7.63 227,242 2.45 0.0715
2014-02-21 2013-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 2,985,382 -22,077 -0.73 221,813 -2.73 0.0711
2014-02-12 2013-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,985,382 221,813
2013-11-13 2013-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,007,459 675,024 28.94 228,027 22.11 0.0803
2013-08-09 2013-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,332,435 2,332,435 186,734 0.0677
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.