| Ausstehende Aktien | 98,051,212 shares |
| Insider-Aktien | 1.704.550 shares |
| Insider-Besitz | 1,74 % |
| Insider gesamt | 41 |
Insider-Stimmungswert
Der Insider-Stimmungswert ermittelt die Unternehmen, die von Unternehmensinsidern gekauft werden.
Es ist das Ergebnis eines ausgeklügelten quantitativen Multifaktormodells, das die Unternehmen mit der höchsten Insiderakkumulation identifiziert. Das Scoring-Modell verwendet eine Kombination aus der Nettozahl der Insiderkäufe der letzten 90 Tage, der Gesamtzahl der gekauften Aktien als Prozentsatz des Streubesitzes und der Gesamtzahl der von Insidern gehaltenen Aktien. Die Zahl reicht von 0 bis 100, wobei höhere Zahlen ein höheres Maß an Insiderkäufen anzeigen als bei anderen Unternehmen und 50 den Durchschnitt darstellt.
Aktualisierungshäufigkeit: Täglich
Führungskräfte-Stimmungswert
Der Führungskräfte-Stimmungswert findet Unternehmen, die von Führungskräften des Unternehmens gekauft werden.
Per Definition sind Führungskräfte des Unternehmens Insider, aber im Gegensatz zu anderen Insidern (10%ige Aktionäre und Vorstandsmitglieder) arbeiten Führungskräfte täglich für das Unternehmen und verwenden beim Handel ihr eigenes Geld. (10%ige Aktionäre und Vorstandsmitglieder sind oft Fondsmanager, die das Geld anderer Leute verwalten.) Daher sind Insider-Geschäfte, die von Führungskräften getätigt werden, viel bedeutender und sollten entsprechend behandelt werden.
Wie der Insider-Stimmungswert ist auch der Führungskräfte-Stimmungswert das Ergebnis eines ausgeklügelten quantitativen Multifaktormodells, das die Unternehmen mit der höchsten Führungskräftekonzentration identifiziert.
Aktualisierungshäufigkeit: Täglich
Wichtige Insider-Kennzahlen
Diese Karte zeigt, wie das Unternehmen bei verschiedenen Insider-Kennzahlen abschneidet. Der Perzentil-Rang zeigt, wie dieses Unternehmen im Vergleich zu anderen Unternehmen auf den US-Märkten abschneidet. Höhere Ränge deuten auf eine bessere Situation hin.
Es ist beispielsweise allgemein anerkannt, dass Insiderkäufe ein positiver Indikator sind, so dass Unternehmen mit mehr Insiderkäufen besser abschneiden würden als Unternehmen mit weniger Insiderkäufen (oder sogar Insiderverkäufen).
Prozent des Streubesitzes von Insidern gekauft (Rang)
307 out of 10786
Prozent des von Insidern gekauften Streubesitzes ist die Gesamtzahl der von Insidern gekauften Aktien abzüglich der Gesamtzahl der von Insidern in den letzten 90 Tagen verkauften Aktien, geteilt durch den gesamten Streubesitz und multipliziert mit 100.
Diagramm zum Insiderhandel
aTyr Pharma, Inc. Insider-Trades sind in der folgenden Grafik dargestellt. Insider sind leitende Angestellte, Direktoren oder bedeutende Investoren in einem Unternehmen. Im Allgemeinen ist es für Insider illegal, auf der Grundlage von wesentlichen, nicht-öffentlichen Informationen mit Aktien ihrer Unternehmen zu handeln. Das bedeutet nicht, dass es für sie illegal ist, irgendwelche Geschäfte in ihren eigenen Unternehmen zu tätigen. Sie müssen jedoch alle Geschäfte der SEC über ein Formular 4 melden.
Kennzahlen zu Insiderlisten und Rentabilität
Diese Tabelle zeigt die Liste der bekannten Insider und wird automatisch aus den bei der SEC eingereichten Unterlagen erstellt. Zusätzlich zu den Namen, dem letzten Titel und der Bezeichnung als Direktor, leitender Angestellter oder 10%-iger Anteilseigner geben wir die zuletzt veröffentlichten Bestände an. Zusätzlich stellen wir, wenn möglich, die historische Handelsperformance für den Insider zur Verfügung. Die historische Handelsperformance ist ein gewichteter Durchschnitt der Performance tatsächlicher offener Kauftransaktionen, die von dem Insider getätigt wurden. Weitere Informationen zur Berechnung dieses Wertes finden Sie in diesem YouTube-Webinar.
See our leaderboard of most profitable insider traders.
| Insider | Durchschnittlicher Gewinn (%) | Aktien in Besitz |
Split Angepasst |
|---|---|---|---|
|
Srinivas Akkaraju
10% Owner -
|
1.866.126 | 133.295 | |
|
Alta Partners VIII, L.P.
10% Owner -
|
1.778.064 | 127.005 | |
| Ashraf Amanullah See Remarks - [O] | 26.264 | 1.876 | |
| Ashlock Melissa A. See Remarks - [O] | 136.328 | 9.738 | |
|
James C Blair
Director, 10% Owner -
[D]
|
20.000 | 958 | |
| Kelly Blackburn See Remarks - [O] | 558 | 40 | |
| Stan Blackburn - | 23.908 | 1.708 | |
| John T Blake Senior Vice President, Finance - [O] | 1.932 | 138 | |
| Jill Marie Broadfoot Chief Financial Officer - [O] | 37.296 | 37.296 | |
|
Chp Ii Lp
10% Owner -
|
1.758.158 | 125.583 | |
| John K Clarke Director - [D] | 19.797 | 19.797 | |
| Frederic Chereau COO & President - [O] | 25.734 | 1.838 | |
| Chrzanowski Holly D. See Remarks - [O] | 3.770 | 269 |
| Insider | Durchschnittlicher Gewinn (%) | Aktien in Besitz |
Split Angepasst |
|---|---|---|---|
| Timothy P Coughlin Director - [D] | 56.000 | 56.000 | |
| Andrew Cubitt | 25.000 | ||
|
Associates Domain
10% Owner -
|
18.858 | 1.347 | |
|
DP VIII Associates, L.P.
10% Owner -
|
13.414 | 958 | |
|
Domain Partners VIII, L.P.
10% Owner -
|
1.807.820 | 129.130 | |
|
EcoR1 Capital Fund Qualified, L.P.
10% Owner -
|
0 | 0 | |
| Kathryn E Falberg Director - [D] | 25.144 | 1.796 | |
|
James E Flynn
10% Owner -
|
255.764 | 18.269 | |
| Mark Alan Goldberg | 20.000 | ||
| Marcy Graham | 12.023 | ||
| Jane A Gross Director - [D] | 9.750 | 9.750 | |
| Hatfield Jeffrey S. | 1.428 | ||
|
Kamdar Kim P.
10% Owner -
|
18.858 | 1.347 | |
| David John King | 150.000 |
| Insider | Durchschnittlicher Gewinn (%) | Aktien in Besitz |
Split Angepasst |
|---|---|---|---|
| Nancy Krueger General Counsel - [O] | 33.124 | 33.124 | |
| Svetlana Lucas Director - [D] | 6.000 | 6.000 | |
| John Mendlein Director - [D] | 615.382 | 43.956 | |
| Grove Matsuoka See Remarks - [O] | 12.412 | 887 | |
| McKew John C. | 40.000 | ||
| Amir Nashat Director - [D] | 17.638 | 1.260 | |
|
Polaris Venture Management Co. V, L.L.C.
10% Owner -
|
17.638 | 1.260 | |
| Fred Ramsdell | 5.393 | ||
| Ravindran Sanuj K. | 40.000 | ||
| Paul Schimmel Director - [D] | 779.143 | 779.143 | |
| Sanjay Shukla President and CEO, Director - [D] [O] | 153.553 | 153.553 | |
|
Sofinnova Venture Partners IX, L.P.
10% Owner -
|
1.866.126 | 133.295 | |
| Weiner David M. Chief Medical Officer - [O] | 10.056 | 718 | |
| Sara Zaknoen Director - [D] | 6.000 | 6.000 |
Report errors via our new Insider Auditing Tool
Erfolgsbilanz der Insiderkäufe - Kurzfristige Gewinnanalyse
In diesem Abschnitt analysieren wir die Rentabilität jedes ungeplanten Insiderkaufs, der auf dem freien Markt in ATYR / aTyr Pharma, Inc. getätigt wurde. Diese Analyse hilft zu verstehen, ob der Insider beständig abnormale Renditen erzielt und es sich lohnt, ihm zu folgen. Diese Analyse bezieht sich auf ein Jahr nach jedem Handel, und die Ergebnisse sind theoretisch .
Die folgende Tabelle zeigt die jüngsten Käufe am offenen Markt, die nicht Teil eines automatischen Handelsplans waren.
Bereinigter Preis ist der splitbereinigte Preis. Bereinigte Aktien sind die um den Split bereinigten Aktien.
Erfolgsbilanz von Insiderverkäufen - Kurzfristige Verlustanalyse
In diesem Abschnitt analysieren wir die kurzfristige Verlustvermeidung jedes ungeplanten Insider-Verkaufs auf dem freien Markt in ATYR / aTyr Pharma, Inc.. Ein konsistentes Muster der Verlustvermeidung kann darauf hindeuten, dass zukünftige Verkaufstransaktionen Kursrückgänge vorhersagen können. Diese Analyse bezieht sich auf ein Jahr nach jedem Handel, und die Ergebnisse sind theoretisch .
Die folgende Tabelle zeigt die jüngsten Verkäufe am offenen Markt, die nicht Teil eines automatischen Handelsplans waren.
Bereinigter Preis ist der splitbereinigte Preis. Bereinigte Aktien sind die um den Split bereinigten Aktien.
