Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionUs Bancorp \de\
Latest Disclosed Ownership29,781 shares
Latest Disclosed Value $ 13,298,415
Us Bancorp \de\ reports 0.23% decrease in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On May 14, 2026 - Us Bancorp \de\ filed a 13F-HR form disclosing ownership of 29,781 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $13,298,408 USD as of March 31, 2026. The entity filed a previous 13F-HR on January 30, 2026 disclosing 29,850 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of -0.23% during the quarter. The current value of the position is $13,155,459 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-14 2026-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 29,781 -69 -0.23 13,298 -1.73 0.0050
2026-01-30 2025-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 29,850 -1,006 -3.26 13,533 11.98 0.0159
2025-11-12 2025-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 30,856 -2,727 -8.12 12,084 -19.17 0.0143
2025-07-24 2025-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 33,583 1,324 4.10 14,951 -4.41 0.0188
2025-05-08 2025-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 32,259 1,916 6.31 15,640 27.99 0.0209
2025-02-05 2024-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 30,343 3,764 14.16 12,219 -1.15 0.0160
2024-10-28 2024-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 26,579 2,273 9.35 12,361 8.51 0.0159
2024-08-07 2024-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 24,306 2,856 13.31 11,393 27.06 0.0155
2024-05-08 2024-03-31 13F VERTEX PHARMACEUTICALS COM 92532F100 21,450 2,288 11.94 8,966 15.01 0.0125
2024-02-09 2023-12-31 13F VERTEX PHARMACEUTICALS COM 92532F100 19,162 6,065 46.31 7,797 71.19 0.0115
2023-11-03 2023-09-30 13F VERTEX PHARMACEUTICALS COM 92532F100 13,097 1,383 11.81 4,554 10.48 0.0074
2023-08-10 2023-06-30 13F VERTEX PHARMACEUTICALS COM 92532F100 11,714 -915 -7.25 4,122 3.59 0.0066
2023-05-09 2023-03-31 13F VERTEX PHARMACEUTICALS INC COM COMMON STOCK 92532F100 12,629 183 1.47 3,979 10.71 0.0067
2023-02-13 2022-12-31 13F VERTEX PHARMACEUTICALS INC COM COMMON STOCK 92532F100 12,446 -726 -5.51 3,594 -5.72 0.0064
2022-10-27 2022-09-30 13F VERTEX PHARMACEUTICALS INC COM COMMON STOCK 92532F100 13,172 578 4.59 3,812 7.41 0.0079
2022-08-01 2022-06-30 13F VERTEX PHARMACEUTICALS INC COM COMMON STOCK 92532F100 12,594 -3,107 -19.79 3,549 -13.38 0.0069
2022-05-11 2022-03-31 13F VERTEX PHARMACEUTICALS INC COM COMMON STOCK 92532F100 15,701 1,512 10.66 4,097 31.48 0.0068
2022-02-11 2021-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 14,189 1,895 15.41 3,116 39.73 0.0049
2021-11-10 2021-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 12,294 -474 -3.71 2,230 -13.40 0.0042
2021-08-05 2021-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 12,768 -3,408 -21.07 2,575 -25.94 0.0048
2021-04-28 2021-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 16,176 2,068 14.66 3,477 4.29 0.0070
2021-02-04 2020-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 14,108 922 6.99 3,334 -7.11 0.0072
2020-11-10 2020-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 13,186 972 7.96 3,589 1.21 0.0088
2020-08-07 2020-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 12,214 -328 -2.62 3,546 18.83 0.0093
2020-05-13 2020-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 12,542 2,052 19.56 2,984 29.97 0.0093
2020-02-04 2019-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 10,490 477 4.76 2,296 35.38 0.0059
2019-11-08 2019-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 10,013 707 7.60 1,696 -0.59 0.0046
2019-08-13 2019-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 9,306 319 3.55 1,706 3.21 0.0048
2019-05-08 2019-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 8,987 685 8.25 1,653 20.13 0.0048
2019-02-13 2018-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 8,302 1,051 14.49 1,376 -1.57 0.0044
2018-10-31 2018-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 7,251 -118 -1.60 1,398 11.57 0.0040
2018-08-08 2018-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 7,369 -1,315 -15.14 1,253 -11.51 0.0038
2018-05-08 2018-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 8,684 1,669 23.79 1,416 34.73 0.0043
2018-02-02 2017-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 7,015 -182 -2.53 1,051 -3.93 0.0032
2017-11-13 2017-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 7,197 456 6.76 1,094 25.89 0.0035
2017-07-19 2017-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 6,741 -583 -7.96 869 8.49 0.0029
2017-05-03 2017-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 7,324 3,749 104.87 801 204.56 0.0027
2017-02-08 2016-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 3,575 -13,961 -79.61 263 -82.80 0.0009
2016-11-04 2016-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 17,536 3,785 27.53 1,529 29.36 0.0057
2016-08-10 2016-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 13,751 10,530 326.92 1,182 361.72 0.0045
2016-05-13 2016-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 3,221 -1,381 -30.01 256 -55.79 0.0010
2016-02-10 2015-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 4,602 -715 -13.45 579 4.51 0.0023
2015-11-16 2015-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 5,317 1,026 23.91 554 4.53 0.0023
2015-08-10 2015-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 4,291 728 20.43 530 26.19 0.0021
2015-05-08 2015-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 3,563 772 27.66 420 26.89 0.0016
2015-02-13 2014-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 2,791 1,114 66.43 331 75.13 0.0013
2014-11-14 2014-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 1,677 -110 -6.16 189 11.18 0.0008
2014-08-14 2014-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 1,787 1,352 310.80 170 448.39 0.0007
2014-05-14 2014-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 435 -1,207 -73.51 31 -74.59 0.0001
2014-02-13 2013-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 1,642 -3,907 -70.41 122 -71.02 0.0005
2013-11-07 2013-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 5,549 4,886 736.95 421 694.34 0.0019
2013-08-09 2013-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 663 663 53 0.0002
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.