Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionProShare Advisors LLC
Latest Disclosed Ownership373,532 shares
Latest Disclosed Value $ 166,796,978
ProShare Advisors LLC reports 18.27% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On April 24, 2026 - ProShare Advisors LLC filed a 13F-HR form disclosing ownership of 373,532 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $166,796,979 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 6, 2026 disclosing 457,046 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -18.27% during the quarter. The current value of the position is $165,004,026 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-04-24 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 373,532 -83,514 -18.27 166,797 -19.50 0.2470
2026-02-06 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 457,046 123,314 36.95 207,206 58.53 0.3657
2025-11-06 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 333,732 -67,512 -16.83 130,703 -26.83 0.2735
2025-08-07 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 401,244 18,214 4.76 178,634 -3.81 0.3564
2025-05-08 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 383,030 38,504 11.18 185,701 33.85 0.4192
2025-02-14 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 344,526 53,116 18.23 138,741 2.37 0.3171
2024-11-14 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 291,410 21,669 8.03 135,529 7.19 0.3322
2024-08-13 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 269,741 -30,529 -10.17 126,433 0.73 0.3383
2024-05-08 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 300,270 48,699 19.36 125,516 22.62 0.3337
2024-02-14 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 251,571 -45,253 -15.25 102,362 -0.83 0.3128
2023-11-13 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 296,824 35,214 13.46 103,218 12.12 0.3218
2023-08-10 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 261,610 -18,485 -6.60 92,063 4.32 0.2670
2023-05-26 2023-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 280,095 24,813 9.72 88,250 19.71 0.2697
2023-05-12 2023-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 280,095 24,813 88,250 0.2806
2023-02-02 2022-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 255,282 -26,430 -9.38 73,720 -9.62 0.2589
2022-11-07 2022-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 281,712 -48,614 -14.72 81,567 -12.37 0.3130
2022-08-01 2022-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 330,326 -158,650 -32.45 93,083 -27.05 0.3087
2022-05-10 2022-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 488,976 -28,213 -5.46 127,605 12.35 0.2741
2022-02-08 2021-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 517,189 144,037 38.60 113,574 67.80 0.2229
2021-11-12 2021-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 373,152 33,518 9.87 67,686 -1.16 0.1902
2021-08-13 2021-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 339,634 -5,069 -1.47 68,480 -7.55 0.2002
2021-05-14 2021-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 344,703 44,967 15.00 74,073 4.56 0.2329
2021-02-09 2020-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 299,736 37,064 14.11 70,840 -0.89 0.2635
2020-11-13 2020-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 262,672 34,849 15.30 71,478 8.07 0.3304
2020-08-03 2020-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 227,823 27,309 13.62 66,139 38.62 0.3533
2020-05-15 2020-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 200,514 -85,641 -29.93 47,712 -23.85 0.3428
2020-02-12 2019-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 286,155 13,551 4.97 62,654 35.66 0.2901
2019-11-12 2019-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 272,604 4,642 1.73 46,185 -6.01 0.2585
2019-08-13 2019-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 267,962 -28,653 -9.66 49,139 -9.94 0.2938
2019-05-15 2019-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 296,615 27,238 10.11 54,562 22.23 0.3265
2019-02-14 2018-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 269,377 26,403 10.87 44,638 -4.68 0.3124
2018-11-14 2018-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 242,974 -25,163 -9.38 46,831 2.76 0.3179
2018-08-13 2018-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 268,137 -47,540 -15.06 45,573 -11.42 0.3054
2018-05-14 2018-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 315,677 37,852 13.62 51,449 23.57 0.3352
2018-02-14 2017-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 277,825 60,520 27.85 41,635 26.02 0.2888
2017-11-13 2017-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 217,305 15,247 7.55 33,039 26.88 0.3036
2017-08-11 2017-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 202,058 -18,043 -8.20 26,039 8.19 0.2594
2017-05-12 2017-03-31 13F/A-2 VERTEX PHARMACEUTICALS COM 92532F100 220,101 -52,376 -19.22 24,068 19.90 0.2517
2017-05-08 2017-03-31 13F/A-1 VERTEX PHARMACEUTICALS COM 92532F100 220,101 0 24,068 0.2517
2017-04-25 2017-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 220,101 24,068
2017-02-13 2016-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 272,477 40,979 17.70 20,073 -0.57 0.2223
2016-11-10 2016-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 231,498 -59,671 -20.49 20,189 -19.39 0.2819
2016-08-12 2016-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 291,169 5,597 1.96 25,046 10.33 0.3226
2016-05-06 2016-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 285,572 -18,521 -6.09 22,700 -40.68 0.3125
2016-02-05 2015-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 304,093 27,344 9.88 38,264 32.76 0.4635
2015-11-06 2015-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 276,749 -662 -0.24 28,821 -15.86 0.4048
2015-08-11 2015-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 277,411 -31,982 -10.34 34,255 -6.15 0.4740
2015-05-08 2015-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 309,393 309,393 0.00 36,499 0.4299
2015-01-30 2014-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 0 -204,396 -100.00 0 -100.00
2014-11-06 2014-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 204,396 -31,473 -13.34 22,956 2.79 0.3043
2014-08-08 2014-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 235,869 -50,171 -17.54 22,332 10.40 0.2893
2014-05-07 2014-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 286,040 97,403 51.64 20,229 44.33 0.2530
2014-02-04 2013-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 188,637 75,747 67.10 14,016 63.76 0.2089
2013-11-07 2013-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 112,890 29,930 36.08 8,559 29.17 0.2031
2013-07-25 2013-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 82,960 82,960 6,626 0.1301
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.