Transaktionshistorie
Klicken Sie auf das Link-Symbol, um den vollständigen Transaktionsverlauf anzuzeigen. Transaktionen, die im Rahmen eines automatischen Handelsplans 10b5-1 gemeldet werden, sind in der Spalte 10b-5 mit einem X gekennzeichnet.
| Datei Datum |
Handel Datum |
Form | Insider | Ticker | Wertpapier-Titel | Code | Direkt | Ausführung Preis |
Einheit Preis |
Eimheiten Verändert |
Wert Geändert (1K) |
Verbleibende Optionen |
Verbleibende Aktien |
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026-05-28 | 2026-05-27 | 4 | SCHIMMEL PAUL | ATYR | Common Stock | I | 0,4963 | 100.000 | 50 | 779.143 | ||||
| 2026-02-04 | 2026-02-04 | 4 | Shukla Sanjay | ATYR | Common Stock | D | 0,9760 | -3.745 | -4 | 153.553 | ||||
| 2026-02-04 | 2026-02-03 | 4 | Shukla Sanjay | ATYR | Common Stock | D | 10.375 | 157.298 | ||||||
| 2026-02-04 | 2026-02-04 | 4 | Broadfoot Jill Marie | ATYR | Common Stock | D | 0,9760 | -1.558 | -2 | 37.296 | ||||
| 2026-02-04 | 2026-02-03 | 4 | Broadfoot Jill Marie | ATYR | Common Stock | D | 3.750 | 38.854 | ||||||
| 2026-02-04 | 2026-02-04 | 4 | Krueger Nancy | ATYR | Common Stock | D | 0,9761 | -1.118 | -1 | 33.124 | ||||
| 2026-02-04 | 2026-02-03 | 4 | Krueger Nancy | ATYR | Common Stock | D | 2.687 | 34.242 | ||||||
| 2025-10-09 | 2025-10-09 | 4 | SCHIMMEL PAUL | ATYR | Common Stock | I | 0,9414 | 317.999 | 299 | 1.413.023 | ||||
| 2025-10-09 | 2025-10-08 | 4 | SCHIMMEL PAUL | ATYR | Common Stock | I | 0,8980 | 682.001 | 612 | 1.095.024 | ||||
| 2025-03-17 | 2025-03-17 | 4 | Gross Jane A | ATYR | Common Stock | D | 4,0000 | 3.750 | 15 | 9.750 | ||||
| 2025-02-04 | 2025-02-03 | 4 | Shukla Sanjay | ATYR | Common Stock | D | 10.375 | 146.923 | ||||||
| 2025-02-04 | 2025-02-04 | 4 | Broadfoot Jill Marie | ATYR | Common Stock | D | 3,7800 | -1.254 | -5 | 31.763 | ||||
| 2025-02-04 | 2025-02-03 | 4 | Broadfoot Jill Marie | ATYR | Common Stock | D | 3.750 | 33.017 | ||||||
| 2025-02-04 | 2025-02-04 | 4 | Krueger Nancy | ATYR | Common Stock | D | 3,7800 | -899 | -3 | 26.555 | ||||
| 2025-02-04 | 2025-02-03 | 4 | Krueger Nancy | ATYR | Common Stock | D | 2.687 | 27.454 | ||||||
| 2024-07-24 | 2024-07-24 | 4 | SCHIMMEL PAUL | ATYR | Common Stock | I | 1,9319 | 52.300 | 101 | 413.023 | ||||
| 2024-07-24 | 2024-07-23 | 4 | SCHIMMEL PAUL | ATYR | Common Stock | I | 1,8163 | 6.648 | 12 | 360.723 | ||||
| 2024-07-24 | 2024-07-22 | 4 | SCHIMMEL PAUL | ATYR | Common Stock | I | 1,7417 | 41.052 | 72 | 354.075 | ||||
| 2024-06-06 | 2024-06-05 | 4 | Krueger Nancy | ATYR | Common Stock | D | 1,8552 | 5.000 | 9 | 22.267 | ||||
| 2024-06-03 | 2024-05-30 | 4 | Coughlin Timothy P | LIFE | Common Stock | I | 1,7500 | 50.000 | 88 | 56.000 | ||||
| 2024-06-03 | 2024-05-31 | 4 | Broadfoot Jill Marie | LIFE | Common Stock | D | 1,7900 | 5.000 | 9 | 27.960 | ||||
| 2024-06-03 | 2024-05-31 | 4 | Shukla Sanjay | LIFE | Common Stock | D | 1,8070 | 20.000 | 36 | 136.548 | ||||
| 2024-02-06 | 2024-02-05 | 4 | Shukla Sanjay | LIFE | Common stock | D | 10.375 | 116.548 | ||||||
| 2024-02-06 | 2024-02-06 | 4 | Broadfoot Jill Marie | LIFE | Common stock | D | 1,6900 | -1.590 | -3 | 20.821 | ||||
| 2024-02-06 | 2024-02-05 | 4 | Broadfoot Jill Marie | LIFE | Common stock | D | 3.750 | 22.411 | ||||||
| 2024-02-06 | 2024-02-05 | 4 | Krueger Nancy | LIFE | Common stock | D | 2.688 | 14.767 | ||||||
| 2023-12-12 | 2023-12-12 | 4 | Shukla Sanjay | LIFE | Common Stock | D | 1,1780 | 12.000 | 14 | 106.173 | ||||
| 2023-12-12 | 2023-12-11 | 4 | Shukla Sanjay | LIFE | Common Stock | D | 1,1700 | 3.000 | 4 | 94.173 | ||||
| 2023-11-13 | 2023-11-13 | 4 | Shukla Sanjay | LIFE | Common Stock | D | 1,1110 | 13.578 | 15 | 91.173 | ||||
| 2023-11-13 | 2023-11-10 | 4 | Shukla Sanjay | LIFE | Common Stock | D | 1,1380 | 1.422 | 2 | 77.595 | ||||
| 2023-08-01 | 2023-07-28 | 4 | Shukla Sanjay | LIFE | Common Stock | D | 2,0149 | 15.000 | 30 | 76.173 | ||||
| 2023-05-19 | 2023-05-17 | 4 | Coughlin Timothy P | LIFE | Common Stock | I | 6.000 | 6.000 | ||||||
| 2023-05-19 | 2023-05-17 | 4 | Coughlin Timothy P | LIFE | Common Stock | D | -6.000 | 0 | ||||||
| 2023-05-11 | 2023-05-10 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 2,2500 | 200.000 | 450 | 313.023 | ||||
| 2023-04-28 | 2023-04-26 | 4 | CLARKE JOHN K | LIFE | Common Stock | D | 6.000 | 19.797 | ||||||
| 2023-04-28 | 2023-04-26 | 4 | Coughlin Timothy P | LIFE | Common stock | D | 6.000 | 6.000 | ||||||
| 2023-04-28 | 2023-04-26 | 4 | Lucas Svetlana | LIFE | Common stock | D | 6.000 | 6.000 | ||||||
| 2023-04-28 | 2023-04-26 | 4 | SCHIMMEL PAUL | LIFE | Common stock | D | 6.000 | 8.890 | ||||||
| 2023-04-28 | 2023-04-26 | 4 | Zaknoen Sara | LIFE | Common stock | D | 6.000 | 6.000 | ||||||
| 2023-04-28 | 2023-04-26 | 4 | Gross Jane A | LIFE | Common stock | D | 6.000 | 6.000 | ||||||
| 2023-02-06 | 2023-02-03 | 4 | Krueger Nancy | LIFE | Common stock | D | 2.688 | 7.079 | ||||||
| 2023-02-06 | 2023-02-06 | 4 | Broadfoot Jill Marie | LIFE | Common stock | D | 2,3600 | -1.566 | -4 | 15.460 | ||||
| 2023-02-06 | 2023-02-03 | 4 | Broadfoot Jill Marie | LIFE | Common stock | D | 3.750 | 17.026 | ||||||
| 2023-02-06 | 2023-02-03 | 4 | Shukla Sanjay | LIFE | Common stock | D | 10.375 | 61.173 | ||||||
| 2022-11-21 | 2022-11-21 | 4 | Shukla Sanjay | LIFE | Common Stock | D | 2,1405 | 10.000 | 21 | 50.798 | ||||
| 2022-07-06 | 2022-07-01 | 4 | Shukla Sanjay | LIFE | Common Stock | D | 2,8776 | 15.000 | 43 | 40.798 | ||||
| 2022-05-26 | 2022-05-24 | 4 | Krueger Nancy | LIFE | Employee Stock Option (right to buy) | D | 2,81 | 88.097 | 88.097 | |||||
| 2022-05-26 | 2022-05-24 | 4 | Broadfoot Jill Marie | LIFE | Employee Stock Option (right to buy) | D | 2,81 | 75.347 | 75.347 | |||||
| 2022-05-26 | 2022-05-24 | 4 | Shukla Sanjay | LIFE | Employee Stock Option (right to buy) | D | 2,81 | 516.280 | 516.280 | |||||
| 2022-04-28 | 2022-04-26 | 4 | CLARKE JOHN K | LIFE | Restricted Stock Units | D | 6.000 | 6.000 | ||||||
| 2022-04-28 | 2022-04-26 | 4 | SCHIMMEL PAUL | LIFE | Restricted Stock Units | D | 6.000 | 6.000 | ||||||
| 2022-04-28 | 2022-04-26 | 4 | Coughlin Timothy P | LIFE | Restricted Stock Units | D | 6.000 | 6.000 | ||||||
| 2022-04-28 | 2022-04-26 | 4 | Zaknoen Sara | LIFE | Restricted Stock Units | D | 6.000 | 6.000 | ||||||
| 2022-04-28 | 2022-04-26 | 4 | Gross Jane A | LIFE | Restricted Stock Units | D | 6.000 | 6.000 | ||||||
| 2022-04-28 | 2022-04-26 | 4 | Lucas Svetlana | LIFE | Restricted Stock Units | D | 6.000 | 6.000 | ||||||
| 2022-02-07 | 2022-02-03 | 4 | Broadfoot Jill Marie | LIFE | Restricted Stock Units | D | 15.000 | 15.000 | ||||||
| 2022-02-07 | 2022-02-03 | 4 | Broadfoot Jill Marie | LIFE | Employee Stock Option (right to buy) | D | 5,52 | 30.000 | 30.000 | |||||
| 2022-02-07 | 2022-02-03 | 4 | Krueger Nancy | LIFE | Restricted Stock Units | D | 10.750 | 10.750 | ||||||
| 2022-02-07 | 2022-02-03 | 4 | Krueger Nancy | LIFE | Employee Stock Option (right to buy) | D | 5,52 | 21.500 | 21.500 | |||||
| 2022-02-07 | 2022-02-03 | 4 | Shukla Sanjay | LIFE | Restricted Stock Units | D | 41.500 | 41.500 | ||||||
| 2022-02-07 | 2022-02-03 | 4 | Shukla Sanjay | LIFE | Employee Stock Option (right to buy) | D | 5,52 | 83.000 | 83.000 | |||||
| 2022-01-18 | 2022-01-13 | 4 | Broadfoot Jill Marie | LIFE | Common stock | D | 6,7500 | 1.923 | 13 | 12.112 | ||||
| 2022-01-10 | 2022-01-07 | 4 | Shukla Sanjay | LIFE | Common Stock | D | 6,7613 | 5.000 | 34 | 25.798 | ||||
| 2021-11-15 | 2021-11-15 | 4 | Shukla Sanjay | LIFE | Common Stock | D | 8,5750 | 2.500 | 21 | 20.798 | ||||
| 2021-09-22 | 2021-09-20 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 250.000 | 679.143 | ||||||
| 2021-09-22 | 2021-09-20 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | D | -250.000 | 2.890 | ||||||
| 2021-09-22 | 2021-09-20 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | D | 8,0000 | 250.000 | 2.000 | 252.890 | ||||
| 2021-05-25 | 2021-05-21 | 4 | CLARKE JOHN K | LIFE | Common Stock | I | 4,3400 | -2.500 | -11 | 108.083 | ||||
| 2021-05-25 | 2021-05-21 | 4 | Krueger Nancy | LIFE | Employee Stock Option (Right to buy) | D | 4,45 | 59.000 | 59.000 | |||||
| 2021-05-25 | 2021-05-21 | 4 | Shukla Sanjay | LIFE | Employee Stock Option (Right to buy) | D | 4,45 | 207.000 | 207.000 | |||||
