Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionPinnacle Associates Ltd
Latest Disclosed Ownership21,590 shares
Latest Disclosed Value $ 9,640,827
Pinnacle Associates Ltd reports 14.45% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On April 21, 2026 - Pinnacle Associates Ltd filed a 13F-HR form disclosing ownership of 21,590 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $9,640,799 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 5, 2026 disclosing 25,238 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -14.45% during the quarter. The current value of the position is $9,247,861 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-04-21 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 21,590 -3,648 -14.45 9,641 -15.75 0.1236
2026-02-05 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 25,238 -129 -0.51 11,442 15.18 0.1445
2025-11-13 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 25,367 259 1.03 9,935 -11.13 0.1318
2025-08-04 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 25,108 210 0.84 11,178 -7.39 0.1618
2025-05-06 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 24,898 12,002 93.07 12,071 132.43 0.1769
2025-02-14 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 12,896 6,857 113.55 5,193 111.36 0.0705
2024-10-25 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 6,039 -4,822 -44.40 2,457 -51.73 0.0418
2024-07-30 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 10,861 1,732 18.97 5,091 33.39 0.0797
2024-04-26 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 9,129 3,090 51.17 3,816 55.31 0.0601
2024-01-19 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 6,039 780 14.83 2,457 34.41 0.0413
2023-10-24 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 5,259 1,531 41.07 1,829 39.44 0.0340
2023-07-27 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,728 1,846 98.09 1,312 121.45 0.0228
2023-05-05 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,882 400 26.99 593 38.64 0.0121
2023-02-01 2022-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 1,482 -180 -10.83 428 -11.23 0.0093
2023-01-25 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,561 -101 489 0.0000
2022-11-01 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,662 159 10.58 481 13.44 0.0110
2022-08-02 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,503 280 22.89 424 32.92 0.0092
2022-05-05 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,223 20 1.66 319 20.83 0.0056
2022-02-02 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,203 -216 -15.22 264 2.72 0.0046
2021-10-19 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,419 -200 -12.35 257 -21.17 0.0047
2021-08-02 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,619 400 32.81 326 24.43 0.0059
2021-05-12 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,219 200 19.63 262 8.71 0.0050
2021-01-26 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,019 96 10.40 241 -3.98 0.0049
2020-10-23 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 923 4 0.44 251 -5.99 0.0060
2020-08-14 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 919 -200 -17.87 267 0.38 0.0066
2020-05-13 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,119 0 0.00 266 8.57 0.0081
2020-02-03 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,119 1,119 245 0.0054
2019-11-08 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 0 -1,100 -100.00 0 -100.00
2019-08-05 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,100 0 0.00 202 0.00 0.0047
2019-05-10 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 1,100 1,100 202 0.0046
2019-02-05 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 0 -1,200 -100.00 0 -100.00
2018-11-09 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,200 0 0.00 231 13.24 0.0048
2018-08-08 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 1,200 1,200 204 0.0042
2017-11-13 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 0 -2,149 -100.00 0 -100.00
2017-08-09 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,149 -1,251 -36.79 277 -25.54 0.0053
2017-05-09 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,400 -300 -8.11 372 36.26 0.0071
2017-02-10 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 3,700 400 12.12 273 -5.21 0.0055
2016-11-14 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 3,300 700 26.92 288 28.57 0.0058
2016-08-15 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 2,600 0 0.00 224 8.21 0.0048
2016-05-13 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 2,600 -1,426 -35.42 207 -59.17 0.0044
2016-02-11 2015-12-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 4,026 -43 -1.06 507 19.58 0.0106
2016-02-09 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 4,026 -43 507 0.0108
2015-11-10 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,069 -81 -1.95 424 -17.19 0.0094
2015-08-12 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 4,150 0 0.00 512 4.49 0.0095
2015-05-15 2015-03-31 13F Vertex Pharmaceuticals Com COM 92532F100 4,150 300 7.79 490 7.22 0.0091
2015-02-12 2014-12-31 13F Vertex Pharmaceuticals Com COM 92532F100 3,850 -300 -7.23 457 -1.93 0.0090
2014-11-12 2014-09-30 13F Vertex Pharmaceuticals Com COM 92532F100 4,150 -300 -6.74 466 10.69 0.0095
2014-08-14 2014-06-30 13F Vertex Pharmaceuticals Com COM 92532F100 4,450 -600 -11.88 421 17.93 0.0082
2014-05-14 2014-03-31 13F Vertex Pharmaceuticals Com COM 92532F100 5,050 -12,500 -71.23 357 -72.62 0.0070
2014-02-12 2013-12-31 13F Vertex Pharmaceuticals Com COM 92532F100 17,550 -1,500 -7.87 1,304 -9.70 0.0255
2013-11-14 2013-09-30 13F Vertex Pharmaceuticals Com COM 92532F100 19,050 800 4.38 1,444 -1.16 0.0299
2013-08-13 2013-06-30 13F Vertex Pharmaceuticals Com COM 92532F100 18,250 18,250 1,461 0.0328
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.