| 2021-05-25 | 2021-05-21 | 4 | Broadfoot Jill Marie | LIFE | Employee Stock Option (Right to buy) | D | 4,45 | 54.000 | 54.000 | |||||
| 2021-05-25 | 2021-05-21 | 4 | Zaknoen Sara | LIFE | Stock Option (right to buy) | D | 4,45 | 2.285 | 2.285 | |||||
| 2021-05-20 | 2021-05-18 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 3,9800 | 50.000 | 199 | 113.023 | ||||
| 2021-05-20 | 2021-05-18 | 4 | Shukla Sanjay | LIFE | Common Stock | D | 4,0100 | 10.000 | 40 | 18.298 | ||||
| 2021-04-29 | 2021-04-28 | 4 | SCHIMMEL PAUL | LIFE | Stock Option (right to buy) | D | 4,21 | 1.428 | 1.428 | |||||
| 2021-04-29 | 2021-04-28 | 4 | Lucas Svetlana | LIFE | Stock Option (right to buy) | D | 4,21 | 1.428 | 1.428 | |||||
| 2021-04-29 | 2021-04-28 | 4 | Gross Jane A | LIFE | Stock Option (right to buy) | D | 4,21 | 1.428 | 1.428 | |||||
| 2021-04-29 | 2021-04-28 | 4 | Coughlin Timothy P | LIFE | Stock Option (right to buy) | D | 4,21 | 1.428 | 1.428 | |||||
| 2021-04-29 | 2021-04-28 | 4 | CLARKE JOHN K | LIFE | Stock Option (right to buy) | D | 4,21 | 1.428 | 1.428 | |||||
| 2021-03-09 | 2021-02-04 | 4/A | Shukla Sanjay | LIFE | Employee Stock Option (right to buy) | D | 4,52 | 112.469 | 112.469 | |||||
| 2021-03-09 | 2020-05-26 | 4/A | Shukla Sanjay | LIFE | Employee Stock Option (right to buy) | D | 4,06 | 73.142 | 73.142 | |||||
| 2021-02-09 | 2021-02-09 | 4 | Broadfoot Jill Marie | LIFE | Common stock | D | 7,6600 | -390 | -3 | 9.833 | ||||
| 2021-02-09 | 2021-02-06 | 4 | Broadfoot Jill Marie | LIFE | Restricted Stock Unit | D | -892 | 0 | ||||||
| 2021-02-09 | 2021-02-06 | 4 | Broadfoot Jill Marie | LIFE | Common stock | D | 892 | 10.223 | ||||||
| 2021-02-09 | 2021-02-09 | 4 | Shukla Sanjay | LIFE | Common stock | D | 7,6600 | -778 | -6 | 8.298 | ||||
| 2021-02-09 | 2021-02-06 | 4 | Shukla Sanjay | LIFE | Restricted Stock Unit | D | -1.785 | 0 | ||||||
| 2021-02-09 | 2021-02-06 | 4 | Shukla Sanjay | LIFE | Common stock | D | 1.785 | 9.076 | ||||||
| 2021-02-08 | 2021-02-04 | 4 | Shukla Sanjay | LIFE | Employee Stock Option (right to buy) | D | 4,52 | 120.000 | 120.000 | |||||
| 2021-02-08 | 2021-02-04 | 4 | Krueger Nancy | LIFE | Employee Stock Option (right to buy) | D | 4,52 | 45.000 | 45.000 | |||||
| 2021-02-08 | 2021-02-04 | 4 | Broadfoot Jill Marie | LIFE | Employee Stock Option (right to buy) | D | 4,52 | 50.000 | 50.000 | |||||
| 2020-09-03 | 2020-09-02 | 4 | CLARKE JOHN K | LIFE | Common Stock | I | 4,0100 | -7.260 | -29 | 110.583 | ||||
| 2020-09-03 | 2020-08-28 | 4 | CLARKE JOHN K | LIFE | Common Stock | I | 4,0000 | -100 | -0 | 117.843 | ||||
| 2020-08-28 | 2020-08-27 | 4 | CLARKE JOHN K | LIFE | Common Stock | I | 4,0900 | -5.440 | -22 | 117.943 | ||||
| 2020-08-28 | 2020-08-26 | 4 | CLARKE JOHN K | LIFE | Common Stock | I | 4,2960 | -2.200 | -9 | 123.383 | ||||
| 2020-06-23 | 2020-06-19 | 4 | Broadfoot Jill Marie | LIFE | Common Stock | D | 4,2200 | 1.850 | 8 | 9.153 | ||||
| 2020-06-23 | 2020-06-19 | 4 | Shukla Sanjay | LIFE | Common Stock | D | 4,2700 | 6.000 | 26 | 7.291 | ||||
| 2020-05-28 | 2020-05-26 | 4 | Shukla Sanjay | LIFE | Employee Stock Option (right to buy) | D | 4,06 | 80.000 | 0 | |||||
| 2020-05-28 | 2020-05-26 | 4 | Broadfoot Jill Marie | LIFE | Employee Stock Option (right to buy) | D | 4,06 | 30.000 | 30.000 | |||||
| 2020-05-28 | 2020-05-26 | 4 | Krueger Nancy | LIFE | Employee Stock Option (right to buy) | D | 4,06 | 30.000 | 30.000 | |||||
| 2020-05-28 | 2020-05-20 | 4 | Krueger Nancy | LIFE | Common Stock | D | 3,6200 | -322 | -1 | 2.735 | ||||
| 2020-05-28 | 2020-05-16 | 4 | Krueger Nancy | LIFE | Restricted Stock Unit | D | -892 | 0 | ||||||
| 2020-05-28 | 2020-05-16 | 4 | Krueger Nancy | LIFE | Common Stock | D | 892 | 3.057 | ||||||
| 2020-05-22 | 2020-05-20 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 3,6390 | -8.447 | -31 | 429.143 | ||||
| 2020-05-08 | 2020-05-06 | 4 | Lucas Svetlana | LIFE | Stock Option (right to buy) | D | 3,65 | 1.428 | 1.428 | |||||
| 2020-05-08 | 2020-05-06 | 4 | SCHIMMEL PAUL | LIFE | Stock Option (right to buy) | D | 3,65 | 1.428 | 1.428 | |||||
| 2020-05-08 | 2020-05-06 | 4 | CLARKE JOHN K | LIFE | Stock Option (right to buy) | D | 3,65 | 1.428 | 1.428 | |||||
| 2020-05-08 | 2020-05-06 | 4 | Coughlin Timothy P | LIFE | Stock Option (right to buy) | D | 3,65 | 1.428 | 1.428 | |||||
| 2020-05-08 | 2020-05-06 | 4 | Gross Jane A | LIFE | Stock Option (right to buy) | D | 3,65 | 1.428 | 1.428 | |||||
| 2020-05-08 | 2020-05-06 | 4 | Hatfield Jeffrey S. | LIFE | Stock Option (right to buy) | D | 3,65 | 1.428 | 1.428 | |||||
| 2020-02-11 | 2020-02-10 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 4,2500 | 254.000 | 1.080 | 437.590 | ||||
| 2020-02-07 | 2020-02-07 | 4 | Broadfoot Jill Marie | LIFE | Common stock | D | 4,0300 | -375 | -2 | 7.125 | ||||
| 2020-02-07 | 2020-02-06 | 4 | Broadfoot Jill Marie | LIFE | Restricted Stock Unit | D | -893 | 893 | ||||||
| 2020-02-07 | 2020-02-06 | 4 | Broadfoot Jill Marie | LIFE | Common stock | D | 893 | 7.500 | ||||||
| 2020-02-07 | 2020-02-05 | 4 | Broadfoot Jill Marie | LIFE | Employee Stock Option (right to buy) | D | 4,39 | 23.359 | 23.359 | |||||
| 2020-02-07 | 2020-02-05 | 4 | Krueger Nancy | LIFE | Employee Stock Option (right to buy) | D | 4,39 | 13.778 | 13.778 | |||||
| 2020-02-07 | 2020-02-07 | 4 | Shukla Sanjay | LIFE | Common stock | D | 4,0300 | -745 | -3 | 1.291 | ||||
| 2020-02-07 | 2020-02-06 | 4 | Shukla Sanjay | LIFE | Restricted Stock Unit | D | -1.786 | 1.786 | ||||||
| 2020-02-07 | 2020-02-06 | 4 | Shukla Sanjay | LIFE | Common stock | D | 1.786 | 2.036 | ||||||
| 2020-02-07 | 2020-02-05 | 4 | Shukla Sanjay | LIFE | Employee Stock Option (right to buy) | D | 4,39 | 39.327 | 39.327 | |||||
| 2019-07-02 | 2019-06-28 | 4 | Gross Jane A | LIFE | Stock Option (right to buy) | D | 5,13 | 2.285 | 2.285 | |||||
| 2019-07-02 | 2019-06-28 | 4 | Lucas Svetlana | LIFE | Stock Option (right to buy) | D | 5,13 | 2.285 | 2.285 | |||||
| 2019-05-20 | 2019-05-17 | 4 | Krueger Nancy | LIFE | Common Stock | D | 0,4501 | -4.651 | -2 | 25.348 | ||||
| 2019-05-20 | 2019-05-16 | 4 | Krueger Nancy | LIFE | Restricted Stock Units | D | 0,00 | -12.500 | 12.500 | |||||
| 2019-05-20 | 2019-05-16 | 4 | Krueger Nancy | LIFE | Common Stock | D | 12.500 | 29.999 | ||||||
| 2019-05-10 | 2019-05-08 | 4 | BLAIR JAMES C | LIFE | Stock Option (right to buy) | D | 0,58 | 20.000 | 20.000 | |||||
| 2019-05-10 | 2019-05-08 | 4 | CLARKE JOHN K | LIFE | Stock Option (right to buy) | D | 0,58 | 20.000 | 20.000 | |||||
| 2019-05-10 | 2019-05-08 | 4 | Coughlin Timothy P | LIFE | Stock Option (right to buy) | D | 0,58 | 20.000 | 20.000 | |||||
| 2019-05-10 | 2019-05-08 | 4 | Hatfield Jeffrey S. | LIFE | Stock Option (right to buy) | D | 0,58 | 20.000 | 20.000 | |||||
| 2019-05-10 | 2019-05-08 | 4 | MENDLEIN JOHN | LIFE | Stock Option (right to buy) | D | 0,58 | 20.000 | 20.000 | |||||
| 2019-05-10 | 2019-05-08 | 4 | SCHIMMEL PAUL | LIFE | Stock Option (right to buy) | D | 0,58 | 20.000 | 20.000 | |||||
| 2019-04-16 | 2019-04-12 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 0,5410 | 1.848.428 | 1.000 | 2.570.242 | ||||
| 2019-02-08 | 3 | Krueger Nancy | LIFE | Common Stock | D | 29.998 | ||||||||
| 2019-02-08 | 3 | Krueger Nancy | LIFE | Common Stock | D | 29.998 | ||||||||
| 2019-02-08 | 3 | Krueger Nancy | LIFE | Common Stock | D | 29.998 | ||||||||
| 2019-02-08 | 2019-02-06 | 4 | Krueger Nancy | LIFE | Employee Stock Option (right to buy) | D | 0,52 | 125.000 | 125.000 | |||||
| 2019-02-08 | 2019-02-06 | 4 | Broadfoot Jill Marie | LIFE | Restricted Stock Unit | D | 25.000 | 25.000 | ||||||
| 2019-02-08 | 2019-02-06 | 4 | Broadfoot Jill Marie | LIFE | Employee Stock Option (right to buy) | D | 0,52 | 50.000 | 50.000 | |||||
| 2019-02-08 | 2019-02-06 | 4 | Shukla Sanjay | LIFE | Restricted Stock Unit | D | 50.000 | 50.000 | ||||||
| 2019-02-08 | 2019-02-06 | 4 | Shukla Sanjay | LIFE | Employee Stock Option (right to buy) | D | 0,52 | 200.000 | 200.000 | |||||
| 2018-12-26 | 2018-12-21 | 4 | MENDLEIN JOHN | LIFE | Common Stock | D | 0,4236 | 195.000 | 83 | 615.382 | ||||
| 2018-12-26 | 2018-12-20 | 4 | MENDLEIN JOHN | LIFE | Common Stock | D | 0,4129 | 50.000 | 21 | 420.382 | ||||
| 2018-11-28 | 2018-11-26 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 0,5420 | 147.225 | 80 | 882.302 | ||||
| 2018-09-21 | 2018-09-20 | 4 | Broadfoot Jill Marie | LIFE | Common Stock | D | 0,8352 | 38.000 | 32 | 90.000 | ||||
| 2018-09-21 | 2018-09-19 | 4 | Broadfoot Jill Marie | LIFE | Common Stock | D | 0,8122 | 26.000 | 21 | 52.000 | ||||
| 2018-09-18 | 2018-09-14 | 4 | Broadfoot Jill Marie | LIFE | Common Stock | D | 0,7329 | 26.000 | 19 | 26.000 | ||||
| 2018-09-05 | 2018-09-04 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 0,7571 | 20.749 | 16 | 735.077 | ||||
| 2018-09-05 | 2018-08-31 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 0,7160 | 22.000 | 16 | 714.328 | ||||
| 2018-08-31 | 2018-08-30 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 0,7559 | 89.275 | 67 | 692.328 | ||||
| 2018-08-31 | 2018-08-29 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 0,7199 | 75.136 | 54 | 603.053 | ||||
| 2018-08-01 | 2018-07-30 | 4 | Broadfoot Jill Marie | LIFE | Employee Stock Option (right to buy) | D | 0,82 | 200.000 | 200.000 | |||||
| 2018-06-07 | 2018-05-31 | 4 | Amanullah Ashraf | LIFE | Restricted Stock Units | D | 0,00 | 3.333 | 3.333 | |||||
| 2018-06-07 | 2018-05-31 | 4 | Amanullah Ashraf | LIFE | Common Stock | D | 3.333 | 26.264 | ||||||
| 2018-05-21 | 2018-05-18 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 0,9963 | 150.000 | 149 | 527.917 | ||||
| 2018-05-17 | 2018-05-15 | 4 | BLAIR JAMES C | LIFE | Stock Option (right to buy) | D | 1,35 | 20.000 | 20.000 | |||||
| 2018-05-17 | 2018-05-15 | 4 | SCHIMMEL PAUL | LIFE | Stock Option (right to buy) | D | 1,35 | 20.000 | 20.000 | |||||
| 2018-05-17 | 2018-05-15 | 4 | Coughlin Timothy P | LIFE | Stock Option (right to buy) | D | 1,35 | 20.000 | 20.000 | |||||
| 2018-05-17 | 2018-05-15 | 4 | Hatfield Jeffrey S. | LIFE | Stock Option (right to buy) | D | 1,35 | 20.000 | 20.000 | |||||
| 2018-05-17 | 2018-05-15 | 4 | MENDLEIN JOHN | LIFE | Stock Option (right to buy) | D | 1,35 | 20.000 | 20.000 | |||||
| 2018-05-17 | 2018-05-15 | 4 | Nashat Amir | LIFE | Stock Option (right to buy) | D | 1,35 | 20.000 | 20.000 | |||||
| 2018-05-17 | 2018-05-15 | 4 | CLARKE JOHN K | LIFE | Stock Option (right to buy) | D | 1,35 | 20.000 | 20.000 | |||||
| 2018-05-16 | 2018-05-16 | 4 | EcoR1 Capital Fund Qualified, L.P. | LIFE | Common Stock | D | 0,8111 | -2.733.231 | -2.217 | 0 | ||||
| 2018-05-16 | 2018-05-15 | 4 | EcoR1 Capital Fund Qualified, L.P. | LIFE | Common Stock | D | 1,4268 | -121.294 | -173 | 2.733.231 | ||||
| 2018-05-16 | 2018-05-14 | 4 | EcoR1 Capital Fund Qualified, L.P. | LIFE | Common Stock | D | 1,7167 | -354.791 | -609 | 2.854.525 | ||||
| 2018-05-02 | 3 | Blackburn Stan By the J. Stanhope and Karlene S. Blackburn Family Trust U.T.D. May 2001 | LIFE | Common Stock | I | 23.908 | ||||||||
| 2018-05-02 | 3 | Blackburn Stan By the J. Stanhope and Karlene S. Blackburn Family Trust U.T.D. May 2001 | LIFE | Common Stock | I | 23.908 | ||||||||
| 2018-05-02 | 3 | Blackburn Stan By the J. Stanhope and Karlene S. Blackburn Family Trust U.T.D. May 2001 | LIFE | Common Stock | I | 23.908 | ||||||||
| 2018-02-08 | 2018-02-06 | 4 | Shukla Sanjay | LIFE | Employee Stock Option (right to buy) | D | 3,30 | 300.000 | 300.000 | |||||
| 2018-02-08 | 2018-02-08 | 4 | Amanullah Ashraf | LIFE | Common Stock | D | 3,4000 | -1.402 | -5 | 1.932 | ||||
| 2018-02-08 | 2018-02-07 | 4 | Amanullah Ashraf | LIFE | Restricted Stock Units | D | 0,00 | -3.334 | 6.666 | |||||
| 2018-02-08 | 2018-02-07 | 4 | Amanullah Ashraf | LIFE | Common Stock | D | 3.334 | 3.334 | ||||||
| 2018-02-08 | 2018-02-06 | 4 | Amanullah Ashraf | LIFE | Employee Stock Option (right to buy) | D | 3,30 | 100.000 | 100.000 | |||||
| 2018-02-08 | 2018-02-08 | 4 | Blake John T | LIFE | Common Stock | D | 3,4000 | -1.402 | -5 | 1.932 | ||||
| 2018-02-08 | 2018-02-07 | 4 | Blake John T | LIFE | Restricted Stock Units | D | 0,00 | -3.334 | 6.666 | |||||
| 2018-02-08 | 2018-02-07 | 4 | Blake John T | LIFE | Common Stock | D | 3.334 | 3.334 | ||||||
| 2018-02-08 | 2018-02-06 | 4 | Blake John T | LIFE | Employee Stock Option (right to buy) | D | 3,30 | 75.000 | 75.000 | |||||
| 2018-02-08 | 2018-02-06 | 4 | King David John | LIFE | Employee Stock Option (right to buy) | D | 3,30 | 150.000 | 150.000 | |||||
| 2018-01-02 | 2018-01-02 | 4 | MENDLEIN JOHN | LIFE | Stock Option (right to buy) | D | 3,80 | 32.000 | 32.000 | |||||
| 2017-12-14 | 2017-11-13 | 4 | EcoR1 Capital Fund Qualified, L.P. | ATYR | Common Stock | D | 3,9500 | -1.083 | -4 | 3.209.316 | ||||
| 2017-12-14 | 2017-11-10 | 4 | EcoR1 Capital Fund Qualified, L.P. | ATYR | Common Stock | D | 4,0008 | -5.860 | -23 | 3.210.399 | ||||
| 2017-12-14 | 2017-11-09 | 4 | EcoR1 Capital Fund Qualified, L.P. | ATYR | Common Stock | D | 4,1504 | -5.819 | -24 | 3.216.259 | ||||
| 2017-12-14 | 2017-11-08 | 4 | EcoR1 Capital Fund Qualified, L.P. | ATYR | Common Stock | D | 4,3000 | -1.070 | -5 | 3.222.078 | ||||
| 2017-12-14 | 2017-11-01 | 4 | EcoR1 Capital Fund Qualified, L.P. | ATYR | Common Stock | D | 4,8000 | 24.728 | 119 | 3.223.148 | ||||
| 2017-12-14 | 2017-10-01 | 4 | EcoR1 Capital Fund Qualified, L.P. | ATYR | Common Stock | D | 5,0500 | 4.879 | 25 | 3.198.420 | ||||
| 2017-11-03 | 2017-11-01 | 4 | Shukla Sanjay | LIFE | Employee Stock Option (right to buy) | D | 4,00 | 450.000 | 450.000 | |||||
| 2017-09-07 | 3 | EcoR1 Capital Fund Qualified, L.P. | ATYR | Common Stock | D | 6.387.082 | ||||||||
| 2017-09-07 | 3 | EcoR1 Capital Fund Qualified, L.P. | ATYR | Common Stock | D | 6.387.082 | ||||||||
| 2017-09-05 | 2017-08-31 | 4 | SCHIMMEL PAUL | LIFE | Warrant to Purchase Common Stock | I | 4,64 | 35.376 | 35.376 | |||||
| 2017-09-05 | 2017-08-31 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 2,6500 | 94.336 | 250 | 377.917 | ||||
| 2017-09-05 | 2017-08-31 | 4 | MENDLEIN JOHN | LIFE | Warrant to Purchase Common Stock | D | 4,64 | 14.151 | 14.151 | |||||
| 2017-09-05 | 2017-08-31 | 4 | MENDLEIN JOHN | LIFE | Common Stock | D | 2,6500 | 37.736 | 100 | 367.883 | ||||
| 2017-05-11 | 3/A | Blackburn Stan By the J. Stanhope and Karlene S. Blackburn Family Trust U.T.D. May 9, 2001 | LIFE | Common Stock | I | 11.805 | ||||||||
| 2017-05-11 | 2017-05-09 | 4 | Nashat Amir | LIFE | Stock Option (right to buy) | D | 3,15 | 20.000 | 20.000 | |||||
| 2017-05-11 | 2017-05-09 | 4 | SCHIMMEL PAUL | LIFE | Stock Option (right to buy) | D | 3,15 | 20.000 | 20.000 | |||||
| 2017-05-11 | 2017-05-09 | 4 | Hatfield Jeffrey S. | LIFE | Stock Option (right to buy) | D | 3,15 | 20.000 | 20.000 | |||||
| 2017-05-11 | 2017-05-09 | 4 | Goldberg Mark Alan | LIFE | Stock Option (right to buy) | D | 3,15 | 20.000 | 20.000 | |||||
| 2017-05-11 | 2017-05-09 | 4 | CLARKE JOHN K | LIFE | Stock Option (right to buy) | D | 3,15 | 20.000 | 20.000 | |||||
| 2017-05-11 | 2017-05-09 | 4 | Coughlin Timothy P | LIFE | Stock Option (right to buy) | D | 3,15 | 20.000 | 20.000 | |||||
| 2017-05-11 | 2017-05-09 | 4 | AKKARAJU SRINIVAS | LIFE | Stock Option (right to buy) | D | 3,15 | 20.000 | 20.000 | |||||
| 2017-05-11 | 2017-05-09 | 4 | BLAIR JAMES C | LIFE | Stock Option (right to buy) | D | 3,15 | 20.000 | 20.000 | |||||
| 2017-04-26 | 2017-04-24 | 4 | MENDLEIN JOHN | LIFE | Common Stock | D | 3,0000 | 124 | 0 | 327.647 | ||||
| 2017-04-20 | 2017-04-20 | 4 | MENDLEIN JOHN | LIFE | Common Stock | D | 3,0000 | 1.552 | 5 | 327.523 | ||||
| 2017-04-20 | 2017-04-18 | 4 | MENDLEIN JOHN | LIFE | Common Stock | D | 3,0000 | 1.000 | 3 | 325.971 | ||||
| 2017-04-10 | 2017-04-07 | 4 | Coughlin Timothy P | LIFE | Stock Option (right to buy) | D | 3,25 | 32.000 | 32.000 | |||||
| 2017-04-04 | 2017-04-03 | 4 | Hatfield Jeffrey S. | LIFE | Stock Option (right to buy) | D | 3,50 | 32.000 | 32.000 | |||||
| 2017-02-09 | 2017-02-07 | 4 | Shukla Sanjay | LIFE | Employee Stock Option (right to buy) | D | 3,30 | 65.000 | 65.000 | |||||
| 2017-02-09 | 2017-02-07 | 4 | Ravindran Sanuj K. | LIFE | Employee Stock Option (right to buy) | D | 3,30 | 40.000 | 40.000 | |||||
| 2017-02-09 | 2017-02-07 | 4 | Matsuoka Grove | LIFE | Employee Stock Option (right to buy) | D | 3,30 | 20.000 | 20.000 | |||||
| 2017-02-09 | 2017-02-07 | 4 | MENDLEIN JOHN | LIFE | Employee Stock Option (right to buy) | D | 3,30 | 185.000 | 185.000 | |||||
| 2017-02-09 | 2017-02-07 | 4 | Blake John T | LIFE | Restricted Stock Unit | D | 10.000 | 10.000 | ||||||
| 2017-02-09 | 2017-02-07 | 4 | Blake John T | LIFE | Employee Stock Option (right to buy) | D | 3,30 | 55.000 | 55.000 | |||||
| 2017-02-09 | 2017-02-07 | 4 | King David John | LIFE | Employee Stock Option (right to buy) | D | 3,30 | 65.000 | 65.000 | |||||
| 2017-02-09 | 2017-02-07 | 4 | Amanullah Ashraf | LIFE | Restricted Stock Unit | D | 10.000 | 10.000 | ||||||
| 2017-02-09 | 2017-02-07 | 4 | Amanullah Ashraf | LIFE | Employee Stock Option (right to buy) | D | 3,30 | 35.000 | 35.000 | |||||
| 2016-12-22 | 2016-12-21 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 2,2818 | 10.000 | 23 | 721.814 | ||||
| 2016-12-22 | 2016-12-20 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 2,2740 | 15.000 | 34 | 711.814 | ||||
| 2016-12-21 | 2016-12-19 | 4 | MENDLEIN JOHN | LIFE | Common Stock | D | 2,1980 | 69.000 | 152 | 324.971 | ||||
| 2016-12-21 | 2016-12-20 | 4 | Amanullah Ashraf | LIFE | Common Stock | D | 2,2499 | 11.000 | 25 | 11.000 | ||||
| 2016-12-19 | 2016-12-16 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 2,3973 | 10.000 | 24 | 696.814 | ||||
| 2016-12-19 | 2016-12-15 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 2,4978 | 40.000 | 100 | 686.814 | ||||
| 2016-12-19 | 2016-09-23 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 12.572 | 646.814 | ||||||
| 2016-12-19 | 2016-09-23 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | D | -12.572 | 40.440 | ||||||
| 2016-09-22 | 2016-09-21 | 4 | King David John | LIFE | Employee Stock Option (right to buy) | D | 3,29 | 145.000 | 145.000 | |||||
| 2016-09-15 | 2016-09-13 | 4 | Cubitt Andrew | LIFE | Employee Stock Option (right to buy) | D | 3,06 | 25.000 | 25.000 | |||||
| 2016-09-15 | 2016-09-13 | 4 | Blake John T | LIFE | Employee Stock Option (right to buy) | D | 3,06 | 19.000 | 19.000 | |||||
| 2016-09-15 | 2016-09-13 | 4 | Ravindran Sanuj K. | LIFE | Employee Stock Option (right to buy) | D | 3,06 | 45.500 | 45.500 | |||||
| 2016-09-15 | 2016-09-13 | 4 | Amanullah Ashraf | LIFE | Employee Stock Option (right to buy) | D | 3,06 | 28.000 | 28.000 | |||||
| 2016-09-15 | 2016-09-13 | 4 | Shukla Sanjay | LIFE | Employee Stock Option (right to buy) | D | 3,06 | 27.500 | 27.500 | |||||
| 2016-09-15 | 2016-09-13 | 4 | Matsuoka Grove | LIFE | Employee Stock Option (right to buy) | D | 3,06 | 20.000 | 20.000 | |||||
| 2016-05-26 | 2016-05-24 | 4 | BLAIR JAMES C | LIFE | Stock Option (right to buy) | D | 3,33 | 18.000 | 18.000 | |||||
| 2016-05-26 | 2016-05-24 | 4 | AKKARAJU SRINIVAS | LIFE | Stock Option (right to buy) | D | 3,33 | 18.000 | 18.000 | |||||
| 2016-05-26 | 2016-05-24 | 4 | CLARKE JOHN K | LIFE | Stock Option (right to buy) | D | 3,33 | 18.000 | 18.000 | |||||
| 2016-05-26 | 2016-05-24 | 4 | FALBERG KATHRYN E | LIFE | Stock Option (right to buy) | D | 3,33 | 18.000 | 18.000 | |||||
| 2016-05-26 | 2016-05-24 | 4 | SCHIMMEL PAUL | LIFE | Stock Option (right to buy) | D | 3,33 | 18.000 | 18.000 | |||||
| 2016-05-26 | 2016-05-24 | 4 | Goldberg Mark Alan | LIFE | Stock Option (right to buy) | D | 3,33 | 18.000 | 18.000 | |||||
| 2016-05-26 | 2016-05-24 | 4 | Nashat Amir | LIFE | Stock Option (right to buy) | D | 3,33 | 18.000 | 18.000 | |||||
| 2016-05-11 | 2016-05-11 | 4 | Matsuoka Grove | LIFE | Common Stock | D | 3,0300 | 10.000 | 30 | 12.412 | ||||
| 2016-05-11 | 2016-05-09 | 4 | Matsuoka Grove | LIFE | Common Stock | D | 3,0800 | 2.412 | 7 | 2.412 | ||||
| 2016-05-03 | 2016-05-03 | 4 | Matsuoka Grove | LIFE | Stock Option (right to buy) | D | 3,67 | 145.000 | 145.000 | |||||
| 2016-04-15 | 2016-04-14 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | D | 4,1434 | 32.600 | 135 | 53.012 | ||||
| 2016-04-15 | 2016-04-14 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 4,2196 | 33.619 | 142 | 283.581 | ||||
| 2016-04-14 | 2016-04-13 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 3,8500 | 9.835 | 38 | 249.962 | ||||
| 2016-04-13 | 2016-04-11 | 4/A | SCHIMMEL PAUL | LIFE | Common Stock | I | 3,5913 | 22.100 | 79 | 233.581 | ||||
| 2016-04-13 | 2016-04-11 | 4/A | SCHIMMEL PAUL | LIFE | Common Stock | I | 3,4481 | 5.300 | 18 | 211.481 | ||||
| 2016-04-13 | 2016-04-11 | 4/A | SCHIMMEL PAUL | LIFE | Common Stock | D | 3,5921 | 5.259 | 19 | 17.831 | ||||
| 2016-04-13 | 2016-04-12 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 3,6999 | 6.546 | 24 | 240.127 | ||||
| 2016-04-13 | 2016-04-12 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | D | 3,7512 | 2.581 | 10 | 20.412 | ||||
| 2016-04-12 | 2016-04-11 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | D | 3,4481 | 5.300 | 18 | 220.231 | ||||
| 2016-04-12 | 2016-04-11 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | D | 3,5915 | 27.359 | 98 | 214.931 | ||||
| 2016-04-11 | 2016-04-08 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | D | 3,2194 | 85.000 | 274 | 187.572 | ||||
| 2016-04-08 | 2016-04-07 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | D | 3,1896 | 40.000 | 128 | 102.572 | ||||
| 2016-04-07 | 2016-04-05 | 4 | MENDLEIN JOHN | LIFE | Common Stock | D | 3,5200 | 2.500 | 9 | 250.971 | ||||
| 2016-04-07 | 2016-04-06 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | D | 3,2000 | 25.000 | 80 | 62.572 | ||||
| 2016-04-06 | 2016-04-05 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | D | 3,5247 | 25.000 | 88 | 37.572 | ||||
| 2016-04-06 | 2016-04-05 | 4 | MENDLEIN JOHN | LIFE | Common Stock | D | 3,5500 | 2.500 | 9 | 248.471 | ||||
| 2016-04-01 | 3 | Shukla Sanjay | LIFE | Common Stock | D | 7.000 | ||||||||
| 2016-04-01 | 3 | Shukla Sanjay | LIFE | Common Stock | D | 7.000 | ||||||||
| 2016-04-01 | 2016-03-30 | 4 | Shukla Sanjay | LIFE | Employee Stock Option (right to buy) | D | 4,86 | 163.000 | 163.000 | |||||
| 2016-03-30 | 2016-03-28 | 4 | Blackburn Kelly | LIFE | Restricted Stock Unit | D | 21.600 | 21.600 | ||||||
| 2016-03-30 | 2016-03-28 | 4 | Cubitt Andrew | LIFE | Restricted Stock Unit | D | 13.000 | 13.000 | ||||||
| 2016-01-29 | 2016-01-27 | 4 | Nashat Amir | LIFE | Stock Option (right to buy) | D | 6,14 | 19.428 | 19.428 | |||||
| 2016-01-29 | 2016-01-27 | 4 | Goldberg Mark Alan | LIFE | Stock Option (right to buy) | D | 6,14 | 19.428 | 19.428 | |||||
| 2016-01-29 | 2016-01-27 | 4 | Blake John T | LIFE | Employee Stock Option (right to buy) | D | 6,14 | 20.000 | 20.000 | |||||
| 2016-01-29 | 2016-01-27 | 4 | Cubitt Andrew | LIFE | Employee Stock Option (right to buy) | D | 6,14 | 8.500 | 8.500 | |||||
| 2016-01-29 | 2016-01-27 | 4 | Ashlock Melissa A. | LIFE | Employee Stock Option (right to buy) | D | 6,14 | 18.250 | 18.250 | |||||
| 2016-01-29 | 2016-01-27 | 4 | Krueger Nancy | LIFE | Employee Stock Option (right to buy) | D | 6,14 | 20.000 | 20.000 | |||||
| 2016-01-29 | 2016-01-27 | 4 | Blackburn Stan | LIFE | Stock Option (right to buy) | D | 6,14 | 4.250 | 4.250 | |||||
| 2016-01-29 | 2016-01-27 | 4 | Blackburn Kelly | LIFE | Employee Stock Option (right to buy) | D | 6,14 | 18.250 | 18.250 | |||||
| 2016-01-29 | 2016-01-27 | 4 | Chrzanowski Holly D. | LIFE | Employee Stock Option (right to buy) | D | 6,14 | 8.500 | 8.500 | |||||
| 2016-01-29 | 2016-01-27 | 4 | AKKARAJU SRINIVAS | LIFE | Stock Option (right to buy) | D | 6,14 | 19.428 | 19.428 | |||||
| 2016-01-29 | 2016-01-27 | 4 | CLARKE JOHN K | LIFE | Stock Option (right to buy) | D | 6,14 | 19.428 | 19.428 | |||||
| 2016-01-29 | 2016-01-27 | 4 | FALBERG KATHRYN E | LIFE | Stock Option (right to buy) | D | 6,14 | 19.428 | 19.428 | |||||
| 2016-01-29 | 2016-01-27 | 4 | BLAIR JAMES C | LIFE | Stock Option (right to buy) | D | 6,14 | 19.428 | 19.428 | |||||
| 2016-01-29 | 2016-01-27 | 4 | MENDLEIN JOHN | LIFE | Employee Stock Option (right to buy) | D | 6,14 | 135.000 | 135.000 | |||||
| 2016-01-29 | 2016-01-27 | 4 | SCHIMMEL PAUL | LIFE | Stock Option (right to buy) | D | 6,14 | 19.428 | 19.428 | |||||
| 2016-01-29 | 2015-09-16 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | -11.925 | 634.242 | ||||||
| 2016-01-29 | 2016-01-27 | 4 | McKew John C. | LIFE | Employee Stock Option (right to buy) | D | 6,14 | 40.000 | 40.000 | |||||
| 2016-01-06 | 2016-01-04 | 4 | MENDLEIN JOHN | LIFE | Employee Stock Option (right to buy) | D | 9,13 | 148.732 | 148.732 | |||||
| 2016-01-06 | 2016-01-04 | 4 | McKew John C. | LIFE | Employee Stock Option (right to buy) | D | 9,13 | 25.913 | 25.913 | |||||
| 2016-01-06 | 2016-01-04 | 4 | Krueger Nancy | LIFE | Employee Stock Option (right to buy) | D | 9,13 | 10.831 | 10.831 | |||||
| 2016-01-06 | 2016-01-04 | 4 | Graham Marcy | LIFE | Employee Stock Option (right to buy) | D | 9,13 | 12.023 | 12.023 | |||||
| 2016-01-06 | 2016-01-04 | 4 | Cubitt Andrew | LIFE | Employee Stock Option (right to buy) | D | 9,13 | 16.874 | 16.874 | |||||
| 2016-01-06 | 2016-01-04 | 4 | Chrzanowski Holly D. | LIFE | Employee Stock Option (right to buy) | D | 9,13 | 14.829 | 14.829 | |||||
| 2016-01-06 | 2016-01-04 | 4 | Blake John T | LIFE | Employee Stock Option (right to buy) | D | 9,13 | 5.038 | 5.038 | |||||
| 2016-01-06 | 2016-01-04 | 4 | Blackburn Stan | LIFE | Employee Stock Option (right to buy) | D | 9,13 | 5.754 | 5.754 | |||||
| 2016-01-06 | 2016-01-04 | 4 | Blackburn Kelly | LIFE | Employee Stock Option (right to buy) | D | 9,13 | 26.470 | 26.470 | |||||
| 2016-01-06 | 2016-01-04 | 4 | Ashlock Melissa A. | LIFE | Employee Stock Option (right to buy) | D | 9,13 | 29.659 | 29.659 | |||||
| 2016-01-06 | 2016-01-04 | 4 | Ravindran Sanuj K. | LIFE | Employee Stock Option (right to buy) | D | 9,13 | 10.750 | 10.750 | |||||
| 2016-01-06 | 2016-01-04 | 4 | Ravindran Sanuj K. | LIFE | Employee Stock Option (right to buy) | D | 9,13 | 153.000 | 153.000 | |||||
| 2015-10-30 | 2015-10-28 | 4 | Blake John T | LIFE | Employee Stock Option (right to buy) | D | 12,49 | 7.500 | 7.500 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Ramsdell Fred | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 5.393 | 5.393 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Ramsdell Fred | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 12.000 | 12.000 | |||||
| 2015-10-05 | 2015-10-01 | 4 | MENDLEIN JOHN | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 65.070 | 65.070 | |||||
| 2015-10-05 | 2015-10-01 | 4 | MENDLEIN JOHN | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 71.000 | 71.000 | |||||
| 2015-10-05 | 2015-10-01 | 4 | McKew John C. | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 11.337 | 11.337 | |||||
| 2015-10-05 | 2015-10-01 | 4 | McKew John C. | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 23.000 | 23.000 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Krueger Nancy | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 4.739 | 4.739 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Krueger Nancy | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 17.000 | 17.000 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Graham Marcy | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 5.260 | 5.260 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Graham Marcy | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 28.000 | 28.000 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Cubitt Andrew | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 7.382 | 7.382 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Cubitt Andrew | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 23.000 | 23.000 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Chrzanowski Holly D. | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 6.488 | 6.488 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Chrzanowski Holly D. | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 24.000 | 24.000 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Blackburn Stan | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 2.518 | 2.518 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Blackburn Stan | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 9.500 | 9.500 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Blackburn Kelly | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 11.581 | 11.581 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Blackburn Kelly | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 45.500 | 45.500 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Ashlock Melissa A. | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 12.976 | 12.976 | |||||
| 2015-10-05 | 2015-10-01 | 4 | Ashlock Melissa A. | LIFE | Employee Stock Option (right to buy) | D | 10,24 | 30.000 | 30.000 | |||||
| 2015-07-10 | 2015-07-08 | 4 | Goldberg Mark Alan | LIFE | Stock Option (right to buy) | D | 14,96 | 6.286 | 6.286 | |||||
| 2015-07-10 | 2015-07-08 | 4 | SCHIMMEL PAUL | LIFE | Stock Option (right to buy) | D | 14,96 | 6.286 | 6.286 | |||||
| 2015-07-10 | 2015-07-08 | 4 | CLARKE JOHN K | LIFE | Stock Option (right to buy) | D | 14,96 | 6.286 | 6.286 | |||||
| 2015-07-10 | 2015-07-08 | 4 | Nashat Amir | LIFE | Stock Option (right to buy) | D | 14,96 | 6.286 | 6.286 | |||||
| 2015-07-10 | 2015-07-08 | 4 | BLAIR JAMES C | LIFE | Stock Option (right to buy) | D | 14,96 | 6.286 | 6.286 | |||||
| 2015-07-10 | 2015-07-08 | 4 | AKKARAJU SRINIVAS | LIFE | Stock Option (right to buy) | D | 14,96 | 6.286 | 6.286 | |||||
| 2015-07-10 | 2015-07-08 | 4 | FALBERG KATHRYN E | LIFE | Stock Option (right to buy) | D | 14,96 | 6.286 | 6.286 | |||||
| 2015-05-14 | 3/A | SCHIMMEL PAUL | LIFE | Common Stock | D | 12.572 | ||||||||
| 2015-05-14 | 2015-05-12 | 4 | SCHIMMEL PAUL | LIFE | Series E Redeemable Convertible Preferred Stock | I | -446.827 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | SCHIMMEL PAUL | LIFE | Series D Redeemable Convertible Preferred Stock | I | -15.031 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | SCHIMMEL PAUL | LIFE | Series C Redeemable Convertible Preferred Stock | I | -558.508 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | SCHIMMEL PAUL | LIFE | Series B-2 Redeemable Convertible Preferred Stock | I | -1.440.058 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | SCHIMMEL PAUL | LIFE | Series B Redeemable Convertible Preferred Stock | I | -1.200.000 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | SCHIMMEL PAUL | LIFE | Series A Redeemable Convertible Preferred Stock | I | -525.000 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | SCHIMMEL PAUL | LIFE | Series D Redeemable Convertible Preferred Stock | I | -248.024 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 46.152 | 646.167 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 470.020 | 600.015 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | SCHIMMEL PAUL | LIFE | Common Stock | I | 31.181 | 31.181 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | AKKARAJU SRINIVAS By Sofinnova Venture Partners IX, L.P. | LIFE | Series E Redeemable Convertible Preferred Stock | I | -14.968.722 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | AKKARAJU SRINIVAS By Sofinnova Venture Partners IX, L.P. | LIFE | Common Stock | I | 14,0000 | 320.000 | 4.480 | 1.866.126 | ||||
| 2015-05-14 | 2015-05-12 | 4 | AKKARAJU SRINIVAS By Sofinnova Venture Partners IX, L.P. | LIFE | Common Stock | I | 1.546.126 | 1.546.126 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | MENDLEIN JOHN | LIFE | Series D Redeemable Convertible Preferred Stock | D | -21.122 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | MENDLEIN JOHN | LIFE | Series C Redeemable Convertible Preferred Stock | D | -170.218 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | MENDLEIN JOHN | LIFE | Common Stock | D | 24.055 | 245.971 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | CLARKE JOHN K | LIFE | Series D Redeemable Convertible Preferred Stock | I | -1.536.787 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | CLARKE JOHN K | LIFE | Series C Redeemable Convertible Preferred Stock | I | -2.127.660 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | CLARKE JOHN K | LIFE | Series B-2 Redeemable Convertible Preferred Stock | I | -4.320.173 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | CLARKE JOHN K | LIFE | Series B Redeemable Convertible Preferred Stock | I | -3.600.000 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | CLARKE JOHN K | LIFE | Series A Redeemable Convertible Preferred Stock | I | -2.400.000 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | CLARKE JOHN K | LIFE | Series E Redeemable Convertible Preferred Stock | D | -893.655 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | CLARKE JOHN K | LIFE | Common Stock | I | 1.758.158 | 1.758.158 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | CLARKE JOHN K | LIFE | Common Stock | D | 92.306 | 104.878 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Alta Partners VIII, L.P. | LIFE | Series E Redeemable Convertible Preferred Stock | D | -893.655 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Alta Partners VIII, L.P. | LIFE | Series D Redeemable Convertible Preferred Stock | D | -1.126.866 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Alta Partners VIII, L.P. | LIFE | Series C Redeemable Convertible Preferred Stock | D | -4.361.703 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Alta Partners VIII, L.P. | LIFE | Series B-2 Redeemable Convertible Preferred Stock | D | -4.320.173 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Alta Partners VIII, L.P. | LIFE | Series B Redeemable Convertible Preferred Stock | D | -3.600.000 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Alta Partners VIII, L.P. | LIFE | Common Stock | D | 92.306 | 1.778.064 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Alta Partners VIII, L.P. | LIFE | Common Stock | D | 1.685.758 | 1.685.758 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | CHP II LP | LIFE | Series D Redeemable Convertible Preferred Stock | D | -1.536.787 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | CHP II LP | LIFE | Series C Redeemable Convertible Preferred Stock | D | -2.127.660 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | CHP II LP | LIFE | Series B-2 Redeemable Convertible Preferred Stock | D | -4.320.173 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | CHP II LP | LIFE | Series B Redeemable Convertible Preferred Stock | D | -3.600.000 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | CHP II LP | LIFE | Series A Redeemable Convertible Preferred Stock | D | -2.400.000 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | CHP II LP | LIFE | Common Stock | D | 1.758.158 | 1.758.158 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Special Founders' Fund V, L.P. | LIFE | Series E Redeemable Convertible Preferred Stock | I | -8.623 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Founders' Fund V, L.P. | LIFE | Series E Redeemable Convertible Preferred Stock | I | -5.906 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Entrepreneurs' Fund V, L.P. | LIFE | Series E Redeemable Convertible Preferred Stock | I | -16.806 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners V, L.P. | LIFE | Series E Redeemable Convertible Preferred Stock | I | -862.318 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Special Founders' Fund V, L.P. | LIFE | Series D Redeemable Convertible Preferred Stock | I | -14.706 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Founders' Fund V, L.P. | LIFE | Series D Redeemable Convertible Preferred Stock | I | -10.074 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Entrepreneurs' Fund V, L.P. | LIFE | Series D Redeemable Convertible Preferred Stock | I | -28.661 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners V, L.P. | LIFE | Series D Redeemable Convertible Preferred Stock | I | -1.470.577 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Special Founders' Fund V, L.P. | LIFE | Series C Redeemable Convertible Preferred Stock | I | -42.087 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Founders' Fund V, L.P. | LIFE | Series C Redeemable Convertible Preferred Stock | I | -28.831 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Entrepreneurs' Fund V, L.P. | LIFE | Series C Redeemable Convertible Preferred Stock | I | -82.029 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners V, L.P. | LIFE | Series C Redeemable Convertible Preferred Stock | I | -4.208.756 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Special Founders' Fund V, L.P. | LIFE | Series B-2 Redeemable Convertible Preferred Stock | I | -41.686 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Founders' Fund V, L.P. | LIFE | Series B-2 Redeemable Convertible Preferred Stock | I | -28.556 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Entrepreneurs' Fund V, L.P. | LIFE | Series B-2 Redeemable Convertible Preferred Stock | I | -81.248 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners V, L.P. | LIFE | Series B-2 Redeemable Convertible Preferred Stock | I | -4.168.683 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. Polaris Venture Partners Special Founders' Fund V, L.P. | LIFE | Series B Redeemable Convertible Preferred Stock | I | -34.737 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Founders' Fund V, L.P. | LIFE | Series B Redeemable Convertible Preferred Stock | I | -23.796 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Entrepreneurs' Fund V, L.P. | LIFE | Series B Redeemable Convertible Preferred Stock | I | -67.704 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners V, L.P. | LIFE | Series B Redeemable Convertible Preferred Stock | I | -3.473.763 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. Polaris Venture Partners Special Founders' Fund V, L.P. | LIFE | Common Stock | I | 890 | 17.638 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Founders' Fund V, L.P. | LIFE | Common Stock | I | 610 | 12.082 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Entrepreneurs' Fund V, L.P. | LIFE | Common Stock | I | 1.736 | 34.378 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners V, L.P. | LIFE | Common Stock | I | 89.069 | 1.763.894 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. Polaris Venture Partners Special Founders' Fund V, L.P. | LIFE | Common Stock | I | 16.748 | 16.748 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Founders' Fund V, L.P. | LIFE | Common Stock | I | 11.472 | 11.472 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners Entrepreneurs' Fund V, L.P. | LIFE | Common Stock | I | 32.642 | 32.642 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Polaris Venture Management Co. V, L.L.C. By Polaris Venture Partners V, L.P. | LIFE | Common Stock | I | 1.674.825 | 1.674.825 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Special Founders' Fund V, L.P. | LIFE | Series E Redeemable Convertible Preferred Stock | I | -8.623 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Founders' Fund V, L.P. | LIFE | Series E Redeemable Convertible Preferred Stock | I | -5.906 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Entrepreneurs' Fund V, L.P. | LIFE | Series E Redeemable Convertible Preferred Stock | I | -16.806 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners V, L.P. | LIFE | Series E Redeemable Convertible Preferred Stock | I | -862.318 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Special Founders' Fund V, L.P. | LIFE | Series D Redeemable Convertible Preferred Stock | I | -14.706 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Founders' Fund V, L.P. | LIFE | Series D Redeemable Convertible Preferred Stock | I | -10.074 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Entrepreneurs' Fund V, L.P. | LIFE | Series D Redeemable Convertible Preferred Stock | I | -28.661 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners V, L.P. | LIFE | Series D Redeemable Convertible Preferred Stock | I | -1.470.577 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Special Founders' Fund V, L.P. | LIFE | Series C Redeemable Convertible Preferred Stock | I | -42.087 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Founders' Fund V, L.P. | LIFE | Series C Redeemable Convertible Preferred Stock | I | -28.831 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Entrepreneurs' Fund V, L.P. | LIFE | Series C Redeemable Convertible Preferred Stock | I | -82.029 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners V, L.P. | LIFE | Series C Redeemable Convertible Preferred Stock | I | -4.208.756 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Special Founders' Fund V, L.P. | LIFE | Series B-2 Redeemable Convertible Preferred Stock | I | -41.686 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Founders' Fund V, L.P. | LIFE | Series B-2 Redeemable Convertible Preferred Stock | I | -28.556 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Entrepreneurs' Fund V, L.P. | LIFE | Series B-2 Redeemable Convertible Preferred Stock | I | -81.248 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners V, L.P. | LIFE | Series B-2 Redeemable Convertible Preferred Stock | I | -4.168.683 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir Polaris Venture Partners Special Founders' Fund V, L.P. | LIFE | Series B Redeemable Convertible Preferred Stock | I | -34.737 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Founders' Fund V, L.P. | LIFE | Series B Redeemable Convertible Preferred Stock | I | -23.796 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Entrepreneurs' Fund V, L.P. | LIFE | Series B Redeemable Convertible Preferred Stock | I | -67.704 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners V, L.P. | LIFE | Series B Redeemable Convertible Preferred Stock | I | -3.473.763 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir Polaris Venture Partners Special Founders' Fund V, L.P. | LIFE | Common Stock | I | 890 | 17.638 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Founders' Fund V, L.P. | LIFE | Common Stock | I | 610 | 12.082 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Entrepreneurs' Fund V, L.P. | LIFE | Common Stock | I | 1.736 | 34.378 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners V, L.P. | LIFE | Common Stock | I | 89.069 | 1.763.894 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir Polaris Venture Partners Special Founders' Fund V, L.P. | LIFE | Common Stock | I | 16.748 | 16.748 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Founders' Fund V, L.P. | LIFE | Common Stock | I | 11.472 | 11.472 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners Entrepreneurs' Fund V, L.P. | LIFE | Common Stock | I | 32.642 | 32.642 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Nashat Amir By Polaris Venture Partners V, L.P. | LIFE | Common Stock | I | 1.674.825 | 1.674.825 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Sofinnova Venture Partners IX, L.P. | LIFE | Series E Redeemable Convertible Preferred Stock | D | -14.968.722 | 0 | ||||||
| 2015-05-14 | 2015-05-12 | 4 | Sofinnova Venture Partners IX, L.P. | LIFE | Common Stock | D | 14,0000 | 320.000 | 4.480 | 1.866.126 | ||||
| 2015-05-14 | 2015-05-12 | 4 | Sofinnova Venture Partners IX, L.P. | LIFE | Common Stock | D | 1.546.126 | 1.546.126 | ||||||
| 2015-05-13 | 2015-05-12 | 4 | Flynn James E Through Deerfield Private Design Fund III, L.P. | LIFE | Series E Preferred Stock | I | -2.234.137 | 0 | ||||||
| 2015-05-13 | 2015-05-12 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | LIFE | Series E Preferred Stock | I | -2.234.137 | 0 | ||||||
| 2015-05-13 | 2015-05-12 | 4 | Flynn James E Through Deerfield Private Design Fund III, L.P. | LIFE | Common Stock | I | 14,0000 | 25.000 | 350 | 255.764 | ||||
| 2015-05-13 | 2015-05-12 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | LIFE | Common Stock | I | 14,0000 | 25.000 | 350 | 255.764 | ||||
| 2015-05-13 | 2015-05-12 | 4 | Flynn James E Through Deerfield Special Situations Fund, L.P. | LIFE | Common Stock | I | 230.764 | 230.764 | ||||||
| 2015-05-13 | 2015-05-12 | 4 | Flynn James E Through Deerfield Private Design Fund III, L.P. | LIFE | Common Stock | I | 230.764 | 230.764 | ||||||
| 2015-05-12 | 2015-05-12 | 4 | DP VIII Associates, L.P. | LIFE | Series E Preferred Stock | D | -6.581 | 0 | ||||||
| 2015-05-12 | 2015-05-12 | 4 | DP VIII Associates, L.P. | LIFE | Series D Preferred Stock | D | -11.182 | 0 | ||||||
| 2015-05-12 | 2015-05-12 | 4 | DP VIII Associates, L.P. | LIFE | Series C Preferred Stock | D | -90.110 | 0 | ||||||
| 2015-05-12 | 2015-05-12 | 4 | DP VIII Associates, L.P. | LIFE | Common Stock | D | 13.414 | 13.414 | ||||||
| 2015-05-12 | 2015-05-12 | 4 | Domain Partners VIII, L.P. | LIFE | Series E Preferred Stock | D | -887.073 | 0 | ||||||
| 2015-05-12 | 2015-05-12 | 4 | Domain Partners VIII, L.P. | LIFE | Series D Preferred Stock | D | -1.506.901 | 0 | ||||||
| 2015-05-12 | 2015-05-12 | 4 | Domain Partners VIII, L.P. | LIFE | Series C Preferred Stock | D | -12.143.933 | 0 | ||||||
| 2015-05-12 | 2015-05-12 | 4 | Domain Partners VIII, L.P. | LIFE | Common Stock | D | 1.807.820 | 1.807.820 | ||||||
| 2015-05-08 | 2015-05-06 | 4 | MENDLEIN JOHN | LIFE | Stock Option (right to buy) | D | 14,00 | 163.437 | 163.437 | |||||
| 2015-05-08 | 2015-05-06 | 4 | Ramsdell Fred | LIFE | Stock Option (right to buy) | D | 14,00 | 17.600 | 17.600 | |||||
| 2015-05-08 | 2015-05-06 | 4 | Chrzanowski Holly D. | LIFE | Stock Option (right to buy) | D | 14,00 | 11.943 | 11.943 | |||||
| 2015-05-08 | 2015-05-06 | 4 | McKew John C. | LIFE | Stock Option (right to buy) | D | 14,00 | 25.144 | 25.144 | |||||
| 2015-05-08 | 2015-05-06 | 4 | Blackburn Kelly | LIFE | Stock Option (right to buy) | D | 14,00 | 34.573 | 34.573 | |||||
| 2015-05-08 | 2015-05-06 | 4 | Blackburn Stan | LIFE | Stock Option (right to buy) | D | 14,00 | 4.085 | 4.085 | |||||
| 2015-05-08 | 2015-05-06 | 4 | Chereau Frederic | LIFE | Stock Option (right to buy) | D | 14,00 | 22.001 | 22.001 | |||||
| 2015-05-08 | 2015-05-06 | 4 | Graham Marcy | LIFE | Stock Option (right to buy) | D | 14,00 | 10.686 | 10.686 | |||||
| 2015-05-08 | 2015-05-06 | 4 | Krueger Nancy | LIFE | Stock Option (right to buy) | D | 14,00 | 8.800 | 8.800 | |||||
| 2015-05-08 | 2015-05-06 | 4 | Ashlock Melissa A. | LIFE | Stock Option (right to buy) | D | 14,00 | 25.144 | 25.144 | |||||
| 2015-05-08 | 2015-05-06 | 4 | Weiner David M. | LIFE | Stock Option (right to buy) | D | 14,00 | 44.002 | 44.002 | |||||
| 2015-05-08 | 2015-05-06 | 4 | Cubitt Andrew | LIFE | Stock Option (right to buy) | D | 14,00 | 5.657 | 5.657 | |||||
| 2015-05-06 | 3 | FALBERG KATHRYN E | LIFE | Common Stock | D | 25.144 | ||||||||
| 2015-05-06 | 3 | FALBERG KATHRYN E | LIFE | Common Stock | D | 25.144 | ||||||||
| 2015-05-06 | 3 | Nashat Amir | LIFE | Common Stock | D | 25.144 | ||||||||
| 2015-05-06 | 3 | Nashat Amir | LIFE | Common Stock | D | 25.144 | ||||||||
| 2015-05-06 | 3 | Ashlock Melissa A. | LIFE | Common Stock | D | 136.328 | ||||||||
| 2015-05-06 | 3 | Ashlock Melissa A. | LIFE | Common Stock | D | 136.328 | ||||||||
| 2015-05-06 | 3 | SCHIMMEL PAUL | LIFE | Common Stock | D | 148.853 | ||||||||
| 2015-05-06 | 3 | SCHIMMEL PAUL By Schimmel Revocable Trust U/A Dtd 9/6/2000 | LIFE | Common Stock | I | 269.419 | ||||||||
| 2015-05-06 | 3 | SCHIMMEL PAUL | LIFE | Common Stock | D | 148.853 | ||||||||
| 2015-05-06 | 3 | SCHIMMEL PAUL By Schimmel Revocable Trust U/A Dtd 9/6/2000 | LIFE | Common Stock | I | 269.419 | ||||||||
| 2015-05-06 | 3 | CLARKE JOHN K | LIFE | Common Stock | D | 25.144 | ||||||||
| 2015-05-06 | 3 | CLARKE JOHN K | LIFE | Common Stock | D | 25.144 | ||||||||
| 2015-05-06 | 3 | MENDLEIN JOHN | LIFE | Common Stock | D | 443.832 | ||||||||
| 2015-05-06 | 3 | MENDLEIN JOHN | LIFE | Common Stock | D | 443.832 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Kamdar Kim P. | LIFE | Common Stock | D | 18.858 | ||||||||
| 2015-05-06 | 3 | Chrzanowski Holly D. | LIFE | Common Stock | D | 3.770 | ||||||||
| 2015-05-06 | 3 | Chrzanowski Holly D. | LIFE | Common Stock | D | 3.770 | ||||||||
| 2015-05-06 | 3 | Blackburn Kelly | LIFE | Common Stock | D | 558 | ||||||||
| 2015-05-06 | 3 | Blackburn Kelly | LIFE | Common Stock | D | 558 | ||||||||
| 2015-05-06 | 3 | Chereau Frederic | LIFE | Common Stock | D | 25.734 | ||||||||
| 2015-05-06 | 3 | Chereau Frederic | LIFE | Common Stock | D | 25.734 | ||||||||
| 2015-05-06 | 3 | Blackburn Stan By the J. Stanhope Blackburn and Karlene S. Blackburn Family Trust U.T.D. May 9, 2001 | LIFE | Common Stock | I | 189.951 | ||||||||
| 2015-05-06 | 3 | Blackburn Stan | LIFE | Common Stock | D | 98.199 | ||||||||
| 2015-05-06 | 3 | Blackburn Stan By the J. Stanhope Blackburn and Karlene S. Blackburn Family Trust U.T.D. May 9, 2001 | LIFE | Common Stock | I | 189.951 | ||||||||
| 2015-05-06 | 3 | Blackburn Stan | LIFE | Common Stock | D | 98.199 | ||||||||
| 2015-05-06 | 3 | Weiner David M. | LIFE | Common Stock | D | 10.056 | ||||||||
| 2015-05-06 | 3 | Weiner David M. | LIFE | Common Stock | D | 10.056 |
